NL159662B - Werkwijze ter bereiding van preparaten met werking tegen micro-organismen op basis van op plaats 1 gesubstitueerde imidazoolderivaten, de aldus gevormde voortbrengselen, alsmede de bereiding van de actieve verbindingen. - Google Patents

Werkwijze ter bereiding van preparaten met werking tegen micro-organismen op basis van op plaats 1 gesubstitueerde imidazoolderivaten, de aldus gevormde voortbrengselen, alsmede de bereiding van de actieve verbindingen.

Info

Publication number
NL159662B
NL159662B NL6912331.A NL6912331A NL159662B NL 159662 B NL159662 B NL 159662B NL 6912331 A NL6912331 A NL 6912331A NL 159662 B NL159662 B NL 159662B
Authority
NL
Netherlands
Prior art keywords
preparation
substituated
organisms
preparations
site
Prior art date
Application number
NL6912331.A
Other languages
English (en)
Dutch (nl)
Other versions
NL6912331A (fr
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NL6912331A publication Critical patent/NL6912331A/xx
Publication of NL159662B publication Critical patent/NL159662B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16Radicals substituted by halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
NL6912331.A 1968-08-19 1969-08-13 Werkwijze ter bereiding van preparaten met werking tegen micro-organismen op basis van op plaats 1 gesubstitueerde imidazoolderivaten, de aldus gevormde voortbrengselen, alsmede de bereiding van de actieve verbindingen. NL159662B (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75372968A 1968-08-19 1968-08-19
US84876769A 1969-07-23 1969-07-23

Publications (2)

Publication Number Publication Date
NL6912331A NL6912331A (fr) 1970-02-23
NL159662B true NL159662B (nl) 1979-03-15

Family

ID=27115803

Family Applications (1)

Application Number Title Priority Date Filing Date
NL6912331.A NL159662B (nl) 1968-08-19 1969-08-13 Werkwijze ter bereiding van preparaten met werking tegen micro-organismen op basis van op plaats 1 gesubstitueerde imidazoolderivaten, de aldus gevormde voortbrengselen, alsmede de bereiding van de actieve verbindingen.

Country Status (23)

