NO137094C - Analogifremgangsm}te til fremstilling av terapeutisk aktive 6-aza-3h-1,4-benzodiazepiner. - Google Patents

Analogifremgangsm}te til fremstilling av terapeutisk aktive 6-aza-3h-1,4-benzodiazepiner.

Info

Publication number
NO137094C
NO137094C NO4536/72A NO453672A NO137094C NO 137094 C NO137094 C NO 137094C NO 4536/72 A NO4536/72 A NO 4536/72A NO 453672 A NO453672 A NO 453672A NO 137094 C NO137094 C NO 137094C
Authority
NO
Norway
Prior art keywords
benzodiazepines
aza
preparation
therapeutic active
analogical procedure
Prior art date
Application number
NO4536/72A
Other languages
English (en)
Norwegian (no)
Other versions
NO137094B (no
Inventor
Walter Von Bebenburg
Heribert Offermanns
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of NO137094B publication Critical patent/NO137094B/no
Publication of NO137094C publication Critical patent/NO137094C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
NO4536/72A 1971-12-09 1972-12-08 Analogifremgangsm}te til fremstilling av terapeutisk aktive 6-aza-3h-1,4-benzodiazepiner. NO137094C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT1060471A AT333284B (de) 1971-12-09 1971-12-09 Verfahren zur herstellung von neuen 6-aza-3h-1,4-benzodiazepinen, deren optischen isomeren und deren salzen

Publications (2)

Publication Number Publication Date
NO137094B NO137094B (no) 1977-09-19
NO137094C true NO137094C (no) 1977-12-28

Family

ID=3623479

Family Applications (1)

Application Number Title Priority Date Filing Date
NO4536/72A NO137094C (no) 1971-12-09 1972-12-08 Analogifremgangsm}te til fremstilling av terapeutisk aktive 6-aza-3h-1,4-benzodiazepiner.

Country Status (26)

Country Link
JP (4) JPS569509B2 (fr)
AR (3) AR201201A1 (fr)
AT (4) AT332878B (fr)
AU (1) AU473253B2 (fr)
BE (1) BE792541A (fr)
CH (4) CH594665A5 (fr)
CS (1) CS212736B2 (fr)
DD (1) DD105448A5 (fr)
DE (1) DE2259471C2 (fr)
DK (1) DK138425B (fr)
EG (1) EG10918A (fr)
ES (2) ES409090A1 (fr)
FI (1) FI54710C (fr)
FR (1) FR2162482B1 (fr)
GB (1) GB1400755A (fr)
HU (1) HU169468B (fr)
IL (1) IL41034A (fr)
IT (1) IT1035053B (fr)
NL (1) NL171986C (fr)
NO (1) NO137094C (fr)
PL (3) PL91828B1 (fr)
RO (4) RO65263A (fr)
SE (1) SE404803B (fr)
SU (4) SU468423A3 (fr)
YU (2) YU305972A (fr)
ZA (1) ZA728497B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2364636C2 (de) * 1973-12-24 1982-11-04 Degussa Ag, 6000 Frankfurt Verfahren zur Herstellung von 2-Benzoyl-6-chlor-3-nitro-pyridinen
DE3067662D1 (en) * 1980-01-16 1984-06-07 Lacer Sa New 2-halo-pyridines, their production and pharmaceutical compositions
JPS60132610A (ja) * 1983-12-20 1985-07-15 Japan Organo Co Ltd 汚泥脱水装置
JPS6219221A (ja) * 1985-07-16 1987-01-28 Chiyoda Chem Eng & Constr Co Ltd 原液中の微細粒子を除去する濾過方法と濾過装置

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3314941A (en) * 1964-06-23 1967-04-18 American Cyanamid Co Novel substituted pyridodiazepins
US3523939A (en) * 1967-07-03 1970-08-11 Hoffmann La Roche 5-(2,6-disubstituted phenyl)-1,4-benzodiazepines and methods for their preparation

Also Published As

Publication number Publication date
SU468423A3 (ru) 1975-04-25
ATA902174A (de) 1976-02-15
ES409090A1 (es) 1975-10-16
DE2259471C2 (de) 1982-08-19
JPS55147282A (en) 1980-11-17
FI54710C (fi) 1979-02-12
NO137094B (no) 1977-09-19
SU674675A3 (ru) 1979-07-15
AT332877B (de) 1976-10-25
NL7216621A (fr) 1973-06-13
NL171986B (nl) 1983-01-17
RO65263A (fr) 1983-07-07
AT332878B (de) 1976-10-25
RO62312A (fr) 1977-12-15
JPS5744678B2 (fr) 1982-09-22
AU473253B2 (en) 1976-06-17
PL91876B1 (en) 1977-03-31
PL91828B1 (en) 1977-03-31
RO65264A (fr) 1979-08-15
AT333284B (de) 1976-11-10
CH603645A5 (fr) 1978-08-31
ZA728497B (en) 1973-09-26
AT338798B (de) 1977-09-12
JPS5742639B2 (fr) 1982-09-09
DK138425C (fr) 1979-02-12
AU4993172A (en) 1974-06-13
RO65263B (ro) 1983-06-30
JPS4864096A (fr) 1973-09-05
JPS5625181A (en) 1981-03-10
CH594665A5 (fr) 1978-01-13
BE792541A (fr) 1973-06-08
ATA902074A (de) 1977-01-15
YU116881A (en) 1984-02-29
GB1400755A (en) 1975-07-23
RO67345A (fr) 1980-07-15
FI54710B (fi) 1978-10-31
CH603644A5 (fr) 1978-08-31
SU564809A3 (ru) 1977-07-05
HU169468B (fr) 1976-11-28
JPS5625180A (en) 1981-03-10
IL41034A0 (en) 1973-02-28
ATA1060471A (de) 1976-03-15
DE2259471A1 (de) 1973-06-14
FR2162482A1 (fr) 1973-07-20
YU305972A (en) 1982-02-28
CH605946A5 (fr) 1978-10-13
IT1035053B (it) 1979-10-20
PL89682B1 (en) 1976-12-31
CS212736B2 (en) 1982-03-26
DK138425B (da) 1978-09-04
ATA902274A (de) 1976-02-15
JPS569509B2 (fr) 1981-03-02
IL41034A (en) 1976-10-31
SE404803B (sv) 1978-10-30
AR201201A1 (es) 1975-02-21
FR2162482B1 (fr) 1976-03-05
AR200309A1 (es) 1974-10-31
SU574156A3 (ru) 1977-09-25
EG10918A (en) 1981-12-31
AR203311A1 (es) 1975-08-29
ES409089A1 (es) 1975-10-16
NL171986C (nl) 1983-06-16
JPS5742638B2 (fr) 1982-09-09
DD105448A5 (fr) 1974-04-20

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