NL192205C - Werkwijze voor het bereiden van 7-amino-3-(Z-1-propenyl)-3-cefem-4 -carbonzuur en esters daarvan. - Google Patents

Werkwijze voor het bereiden van 7-amino-3-(Z-1-propenyl)-3-cefem-4 -carbonzuur en esters daarvan. Download PDF

Info

Publication number
NL192205C
NL192205C NL8601011A NL8601011A NL192205C NL 192205 C NL192205 C NL 192205C NL 8601011 A NL8601011 A NL 8601011A NL 8601011 A NL8601011 A NL 8601011A NL 192205 C NL192205 C NL 192205C
Authority
NL
Netherlands
Prior art keywords
formula
liters
solution
stirred
mixture
Prior art date
Application number
NL8601011A
Other languages
English (en)
Dutch (nl)
Other versions
NL8601011A (nl
NL192205B (nl
Original Assignee
Squibb Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Publication of NL8601011A publication Critical patent/NL8601011A/xx
Publication of NL192205B publication Critical patent/NL192205B/xx
Application granted granted Critical
Publication of NL192205C publication Critical patent/NL192205C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
NL8601011A 1985-04-22 1986-04-21 Werkwijze voor het bereiden van 7-amino-3-(Z-1-propenyl)-3-cefem-4 -carbonzuur en esters daarvan. NL192205C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72587185A 1985-04-22 1985-04-22
US72587185 1985-04-22

Publications (3)

Publication Number Publication Date
NL8601011A NL8601011A (nl) 1986-11-17
NL192205B NL192205B (nl) 1996-11-01
NL192205C true NL192205C (nl) 1997-03-04

Family

ID=24916301

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8601011A NL192205C (nl) 1985-04-22 1986-04-21 Werkwijze voor het bereiden van 7-amino-3-(Z-1-propenyl)-3-cefem-4 -carbonzuur en esters daarvan.

Country Status (38)