Country Link
US (1) US3717655A (fr)
JP (2) JPS5039664B1 (fr)
AT (2) AT296289B (fr)
BE (1) BE737575A (fr)
BR (1) BR6911658D0 (fr)
CH (1) CH526553A (fr)
CS (3) CS184772B2 (fr)
DE (1) DE1940388C3 (fr)
DK (1) DK135769B (fr)
ES (3) ES370593A1 (fr)
FI (2) FI52858C (fr)
FR (1) FR2015913A1 (fr)
GB (1) GB1244530A (fr)
IE (1) IE33297B1 (fr)
IL (1) IL32840A (fr)
IT (1) IT974527B (fr)
LU (1) LU59301A1 (fr)
NL (1) NL159662B (fr)
NO (1) NO126180B (fr)
RO (1) RO56625A (fr)
SE (3) SE394432B (fr)
SU (1) SU557755A3 (fr)
YU (1) YU34194B (fr)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3658813A (en) * 1970-01-13 1972-04-25 Janssen Pharmaceutica Nv 1-(beta-aryl-beta-(r-oxy)-ethyl)-imidazoles
DE2037610A1 (de) * 1970-07-29 1972-02-03 Bayer Ag Neue alpha-substituierte Benzyl-azole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US3892764A (en) * 1970-08-22 1975-07-01 Bayer Ag Phenyl-imidazolyl-alkanyl derivatives, their production and use
DE2041771C3 (de) * 1970-08-22 1979-07-26 Bayer Ag, 5090 Leverkusen derivate
DE2105490C3 (de) * 1971-02-05 1979-06-13 Bayer Ag, 5090 Leverkusen 1 -Imidazolylketonderivate
DE2242454A1 (de) * 1972-08-29 1974-03-07 Bayer Ag 1-aethyl-imidazole, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2333354C2 (de) * 1973-06-30 1983-12-15 Bayer Ag, 5090 Leverkusen 2-Aryloxy-2-(imidazol-1-yl)-äthanole sowie deren Salze, Verfahren zu ihrer Herstellung und ihre Verwendung als Fungizide
JPS5347105B2 (fr) * 1973-07-06 1978-12-19
US3873539A (en) * 1973-10-03 1975-03-25 Sandoz Ag Substituted-4-aminoacetyl alkanoylphenones
DE2350123C2 (de) * 1973-10-05 1983-04-14 Bayer Ag, 5090 Leverkusen 1-Propyl-imidazol-Derivate und deren Salze, Verfahren zu ihrer Herstellung und ihre Verwendung als Fungizide
US3991202A (en) * 1974-01-31 1976-11-09 Janssen Pharmaceutica N.V. Imidazolium salts
US3927017A (en) * 1974-06-27 1975-12-16 Janssen Pharmaceutica Nv 1-({62 -Aryl-{62 -R-ethyl)imidazoles
DE2431407C2 (de) * 1974-06-29 1982-12-02 Bayer Ag, 5090 Leverkusen 1,2,4-Triazol-1-yl-alkanone und -alkanole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide
IL47885A (en) * 1974-09-23 1979-01-31 Syntex Inc Imidazole derivatives,their preparation and antifungal and antibacterial compositions containing them
US4017631A (en) * 1974-11-19 1977-04-12 Janssen Pharmaceutica N.V. Imidazolium salts
CA1065873A (fr) * 1975-01-27 1979-11-06 Janssen Pharmaceutica Naamloze Vennootschap Derives de l'imidazole
US3936470A (en) * 1975-01-27 1976-02-03 Janssen Pharmaceutica N.V. 1,3-Dioxolan-2-ylmethylimidazoles
GB1475271A (en) * 1975-04-30 1977-06-01 Pfizer Ltd 1-aryl-2-1-imidazolyl-alkyl ethers and thioethers and their use as antifungal agents
US3949076A (en) * 1975-05-29 1976-04-06 Smithkline Corporation N-(Heterocycl ic-alkyl)-9-xanthenylamines
US4055652A (en) * 1975-07-07 1977-10-25 Syntex (U.S.A.) Inc. 1-[β(R-thio)phenethyl]imidazoles and derivatives thereof
US4045568A (en) * 1975-07-28 1977-08-30 Syntex (U.S.A.) Inc. Derivatives of substituted N-alkyl imidazoles
US4078071A (en) * 1976-03-08 1978-03-07 Syntex (U.S.A.) Inc. Derivatives of substituted N-alkyl imidazoles
MX3866E (es) * 1975-07-28 1981-08-26 Syntex Inc Metodo mejorado para preparar derivados de imidazoles n-alquil sustituidos
US4079143A (en) * 1975-08-26 1978-03-14 Imperial Chemical Industries Limited Fungicidal 1H-1,2,4-triazoles
NZ181916A (en) * 1975-09-10 1979-01-11 Ici Ltd 1-substituted-1,2,4-triazoles and fungicidal compositions
