NL7507462A - Benzcyclohexylamidederivaten en farmaceutisch pre- paraat alsmede werkwijze voor het bereiden daarvan. - Google Patents

Benzcyclohexylamidederivaten en farmaceutisch pre- paraat alsmede werkwijze voor het bereiden daarvan.

Info

Publication number
NL7507462A
NL7507462A NL7507462A NL7507462A NL7507462A NL 7507462 A NL7507462 A NL 7507462A NL 7507462 A NL7507462 A NL 7507462A NL 7507462 A NL7507462 A NL 7507462A NL 7507462 A NL7507462 A NL 7507462A
Authority
NL
Netherlands
Prior art keywords
benzcyclohexylamide
derivatives
preparing
procedure
pharmaceutical preparation
Prior art date
Application number
NL7507462A
Other languages
English (en)
Other versions
NL162376B (nl
NL162376C (nl
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP49072473A external-priority patent/JPS511481A/ja
Priority claimed from JP49072472A external-priority patent/JPS511480A/ja
Priority claimed from JP49077660A external-priority patent/JPS516970A/ja
Priority claimed from JP49077661A external-priority patent/JPS5182279A/ja
Priority claimed from JP49094376A external-priority patent/JPS5123271A/ja
Priority claimed from JP50053027A external-priority patent/JPS51128977A/ja
Priority claimed from JP50053026A external-priority patent/JPS51128976A/ja
Priority claimed from JP50053028A external-priority patent/JPS51128978A/ja
Priority claimed from JP50058127A external-priority patent/JPS51133276A/ja
Priority claimed from JP50058129A external-priority patent/JPS51133278A/ja
Priority claimed from JP50058134A external-priority patent/JPS51133283A/ja
Priority claimed from JP50058128A external-priority patent/JPS51133277A/ja
Priority claimed from JP50058135A external-priority patent/JPS51133284A/ja
Priority claimed from JP50058872A external-priority patent/JPS604173B2/ja
Priority claimed from JP50058874A external-priority patent/JPS51136677A/ja
Priority claimed from JP50066729A external-priority patent/JPS51141864A/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of NL7507462A publication Critical patent/NL7507462A/nl
Publication of NL162376B publication Critical patent/NL162376B/nl
Application granted granted Critical
Publication of NL162376C publication Critical patent/NL162376C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NL7507462.A 1974-06-24 1975-06-23 Werkwijze ter bereiding van farmaceutische preparaten, de door toepassing daarvan verkregen gevormde voort- brengselen, alsmede werkwijze ter bereiding van benz- cyclamidederivaten met een de aggregatie van bloed- plaatjes remmende werking. NL162376C (nl)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
JP49072473A JPS511481A (ja) 1974-06-24 1974-06-24 Karubokishiarukokishi 3*44 jihidorokarubosuchirirujudotaino seizoho
JP49072472A JPS511480A (ja) 1974-06-24 1974-06-24 Etokishikaruboniruarukokishi 3*44 jihidorokarubosuchirirujudotaino seizoho
JP49077661A JPS5182279A (en) 1974-07-05 1974-07-05 Karubokishetokishi 3*44 jihidorokarubosuchirirujudotainoseizoho
JP49077660A JPS516970A (en) 1974-07-05 1974-07-05 Shianoetokishi 3*44 jihidorokarubosuchirirujudotaino seizoho
JP49094376A JPS5123271A (ja) 1974-08-16 1974-08-16 Karubamoiruarukokishi 3*44 jihidorokarubosuchirirujudotaiseizoho
JP50053027A JPS51128977A (en) 1975-04-30 1975-04-30 Process for preparing carbostyril derivatives
JP50053026A JPS51128976A (en) 1975-04-30 1975-04-30 Process for preparing carbostyril derivatives
JP50053028A JPS51128978A (en) 1975-04-30 1975-04-30 Process for preparing carbostyril derivatives
JP50058129A JPS51133278A (en) 1975-05-15 1975-05-15 A process for preparing novel carbostyril derivatives
JP50058134A JPS51133283A (en) 1975-05-15 1975-05-15 A process for preparing carbostyril derivatives
JP50058127A JPS51133276A (en) 1975-05-15 1975-05-15 Process for preparing carbostyril derivatives
JP50058128A JPS51133277A (en) 1975-05-15 1975-05-15 A process for preparing novel carbostyril derivatives
JP50058135A JPS51133284A (en) 1975-05-15 1975-05-15 A process for preparing carbostyril derivatives
JP50058872A JPS604173B2 (ja) 1975-05-16 1975-05-16 カルボスチリル誘導体の製法
JP50058874A JPS51136677A (en) 1975-05-16 1975-05-16 Process for preparation of carbostyril derivatives
JP50066729A JPS51141864A (en) 1975-06-02 1975-06-02 Process for preparing oxyindole derivatives.