Country Link
JP (1) JPS61249989A (fi)
KR (1) KR860008189A (fi)
CN (1) CN1015714B (fi)
AR (1) AR242581A1 (fi)
AT (1) AT392072B (fi)
AU (1) AU589170B2 (fi)
BE (1) BE904646A (fi)
CA (1) CA1273629A (fi)
CH (1) CH671399A5 (fi)
CS (1) CS270435B2 (fi)
CY (1) CY1571A (fi)
DD (1) DD244557A5 (fi)
DE (1) DE3613365A1 (fi)
DK (1) DK163584C (fi)
EG (1) EG18001A (fi)
ES (1) ES8800236A1 (fi)
FI (1) FI84268C (fi)
FR (1) FR2580652B1 (fi)
GB (1) GB2173798B (fi)
GR (1) GR861065B (fi)
HK (1) HK106290A (fi)
HU (1) HU195223B (fi)
IE (1) IE59014B1 (fi)
IT (1) IT1228241B (fi)
LU (1) LU86402A1 (fi)
MY (1) MY100694A (fi)
NL (1) NL192205C (fi)
NO (1) NO164659C (fi)
NZ (1) NZ215717A (fi)
OA (1) OA08245A (fi)
PT (1) PT82436B (fi)
SE (1) SE500217C2 (fi)
SG (1) SG90890G (fi)
SU (1) SU1435155A3 (fi)
YU (1) YU43697B (fi)
ZA (1) ZA862985B (fi)
ZM (1) ZM4286A1 (fi)
ZW (1) ZW9086A1 (fi)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
US4870168A (en) * 1987-02-26 1989-09-26 Bristol-Myers Company 3-Unsaturated alkyl cephems from 3-triflyl cephems
DE3933934A1 (de) * 1989-10-03 1991-04-11 Bayer Ag Verfahren zur herstellung von 7-amino-3-((z)-1-propen-1-yl)-3-cephem-4-carbonsaeure
ES2157199T3 (es) * 1991-03-08 2001-08-16 Biochemie Gmbh Nuevo procedimiento para la produccion de cefalosporinas y nuevos compuestos intermedios para este procedimiento.
KR950700311A (ko) 1992-02-05 1995-01-16 게오르게스 그렐리니, 한스 루돌프하우스 3-세펨-4-카복실산 유도체의 정제방법(Process for the purification of a 3-cephem-4-carboxylic acid derivatives)
AT399876B (de) * 1992-02-05 1995-08-25 Biochemie Gmbh Verfahren zur abreicherung von 7-amino-3-((e)-1- propen-1-yl)-3-cephem-4-carbonsäure
JPH07173168A (ja) * 1993-07-14 1995-07-11 Sumitomo Chem Co Ltd セフェム系化合物、その製法、およびそれのセフェム系抗生物質製造への利用
WO2004033464A1 (en) * 2002-10-08 2004-04-22 Ranbaxy Laboratories Limited Process for the preparation of (z)-isomer enriched 7-amino-3-propen-1-yl-3-cephem-4- carboxylic acid
EP1678186A4 (en) * 2003-10-30 2007-04-25 Cj Corp PROCESS FOR THE PREPARATION OF CEPHEM DERIVATIVES
JP4046708B2 (ja) * 2004-06-04 2008-02-13 明治製菓株式会社 ３−アルケニルセフェム化合物の製造方法
EP1809638B1 (en) 2004-11-01 2010-02-17 Hetero Drugs Limited A novel process for preparation of cefprozil intermediate
CN103183686B (zh) * 2011-12-30 2016-06-29 浙江新和成股份有限公司 7β-氨基-7α-甲氧基-3-头孢烯化合物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110534A (en) * 1970-01-23 1978-08-29 Glaxo Laboratories Limited Process for the preparation of 3-vinyl and substituted vinyl cephalosporins
US3769277A (en) * 1970-01-23 1973-10-30 Glaxo Lab Ltd Preparation of delta3-4 carboxy cephalosporins having a 3-vinyl or substituted 3-vinyl group
GB1342241A (en) * 1970-01-23 1974-01-03 Glaxo Lab Ltd Cephalosporin compounds
US4065620A (en) * 1971-06-14 1977-12-27 Eli Lilly And Company 3-(Substituted) vinyl cephalosporins
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4520022A (en) * 1983-01-28 1985-05-28 Bristol-Myers Company Substituted vinyl cephalosporins
AU566944B2 (en) * 1983-10-07 1987-11-05 Gist-Brocades N.V. Preparation of 3-cephem derivatives