US4101665A (en) * 1975-10-06 1978-07-18 Janssen Pharmaceutica N.V. 1-(2-Ar-4-aryloxymethyl-1,3-dioxolan-2-ylmethyl)imidazoles
DE2547953A1 (de) * 1975-10-27 1977-04-28 Bayer Ag (1-phenyl-2-triazolyl-aethyl)-aether- derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
IE44186B1 (en) * 1975-12-03 1981-09-09 Ici Ltd 1,2,4-triazolyl alkanols and their use as pesticides
GB1511390A (en) * 1975-12-04 1978-05-17 Pfizer Ltd Imidazolylalkyl sulphide antifungal agents
US4039677A (en) * 1976-03-01 1977-08-02 Syntex (U.S.A.) Inc. Novel 1-phenethylimidazoles
US4038409A (en) * 1976-03-01 1977-07-26 Syntex (U.S.A.) Inc. 1-phenethylimidazoles
US4172141A (en) * 1976-03-17 1979-10-23 Syntex (U.S.A.) Inc. N-(naphthylethyl)imidazole derivatives
DE2623129C3 (de) * 1976-05-22 1980-04-10 Nordmark-Werke Gmbh, 2000 Hamburg U-Diphenyl-3-(imidazol-l-yl) -propan-2-ole, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2628421A1 (de) * 1976-06-24 1978-01-05 Bayer Ag Antimikrobielle mittel
AU515134B2 (en) * 1976-08-10 1981-03-19 Janssen Pharmaceutica N.V. 1-(2-aryl-2-r-ethyl)-1h-1,2,4-triazoles
IE45765B1 (en) * 1976-08-19 1982-11-17 Ici Ltd Triazoles and imidazoles useful as plant fungicides and growth regulating agents
SE443783B (sv) * 1977-01-10 1986-03-10 Syntex Inc Sett att framstella 1-/2-(halofenyltio)-4-(p-klor-eller-fluorfenyl)-n-butyl/-imidazoler
US4123542A (en) * 1977-01-19 1978-10-31 Syntex (U.S.A.) Inc. Derivatives of N-alkyl imidazoles
US4598085A (en) * 1977-04-27 1986-07-01 Janssen Pharmaceutica N.V. Fungicidal 1-(2-aryl-2-R-ethyl)-1H-1,2,4-triazoles
US4413003A (en) 1977-07-29 1983-11-01 Rohm And Haas Company β-Hydroxyarylethylimidazoles
DE2860862D1 (en) * 1977-10-13 1981-10-29 Siegfried Ag Imidazolylethylene-oxyalkyloxy derivatives and their thio analogues, methods for their preparation and pharmaceutical compositions containing them
IT1096361B (it) * 1978-05-18 1985-08-26 Recordati Chem Pharm Dibenzileteri sostituiti terapeuticamente attivi
IL57440A0 (en) * 1978-06-12 1979-09-30 Erba Farmitalia N-phenethylimidazole derivatives and process for their preparation
US4159380A (en) * 1978-07-10 1979-06-26 E. R. Squibb & Sons, Inc. Imidazolylethoxy derivatives of pyrazolo[3,4-b]pyridine-5-methanols
US4215220A (en) * 1978-09-11 1980-07-29 Cilag-Chemie A.G. 1-(2-Oxysubstituted-3-anilinopropyl)-imidazoles
US4272545A (en) * 1979-02-02 1981-06-09 Syntex (U.S.A.) Inc. Derivatives of thienyl- and furyl-substituted N-butyl and N-phenyl imidazoles
US4221803A (en) * 1979-05-09 1980-09-09 Recordati, S.A. Substituted dibenzyl ethers and pharmaceutical compositions containing said ethers for the treatment of infections
EP0023103A1 (fr) * 1979-07-04 1981-01-28 Pfizer Limited Dérivés d'imidazole à activité antifongique, procédé pour leur préparation et leurs compositions pharmaceutiques
DE3042303A1 (de) * 1979-11-13 1981-08-27 Sandoz-Patent-GmbH, 7850 Lörrach Organische verbindungen, deren herstellung und verwendung
US4282230A (en) * 1979-11-15 1981-08-04 E. R. Squibb & Sons, Inc. Imidazolylethoxy derivatives of quinoline-2- or 4-methanols, antimicrobial compositions containing them and method for treating bacterial or fungal infections with them
DE2946957A1 (de) * 1979-11-21 1981-06-04 Bayer Ag, 5090 Leverkusen Antimikrobielle mittel
US4248881A (en) * 1979-12-20 1981-02-03 E. R. Squibb & Sons, Inc. Imidazolylethoxymethyl derivatives of pyrazole