Publications (3)

Publication Number Publication Date
NL7507462A true NL7507462A (nl) 1975-12-30
NL162376B NL162376B (nl) 1979-12-17
NL162376C NL162376C (nl) 1980-05-16

Family

ID=27585697

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7507462.A NL162376C (nl) 1974-06-24 1975-06-23 Werkwijze ter bereiding van farmaceutische preparaten, de door toepassing daarvan verkregen gevormde voort- brengselen, alsmede werkwijze ter bereiding van benz- cyclamidederivaten met een de aggregatie van bloed- plaatjes remmende werking.

Country Status (11)

Country Link
US (2) US4070470A (nl)
CA (1) CA1048497A (nl)
CH (1) CH621339A5 (nl)
DE (2) DE2527937C2 (nl)
DK (1) DK150155C (nl)
FI (1) FI59246C (nl)
FR (1) FR2276043A1 (nl)
GB (1) GB1505305A (nl)
IE (1) IE41172B1 (nl)
NL (1) NL162376C (nl)
NO (1) NO149106C (nl)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4313947A (en) * 1974-06-24 1982-02-02 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use
NZ187452A (en) * 1977-06-10 1980-05-27 Otsuka Pharma Co Ltd N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation
AT374184B (de) * 1978-02-17 1984-03-26 Thomae Gmbh Dr K Verfahren zur herstellung von neuen carbostyril- und oxindolderivaten
SU843739A3 (ru) * 1978-02-17 1981-06-30 Карл Томэ Гмбх (Фирма) Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ
AT374185B (de) * 1978-02-17 1984-03-26 Thomae Gmbh Dr K Verfahren zur herstellung von neuen carbostyril- und oxindolderivaten
JPS5535019A (en) * 1978-09-01 1980-03-11 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
DE2909035A1 (de) * 1979-03-08 1980-09-18 Hoechst Ag 8-oxo-5,6,7,8-tetrahydro-2-chinolon und verfahren zu dessen herstellung
DE2909779A1 (de) * 1979-03-13 1980-09-18 Thomae Gmbh Dr K Neue indolderivate, deren herstellung und deren verwendung als arzneimittel
AT375925B (de) * 1979-07-14 1984-09-25 Thomae Gmbh Dr K Verfahren zur herstellung von neuen carbostyrilderivaten
AT376209B (de) * 1979-07-14 1984-10-25 Thomae Gmbh Dr K Verfahren zur herstellung von neuen carbostyrilderivaten
AT383594B (de) * 1980-02-29 1987-07-27 Otsuka Pharma Co Ltd Verfahren zum herstellen von neuen carbostyrilderivaten und ihren salzen
JPS56122356A (en) 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
HU183480B (en) * 1980-06-18 1984-05-28 May & Baker Ltd Process for producing new indol- and indoline derivatives
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
DE3124699A1 (de) * 1981-06-24 1983-01-13 Basf Ag, 6700 Ludwigshafen Neue 2-aryl-3,4-diaza-bicyclo(4.n.0.)alken-(2)-one-(5),verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
DE3300522A1 (de) * 1982-01-21 1983-07-28 Sandoz-Patent-GmbH, 7850 Lörrach 3,3-dialkyl- und 3,3-alkylen-indolinderivate, verfahren zu ihrer herstellung und pharmazeutische praeparate sie enthaltend
FI80022C (fi) * 1982-07-05 1990-04-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat.
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
US4551459A (en) * 1983-02-16 1985-11-05 Syntex (U.S.A.) Inc. Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
