NL192739C - £3H|-imidazo-£5,1-d|-1,2,3,5-tetrazine-4-on derivaten en farmaceutische samenstellingen, die deze derivaten bevatten. - Google Patents

£3H|-imidazo-£5,1-d|-1,2,3,5-tetrazine-4-on derivaten en farmaceutische samenstellingen, die deze derivaten bevatten. Download PDF

Info

Publication number
NL192739C
NL192739C NL8203286A NL8203286A NL192739C NL 192739 C NL192739 C NL 192739C NL 8203286 A NL8203286 A NL 8203286A NL 8203286 A NL8203286 A NL 8203286A NL 192739 C NL192739 C NL 192739C
Authority
NL
Netherlands
Prior art keywords
tetrazine
imidazo
derivatives
chloroethyl
carbamoyl
Prior art date
Application number
NL8203286A
Other languages
English (en)
Dutch (nl)
Other versions
NL192739B (nl
NL8203286A (nl
Original Assignee
Cancer Res Campaign Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Res Campaign Tech filed Critical Cancer Res Campaign Tech
Publication of NL8203286A publication Critical patent/NL8203286A/nl
Publication of NL192739B publication Critical patent/NL192739B/xx
Application granted granted Critical
Publication of NL192739C publication Critical patent/NL192739C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NL8203286A 1981-08-24 1982-08-23 £3H|-imidazo-£5,1-d|-1,2,3,5-tetrazine-4-on derivaten en farmaceutische samenstellingen, die deze derivaten bevatten. NL192739C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8125791 1981-08-24
GB8125791 1981-08-24

Publications (3)

Publication Number Publication Date
NL8203286A NL8203286A (nl) 1983-03-16
NL192739B NL192739B (nl) 1997-09-01
NL192739C true NL192739C (nl) 1998-01-06

Family

ID=10524141

Family Applications (2)

Application Number Title Priority Date Filing Date
NL8203286A NL192739C (nl) 1981-08-24 1982-08-23 £3H|-imidazo-£5,1-d|-1,2,3,5-tetrazine-4-on derivaten en farmaceutische samenstellingen, die deze derivaten bevatten.
NL990010C NL990010I2 (nl) 1981-08-24 1999-04-01 Ä3HÜ-imidazo-Ä5,1-dÜ-1,2,3,5-tetrazine-4-on derivaten en farmaceutische samenstellingen, die deze d erivaten bevatten.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL990010C NL990010I2 (nl) 1981-08-24 1999-04-01 Ä3HÜ-imidazo-Ä5,1-dÜ-1,2,3,5-tetrazine-4-on derivaten en farmaceutische samenstellingen, die deze d erivaten bevatten.

Country Status (29)

