NL8802393A - Vaccin dat tumor-antigenen en hulpstoffen bevat en werkwijze voor de bereiding daarvan. - Google Patents
Vaccin dat tumor-antigenen en hulpstoffen bevat en werkwijze voor de bereiding daarvan. Download PDFInfo
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- NL8802393A NL8802393A NL8802393A NL8802393A NL8802393A NL 8802393 A NL8802393 A NL 8802393A NL 8802393 A NL8802393 A NL 8802393A NL 8802393 A NL8802393 A NL 8802393A NL 8802393 A NL8802393 A NL 8802393A
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- Prior art keywords
- tumor
- mpl
- tumors
- endotoxin
- cell wall
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A—HUMAN NECESSITIES
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/5555—Muramyl dipeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
- A61K2039/55594—Adjuvants of undefined constitution from bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
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- Immunology (AREA)
- Medicinal Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/102,909 US4877611A (en) | 1986-04-15 | 1987-09-30 | Vaccine containing tumor antigens and adjuvants |
| US10290987 | 1987-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8802393A true NL8802393A (nl) | 1989-04-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8802393A NL8802393A (nl) | 1987-09-30 | 1988-09-29 | Vaccin dat tumor-antigenen en hulpstoffen bevat en werkwijze voor de bereiding daarvan. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4877611A (it) |
| JP (1) | JPH01163130A (it) |
| BE (1) | BE1001634A4 (it) |
| CA (1) | CA1333152C (it) |
| CH (1) | CH678492A5 (it) |
| DE (1) | DE3833319A1 (it) |
| FR (1) | FR2620941B1 (it) |
| GB (1) | GB2210557B (it) |
| IT (1) | IT1226861B (it) |
| NL (1) | NL8802393A (it) |
Families Citing this family (222)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05503837A (ja) * | 1987-12-09 | 1993-06-24 | ザ・ジェネラル・ホスピタル・コーポレーション | 癌関連抗原およびその抗原を認識する抗体 |
| US5212085A (en) * | 1987-12-09 | 1993-05-18 | The General Hospital Corporation | Sf-25 colon adenocarcinoma antigen, and antibodies with recognize this antigen |
| DE3922444A1 (de) * | 1988-03-01 | 1991-01-10 | Deutsches Krebsforsch | Virusmodifizierte tumorvakzine fuer die immuntherapie von tumormetastasen |
| US6093406A (en) * | 1988-06-02 | 2000-07-25 | The United States Of America As Represented By The Secretary Of The Army | Vaccine for induction of immunity to malaria |
| JPH04501663A (ja) * | 1988-09-23 | 1992-03-26 | ユニバーシティ・オブ・サザン・カリフォルニア | 黒色腫用免疫療法ワクチン |
| US4963364A (en) * | 1989-04-10 | 1990-10-16 | Fox Sidney W | Microencapsulated antitumor agent |
| EP0474727B1 (en) * | 1989-05-19 | 1997-07-23 | Genentech, Inc. | Her2 extracellular domain |
| US6177083B1 (en) * | 1990-07-26 | 2001-01-23 | Evax Technologies Gmbh | Process for the production of vaccines and their use |
| EP0472467A3 (en) * | 1990-08-20 | 1993-03-17 | Chiba Flour Milling Co. Ltd. | Lps-containing analgesics and veterinary analgesics |
| GB9105992D0 (en) * | 1991-03-21 | 1991-05-08 | Smithkline Beecham Biolog | Vaccine |
| US6197311B1 (en) * | 1991-07-25 | 2001-03-06 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
| US5709860A (en) * | 1991-07-25 | 1998-01-20 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
| EP0533517A1 (en) * | 1991-08-20 | 1993-03-24 | Chiba Flour Milling Co. Ltd. | LPS-containing anti-withdrawal agents |
| AU660325B2 (en) * | 1991-10-11 | 1995-06-22 | Eisai Co. Ltd. | Anti-endotoxin compounds and related molecules and methods |
| US5530113A (en) * | 1991-10-11 | 1996-06-25 | Eisai Co., Ltd. | Anti-endotoxin compounds |
| ES2143716T3 (es) * | 1992-06-25 | 2000-05-16 | Smithkline Beecham Biolog | Composicion de vacuna que contiene adyuvantes. |
| EP0681480B1 (en) * | 1993-03-16 | 2004-01-07 | Samuel Dr. Bogoch | Recognin vaccines |
| SG48309A1 (en) * | 1993-03-23 | 1998-04-17 | Smithkline Beecham Biolog | Vaccine compositions containing 3-0 deacylated monophosphoryl lipid a |