NZ196075A (en) * 1980-02-04 1982-12-07 Janssen Pharmaceutica Nv Agent to protect wood coatings and detergents from micro-organisms using a triazole
US4458079A (en) * 1980-08-08 1984-07-03 Bristol-Myers Company Sulfur-containing imidazoles
CA1189857A (fr) * 1981-03-27 1985-07-02 Janssen Pharmaceutica Naamloze Vennootschap Triazoles derives antimicrobiens
JPS5815909A (ja) * 1981-07-22 1983-01-29 Toko Yakuhin Kogyo Kk 抗真菌外用剤
DE3208194A1 (de) * 1982-03-06 1983-09-08 Bayer Ag, 5090 Leverkusen Substituierte azolylethyl-oximinoalkyl-ether, verfahren zu ihrer herstellung und ihre verwendung als fungizide
AT376436B (de) * 1982-11-05 1984-11-26 Laevosan Gmbh & Co Kg Verfahren zur herstellung neuer thiophen-2carbons[urederivate und pharmazeutisch vertraeglicher saeure- oder basenadditionssalze davon
DE3307218A1 (de) * 1983-03-02 1984-09-06 Bayer Ag, 5090 Leverkusen Substituierte diazolylalkyl-carbinole, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel
CH655103A5 (de) * 1983-03-11 1986-03-27 Sandoz Ag Azolderivate, verfahren zu ihrer herstellung und ihre verwendung.
US4518607A (en) * 1983-07-18 1985-05-21 Syntex (U.S.A.) Inc. Male oral contraceptive N-alkylimidazole derivatives, compositions, and method of use therefor
DE3401694A1 (de) * 1984-01-19 1985-07-25 Basf Ag, 6700 Ludwigshafen Azolylmethylcycloacetale, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CA1250586A (fr) * 1984-02-02 1989-02-28 Manuel Raga Derives de 1h-imidazole et procede de production
CA1241602A (fr) * 1984-02-23 1988-09-06 Ortho Pharmaceutical Corporation Solution fongifuge en aerosol
US4912124A (en) * 1984-02-23 1990-03-27 Ortho Pharmaceutical Corporation Antifungal dermatological solution
DE3413365A1 (de) * 1984-04-09 1985-12-19 Merz + Co GmbH & Co, 6000 Frankfurt Substituierte phenylethylderivate, verfahren zu ihrer herstellung und pharmazeutische mittel
JPS61130272A (ja) * 1984-11-30 1986-06-18 Nippon Tokushu Noyaku Seizo Kk β―置換アミノ―フェネチルアゾール誘導体、その製法及び農園芸用殺菌剤
DK8503352A (fr) * 1985-09-05 1987-01-24
DE3644616A1 (de) * 1986-12-29 1988-07-07 Lentia Gmbh Imidazolderivate, verfahren zur herstellung und deren verwendung
DE3644615A1 (de) * 1986-12-29 1988-07-07 Lentia Gmbh Imidazol- und triazolderivate zur verwendung als antimykotische mittel
NZ229783A (en) * 1988-07-22 1990-12-21 Cl Pharma Allylaminoethylazoles; fungicidal and antimycotic compositions, methods for preparation and combating fungi
DE3932552A1 (de) * 1989-09-29 1991-04-11 Basf Ag Verfahren zur herstellung von 1-hydroxyimidazol
GB9127304D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
GB9226581D0 (en) * 1992-12-21 1993-02-17 Merck Sharp & Dohme Therapeutic agents
GB9312893D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
JP2875140B2 (ja) * 1993-08-16 1999-03-24 明治製菓株式会社 抗mrsa組成物
US5461068A (en) * 1993-09-29 1995-10-24 Corwood Laboratories, Inc. Imidazole derivative tincture and method of manufacture
JPH09510185A (ja) * 1993-12-23 1997-10-14 ザ、プロクター、エンド、ギャンブル、カンパニー 組織モイスチャライジング及び抗菌組成物
DE69426727D1 (de) * 1993-12-23 2001-03-29 Procter & Gamble Antimikrobielle zusammensetzungen für abwischtücher
US5565478A (en) * 1994-03-14 1996-10-15 The United States Of America As Represented By The Department Of Health & Human Services Combination therapy using signal transduction inhibitors with paclitaxel and other taxane analogs
US5591726A (en) * 1994-09-26 1997-01-07 American Cyanamid Company Heterocyclylalkyl diarylboron ester and thioester fungicidal agents
