NO151797B - Apparat for toemming av beholdere hvori gass er lagret opploest under trykk i et opploesningsmiddel - Google Patents

Apparat for toemming av beholdere hvori gass er lagret opploest under trykk i et opploesningsmiddel Download PDF

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Publication number
NO151797B
NO151797B NO802984A NO802984A NO151797B NO 151797 B NO151797 B NO 151797B NO 802984 A NO802984 A NO 802984A NO 802984 A NO802984 A NO 802984A NO 151797 B NO151797 B NO 151797B
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Norway
Prior art keywords
dimethoxy
pyrimidine
amino group
emptying
group
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NO802984A
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English (en)
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NO151797C (no
NO802984L (no
Inventor
Helmut Meinass
Berhard Volz
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Linde Ag
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Publication date
Priority claimed from DE2940755A external-priority patent/DE2940755C2/de
Priority claimed from DE19803024251 external-priority patent/DE3024251A1/de
Application filed by Linde Ag filed Critical Linde Ag
Publication of NO802984L publication Critical patent/NO802984L/no
Publication of NO151797B publication Critical patent/NO151797B/no
Publication of NO151797C publication Critical patent/NO151797C/no

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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C13/00—Details of vessels or of the filling or discharging of vessels
    • F17C13/04—Arrangement or mounting of valves
    • F17C13/045—Automatic change-over switching assembly for bottled gas systems with two (or more) gas containers
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C7/00—Methods or apparatus for discharging liquefied, solidified, or compressed gases from pressure vessels, not covered by another subclass
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2203/00—Vessel construction, in particular walls or details thereof
    • F17C2203/06—Materials for walls or layers thereof; Properties or structures of walls or their materials
    • F17C2203/0634—Materials for walls or layers thereof
    • F17C2203/0636—Metals
    • F17C2203/0639—Steels
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2205/00—Vessel construction, in particular mounting arrangements, attachments or identifications means
    • F17C2205/01—Mounting arrangements
    • F17C2205/0123—Mounting arrangements characterised by number of vessels
    • F17C2205/013—Two or more vessels
    • F17C2205/0134—Two or more vessels characterised by the presence of fluid connection between vessels
    • F17C2205/0142—Two or more vessels characterised by the presence of fluid connection between vessels bundled in parallel
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2205/00—Vessel construction, in particular mounting arrangements, attachments or identifications means
    • F17C2205/03—Fluid connections, filters, valves, closure means or other attachments
    • F17C2205/0302—Fittings, valves, filters, or components in connection with the gas storage device
    • F17C2205/0323—Valves
    • F17C2205/0326—Valves electrically actuated
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2205/00—Vessel construction, in particular mounting arrangements, attachments or identifications means
    • F17C2205/03—Fluid connections, filters, valves, closure means or other attachments
    • F17C2205/0302—Fittings, valves, filters, or components in connection with the gas storage device
    • F17C2205/0323—Valves
    • F17C2205/0329—Valves manually actuated
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2205/00—Vessel construction, in particular mounting arrangements, attachments or identifications means
    • F17C2205/03—Fluid connections, filters, valves, closure means or other attachments
    • F17C2205/0302—Fittings, valves, filters, or components in connection with the gas storage device
    • F17C2205/0338—Pressure regulators
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2221/00—Handled fluid, in particular type of fluid
    • F17C2221/01—Pure fluids
    • F17C2221/018—Acetylene
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2223/00—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel
    • F17C2223/01—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel characterised by the phase
    • F17C2223/0146—Two-phase
    • F17C2223/0153—Liquefied gas, e.g. LPG, GPL
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2223/00—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel
    • F17C2223/03—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel characterised by the pressure level
    • F17C2223/033—Small pressure, e.g. for liquefied gas
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
    • F17C2227/01—Propulsion of the fluid
    • F17C2227/0114—Propulsion of the fluid with vacuum injectors, e.g. venturi
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
    • F17C2227/04—Methods for emptying or filling
    • F17C2227/041—Methods for emptying or filling vessel by vessel
    • F17C2227/042—Methods for emptying or filling vessel by vessel with change-over from one vessel to another
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
    • F17C2227/04—Methods for emptying or filling
    • F17C2227/046—Methods for emptying or filling by even emptying or filling
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2250/00—Accessories; Control means; Indicating, measuring or monitoring of parameters
    • F17C2250/04—Indicating or measuring of parameters as input values
    • F17C2250/0404—Parameters indicated or measured
    • F17C2250/043—Pressure
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2250/00—Accessories; Control means; Indicating, measuring or monitoring of parameters
    • F17C2250/04—Indicating or measuring of parameters as input values
    • F17C2250/0404—Parameters indicated or measured
    • F17C2250/0443—Flow or movement of content
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2250/00—Accessories; Control means; Indicating, measuring or monitoring of parameters
    • F17C2250/06—Controlling or regulating of parameters as output values
    • F17C2250/0605—Parameters
    • F17C2250/0626—Pressure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/2496—Self-proportioning or correlating systems
    • Y10T137/2559—Self-controlled branched flow systems
    • Y10T137/2562—Dividing and recombining
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/2496—Self-proportioning or correlating systems
    • Y10T137/2559—Self-controlled branched flow systems
    • Y10T137/2564—Plural inflows
    • Y10T137/2567—Alternate or successive inflows
    • Y10T137/2569—Control by depletion of source