Also Published As

Publication number Publication date
LU86402A1 (fr) 1986-11-05
IT8620162A0 (it) 1986-04-21
SU1435155A3 (ru) 1988-10-30
CS287286A2 (en) 1989-11-14
AR242581A1 (es) 1993-04-30
PT82436B (pt) 1988-11-30
FI84268C (fi) 1991-11-11
GB2173798B (en) 1988-11-30
FI861634A0 (fi) 1986-04-17
SE500217C2 (sv) 1994-05-09
DK182486D0 (da) 1986-04-21
ES554215A0 (es) 1987-10-16
ZM4286A1 (en) 1989-03-27
HU195223B (en) 1988-04-28
FR2580652A1 (fr) 1986-10-24
CA1273629A (en) 1990-09-04
DE3613365C2 (fi) 1989-06-15
DE3613365A1 (de) 1987-01-02
JPS61249989A (ja) 1986-11-07
CY1571A (en) 1991-12-20
NO164659B (no) 1990-07-23
DK182486A (da) 1986-10-23
SG90890G (en) 1991-01-18
NO861430L (no) 1986-10-23
FI84268B (fi) 1991-07-31
NL8601011A (nl) 1986-11-17
OA08245A (fr) 1987-10-30
IT1228241B (it) 1991-06-05
EG18001A (en) 1991-11-30
AT392072B (de) 1991-01-25
GR861065B (en) 1986-09-01
IE861048L (en) 1986-10-22
DD244557A5 (de) 1987-04-08
SE8601825L (sv) 1986-10-23
GB8609661D0 (en) 1986-05-29
CS270435B2 (en) 1990-06-13
DK163584B (da) 1992-03-16
PT82436A (en) 1986-05-01
CN86102630A (zh) 1987-02-04
ZA862985B (en) 1986-12-30
FR2580652B1 (fr) 1989-01-06
GB2173798A (en) 1986-10-22
NL192205B (nl) 1996-11-01
NZ215717A (en) 1989-06-28
JPH0327554B2 (fi) 1991-04-16
YU65986A (en) 1987-12-31
YU43697B (en) 1989-10-31
IE59014B1 (en) 1993-12-15
MY100694A (en) 1991-01-17
NO164659C (no) 1990-10-31
BE904646A (fr) 1986-10-21
HK106290A (en) 1990-12-28
AU5616886A (en) 1986-11-06
KR860008189A (ko) 1986-11-12
HUT41033A (en) 1987-03-30
SE8601825D0 (sv) 1986-04-21
ATA106786A (de) 1990-07-15
ZW9086A1 (en) 1986-12-03
FI861634A (fi) 1986-10-23
DK163584C (da) 1992-08-10
AU589170B2 (en) 1989-10-05
CN1015714B (zh) 1992-03-04
ES8800236A1 (es) 1987-10-16
CH671399A5 (fi) 1989-08-31

Similar Documents

Publication Publication Date Title
NL192205C (nl) Werkwijze voor het bereiden van 7-amino-3-(Z-1-propenyl)-3-cefem-4 -carbonzuur en esters daarvan.
CA1110231A (en) 7.beta.-AMINO-CEPHAM-3-ONE-4-CARBOXYLIC ACIDS
US4296236A (en) 7-(or 6-) Substituted-7-(or 6-)acylimino cephalosporin (or penicillin) compounds
IE43845B1 (en) 4-thia-1-azabicyclo/4.2.0/oct-2-ene derivatives
US4122086A (en) Isopenicillins
US4699979A (en) 7-amino-3-propenylcephalosporanic acid and esters thereof
US4139618A (en) Cephalosporin type antibacterials
US4888429A (en) Process for producing allyl aminothiazole acetate intermediates
US5925632A (en) Derivatives of 3-pyrrolidylidene-2-one-cephalsporines
FI75165B (fi) Foerbaettrat foerfarande foer framstaellning av penicillansyraklormetylestrar.
US4145540A (en) 7β-Phosphoramido-7α-methoxycephalosporanic acid derivatives
US4564676A (en) Process for preparing cephalosporin derivatives
AU619201B2 (en) Process for the preparation of 3-exomethylene cepham derivatives
US4051129A (en) Process for preparing 7-methoxycephalosporin compounds
US4048155A (en) Process for preparing 7 α-alkoxycephalosporin derivatives
US4959495A (en) Process for the preparation of intermediates used to produce aminothiazoloximino cephalosporins
US4334063A (en) Cephalosporin vinyl halides
US4079179A (en) 6-Loweralkoxy or loweralkylthio-3-cephem-4-carboxylic acids
CA1052373A (en) Cephalosporin and penicillin derivatives
DE2455358A1 (de) In 2-stellung thiosubstituierte cephalosporinsulfoxide
US4558124A (en) Preparation of cephalosporin intermediate compounds
US4560750A (en) Cephem compounds and process for preparing the same
US4166904A (en) ⊕-lactam containing compounds
US3993758A (en) Cephalosporin compounds
US4299954A (en) Cephalosporin vinyl halides

Legal Events

Date Code Title Description
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
DNT Communications of changes of names of applicants whose applications have been laid open to public inspection

Free format text: BRISTOL-MYERS SQUIBB COMPANY

V4 Discontinued because of reaching the maximum lifetime of a patent

Effective date: 20060421