| AU686660B2 (en) * | 1993-08-11 | 1998-02-12 | Jenner Technologies | Prostatic cancer vaccine |
| CA2261433A1 (en) * | 1993-12-09 | 1995-06-10 | Belinda Sanchez Ramirez | Composition comprising autologous epidermal growth factor |
| USD365131S (en) | 1994-05-25 | 1995-12-12 | Royal Grip, Inc. | Golf club grip |
| US6218166B1 (en) | 1994-12-09 | 2001-04-17 | John Wayne Cancer Institute | Adjuvant incorporation into antigen carrying cells: compositions and methods |
| FR2733151B1 (fr) * | 1995-04-20 | 1997-05-23 | Seppic Sa | Composition therapeutique comprenant un antigene ou un generateur in vivo d'un compose comprenant une sequence d'acides amines |
| US6689370B1 (en) | 1995-04-20 | 2004-02-10 | Societe D'exploitation De Produits Pour Les Industries Chimiques (S.E.P.P.I.C.) | Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence |
| US6117432A (en) * | 1995-04-20 | 2000-09-12 | Societe D'exploitation De Produits Pour Les Industries Chimiques (S.E.P.P.I.C.) | Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence |
| US6290969B1 (en) * | 1995-09-01 | 2001-09-18 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
| US6592877B1 (en) * | 1995-09-01 | 2003-07-15 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
| US6458366B1 (en) | 1995-09-01 | 2002-10-01 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
| US6406689B1 (en) | 1995-10-03 | 2002-06-18 | Frank W. Falkenberg | Compositions and methods for treatment of tumors and metastatic diseases |
| US6303584B1 (en) | 1996-11-20 | 2001-10-16 | The University Of Montana | Water soluble lipidated arabinogalactan |
| ATE227996T1 (de) | 1997-08-05 | 2002-12-15 | Bioniche Life Sciences Inc | Zusammensetzung und verfahren zur regulierung von zellproliferation und zelltod |
| US20020147143A1 (en) | 1998-03-18 | 2002-10-10 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US6280742B1 (en) | 1998-06-17 | 2001-08-28 | Zonagen, Inc. | Methods and materials for the treatment of prostatic carcinoma |
| US7534443B1 (en) * | 1998-07-16 | 2009-05-19 | Ichiro Azuma | Preparations for immunotherapy for cancer having bacterial somatic constituent as the active ingredient |
| KR20010085348A (ko) | 1998-08-07 | 2001-09-07 | 추후보정 | 면역능을 갖는 헤르페스 심플렉스 바이러스 항원 및 이를이용하는 방법 |
| US20030235557A1 (en) | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US20010033839A1 (en) * | 1999-10-04 | 2001-10-25 | Emilio Barbera-Guillem | Vaccine and immunotherapy for solid nonlymphoid tumor and related immune dysregulation |
| KR20100132086A (ko) | 1998-12-08 | 2010-12-16 | 코릭사 코포레이션 | 클라미디아 감염을 치료 및 진단하기 위한 조성물 및 이를 포함하는 약제학적 조성물 및 진단 키트 |
| US20020119158A1 (en) | 1998-12-17 | 2002-08-29 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
| US6579973B1 (en) | 1998-12-28 | 2003-06-17 | Corixa Corporation | Compositions for the treatment and diagnosis of breast cancer and methods for their use |
| CZ20013527A3 (cs) | 1999-04-02 | 2002-10-16 | Corixa Corporation | Sloučeniny a způsoby pro terapii a diagnostiku karcinomu plic |
| US8143386B2 (en) * | 1999-04-07 | 2012-03-27 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis antigens and their uses |
| WO2001024820A1 (en) * | 1999-10-07 | 2001-04-12 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis |
| ES2340807T3 (es) * | 1999-12-13 | 2010-06-09 | Bioniche Life Sciences Inc. | Oligonucleotidos sinteticos utiles terapeuticamente. |
| EP1250152B1 (en) * | 1999-12-28 | 2013-05-15 | Bioniche Urology IP Inc. | Synergistic composition containing hyaluronic acid in the treatment of cancer |
| DK1265915T3 (da) | 2000-02-23 | 2011-02-14 | Glaxosmithkline Biolog Sa | Nye forbindelser |
| AU2001241738A1 (en) * | 2000-02-25 | 2001-09-03 | Corixa Corporation | Compounds and methods for diagnosis and immunotherapy of tuberculosis |
| US20040002068A1 (en) | 2000-03-01 | 2004-01-01 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
| DE60133190T2 (de) | 2000-04-21 | 2009-04-02 | CORIXA CORP., Wilmington | Verbindungen und verfahren zur behandlung und diagnose von chlamydia-infektionen |
