NL8102005A - Als geneesmiddelen toepasbare gesubstitueerde derivaten van 4-fenyl-4-oxo-2-buteenzuur. - Google Patents

Als geneesmiddelen toepasbare gesubstitueerde derivaten van 4-fenyl-4-oxo-2-buteenzuur. Download PDF

Info

Publication number
NL8102005A
NL8102005A NL8102005A NL8102005A NL8102005A NL 8102005 A NL8102005 A NL 8102005A NL 8102005 A NL8102005 A NL 8102005A NL 8102005 A NL8102005 A NL 8102005A NL 8102005 A NL8102005 A NL 8102005A
Authority
NL
Netherlands
Prior art keywords
metal salts
formula
products
hydrogen atom
alkaline earth
Prior art date
Application number
NL8102005A
Other languages
English (en)
Dutch (nl)
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of NL8102005A publication Critical patent/NL8102005A/nl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • C07C59/88Unsaturated compounds containing keto groups containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • C07C59/90Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NL8102005A 1980-04-24 1981-04-23 Als geneesmiddelen toepasbare gesubstitueerde derivaten van 4-fenyl-4-oxo-2-buteenzuur. NL8102005A (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8009216 1980-04-24
FR8009216A FR2481118A1 (fr) 1980-04-24 1980-04-24 Application a titre de medicaments de derives substitues de l'acide phenyl-4-oxo-2-butenoique

Publications (1)

Publication Number Publication Date
NL8102005A true NL8102005A (nl) 1981-11-16

Family

ID=9241314

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8102005A NL8102005A (nl) 1980-04-24 1981-04-23 Als geneesmiddelen toepasbare gesubstitueerde derivaten van 4-fenyl-4-oxo-2-buteenzuur.

Country Status (13)