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)

Description

Fremgangsmåte for fremstilling av antibakterielt virksomme 4-(NI-acyl-sulfanilamido)-5,6-dimethoxy-pyrimidiner.
Oppfinnelsen vedrører en fremgangsmåte for fremstilling av 4-(N,-acyl-sul-
fanilamido-5,6-dimethoxy-pyrimidin med den generelle formel II.
I denne formel betyr Ac en acylrest, f. eks. acylresten av en mettet eller umettet alifatisk karboxylsyre med 1—18 C-atomer, som maursyre, eddiksyre, propionsyre, smørsyre, laurinsyre, palmitinsyre, stearin-syre, oljesyre, av en aromatisk karboxylsyre, som benzoesyre, eller en aralifatisk karboxylsyre, som fenyleddiksyre. Fremgangsmåten ifølge oppfinnelsen som karakteriseres ved at man behandler en forbindelse med den generelle formel I
hvor R betyr en reduksjon eller hydrolyse i aminogruppen overførbar rest, med et acyleringsmiddel, f. eks. med et syre-halogenid eller med et syreanhydrid, og overfører deretter resten R ved reduksjon eller hydrolyse i den frie aminogruppe.
De i aminogruppen ved reduksjon eller hydrolyse overførbare R-rester kan f. eks. nevnes: nitrogruppen, en arylazogruppe, som fenylazogruppe, en gruppe med den generelle formel -N-CH-R', hvor R' betyr en fenylgruppe eller en alkyl- eller alkoxy-substituert fenylgruppe, således f. eks. ben-zylidenaminogruppen. Videre en acylamino-gruppe, en carbalkoxyamino- eller carbar-alkoxyaminogruppe, som carbethoxy- eller carbobenzoxyaminogruppen. Foretrukket blir vanligvis slike R-substituenter som re-duktivt lar seg overføre i aminogruppen, som nitro-, fenylazo- eller benzyliden-aminogruppen, idet derved N,-acylgruppen forblir intakt. Ved anvendelse av utgangs-materialer med hydrolyserbare R-substituenter må man huske på at R-substituentene med tilstrekkelig selektivitet, dvs. uten samtidig avspaltning av N,-acylgruppen, lar seg hydrolysere. En i denne hensikt spesielt egnet R-substituent er benzyliden-aminogruppen. Som det er funnet ut, lar denne gruppe seg lett forsåpe ved svak opp-varmning i vandig alkoholisk medium til aminogruppen uten at derved N,-acylgrup-pen avspaltes.
For reduksjonen av på reduktiv måte i aminogruppen overførbare R-substituenter egner seg spesielt katalytisk aktivert hydrogen, hvorved som katalysator f. eks. edel-metallkatalysatorer som palladium, kan finne anvendelse.
Behandlingen av utgangsforbindelsen med den generelle formel I med acylerings-midlet kan finne sted etter på i og for seg kjente metoder. Som regel foretar man omsetningen i nærvær av syrebindende middel, som uorganiske eller organiske baser, i særdeleshet tertiære aminer, som pyridin etc. Ved anvendelse av acylhalogenider som acyleringsmiddel kan man også gå ut fra metallsalter, som alkalimetallsaltene eller fortrinnsvis sølvsaltet av utgangssulfon-amidet. Omsetningen kan forøvrig foretas med eller uten anvendelse av organisk opp-løsnings- henholdsvis fortynningsmiddel, som dioxan, benzol, aceton, etc.
De etter fremgangsmåten ifølge oppfinnelsen erholdte 4-(N,-acyl-sulf anilamido)-5,6-dimethoxy-pyrimidiner, i særdeleshet 4- (N, -acyl-sulf anilamido) -5,6-di-methoxy-pyrimidiner utmerker seg ved høy antibakteriell virkning. Overfor det ikke acylerte grunnlegeme, 4-sulfanil-amido-5,6-dimethoxy-pyrimidinet, er de i smaklig henseende overlegne. De egner seg derfor særlig for peroral administrasjon, f. eks. i form av tabletter eller siruper. Av fordel er videre den overfor grunnlegemet økete opp-holdstid i organismen.
Fremgangsmåteproduktene kan finne anvendelse som legemiddel, f. eks. i form av farmasøytiske preparater, som inneholder disse i blanding med et for enteral eller parenteral administrasjon egnet farmasøy-tisk, organisk eller uorganisk inert bære-material.