| US20030139356A1 (en) | 2001-05-18 | 2003-07-24 | Persing David H. | Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide-based compounds |
| CN1606446A (zh) | 2000-05-19 | 2005-04-13 | 科里克萨有限公司 | 用单糖和二糖类化合物预防和治疗传染病和其他疾病的方法 |
| SI1542732T1 (sl) * | 2000-06-20 | 2010-01-29 | Corixa Corp Csc The United Sta | Fuzijski proteini Mycobacterium tuberculosis |
| WO2002000174A2 (en) | 2000-06-28 | 2002-01-03 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US8568766B2 (en) | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
| GB0105360D0 (en) * | 2001-03-03 | 2001-04-18 | Glaxo Group Ltd | Chimaeric immunogens |
| DE10112851C1 (de) | 2001-03-16 | 2002-10-10 | Gsf Forschungszentrum Umwelt | Semi-allogene Antitumor-Vakzine mit HLA-haplo-identischen Antigen-präsentierenden Zellen |
| CU22999A1 (es) * | 2001-12-04 | 2004-10-12 | Centro Inmunologia Molecular | Método de tratamiento de enfermedades malignas e infecciosas crónicas |
| WO2002089747A2 (en) | 2001-05-09 | 2002-11-14 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| DE10132502A1 (de) * | 2001-07-05 | 2003-01-23 | Gsf Forschungszentrum Umwelt | Angriff auf Tumorzellen mit fehlender, niedriger oder anormaler MHC-Expression durch kombinieren von nicht MHC-Restringierten T-Zellen/NK-Zellen und MHC-Restringierten Zellen |
| WO2003005952A2 (en) | 2001-07-10 | 2003-01-23 | Corixa Corporation | Compositions and methods for delivery of proteins and adjuvants encapsulated in microspheres |
| EP1427826B1 (en) * | 2001-09-20 | 2011-04-20 | Glaxo Group Limited | HIV- RT-nef-Gag codon optimised DNA vaccines |
| US20050002951A1 (en) * | 2001-09-28 | 2005-01-06 | Haruo Sugiyama | Novel method of inducing antigen-specific t cells |
| US20030215460A1 (en) * | 2002-05-07 | 2003-11-20 | Schall Thomas J. | Methods and compositions for inducing an immune response |
| US20030157101A1 (en) * | 2001-11-15 | 2003-08-21 | Carlo Gambacorti-Passerini | Immunogenic ALK peptides |
| CA2476755C (en) | 2001-12-17 | 2014-08-26 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of inflammatory bowel disease |
| US7026465B2 (en) * | 2002-02-15 | 2006-04-11 | Corixa Corporation | Fusion proteins of Mycobacterium tuberculosis |
| AU2003213640A1 (en) * | 2002-02-28 | 2003-09-16 | Corixa Corporation | Methods of modulating dendritic cells using adjuvants |
| US20030224013A1 (en) * | 2002-04-19 | 2003-12-04 | Cole Garry T. | Methods for protection against Coccidioides spp. infection using Coccidioides spp. urea amidohydrolase (Ure) protein |
| DK1523582T3 (da) | 2002-07-18 | 2009-03-02 | Univ Washington | Hurtig, effektiv rensning af HSV-specifikke T-lymfocytter samt HSV-antigener identificeret derved |
| EP1547607A4 (en) * | 2002-08-02 | 2008-11-26 | Dainippon Sumitomo Pharma Co | PREPARATION OF A COMPONENT OF BACTERIA CELL WALL SKELETON |
| CA2514303C (en) * | 2002-11-13 | 2012-09-18 | The Uab Research Foundation | Synthetic single domain polypeptides mimicking apolipoprotein e and methods of use |
| RU2389732C2 (ru) | 2003-01-06 | 2010-05-20 | Корикса Корпорейшн | Некоторые аминоалкилглюкозаминидфосфатные производные и их применение |
| US7960522B2 (en) | 2003-01-06 | 2011-06-14 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
| EP1713900A4 (en) * | 2004-01-27 | 2009-06-17 | Compugen Ltd | METHOD AND SYSTEMS FOR COMMENTING BIOMOLECULAR SEQUENCES |
| EP1741438A4 (en) * | 2004-04-22 | 2009-08-26 | Dainippon Sumitomo Pharma Co | PHARMACEUTICAL PREPARATION CONTAINING SKELETAL COMPONENT OF BACTERIAL CELL WALL |
| AU2005285513B2 (en) | 2004-05-25 | 2011-02-24 | Oregon Health And Science University | SIV and HIV vaccination using RhCMV- and HCMV-based vaccine vectors |
| DE602005025342D1 (de) | 2004-05-28 | 2011-01-27 | Glaxosmithkline Biolog Sa | Impfstoffzusammensetzungen mit virosomen und einem saponin-adjuvans |
| EP2808384B1 (en) | 2004-10-08 | 2017-12-06 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Modulation of replicative fitness by using less frequently used synonymous codons |
| US7332324B2 (en) | 2004-12-03 | 2008-02-19 | University Of Toledo | Attenuated vaccine useful for immunizations against Coccidioides spp. infections |