Country Link
US (1) US4483868A (US20020095090A1-20020718-M00002.png)
JP (1) JPS5726641A (US20020095090A1-20020718-M00002.png)
AU (1) AU543641B2 (US20020095090A1-20020718-M00002.png)
BE (1) BE888540A (US20020095090A1-20020718-M00002.png)
CA (1) CA1179601A (US20020095090A1-20020718-M00002.png)
CH (1) CH649920A5 (US20020095090A1-20020718-M00002.png)
DE (1) DE3116416A1 (US20020095090A1-20020718-M00002.png)
FR (1) FR2481118A1 (US20020095090A1-20020718-M00002.png)
GB (1) GB2075836B (US20020095090A1-20020718-M00002.png)
IT (1) IT1170915B (US20020095090A1-20020718-M00002.png)
NL (1) NL8102005A (US20020095090A1-20020718-M00002.png)
SE (2) SE451838B (US20020095090A1-20020718-M00002.png)
ZA (1) ZA812672B (US20020095090A1-20020718-M00002.png)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2504127B1 (fr) * 1981-04-17 1985-07-19 Roussel Uclaf Nouveaux derives d'acides phenyl aliphatique carboxyliques, procede pour leur preparation et leur application comme medicaments
FR2504004A1 (fr) * 1981-04-17 1982-10-22 Roussel Uclaf Application a titre de medicaments de derives d'acides phenyl aliphatique carboxyliques
IT1171604B (it) * 1981-10-22 1987-06-10 Roussel Maestretti Spa Derivati di acido 4-fenil-4-ossobuten-2-oico dotati di proprieta' farmacologiche e loro procedimento di preparazione
FR2515037A1 (fr) * 1981-10-22 1983-04-29 Roussel Uclaf A titre de medicaments, certains derives mono-substitues de l'acide 4-phenyl 4-oxo buten-2-oique, ainsi que les compositions les renfermant
DE3228842A1 (de) * 1982-08-02 1984-02-02 Henkel Kgaa Sebosuppressive kosmetische mittel, enthaltend aryloxobutensaeurederivate sowie neue aryloxobutensaeurederivate
SE454355B (sv) * 1983-01-24 1988-04-25 Roussel Uclaf Akrylsyraderivat innehallande en furyl-, pyranyl-, bensofuranyl-, oxazolyl- eller isoxazolylgrupp, forfarande for framstellning derav samt farmaceutiska kompositioner innehallande nemnda derivat
FR2567883B2 (fr) * 1983-01-24 1987-03-06 Roussel Uclaf Nouveaux derives de l'acide trans 4-oxo 2-butenoique substitues en 4 par un radical furyle, eventuellement substitue a titre de medicaments, produits industriels nouveaux et procede de preparation
US4649157A (en) * 1986-03-28 1987-03-10 G. D. Searle & Co. Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl compounds
IT1190340B (it) * 1986-06-06 1988-02-16 Roussel Maestretti Spa Derivati dell'acido 4-fenil 4-osso 2-butenoico,loro procedimento di preparazione e loro impiego come prodotti medicinali
DK49688A (da) * 1987-03-20 1988-09-21 Hoffmann La Roche Propiolophenonderivater
HU198292B (en) * 1987-09-25 1989-09-28 Richter Gedeon Vegyeszet Process for producing salicilates and pharmaceutical compositions comprising such active ingredient
JPH04235142A (ja) * 1991-01-09 1992-08-24 Kanegafuchi Chem Ind Co Ltd トランス−β−アロイルアクリル酸エステル類の製造法
JPH064812U (ja) * 1992-06-29 1994-01-21 オンキヨー株式会社 定電流回路
GB9522617D0 (en) * 1995-11-03 1996-01-03 Pharmacia Spa 4-Phenyl-4-oxo-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB588108A (en) * 1944-10-23 1947-05-14 Roche Products Ltd Manufacture of bacteriostatic substances
US2532579A (en) * 1946-08-06 1950-12-05 Du Pont Pest control compositions containing beta-acyl acrylates
US2562208A (en) * 1947-04-14 1951-07-31 Schering Corp Fungistatic composition
DE1282644B (de) * 1962-09-08 1968-11-14 Hoechst Ag Verfahren zur Herstellung von ungesaettigten ª€-Ketocarbonsaeureestern
BE708617A (US20020095090A1-20020718-M00002.png) * 1966-12-30 1968-06-28
NL6717403A (US20020095090A1-20020718-M00002.png) * 1966-12-30 1968-07-01
DE2047806A1 (en) * 1970-09-29 1972-04-06 Dr Karl Thomae GmbH, 7950 Biberach 3-aroyl-acrylic acids - pharmaceutical intermediates prepd from acetophenones and glyoxylic acid derivs
DE2103749A1 (en) * 1971-01-27 1972-08-10 Dr. Karl Thomae GmbH, 7951 Biberach 3-acyl-acrylic acids prepn - from a ketone and glyoxylic acid (deriv)
DE2116293A1 (de) * 1971-04-02 1972-10-19 Cassella Farbwerke Mainkur Ag, 6000 Frankfurt Ketonderivate und Verfahren zu ihrer Herstellung
US3753997A (en) * 1971-06-07 1973-08-21 A Ash Trifluoromethly substituted-2,6-diphenyl-4-pyridyl carbinolamine antimalarials
BE788749A (fr) * 1971-09-13 1973-03-13 Takeda Chemical Industries Ltd Acide 3-(benzoyl trisubstitue)-propionique et son procede de preparation
US4017517A (en) * 1971-09-13 1977-04-12 Takeda Chemical Industries, Ltd. 2-(Trisubstituted benzoyl)-propionic acid and a method for the production thereof
BE795893A (fr) * 1972-02-28 1973-06-18 Unicler Derives de (methylene dioxy-3,4 phenyl)-1 dimethyl-4,4 pentene-1, leur preparation et leur application en therrapeutique
CH591415A5 (en) * 1972-09-13 1977-09-15 Takeda Chemical Industries Ltd 3-(Tri-substd. benzoyl) propionic acids - as relaxants or spasmolytics for the gall bladder
GB1392100A (en) * 1972-09-13 1975-04-23 Beecham Group Ltd Insecticides
FR2270856B1 (US20020095090A1-20020718-M00002.png) * 1974-01-17 1978-07-21 Screen
US3940404A (en) * 1974-03-06 1976-02-24 The United States Of America As Represented By The Secretary Of The Army 2-Substituted phenyl-6-trifluoromethyl-4-pyridyl-carbinolamines
US3953463A (en) * 1974-03-06 1976-04-27 The United States Of America As Represented By The Secretary Of The Army 2-Aryl-6-trifluoromethyl-4-pyridyl-carbinolamine antimalarials
JPS5536434A (en) * 1978-09-07 1980-03-14 Sankyo Co Ltd 4-phenyl-4-oxo-2-butenoic acid derivative and its preparation
ES496382A0 (es) * 1979-10-31 1982-03-01 Byk Gulden Lomberg Chem Fab Procedimiento para la preparacion de acidos oxocarboxilicos sustituidos
FR2481270A1 (fr) * 1980-04-24 1981-10-30 Roussel Uclaf Nouveaux derives substitues de l'acide 4-phenyl 4-oxo 2-hydroxy butanoique, procede pour leur preparation et applications comme medicaments