Eksempel 1.
a) 33 g 4-(4'-nitro-benzolsulfonamido)-5,6-dimethoxy-pyrimidin i 70 ml absolutt
pyrimidin oppvarmes med 33 ml eddiksyreanhydrid 3 timer på dampbad. Oppløsnin-gen inndampes så under redusert trykk, resten tilsettes ethanol og krystallisatet nutsjes av. Det således erholdte 4-(N,-ace-tyl-4-nitro-benzolsulfonamido)-5,6-dime-thoxy-pyrimidin smelter etter krystallisasjon fra acetonitril ved 160—161° C. Utbytte: 94 pst. av det teoretiske.
b) 13 g av den således erholdte N,-acetylforbindelse hydreres i 450 ml iseddik
med 13 g palladiumkull (5 pst. Pd) som katalysator ved værelsestemperatur og atmosfæretrykk. Den beregnete mengde hydrogen opptas i løpet av 2 timer. Etter filtrering inndampes oppløsningen under redusert trykk, resten tilsettes absolutt alkohol og etter endt krystallisasjon nutsjes det erholdte 4- (N, -acyl-sulfanilamido) -5,6-dimethoxy-pyrimidin av. Utbyttet er prak-tisk talt kvantitativt. Smeltepunkt 201— 203° C (fra acetonitril).
Det som utgangsstoff anvendte 4-(4'-nitro-benzolsulfonamido)-5,6-dimethoxy-pyrimidin kan oppnås ved a) omsetning av 4-amino-5,6-dimethoxy-pyrimidin med 2 molekvivalenter p-nitro-benzolsulfoklorid og hydrolyse av det erholdte 4- (bis-4'-nitro-benzolsulfonamido)-5,6-dimethoxy-pyrimidin eller b) ved omsetning av 4,6-diklor-5-methoxy-pyrimidin med 2 molekvivalenter p-nitro-benzolsulfonamid-natrium og behandling av det erholdte 4-(4'-nitro-benzolsulfonamido)-5-methoxy-6-klor-pyrimidin med natriummethylat.
Eksempel 2.
a) 153 g 4-(4'-benzylidenamino-benzol-sulfonamido)-5,6-dimethoxy-pyrimidin
oppvarmes med 180 ml eddiksyreanhydrid 15 minutter under røring ved 55° C. Ved
55° C badtemperatur avdestilleres under redusert trykk ca. 360—370 ml av oppløs-ningsmidlet. Resten tilsettes under iskjøl-ing og røring 200 ml absolutt etanol. Blandingen røres 30 minutter ved 20—25° C og en time ved 5° C. Deretter nutsjes krystallisatet av. Man oppnår således 157 g (92 pst. av det teoretiske ) 4-(N,-acetyl-4'-benzyl-idenamino-benzolsulf onamido) -5,6-dimethoxy-pyrimidin med smeltepunkt 145 —146° C.
b) Man oppvarmer 1200 ml 80 pst. etanol til 55° C og tilsetter i løpet av 15 minutter 157 g av den erholdte N,-acetylforbin-delse. Etter at alt har løst seg ved 75° C
kokes oppløsningen enda 10 minutter under
tilbakeløp. Etter avkjølingen av oppløsnin-gen til 5° C og henstand (iy2 time) nutsjes
det erholdte 4- (N,-acetyl-sulfanilamido) -
5,6-dimethoxy-pyrimidin av. Smeltepunkt
201—203° C. Utbytte 97 pst.
Benzylidenresten lar seg også avspalte
på følgende måte:
10 g 4-(N,-acetyl-4'-benzylidenamino-benzolsulfonamido)-5,6-dimethoxy-pyrimidin oppløses i 800 ml methanol og hydreres i nærvær av 5 g palladiumkull (5 pst.) som katalysator ved værelsestemperatur og atmosfæretrykk. Etter 2 timer er den teoretiske hydrogenmengde opptatt. Man filtre-rer fra katalysatoren, inndamper filtratet under redusert trykk til et volum på ca. 30 ml og nutsjer det erholdte krystallisat av.
Man oppnår således 6 g 4-(N,-acetyl-sulfanilamido) -5,6-dimethoxy-pyrimidin med
smeltepunkt 201—203° C.
Det som utgangsstoff anvendte 4'-benzylidenaminoderivat kan oppnås på følgende måte: 124 g 4-sulfanilamido-5,6-dimethoxy-pyrimidin i 480 ml absolutt ethanol tilsettes ved 30° C 120 ml benzaldehyd. Blandingen oppvarmes i løpet av en time til 60° C, tilsettes 250 ml benzol og kokes derpå 20 minutter under tilbakeløp. Den noe avkjølte oppløsning inndampes under redusert trykk, og resten bringes til krystallisasjon med 100 ml absolutt methanol. Man oppnår således 153 g (96 pst. av det teoretiske) 4-(4'-benzylidenamino-benzolsulfon-amido) -5,6-dimethoxy-pyrimidin med smeltepunkt 179—181° C.