Country Link
JP (1) JPS5843975A (xx)
KR (1) KR890000094B1 (xx)
AT (1) AT380256B (xx)
AU (1) AU571430B2 (xx)
BE (1) BE894175A (xx)
CA (1) CA1197247A (xx)
CH (1) CH655114A5 (xx)
DE (2) DE3231255A1 (xx)
DK (1) DK161147C (xx)
ES (1) ES515176A0 (xx)
FI (1) FI73434C (xx)
FR (1) FR2511679A1 (xx)
GB (1) GB2104522B (xx)
GE (1) GEP19960641B (xx)
GR (1) GR76863B (xx)
HU (1) HU186107B (xx)
IE (1) IE53408B1 (xx)
IL (1) IL66606A (xx)
IT (1) IT1152505B (xx)
LT (1) LT2436B (xx)
LU (1) LU84347A1 (xx)
LV (2) LV5511A3 (xx)
NL (2) NL192739C (xx)
NZ (1) NZ201668A (xx)
OA (1) OA07174A (xx)
SE (1) SE448543B (xx)
SU (1) SU1447284A3 (xx)
UA (1) UA5971A1 (xx)
ZA (1) ZA826120B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260291A (en) * 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
GB2125402B (en) * 1982-08-17 1985-11-13 May & Baker Ltd New tetrazine derivatives
GR78688B (xx) * 1982-08-17 1984-09-27 May & Baker Ltd
US4517182A (en) * 1983-05-24 1985-05-14 Warner-Lambert Company 3-(Haloethyl)-4-oxopyrazolo-[5,1-d]-1,2,3,5-tetrazine-8-carboxamide composition
GB8616125D0 (en) * 1986-07-02 1986-08-06 May & Baker Ltd Compositions of matter
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
BRPI0417117A (pt) * 2003-12-30 2007-03-06 Chemagis Ltd temozolomida cristalizada, processo de preparação de temozolomida cristalizada, composição farmacêutica, método de produção de medicamento contendo temozolomida e método de tratamento de uma condição médica para a qual a termozolomida é benéfica
MX2007008781A (es) 2005-01-21 2007-09-11 Astex Therapeutics Ltd Compuestos farmaceuticos.
PE20080695A1 (es) 2006-04-27 2008-06-28 Banyu Pharma Co Ltd Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
CA2703489A1 (en) 2007-10-23 2009-04-30 Banyu Pharmaceutical Co., Ltd. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
PE20091101A1 (es) * 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
US8716471B2 (en) * 2008-11-24 2014-05-06 Reliance Life Sciences Pvt. Ltd. Process for the preparation of tetrazine derivatives
EP2403339B1 (en) 2009-03-06 2017-01-18 Merck Sharp & Dohme Corp. Combination cancer therapy with an akt inhibitor and other anticancer agents
JP2012530775A (ja) 2009-06-23 2012-12-06 ファーミノックス リミテッド ３−置換−８−置換−３Ｈ−イミダゾ［５，１−ｄ］［１，２，３，５−テトラジン−４−オン化合物及びその使用
RU2462466C1 (ru) * 2011-06-24 2012-09-27 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Замещенные азоло[1,2,4,5]тетразины - ингибиторы актинобактериальных серин-треониновых протеинкиназ
US20140271657A1 (en) 2011-10-12 2014-09-18 Children's Medical Center Corporation Combinatorial compositions and methods of treating hemoglobinopathies
SG10201913331VA (en) 2016-03-15 2020-03-30 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of solid tumors
KR101847342B1 (ko) * 2017-05-08 2018-04-11 (주)센텍코리아 웨어러블 체지방 연소량 측정기

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2932305A1 (de) * 1979-08-09 1981-02-26 Basf Ag Azolo- eckige klammer auf 5,1-d eckige klammer zu - eckige klammer auf 1,2,3,5 eckige klammer zu -tetrazin-4-one und verfahren zur herstellung dieser verbindungen

Also Published As

Publication number Publication date
BE894175A (fr) 1983-02-23
JPS5843975A (ja) 1983-03-14
NL990010I2 (nl) 1999-09-01
GB2104522A (en) 1983-03-09
KR890000094B1 (ko) 1989-03-07
HU186107B (en) 1985-06-28
GB2104522B (en) 1985-06-12
ATA319182A (de) 1985-09-15
DK161147C (da) 1991-11-18
IT1152505B (it) 1987-01-07
AT380256B (de) 1986-05-12
DK377882A (da) 1983-02-25
NL990010I1 (nl) 1999-07-01
ES8400438A1 (es) 1983-11-01
SE8204817D0 (sv) 1982-08-23
FI822921A0 (fi) 1982-08-23
OA07174A (fr) 1984-04-30
FR2511679A1 (fr) 1983-02-25
IE53408B1 (en) 1988-11-09
IT8222938A0 (it) 1982-08-23
IE822026L (en) 1983-02-24
KR840001175A (ko) 1984-03-28
DE3231255A1 (de) 1983-03-03
SE8204817L (sv) 1983-02-25
SU1447284A3 (ru) 1988-12-23
GR76863B (xx) 1984-09-04
NZ201668A (en) 1985-08-16
IL66606A0 (en) 1982-12-31
AU8749382A (en) 1983-03-03
CH655114A5 (fr) 1986-03-27
LT2436B (lt) 1994-02-15
IL66606A (en) 1987-07-31
FR2511679B1 (xx) 1985-02-01
NL192739B (nl) 1997-09-01
UA5971A1 (uk) 1994-12-29
DE3231255C2 (xx) 1992-02-27
JPH045029B2 (xx) 1992-01-30
NL8203286A (nl) 1983-03-16
LV5511A3 (lv) 1994-03-10
CA1197247A (fr) 1985-11-26
SE448543B (sv) 1987-03-02
ES515176A0 (es) 1983-11-01
DE19975037I2 (de) 2001-06-13
LU84347A1 (fr) 1983-06-07
LV5621A3 (lv) 1994-05-10
DK161147B (da) 1991-06-03
FI73434B (fi) 1987-06-30
AU571430B2 (en) 1988-04-21
FI73434C (fi) 1987-10-09
GEP19960641B (en) 1996-11-15
ZA826120B (en) 1983-07-27
FI822921L (fi) 1983-02-25