DE3310891A1 (de) * 1983-03-25 1984-09-27 Boehringer Mannheim Gmbh, 6800 Mannheim Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte
DE3317653A1 (de) * 1983-05-14 1984-11-15 Gödecke AG, 1000 Berlin 2-alkylthio-1-aminoalkyl-2-pyrrolin-3-carbonitrile, verfahren zu deren herstellung sowie deren verwendung bei der prophylaxe und therapie thrombotischer zustaende
US4657929A (en) * 1983-10-25 1987-04-14 Fisons Plc Compounds
US4582909A (en) * 1984-02-02 1986-04-15 Warner-Lambert Company Benzobicyclic lactam acids and derivatives as cognition activators
EP0153152A3 (en) * 1984-02-15 1987-07-15 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo-/2,1-b/quinnazolinyl)-oxyalkylamides, their preparation, compositions containing them and their use in making medicaments
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
DK167187A (da) 1986-04-02 1987-10-03 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
CA2093633A1 (en) * 1991-08-23 1993-02-24 Seiji Sato Carbostyril derivative and platelets aggregation inhibitory agent
WO1999050263A1 (en) * 1998-03-31 1999-10-07 Warner-Lambert Company Quinolones as serine protease inhibitors
DE19839499A1 (de) * 1998-08-29 2000-03-02 Merck Patent Gmbh 2-Oxo-2H-chinolinderivate
GB201520550D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520568D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd Peptides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1216878B (de) * 1963-04-02 1966-05-18 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von coronargefaesserweiternden Derivaten des 7-Hydroxy-2-oxo-1, 2-dihydrochinolins
GB1058822A (en) * 1963-07-30 1967-02-15 Ici Ltd 3-amino-2-hydroxypropoxy heterocyclic derivatives
CH489497A (de) * 1967-01-25 1970-04-30 Geigy Ag J R Verfahren zur Herstellung von neuen Indolderivaten
US3749731A (en) * 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
DE2331223C2 (de) 1972-06-19 1984-11-22 Kohjin Co., Ltd., Tokio / Tokyo S-substituierte-2-Thioadenosine, deren 5'-Monophosphate, Verfahren zu deren Herstellung und Arzneimittel, welche diese enthalten
CH578526A5 (nl) 1972-06-23 1976-08-13 Sandoz Ag
AR207554A1 (es) * 1972-12-02 1976-10-15 Otsuka Pharma Co Ltd Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2)

Also Published As

Publication number Publication date
FI59246B (fi) 1981-03-31
DK150155B (da) 1986-12-22
FR2276043B1 (nl) 1978-03-24
GB1505305A (en) 1978-03-30
DE2527937C2 (de) 1983-09-08
NO752220L (nl) 1975-12-30
NL162376B (nl) 1979-12-17
CH621339A5 (nl) 1981-01-30
DE2527937A1 (de) 1976-01-08
DK150155C (da) 1987-11-09
NO149106C (no) 1984-02-22
DE2559509C2 (de) 1983-02-17
NL162376C (nl) 1980-05-16
IE41172B1 (en) 1979-11-07
DK283175A (da) 1975-12-25
DE2559509A1 (de) 1976-12-30
FI59246C (fi) 1981-07-10
FI751842A (nl) 1975-12-25
US4216220A (en) 1980-08-05
FR2276043A1 (fr) 1976-01-23
CA1048497A (en) 1979-02-13
IE41172L (en) 1975-12-24
NO149106B (no) 1983-11-07
US4070470A (en) 1978-01-24

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Legal Events

Date Code Title Description
V1 Lapsed because of non-payment of the annual fee