| GB0427131D0 (en) * | 2004-12-10 | 2005-01-12 | Glaxosmithkline Biolog Sa | Novel combination |
| EA201001322A1 (ru) | 2005-03-31 | 2011-02-28 | Глаксосмитклайн Байолоджикалс С.А. | Вакцины против хламидиоза |
| ATE543832T1 (de) | 2005-04-29 | 2012-02-15 | Glaxosmithkline Biolog Sa | Verfahren zur vorbeugung oder behandlung einer m.-tuberculosis-infektion |
| WO2007015783A2 (en) * | 2005-07-22 | 2007-02-08 | Research Development Foundation | Attenuated strains of flaviviruses , and uses thereof |
| AU2006304640B2 (en) | 2005-10-18 | 2012-10-11 | Novavax, Inc. | Functional influenza virus like particles (VLPs) |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| US7622128B2 (en) * | 2005-12-13 | 2009-11-24 | University Of Washington | Porphyromonas gingivalis 1435/1449 LPS as an immune modulator |
| EP1981905B1 (en) | 2006-01-16 | 2016-08-31 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Chlamydia vaccine |
| US8153116B2 (en) | 2006-07-11 | 2012-04-10 | University Of Connecticut | Use of conditional plasmodium strains lacking an essential gene in malaria vaccination |
| US8128921B2 (en) * | 2006-07-11 | 2012-03-06 | University Of Connecticut | Use of conditional plasmodium strains lacking nutrient transporters in malaria vaccination |
| TR201807756T4 (tr) | 2006-09-26 | 2018-06-21 | Infectious Disease Res Inst | Sentetik adjuvan içeren aşı bileşimi. |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| JP5578390B2 (ja) * | 2007-03-05 | 2014-08-27 | 株式会社 Ｍｂｒ | 細菌細胞壁骨格成分の製造方法 |
| US8486414B2 (en) | 2007-04-04 | 2013-07-16 | Infectious Disease Research Institute | Immunogenic compositions comprising Mycobacterium tuberculosis polypeptides and fusions thereof |
| TW200908994A (en) | 2007-04-20 | 2009-03-01 | Glaxosmithkline Biolog Sa | Vaccine |
| ES2725450T3 (es) | 2007-07-02 | 2019-09-24 | Etubics Corp | Métodos y composiciones para la producción de un vector adenoviral para su uso en vacunaciones múltiples |
| JP2010533737A (ja) | 2007-07-19 | 2010-10-28 | ノババックス，インコーポレイテッド | キメラ水痘帯状疱疹ウイルス−ウイルス様粒子 |
| AU2008296487A1 (en) | 2007-08-28 | 2009-03-12 | The Uab Research Foundation | Synthetic apolipoprotein E mimicking polypeptides and methods of use |
| EP2682400B1 (en) | 2007-08-28 | 2017-09-20 | Uab Research Foundation | Synthetic apolipoprotein E mimicking polypeptides and methods of use |
| US20090215710A1 (en) * | 2007-09-24 | 2009-08-27 | Reliance Life Sciences Pvt. Ltd. | Carbohydrate based toll-like receptor (tlr) antagonists |
| US20090215908A1 (en) * | 2007-09-24 | 2009-08-27 | Reliance Life Sciences Pvt. Ltd. | Toll like receptor (tlr) signaling antagonist |
| ES2445755T3 (es) | 2007-11-07 | 2014-03-05 | Celldex Therapeutics, Inc. | Anticuerpos que se unen a células dendríticas y epiteliales humanas 205 (DEC-205) |
| EP4206231A1 (en) * | 2007-12-24 | 2023-07-05 | ID Biomedical Corporation of Quebec | Recombinant rsv antigens |
| EP2245055A2 (en) * | 2008-01-31 | 2010-11-03 | Compugen Ltd. | Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics |
| EP2300041B1 (en) | 2008-04-16 | 2016-01-27 | The Johns Hopkins University | Method for determining risk of recurrence of prostate cancer |
| BRPI0915960A2 (pt) * | 2008-07-18 | 2019-09-24 | Id Biomedical Corp | antígenos de polipeptídeos do vírus sincicial respiratório qimérico |
| US8697854B2 (en) | 2008-11-24 | 2014-04-15 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt Gmbh | High affinity T cell receptor and use thereof |
| EP2370455B1 (en) | 2008-11-26 | 2019-07-03 | Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | Virus like particle compositions and methods of use |
| MX2011006205A (es) | 2008-12-09 | 2011-09-01 | Novavax Inc | Proteinas f del vrs modificadas y metodos de uso de las mismas. |
| WO2010094663A1 (en) | 2009-02-17 | 2010-08-26 | Glaxosmithkline Biologicals S.A. | Inactivated dengue virus vaccine with aluminium-free adjuvant |