WO1997036886A1 (fr) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibiteurs de la farnesyl-proteine transferase
US6403806B1 (en) 1998-12-23 2002-06-11 Maxim Pharmaceuticals, Inc. Synthesis of histamine dihydrochloride
US6080744A (en) * 1999-02-10 2000-06-27 Ayon-Covarrubias; Blas Topical antifungal treatment
US6793678B2 (en) 2002-06-27 2004-09-21 Depuy Acromed, Inc. Prosthetic intervertebral motion disc having dampening
US7053248B2 (en) * 2002-08-09 2006-05-30 Central Glass Company, Limited Process for producing trifluoromethyl- substituted 2- alkoxyacetophenone derivatives
BRPI0407142A (pt) * 2003-02-14 2006-01-10 Depuy Spine Inc Dispositivo de fusão intervertebral formado in situ
US20040267367A1 (en) 2003-06-30 2004-12-30 Depuy Acromed, Inc Intervertebral implant with conformable endplate
WO2005060951A2 (fr) * 2003-12-19 2005-07-07 Bionaut Pharmaceuticals, Inc. Argents anti-neoplasiques, therapies de combinaison et techniques associees
US20080027010A1 (en) * 2004-09-02 2008-01-31 Bionaut Pharmaceuticals, Inc. Treatment of refractory cancers using Na+/K+-ATPase inhibitors
US20070105790A1 (en) * 2004-09-02 2007-05-10 Bionaut Pharmaceuticals, Inc. Pancreatic cancer treatment using Na+/K+ ATPase inhibitors
WO2006029018A2 (fr) * 2004-09-02 2006-03-16 Bionaut Pharmaceuticals, Inc. Traitement chimiotherapeutique combinatoire utilisant des inhibiteurs de na+/k+-atpase
US20060135468A1 (en) * 2004-09-02 2006-06-22 Bionaut Pharmaceuticals, Inc. Treatment of refractory cancers using NA+/K+ ATPase inhibitors
WO2006028969A1 (fr) * 2004-09-02 2006-03-16 Bionaut Pharmaceuticals, Inc. Traitement du cancer du pancreas au moyen d'inhibiteurs d'aptase na+/k+
EP1812010A2 (fr) * 2004-10-18 2007-08-01 BTG International Limited Utilisation d'inhibiteurs de la na+/k+-atpase et leurs antagonistes
US8034110B2 (en) 2006-07-31 2011-10-11 Depuy Spine, Inc. Spinal fusion implant
US8680270B2 (en) * 2006-11-21 2014-03-25 Viamet Pharmaceuticals, Inc. Metallo-oxidoreductase inhibitors using metal binding moieties in combination with targeting moieties
WO2008070863A2 (fr) 2006-12-07 2008-06-12 Interventional Spine, Inc. Implant intervertébral
US8900307B2 (en) 2007-06-26 2014-12-02 DePuy Synthes Products, LLC Highly lordosed fusion cage
EP2237748B1 (fr) 2008-01-17 2012-09-05 Synthes GmbH Implant intervertébral extensible
CA2720580A1 (fr) 2008-04-05 2009-10-08 Synthes Usa, Llc Implant intervertebral extensible
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
US9526620B2 (en) 2009-03-30 2016-12-27 DePuy Synthes Products, Inc. Zero profile spinal fusion cage
BRPI0904249B1 (pt) * 2009-08-28 2018-03-06 Biolab Sanus Farmacêutica Ltda. Compostos éteres aralquil benzílicos, processo de preparação dos mesmos, uso dos referidos compostos, composição farmacêutica
US9168138B2 (en) 2009-12-09 2015-10-27 DePuy Synthes Products, Inc. Aspirating implants and method of bony regeneration
US9393129B2 (en) 2009-12-10 2016-07-19 DePuy Synthes Products, Inc. Bellows-like expandable interbody fusion cage
US8979860B2 (en) 2010-06-24 2015-03-17 DePuy Synthes Products. LLC Enhanced cage insertion device
US9282979B2 (en) 2010-06-24 2016-03-15 DePuy Synthes Products, Inc. Instruments and methods for non-parallel disc space preparation
JP5850930B2 (ja) 2010-06-29 2016-02-03 ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング 離反椎間インプラント