Claims (1)

  1. Fremgangsmåte for fremstilling av antibakterielt virksomme 4-(N,-acyl-sulf anilamido) -5,6-dimethoxy-pyrimidiner, karakterisert ved at man behandler en forbindelse med den generelle formel I
    hvor R betyr en ved reduksjon eller hydrolyse til aminogruppen overførbar rest, i særdeleshet en nitro- eller benzyliden-aminogruppe, med et acyleringsmiddel, for- trinnsvis med et acetyleringsmiddel, og overfører deretter resten R ved reduksjon eller hydrolyse i den frie aminogruppe.
NO802984A 1979-10-08 1980-10-07 Apparat for toemming av beholdere hvori gass er lagret opploest under trykk i et opploesningsmiddel NO151797C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2940755A DE2940755C2 (de) 1979-10-08 1979-10-08 Vorrichtung zum Entleeren von Behältern
DE19803024251 DE3024251A1 (de) 1980-06-27 1980-06-27 Verfahren und vorrichtung zum entleeren von behaeltern, in denen gas unter druck in einem loesungsmittel geloest gespeichert ist

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NO802984L NO802984L (no) 1981-04-09
NO151797B true NO151797B (no) 1985-02-25
NO151797C NO151797C (no) 1985-06-05

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NO802984A NO151797C (no) 1979-10-08 1980-10-07 Apparat for toemming av beholdere hvori gass er lagret opploest under trykk i et opploesningsmiddel

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US (1) US4341234A (no)
EP (1) EP0026934B1 (no)
AU (1) AU534700B2 (no)
BR (1) BR8006432A (no)
DE (1) DE3068611D1 (no)
DK (1) DK423480A (no)
ES (1) ES8106049A1 (no)
GR (1) GR70687B (no)
NO (1) NO151797C (no)