Also Published As

Publication number Publication date
BE888540A (fr) 1981-10-23
FR2481118B1 (US20020095090A1-20020718-M00002.png) 1983-05-27
FR2481118A1 (fr) 1981-10-30
AU543641B2 (en) 1985-04-26
DE3116416C2 (US20020095090A1-20020718-M00002.png) 1990-01-18
ZA812672B (en) 1982-04-28
SE8102220L (sv) 1981-10-25
US4483868A (en) 1984-11-20
CA1179601A (fr) 1984-12-18
SE463366B (sv) 1990-11-12
SE451838B (sv) 1987-11-02
AU6980381A (en) 1981-10-29
GB2075836A (en) 1981-11-25
GB2075836B (en) 1985-03-13
IT8148336A0 (it) 1981-04-23
IT1170915B (it) 1987-06-03
JPH0227326B2 (US20020095090A1-20020718-M00002.png) 1990-06-15
DE3116416A1 (de) 1982-04-01
JPS5726641A (en) 1982-02-12
SE8700714L (sv) 1987-02-20
SE8700714D0 (sv) 1987-02-20
CH649920A5 (fr) 1985-06-28

Similar Documents

Publication Publication Date Title
NL8102005A (nl) Als geneesmiddelen toepasbare gesubstitueerde derivaten van 4-fenyl-4-oxo-2-buteenzuur.
KR0150646B1 (ko) 치환 설포닐 인데닐 아세트산, 프로피온산과 에스테르를 이용한 암전구증 환자 치료방법
EP0490772A1 (fr) Piperazines 1,4-disubstiuées, leur procédé de préparation et les compositions pharmaceutiques les renfermant
JP2010501473A (ja) 抗腫瘍及び抗寄生虫性を有するペンタ−1,4−ジエン−3−オン及び置換シクロヘキサノン、及び誘導体の調製方法、その化合物並びにその使用
JPS61268664A (ja) リポキシゲナ−ゼ阻害組成物
DK157673B (da) Analogifremgangsmaade til fremstilling af phenylaliphatiske carboxylsyrederivater
JPS62228059A (ja) アミド誘導体およびこれを含有する抗アレルギ−剤
CA1189520A (fr) Procede de preparation de nouveaux derives de l'acide 4-phenyl-4-oxo-2-butenoique et de leurs sels
EP0293900B1 (en) Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase
DE3116414C2 (US20020095090A1-20020718-M00002.png)
US4436752A (en) Treatment of gastric and gastro-duodenal disorders with derivatives of phenyl aliphatic carboxylic acids
WO2003099269A1 (en) Cinnamic acid dimers, their preparation and the use thereof for treating neurodegenerative disease
WO2005037760A1 (ja) 新規フェノール誘導体およびそれらを有効成分とする抗トリパノソーマ予防・治療剤
JPH0629184B2 (ja) 骨粗鬆症治療剤
DK145041B (da) Analogifremgangsmaade til fremstilling af et benzophenonderivat eller syreadditionssalte deraf
FR2504005A2 (fr) Application a titre de medicaments de derives substitues de l'acide 4-phenyl 4-oxo-2-butenoique
EP0293895A1 (en) Phenolic thioethers as inhibitors of 5-lipoxygenase
FR2526789A2 (fr) Nouveaux derives d'acides phenyl aliphatique carboxyliques, procede pour leur preparation et leur application comme medicaments
JPS646167B2 (US20020095090A1-20020718-M00002.png)
CS252338B1 (cs) Způsob přípravy nových [2-(4-terc.aminofenylthio)fenyl]octových kyselin
FR2504006A1 (fr) Application a titre de medicaments de derives substitues par un groupement methylenedioxy sur le noyau d'acides phenyl aliphatique carboxyliques

Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
BV The patent application has lapsed