TWI579007B (zh) 2010-07-02 2017-04-21 艾格諾福斯保健公司 骨再生材料之用途
US9402732B2 (en) 2010-10-11 2016-08-02 DePuy Synthes Products, Inc. Expandable interspinous process spacer implant
EP2551351A1 (fr) 2011-07-29 2013-01-30 Interquim, S.A. Procédé de préparation du (R)-(-)-1-(2,4-dichloro-phényl)-2-imidazole-1-yl-éthanol optiquement actif
US9717601B2 (en) 2013-02-28 2017-08-01 DePuy Synthes Products, Inc. Expandable intervertebral implant, system, kit and method
US9522070B2 (en) 2013-03-07 2016-12-20 Interventional Spine, Inc. Intervertebral implant
TWI651103B (zh) 2013-12-13 2019-02-21 萊特醫技股份有限公司 多相骨移植替代材料
US11426290B2 (en) 2015-03-06 2022-08-30 DePuy Synthes Products, Inc. Expandable intervertebral implant, system, kit and method
CN109688980B (zh) 2016-06-28 2022-06-10 Eit 新兴移植技术股份有限公司 具有关节运动接头的可扩张和角度可调节的椎间笼
JP6995789B2 (ja) 2016-06-28 2022-01-17 イーアイティー・エマージング・インプラント・テクノロジーズ・ゲーエムベーハー 拡張可能かつ角度調節可能な椎間ケージ
CN109982999A (zh) 2016-09-29 2019-07-05 拜耳作物科学股份公司 新的5-取代的咪唑基甲基衍生物
CA3038362A1 (fr) 2016-09-29 2018-04-05 Bayer Cropscience Aktiengesellschaft Derives d'imidazolylmethyldioxolane a substitution en position 5 en tant que fongicides
BR112019006451A2 (pt) 2016-09-29 2019-06-25 Bayer Ag derivados substituídos de 1,5 imidazóis como fungicidas para proteção de plantação.
BR112019006450A2 (pt) 2016-09-29 2019-06-25 Bayer Cropscience Ag novos derivados de imidazolilmetila substituídos na posição 5
US20200045972A1 (en) 2016-09-29 2020-02-13 Bayer Cropscience Aktiengesellschaft Novel 5-substituted imidazolylmethyl derivatives
CN110198929A (zh) * 2016-11-28 2019-09-03 赛力克斯生物私人有限公司 用于治疗真菌感染的组合物和方法
CA3044734A1 (fr) * 2016-11-28 2018-05-31 Cellix Bio Private Limited Compositions et methodes pour le traitement de maladies infectieuses buccales
US10888433B2 (en) 2016-12-14 2021-01-12 DePuy Synthes Products, Inc. Intervertebral implant inserter and related methods
US11185548B2 (en) 2016-12-23 2021-11-30 Helmholtz Zentrum Munchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Inhibitors of cytochrome P450 family 7 subfamily B member 1 (CYP7B1) for use in treating diseases
US10398563B2 (en) 2017-05-08 2019-09-03 Medos International Sarl Expandable cage
US11344424B2 (en) 2017-06-14 2022-05-31 Medos International Sarl Expandable intervertebral implant and related methods
US10940016B2 (en) 2017-07-05 2021-03-09 Medos International Sarl Expandable intervertebral fusion cage
CN108047147A (zh) * 2017-12-08 2018-05-18 长江大学 一类三唑类化合物以及作为杀菌剂的用途
CN109320458B (zh) * 2018-10-12 2022-05-31 中国药科大学 一类含二芳基咪唑类化合物及其制备方法和医药用途
US11446156B2 (en) 2018-10-25 2022-09-20 Medos International Sarl Expandable intervertebral implant, inserter instrument, and related methods
US20220267280A1 (en) * 2019-08-16 2022-08-25 Purdue Research Foundation Small molecule stimulators of the core particle of the proteasome
US20230347019A1 (en) 2020-01-31 2023-11-02 Wright Medical Technology, Inc. Improved bone graft substitute formulation
US11426286B2 (en) 2020-03-06 2022-08-30 Eit Emerging Implant Technologies Gmbh Expandable intervertebral implant
US11850160B2 (en) 2021-03-26 2023-12-26 Medos International Sarl Expandable lordotic intervertebral fusion cage
US11752009B2 (en) 2021-04-06 2023-09-12 Medos International Sarl Expandable intervertebral fusion cage
US12090064B2 (en) 2022-03-01 2024-09-17 Medos International Sarl Stabilization members for expandable intervertebral implants, and related systems and methods

