NL192109C - Kristallijne iminiumzouten, werkwijze ter bereiding daarvan, cardiotonische preparaten die deze zouten bevatten, alsmede hun toepassing ter bereiding van bypiridinonderivaten. - Google Patents

Kristallijne iminiumzouten, werkwijze ter bereiding daarvan, cardiotonische preparaten die deze zouten bevatten, alsmede hun toepassing ter bereiding van bypiridinonderivaten. Download PDF

Info

Publication number
NL192109C
NL192109C NL8100922A NL8100922A NL192109C NL 192109 C NL192109 C NL 192109C NL 8100922 A NL8100922 A NL 8100922A NL 8100922 A NL8100922 A NL 8100922A NL 192109 C NL192109 C NL 192109C
Authority
NL
Netherlands
Prior art keywords
pyridinyl
salt
dimethylamino
propenylidene
acid
Prior art date
Application number
NL8100922A
Other languages
English (en)
Dutch (nl)
Other versions
NL8100922A (nl
NL192109B (nl
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of NL8100922A publication Critical patent/NL8100922A/nl
Publication of NL192109B publication Critical patent/NL192109B/xx
Application granted granted Critical
Publication of NL192109C publication Critical patent/NL192109C/nl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • C07D213/82Amides; Imides in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84Nitriles
    • C07D213/85Nitriles in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NL8100922A 1980-02-26 1981-02-25 Kristallijne iminiumzouten, werkwijze ter bereiding daarvan, cardiotonische preparaten die deze zouten bevatten, alsmede hun toepassing ter bereiding van bypiridinonderivaten. NL192109C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/124,808 US4264609A (en) 1980-02-26 1980-02-26 N-[3-Dimethylamino-2-(4-pyridinyl)-2-propenylidene]-N-methylmethaniminium chloride hydrochloride, its use in preparing 5-(cyano or carbamyl)-[3,4'-bipyridin]-6(1H)-one and its use as a cardiotonic
US12480880 1980-02-26

Publications (3)

Publication Number Publication Date
NL8100922A NL8100922A (nl) 1981-09-16
NL192109B NL192109B (nl) 1996-10-01
NL192109C true NL192109C (nl) 1997-02-04

Family

ID=22416880

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8100922A NL192109C (nl) 1980-02-26 1981-02-25 Kristallijne iminiumzouten, werkwijze ter bereiding daarvan, cardiotonische preparaten die deze zouten bevatten, alsmede hun toepassing ter bereiding van bypiridinonderivaten.

Country Status (28)

Country Link
US (1) US4264609A (fr)
JP (1) JPS56128758A (fr)
KR (2) KR840002067B1 (fr)
AR (1) AR230630A1 (fr)
AT (2) AT380237B (fr)
AU (1) AU541644B2 (fr)
BE (1) BE887663A (fr)
CA (1) CA1128523A (fr)
CH (1) CH647509A5 (fr)
DE (1) DE3107306A1 (fr)
DK (1) DK171253B1 (fr)
ES (1) ES499776A1 (fr)
FI (1) FI76787C (fr)
FR (1) FR2476646A1 (fr)
GB (1) GB2070600B (fr)
HK (1) HK71789A (fr)
IE (1) IE51696B1 (fr)
IL (1) IL62161A (fr)
IT (1) IT1210992B (fr)
LU (1) LU83169A1 (fr)
MX (1) MX6908E (fr)
NL (1) NL192109C (fr)
NO (1) NO156689C (fr)
NZ (1) NZ196282A (fr)
PH (2) PH19904A (fr)
PT (1) PT72573B (fr)
SE (2) SE437514B (fr)
ZA (1) ZA811124B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3685840D1 (de) 1985-04-30 1992-08-06 Dresden Arzneimittel 3-cyan-pyridine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072746A (en) * 1975-10-14 1978-02-07 Sterling Drug Inc. 3-Amino-5-(pyridinyl)-2(1H)-pyridinones
US4004012A (en) * 1975-10-14 1977-01-18 Sterling Drug Inc. 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones

Also Published As

Publication number Publication date
DE3107306A1 (de) 1981-12-17
FI76787B (fi) 1988-08-31
FI76787C (fi) 1988-12-12
KR840002067B1 (ko) 1984-11-09
KR830005143A (ko) 1983-08-03
PT72573A (pt) 1981-03-01
FR2476646A1 (fr) 1981-08-28
DK171253B1 (da) 1996-08-12
ES499776A1 (es) 1984-06-16
GB2070600A (en) 1981-09-09
GB2070600B (en) 1984-07-11
SE8402727D0 (sv) 1984-05-21
SE8101205L (sv) 1981-08-27
SE8402727L (sv) 1984-05-21
NO156689B (no) 1987-07-27
IL62161A0 (en) 1981-03-31
FR2476646B1 (fr) 1984-08-17
LU83169A1 (fr) 1981-09-11
PT72573B (en) 1982-02-12
ATA305683A (de) 1985-09-15
PH19904A (en) 1986-08-13
PH17145A (en) 1984-06-04
ATA88581A (de) 1985-09-15
NL8100922A (nl) 1981-09-16
JPS56128758A (en) 1981-10-08
AT380236B (de) 1986-04-25
AU541644B2 (en) 1985-01-17
AT380237B (de) 1986-04-25
ZA811124B (en) 1982-03-31
AU6748781A (en) 1981-09-03
NL192109B (nl) 1996-10-01
JPH0141626B2 (fr) 1989-09-06
DE3107306C2 (fr) 1990-11-29
CH647509A5 (fr) 1985-01-31
IE810397L (en) 1981-08-26
IE51696B1 (en) 1987-02-18
MX6908E (es) 1986-11-07
HK71789A (en) 1989-09-14
SE452764B (sv) 1987-12-14
NO156689C (no) 1987-11-04
IT1210992B (it) 1989-09-29
IT8119952A0 (it) 1981-02-24
US4264609A (en) 1981-04-28
SE437514B (sv) 1985-03-04
IL62161A (en) 1984-06-29
CA1128523A (fr) 1982-07-27
NO810639L (no) 1981-08-27
KR840002066B1 (ko) 1984-11-09
DK83981A (da) 1981-08-27
FI810582L (fi) 1981-08-27
NZ196282A (en) 1983-12-16
AR230630A1 (es) 1984-05-31
BE887663A (fr) 1981-08-25

Similar Documents

Publication Publication Date Title
DE69303191T2 (de) Naphthalinderivate, ihre Herstellungsverfahren und synthetische Zwischenprodukte dafür
SU999972A3 (ru) Способ получени производных пиридо-(1,2-а) пиримидина или их фармацевтически приемлемых солей,или их оптически активных изомеров
US4305944A (en) N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones
NL192109C (nl) Kristallijne iminiumzouten, werkwijze ter bereiding daarvan, cardiotonische preparaten die deze zouten bevatten, alsmede hun toepassing ter bereiding van bypiridinonderivaten.
NZ203519A (en) 2(1h)-pyridinone derivatives and pharmaceutical compositions
EP0094080B1 (fr) Dérivés de la pyrido(2,1-b)quinazoline
WO1985000603A1 (fr) Urees de ad(pyridinyl)-2-pyrimidinyle bd utiles comme cardiotoniques et leur preparation
US4271168A (en) Selected 3-acylamino-5-[4(or 3)-pyridinyl]-2(1H)-pyridinones
US4346221A (en) Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones
US4463008A (en) 2-Alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof
US4305943A (en) 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics
US4304776A (en) 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics
US4338446A (en) Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates
US4337253A (en) 4,5-Dihydro-2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone and its use as a cardiotonic
NL8102582A (nl) Nieuwe pyridinederivaten, werkwijze ter bereiding hiervan en cardiotonische preparaten.
US4363911A (en) 1,2-Dihydro-6-[2-(dimethylamino)ethenyl]-2-oxo-5-(pyridinyl) nicotinonitriles
US4361569A (en) 3-(Hydroxy or hydroxymethyl)-6-methyl-5-(4-pyridinyl)-2(1H)-pyridinone and cardiotonic use thereof
NL8103362A (nl) Nieuwe pyridinyl-aminofenolen, werkwijze ter bereiding daarvan en cardiotonische preparaten.
KR850000632B1 (ko) 1-py-2[디(저급알킬)아미노]-에테닐 저급알킬 케톤의 제조방법
NL8102077A (nl) Nieuwe pyridazinonen, werkwijze ter bereiding hiervan en cardiotonische preparaten.
NL8105204A (nl) (pyridinyl) benzeenderivaten, werkwijze ter bereiding daarvan en cardiotonische preparaten.
JPS60214776A (ja) 5−ピリジニル−2(1h)−ピリジノン製造のための中間体およびその製法
EP0095152A1 (fr) Procédé pour la préparation de nicotinonitriles et produits intermédiaires utilisés dans ce procédé
NL8101269A (nl) Nieuwe pyrazolopyridinonen en pyridinylnicotinaten, alsmede cardiotonische preparaten die deze verbindingen bevatten.
CS208497B2 (cs) Způsob výroby pyrimidonů

Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
SNR Assignments of patents or rights arising from examined patent applications

Owner name: SANOFI PHARMACEUTICALS, INC.

TNT Modifications of names of proprietors of patents or applicants of examined patent applications

Owner name: STERLING WINTHROP INC.

TNT Modifications of names of proprietors of patents or applicants of examined patent applications

Owner name: SANOFI-SYNTHELABO INC.

V4 Discontinued because of reaching the maximum lifetime of a patent

Free format text: 20010225