| EP2437753B1 (en) | 2009-06-05 | 2016-08-31 | Infectious Disease Research Institute | Synthetic glucopyranosyl lipid adjuvants and vaccine compositions containing them |
| MX2012000036A (es) | 2009-06-24 | 2012-02-28 | Glaxosmithkline Biolog Sa | Vacuna. |
| WO2010149745A1 (en) | 2009-06-24 | 2010-12-29 | Glaxosmithkline Biologicals S.A. | Recombinant rsv antigens |
| US9907746B2 (en) | 2009-07-06 | 2018-03-06 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| WO2011005769A1 (en) | 2009-07-06 | 2011-01-13 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| HRP20220756T1 (hr) | 2009-07-15 | 2022-09-02 | Glaxosmithkline Biologicals S.A. | Proteinski pripravci rsv f i postupci za izradu istih |
| GB0919117D0 (en) | 2009-10-30 | 2009-12-16 | Glaxosmithkline Biolog Sa | Process |
| KR101125764B1 (ko) | 2010-01-27 | 2012-03-27 | 백태현 | 항산균 세포벽골격을 이용한 백신매개체 및 그에 의한 백신의 제조 방법 |
| WO2011130434A2 (en) | 2010-04-13 | 2011-10-20 | Celldex Therapeutics Inc. | Antibodies that bind human cd27 and uses thereof |
| ES2661088T3 (es) * | 2010-07-02 | 2018-03-27 | Intervet International B.V. | Vacuna contra Ehrlichia canis y métodos asociados |
| US9610248B2 (en) | 2010-07-06 | 2017-04-04 | Variation Biotechnologies, Inc. | Compositions and methods for treating influenza |
| AU2011315447A1 (en) | 2010-10-15 | 2013-05-09 | Glaxosmithkline Biologicals S.A. | Cytomegalovirus gB antigen |
| WO2012057904A1 (en) | 2010-10-27 | 2012-05-03 | Infectious Disease Research Institute | Mycobacterium tuberculosis antigens and combinations thereof having high seroreactivity |
| HUE034247T2 (en) | 2010-11-05 | 2018-02-28 | Novavax Inc | Rabies glycoprotein virus-like particles (VLP-K) |
| EA201390676A1 (ru) | 2010-11-08 | 2013-11-29 | Инфекшес Дизиз Рисерч Инститьют | Вакцины, содержащие полипептиды неспецифической нуклеозидгидролазы и стерол 24-c-метилтрансферазы (smt), для лечения и диагностики лейшманиоза |
| EP3593813A1 (en) | 2010-12-14 | 2020-01-15 | GlaxoSmithKline Biologicals S.A. | Mycobacterium antigenic composition |
| BR112013017939B1 (pt) | 2011-01-13 | 2022-11-16 | Variation Biotechnologies Inc | Composição imunogênica liofilizada termoestável, uso e método para preparação da mesma |
| WO2012106356A2 (en) | 2011-01-31 | 2012-08-09 | GOVERNMENT OF THE USA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES | Virus-like particles and methods of use |
| GB201106357D0 (en) | 2011-04-14 | 2011-06-01 | Pessi Antonello | Composition and uses thereof |
| AU2012243039B2 (en) | 2011-04-08 | 2017-07-13 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
| AU2012273153A1 (en) | 2011-06-21 | 2013-05-02 | Oncofactor Corporation | Compositions and methods for the therapy and diagnosis of cancer |
| GB201113570D0 (en) | 2011-08-05 | 2011-09-21 | Glaxosmithkline Biolog Sa | Vaccine |
| GB201116248D0 (en) | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
| GB201120000D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
| GB201119999D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
| AU2013208693B2 (en) | 2012-01-12 | 2017-12-07 | Variation Biotechnologies Inc. | Compositions and methods for treating viral infections |
| EP4008354A1 (en) | 2012-01-27 | 2022-06-08 | Variation Biotechnologies Inc. | Methods and compositions for therapeutic agents |
| US20150110824A1 (en) | 2012-03-18 | 2015-04-23 | Glaxosmithkline Biologicals, Sa | Method of vaccination against human papillomavirus |
| RS57420B1 (sr) | 2012-05-16 | 2018-09-28 | Immune Design Corp | Vakcine za hsv-2 |
| EP2666785A1 (en) | 2012-05-23 | 2013-11-27 | Affiris AG | Complement component C5a-based vaccine |
| WO2014042780A1 (en) | 2012-08-03 | 2014-03-20 | Infectious Disease Research Institute | Compositions and methods for treating an active mycobacterium tuberculosis infection |
| AU2013301312A1 (en) | 2012-08-06 | 2015-03-19 | Glaxosmithkline Biologicals S.A. | Method for eliciting in infants an immune response against RSV and B. pertussis |
| US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
| US9605276B2 (en) | 2012-08-24 | 2017-03-28 | Etubics Corporation | Replication defective adenovirus vector in vaccination |