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Publication number Priority date Publication date Assignee Title
US4523548A (en) * 1983-04-13 1985-06-18 Michigan Consolidated Gas Company Gaseous hydrocarbon fuel storage system and power plant for vehicles
US4531558A (en) * 1983-04-13 1985-07-30 Michigan Consolidated Gas Co. Gaseous fuel refueling apparatus
US4522159A (en) * 1983-04-13 1985-06-11 Michigan Consolidated Gas Co. Gaseous hydrocarbon fuel storage system and power plant for vehicles and associated refueling apparatus
US4930550A (en) * 1985-11-13 1990-06-05 Fuel Concepts, Inc. Gaseous fueled torch apparatus and fueling module therefor
US4776366A (en) * 1985-11-13 1988-10-11 Michigan Consolidated Gas Company Gaseous fueled torch apparatus and fueling module therefor
JPS6326500A (ja) * 1986-07-18 1988-02-04 Fujitsu Ltd 圧縮ガス容器系統自動切換装置
DE3733442A1 (de) * 1987-10-02 1989-04-13 Linde Ag Verfahren und vorrichtung zum entleeren von mit gas gefuellten behaeltern
US5025824A (en) * 1990-09-26 1991-06-25 Union Carbide Canada Limited Automatic changeover manifold
US5062443A (en) * 1990-09-26 1991-11-05 Union Carbide Canada Limited Automatic changeover manifold
US6105598A (en) * 1996-06-14 2000-08-22 United States Filter Corporation Low capacity chlorine gas feed system
US6308724B1 (en) 1998-04-03 2001-10-30 United States Filter Corporation Low capacity chlorine gas feed system
US6120606A (en) * 1998-06-26 2000-09-19 Acer Semiconductor Manufacturing Inc. Gas vent system for a vacuum chamber
US6263900B1 (en) 2000-02-17 2001-07-24 United States Filter Corporation Low capacity chlorine gas feed system
US6615861B2 (en) 2001-04-20 2003-09-09 Chart Inc. Liquid cylinder manifold system
US6763846B2 (en) * 2001-08-20 2004-07-20 United States Filter Corporation Fluid distribution device
FR2841890B1 (fr) * 2002-07-03 2004-08-06 Air Liquide Procede de vidage/remplissage sequentiel et cyclique d'un ensemble multi-reservoirs de stockage-alimentation en fluide et installation correspondante
FR2872562A1 (fr) * 2004-07-01 2006-01-06 Air Liquide Procede et dispositif pour fournir de l'acetylene pendant un pic de consommation
FR2918734A1 (fr) * 2007-07-09 2009-01-16 Air Liquide Procede de transfert d'un fluide a un poste utilisateur et centrale d'inversion mettant en oeuvre ce procede.
DE102008020803A1 (de) * 2008-04-23 2009-10-29 Volkswagen Ag Gastank-Entleerungs-System zur Entleerung von Gasdruckbehältern
US8453682B2 (en) * 2010-05-24 2013-06-04 Air Products And Chemicals, Inc. Compressed gas dispensing method
JP5722186B2 (ja) * 2010-11-04 2015-05-20 大陽日酸株式会社 液化ガス供給方法
DE102011012154A1 (de) * 2011-02-24 2012-08-30 Linde Ag Vorrichtung zur Druckreduzierung
US10386019B2 (en) 2013-03-15 2019-08-20 Southwire Company, Llc Flow control and gas metering process
US9857804B2 (en) 2015-12-23 2018-01-02 Praxair Technology, Inc. Method and system for optimizing acetylene delivery
DK201770842A1 (en) * 2017-11-09 2019-05-21 Steeper Energy Aps Modular processing system
TWI809498B (zh) * 2020-09-18 2023-07-21 美商慧盛材料美國責任有限公司 材料供應系統及使從氣體供應和分配系統分配的氣體的壓力變化實質上降低之方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1841325A (en) * 1928-12-24 1932-01-12 Air Reduction Means for draining gas cylinders
GB525854A (en) * 1939-03-02 1940-09-05 Reyrolle A & Co Ltd Improvements in or relating to the delivery of gas under pressure
US2547823A (en) * 1944-05-10 1951-04-03 Josephian William Regulator system
US2968162A (en) * 1959-01-26 1961-01-17 Union Carbide Corp Automatic changeover manifold
DE1257176B (de) * 1965-02-26 1967-12-28 Draegerwerk Ag Umschaltvorrichtung fuer eine Druckgasversorgungsanlage mit zwei Druckgasbatterien
GB1266163A (no) * 1969-08-07 1972-03-08
DE1960448A1 (de) * 1969-12-02 1971-06-09 Philipp Kreis Zuschalteinrichtung fuer Gasflaschenanschluesse
US3643677A (en) * 1970-04-29 1972-02-22 Miner Ind Inc Compressed gas supply system
DE2441886A1 (de) * 1974-09-02 1976-03-11 Basi Schoeberl & Co Rastatt Umschalt- und kontrolleinrichtung fuer zentrale gas-versorgungsanlagen
US4202180A (en) * 1978-10-13 1980-05-13 The Scott & Fetzer Company Liquefied gas supply system

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BR8006432A (pt) 1981-04-14
ES495667A0 (es) 1981-07-01
AU534700B2 (en) 1984-02-09
AU6305080A (en) 1981-04-16
GR70687B (no) 1982-12-20
DE3068611D1 (en) 1984-08-23
DK423480A (da) 1981-04-09
NO151797C (no) 1985-06-05
US4341234A (en) 1982-07-27
EP0026934B1 (de) 1984-07-18
NO802984L (no) 1981-04-09
ES8106049A1 (es) 1981-07-01
EP0026934A1 (de) 1981-04-15

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