Similar Documents

Publication Publication Date Title
NL192739C (nl) £3H|-imidazo-£5,1-d|-1,2,3,5-tetrazine-4-on derivaten en farmaceutische samenstellingen, die deze derivaten bevatten.
US5260291A (en) Tetrazine derivatives
DE2844292A1 (de) Pyrrolobenzodiazepine, verfahren zu ihrer herstellung und ihre verwendung zur behandlung von tumorerkrankungen
DE3324034A1 (de) Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten
Anderson et al. Synthesis and antileukemic activity of 5-substituted 2, 3-dihydro-6, 7-bis (hydroxymethyl)-1H-pyrrolizine diesters
Anderson et al. Synthesis and murine antineoplastic activity of bis [carbamoyloxymethyl] derivatives of pyrrolo [2, 1-a] isoquinoline
Ogura et al. Heterocyclic compounds. XI. 1, 3-Dipolar cycloaddition of benzimidazolium ylide with acetylenic compounds
EP0591058B1 (fr) Dérivés d'Ellipticine à activité antitumorale
WO1993008190A1 (de) Pyrrolo-pyridazine mit magen- und darmschutzwirkungen
US3669950A (en) DIPYRAZOLO{8 3,4-b:3,4d{9 -PYRIDIN-3-ONES
JPH0249784A (ja) 三環式縮合ピリミジン誘導体
Attanasi et al. Study of reactions between 1, 2-diaza-1, 3-butadienes and N, N′-diaryl-or N, N′-dialkylthioureas
Castro et al. New aporphine alkaloids from Phoebe valeriana
Carboni et al. Investigation of some tetrazole derivatives of 1, 8‐naphthyridines
Tamura et al. Synthescs and some reactions of N, N'‐diamino‐2, 2′‐and− 4, 4′‐bipyridinium salts
US4293695A (en) Furonaphthyridine compounds
US4587052A (en) 1H-pyrrolo-[2,1-C][1,4]benzodiazepine-2-acrylamide compounds having antitumor activity
Chapman Synthesis of some quinoxaline ring systems
Silina et al. Synthesis and Antimicrobial Activity of 3-Hydroxy-and 3-Arylamino-5-aryl-4-acyl-1-(pyridyl)-3-pyrrolin-2-ones.
Kurihara et al. Ring transformation of 6H‐cyclopropa [e] pyrazolo [1, 5‐a] pyrimidine. VI. Substituent effect of 6‐substituted 5a‐acetyl‐6a‐ethoxycarbonyl‐5a, 6a‐dihydro‐6H‐cyclopropa [e] pyrazolo [1, 5‐a] pyrimidine‐3‐carbonitriles
PT595467E (pt) Processo para preparar derivados de antifolato de 4-hidroxipirrolo¬2,3-d|pirimidina
Itoh et al. Photochemical Synthesis of Fused Tricyclic Compounds from Bis-6, 6'-(1, 3-dialkyluracilyl) sulfides
FI80273B (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara /3h/-imidazo/5,1-d/-1,2,3,5,-tetrazin-4-on- derivat.
Breining et al. Nitrogen bridgehead compounds. Part 51 Autoxidation of 9‐aminotetrahydro‐4H‐pyrido [1, 2‐a] pyrimidin‐4‐ones. Synthesis and stereochemistry of 9‐amino‐and 9‐hydroxy‐6, 7‐dihydro‐4H‐pyrido [1, 2‐a]‐pyrimidin‐4‐ones
伊東常男 et al. Photochemical synthesis of fused tricyclic compounds from bis-6, 6'-(1, 3-dialkyluracilyl) sulfides.

Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
DNT Communications of changes of names of applicants whose applications have been laid open to public inspection

Free format text: MBL (1991) LIMITED

CNR Transfer of rights (patent application after its laying open for public inspection)

Free format text: CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED

AC1 Application for a supplementary protection certificate

Free format text: 990010, 19990401

KC1 Grant of a supplementary protection certificate

Free format text: 990010, 20020823, EXPIRES: 20070822

V4 Discontinued because of reaching the maximum lifetime of a patent

Free format text: 20020823