| EP2703483A1 (en) | 2012-08-29 | 2014-03-05 | Affiris AG | PCSK9 peptide vaccine |
| EP3513806B1 (en) | 2012-12-05 | 2023-01-25 | GlaxoSmithKline Biologicals SA | Immunogenic composition |
| WO2014160463A1 (en) | 2013-03-13 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Prefusion rsv f proteins and their use |
| EP2968370A4 (en) | 2013-03-14 | 2016-09-21 | Univ Maryland | AGENT FOR ANDROGEN RECEPTOR DOWNWARD CONTROL AND USES THEREOF |
| AR095425A1 (es) | 2013-03-15 | 2015-10-14 | Glaxosmithkline Biologicals Sa | Vacuna, uso y procedimiento para prevenir una infección por picornavirus |
| ES2728865T3 (es) | 2013-03-28 | 2019-10-29 | Infectious Disease Res Inst | Vacunas que comprenden polipéptidos de Leishmania para el tratamiento y el diagnóstico de la leishmaniasis |
| CA2909221A1 (en) | 2013-04-18 | 2014-10-23 | Immune Design Corp. | Gla monotherapy for use in cancer treatment |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| EP3632458A1 (en) | 2013-07-26 | 2020-04-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of bacterial infections |
| KR20160040290A (ko) | 2013-08-05 | 2016-04-12 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 조합 면역원성 조성물 |
| BR112016002970A2 (pt) | 2013-08-12 | 2017-09-12 | Tokai Pharmaceuticals Inc | biomarcadores para o tratamento de distúrbios neoplásicos que usa terapias direcionadas ao androgênio |
| CN105555306B (zh) | 2013-09-19 | 2019-12-03 | 诺瓦瓦克斯股份有限公司 | 免疫原性中东呼吸综合征冠状病毒(MERS-CoV)组合物和方法 |
| WO2015179404A1 (en) | 2014-05-19 | 2015-11-26 | The Johns Hopkins University | Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer |
| US11571472B2 (en) | 2014-06-13 | 2023-02-07 | Glaxosmithkline Biologicals Sa | Immunogenic combinations |
| DK3160500T3 (da) | 2014-06-25 | 2019-11-11 | Glaxosmithkline Biologicals Sa | Clostridium difficile immunogen sammensætning |
| AU2015298263B2 (en) | 2014-07-31 | 2020-05-14 | Anji Pharmaceuticals, Inc. | ApoE mimetic peptides and higher potency to clear plasma cholesterol |
| WO2016033114A1 (en) | 2014-08-25 | 2016-03-03 | The Johns Hopkins University | Methods and compositions related to prostate cancer therapeutics |
| CA2971542A1 (en) | 2014-12-19 | 2016-06-23 | Regenesance B.V. | Antibodies that bind human c6 and uses thereof |
| CN113456812B (zh) | 2015-01-09 | 2024-08-20 | 埃图比克斯公司 | 用于联合免疫治疗的方法和组合物 |
| EP3268037B1 (en) | 2015-03-09 | 2022-08-31 | Celldex Therapeutics, Inc. | Cd27 agonists |
| US11149087B2 (en) | 2015-04-20 | 2021-10-19 | Etubics Corporation | Methods and compositions for combination immunotherapy |
| WO2016180852A1 (en) | 2015-05-12 | 2016-11-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preparing antigen-specific t cells from an umbilical cord blood sample |
| RU2017140856A (ru) | 2015-05-26 | 2019-06-26 | Огайо Стейт Инновейшн Фаундейшн | Стратегия вакцинации против вируса свиного гриппа вакциной на основе наночастиц |
| US20170226171A1 (en) * | 2016-02-09 | 2017-08-10 | Vaccinogen, Inc. | Adenocarcinoma antigenic determinants and methods |
| CN109069440A (zh) | 2016-03-02 | 2018-12-21 | 得克萨斯州大学系统董事会 | 用于免疫治疗的激活sting的纳米疫苗 |
| EP3445783A2 (en) | 2016-04-18 | 2019-02-27 | Celldex Therapeutics, Inc. | Agonistic antibodies that bind human cd40 and uses thereof |
| JP2019521095A (ja) | 2016-05-21 | 2019-07-25 | インフェクシャス ディズィーズ リサーチ インスティチュート | 二次性結核および非結核性マイコバクテリウム感染症を治療するための組成物および方法 |
| SG11201810332TA (en) | 2016-05-27 | 2018-12-28 | Etubics Corp | Neoepitope vaccine compositions and methods of use thereof |
| CA3036218A1 (en) | 2016-09-16 | 2018-03-22 | Infectious Disease Research Institute | Vaccines comprising mycobacterium leprae polypeptides for the prevention, treatment, and diagnosis of leprosy |
| GB201616904D0 (en) | 2016-10-05 | 2016-11-16 | Glaxosmithkline Biologicals Sa | Vaccine |
| CA3045952A1 (en) | 2016-12-07 | 2018-06-14 | Glaxosmithkline Biologicals Sa | Novel process |
| MX2019006349A (es) | 2016-12-16 | 2019-08-22 | Inst Res Biomedicine | Proteinas recombinantes rsv f de prefusion nuevas y usos de las mismas. |
| GB201621686D0 (en) | 2016-12-20 | 2017-02-01 | Glaxosmithkline Biologicals Sa | Novel methods for inducing an immune response |
| CN110945022B (zh) | 2017-04-19 | 2024-04-05 | 生物医学研究所 | 作为疫苗及新疟疾疫苗和抗体结合靶标的疟原虫子孢子npdp肽 |
| EP3615061A1 (en) | 2017-04-28 | 2020-03-04 | GlaxoSmithKline Biologicals S.A. | Vaccination |
| GB201707700D0 (en) | 2017-05-12 | 2017-06-28 | Glaxosmithkline Biologicals Sa | Dried composition |
| JP7291633B2 (ja) | 2017-05-30 | 2023-06-15 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | アジュバントを製造する方法 |
| KR102673794B1 (ko) | 2017-06-15 | 2024-06-11 | 액세스 투 어드밴스드 헬스 인스티튜트 | 나노구조 지질 담체 및 안정적인 에멀션 그리고 이들의 용도 |
| US20200254083A1 (en) | 2017-06-16 | 2020-08-13 | Glaxosmithkline Biologicals Sa | Method of treatment |
| US11123415B2 (en) | 2017-08-16 | 2021-09-21 | Ohio State Innovation Foundation | Nanoparticle compositions for Salmonella vaccines |
| CA3083078A1 (en) | 2017-12-01 | 2019-06-06 | Glaxosmithkline Biologicals Sa | Saponin purification |
| CN111836639A (zh) | 2018-01-26 | 2020-10-27 | 河谷细胞有限公司 | 用于联合癌症疫苗和免疫辅助疗法的组合物和方法 |
| WO2019175147A1 (en) | 2018-03-12 | 2019-09-19 | Janssen Vaccines & Prevention B.V. | Vaccines against intra-abdominal infections |
| BR112020021271A2 (pt) | 2018-04-17 | 2021-01-26 | Celldex Therapeutics, Inc. | construtos bispecíficos e anticorpos anti- cd27 e anti-pd-l1 |
| EP3581201A1 (en) | 2018-06-15 | 2019-12-18 | GlaxoSmithKline Biologicals S.A. | Escherichia coli o157:h7 proteins and uses thereof |
| WO2020026147A1 (en) | 2018-07-31 | 2020-02-06 | Glaxosmithkline Biologicals Sa | Antigen purification method |
| JP7320601B2 (ja) | 2018-09-11 | 2023-08-03 | 上▲海▼市公共▲衛▼生▲臨▼床中心 | 広域スペクトルな抗インフルエンザワクチン免疫原及びその使用 |
| US20220133872A1 (en) * | 2019-02-08 | 2022-05-05 | University Of Florida Research Foundation, Inc. | A monophosphoryl lipid-a liposome based cancer vaccine |
| US20220235095A1 (en) | 2019-06-05 | 2022-07-28 | Glaxosmithkline Biologicals Sa | Saponin purification |
| EP4004018A1 (en) | 2019-07-24 | 2022-06-01 | GlaxoSmithKline Biologicals SA | Modified human cytomegalovirus proteins |
| EP3777884A1 (en) | 2019-08-15 | 2021-02-17 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
| EP4028051A1 (en) | 2019-09-09 | 2022-07-20 | GlaxoSmithKline Biologicals S.A. | Immunotherapeutic compositions |
| AU2020358862A1 (en) | 2019-10-02 | 2022-04-14 | Janssen Vaccines & Prevention B.V. | Staphylococcus peptides and methods of use |
| US20230045642A1 (en) | 2019-12-19 | 2023-02-09 | Glaxosmithkline Biologicals Sa | S. aureus antigens and compositions thereof |
| EP4090363B1 (en) | 2020-01-16 | 2024-09-04 | Janssen Pharmaceuticals, Inc. | Fimh mutant, compositions therewith and use thereof |
| US11376320B2 (en) | 2020-03-05 | 2022-07-05 | Iowa State University Research Foundation, Inc. | Immunogenic and vaccine compositions against SARS-CoV-2 |
| WO2021214766A1 (en) | 2020-04-21 | 2021-10-28 | Yeda Research And Development Co. Ltd. | Methods of diagnosing viral infections and vaccines thereto |
| EP4146378A1 (en) | 2020-05-05 | 2023-03-15 | GlaxoSmithKline Biologicals S.A. | Microfluidic mixing device and methods of use |
| WO2021245025A1 (en) | 2020-06-01 | 2021-12-09 | Loop Diagnostics, S.L. | Method and kit for the early detection of sepsis |
| US20230293659A1 (en) | 2020-08-03 | 2023-09-21 | Glaxosmithkline Biologicals Sa | Truncated fusobacterium nucleatum fusobacterium adhesin a (fada) protein and immunogenic compositions thereof |
| AU2021337493A1 (en) | 2020-09-04 | 2023-05-18 | Access To Advanced Health Institute | Co-lyophilized rna and nanostructured lipid carrier |
| EP4255919A2 (en) | 2020-12-02 | 2023-10-11 | GlaxoSmithKline Biologicals S.A. | Donor strand complemented fimh |
| US20240026407A1 (en) | 2020-12-09 | 2024-01-25 | Glaxosmithkline Biologicals Sa | Modification of saponins |
| US20240102069A1 (en) | 2020-12-24 | 2024-03-28 | Plant Bioscience Limited | Methods and compositions |
| EP4277921A1 (en) | 2021-01-12 | 2023-11-22 | Janssen Pharmaceuticals, Inc. | Fimh mutants, compositions therewith and use thereof |
| WO2022171681A1 (en) | 2021-02-11 | 2022-08-18 | Glaxosmithkline Biologicals Sa | Hpv vaccine manufacture |
| WO2022208430A1 (en) | 2021-04-01 | 2022-10-06 | Janssen Pharmaceuticals, Inc. | Production of e. coli o18 bioconjugates |
| AU2022253269A1 (en) | 2021-04-09 | 2023-11-23 | Celldex Therapeutics, Inc. | Antibodies against ilt4, bispecific anti-ilt4/pd-l1 antibody and uses thereof |
| WO2023020994A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| WO2023020993A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| WO2023020992A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| WO2023077521A1 (en) | 2021-11-08 | 2023-05-11 | Celldex Therapeutics, Inc | Anti-ilt4 and anti-pd-1 bispecific constructs |
| WO2023144665A1 (en) | 2022-01-28 | 2023-08-03 | Glaxosmithkline Biologicals Sa | Modified human cytomegalovirus proteins |
| WO2023180677A1 (en) | 2022-03-25 | 2023-09-28 | Plant Bioscience Limited | Biosynthesis |
| WO2023242187A1 (en) | 2022-06-15 | 2023-12-21 | Glaxosmithkline Biologicals Sa | Enzymatic modification of saponins |
| GB202209588D0 (en) | 2022-06-29 | 2022-08-10 | Plant Bioscience Ltd | Methods and compositions |
| WO2024052882A1 (en) | 2022-09-09 | 2024-03-14 | Access To Advanced Health Institute | Immunogenic vaccine composition incorporating a saponin |
| WO2024160901A1 (en) | 2023-02-02 | 2024-08-08 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| WO2024186635A2 (en) | 2023-03-03 | 2024-09-12 | Celldex Therapeutics, Inc. | Anti-stem cell factor (scf) and anti-thymic stromal lymphopoietin (tslp) antibodies and bispecific constructs |
Family Cites Families (8)
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| FR2160326B1 (it) * | 1971-11-19 | 1975-02-07 | Anvar | |
| US4338334A (en) * | 1977-12-29 | 1982-07-06 | Merck & Co., Inc. | 1-[4-(4-Sulfanilyl)phenyl] urea and derivatives in compositions and methods of treating rheumatoid arthritis and immune complex diseases |
| US4307229A (en) * | 1979-11-07 | 1981-12-22 | Avraham Liav | 6,6'-Diesters of trehalose and process for the synthesis thereof |
| US4436727A (en) * | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4436728A (en) * | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4505903A (en) * | 1982-06-30 | 1985-03-19 | Ribi Immunochem Research, Inc. | Pyridine soluble extract of a microorganism |
| US4606918A (en) * | 1983-08-22 | 1986-08-19 | Syntex (U.S.A.) Inc. | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
| US4663306A (en) * | 1983-09-23 | 1987-05-05 | Ribi Immunochem Research, Inc. | Pyridine-soluble extract-refined detoxified endotoxin composition and use |
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1987
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1988
- 1988-09-28 GB GB8822749A patent/GB2210557B/en not_active Expired - Lifetime
- 1988-09-28 CA CA000578719A patent/CA1333152C/en not_active Expired - Fee Related
- 1988-09-29 NL NL8802393A patent/NL8802393A/nl active Search and Examination
- 1988-09-30 IT IT8822145A patent/IT1226861B/it active
- 1988-09-30 CH CH3632/88A patent/CH678492A5/de not_active IP Right Cessation
- 1988-09-30 FR FR888812793A patent/FR2620941B1/fr not_active Expired - Fee Related
- 1988-09-30 DE DE3833319A patent/DE3833319A1/de active Granted
- 1988-09-30 BE BE8801122A patent/BE1001634A4/fr not_active IP Right Cessation
- 1988-09-30 JP JP63244691A patent/JPH01163130A/ja active Granted
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| JPH0575731B2 (it) | 1993-10-21 |
| CH678492A5 (it) | 1991-09-30 |
| GB2210557A (en) | 1989-06-14 |
| GB8822749D0 (en) | 1988-11-02 |
| FR2620941A1 (fr) | 1989-03-31 |
| IT8822145A0 (it) | 1988-09-30 |
| GB2210557B (en) | 1991-11-13 |
| BE1001634A4 (fr) | 1990-01-02 |
| US4877611A (en) | 1989-10-31 |
| CA1333152C (en) | 1994-11-22 |
| JPH01163130A (ja) | 1989-06-27 |
| IT1226861B (it) | 1991-02-19 |
| DE3833319C2 (it) | 1992-06-11 |
| FR2620941B1 (fr) | 1990-08-10 |
| DE3833319A1 (de) | 1989-04-13 |
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