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1486817A (fr) * 1965-07-22 1967-06-30 Basf Ag Insecticides

Also Published As

Publication number Publication date
FR2015913A1 (fr) 1970-04-30
ES390807A1 (es) 1974-03-16
AT296289B (de) 1972-02-10
IL32840A0 (en) 1969-11-12
IT974527B (it) 1974-07-10
FI751886A (fr) 1975-06-25
JPS5039664B1 (fr) 1975-12-18
JPS51115B1 (fr) 1976-01-05
NL6912331A (fr) 1970-02-23
YU212669A (en) 1978-09-18
DE1940388B2 (de) 1977-09-15
SE363330B (fr) 1974-01-14
AT291249B (de) 1971-07-12
IE33297L (en) 1970-02-19
CH526553A (fr) 1972-08-15
BE737575A (fr) 1970-02-18
IE33297B1 (en) 1974-05-15
DE1940388A1 (de) 1970-02-26
CS184753B2 (en) 1978-09-15
CS184771B2 (en) 1978-09-15
FI52858B (fr) 1977-08-31
ES370593A1 (es) 1971-07-01
CS184772B2 (en) 1978-09-15
RO56625A (fr) 1974-11-11
SE394432B (sv) 1977-06-27
ES393167A2 (es) 1977-12-16
US3717655A (en) 1973-02-20
DK135769C (fr) 1977-11-21
FI52858C (fi) 1977-12-12
FI55434C (fi) 1979-08-10
GB1244530A (en) 1971-09-02
YU34194B (en) 1979-02-28
BR6911658D0 (pt) 1973-04-19
DK135769B (da) 1977-06-20
FI55434B (fi) 1979-04-30
LU59301A1 (fr) 1970-01-06
SE395690B (sv) 1977-08-22
NO126180B (fr) 1973-01-02
SU557755A3 (ru) 1977-05-05
IL32840A (en) 1972-09-28
DE1940388C3 (de) 1978-05-11

Similar Documents

Publication Publication Date Title
NL159662B (nl) Werkwijze ter bereiding van preparaten met werking tegen micro-organismen op basis van op plaats 1 gesubstitueerde imidazoolderivaten, de aldus gevormde voortbrengselen, alsmede de bereiding van de actieve verbindingen.
NL160150C (nl) Werkwijze ter bereiding van 3-acyloxy-2-fenyl-1h- -indeen-1-on-derivaten met herbicide- en acaricide werking, alsmede herbicide- en acaricidepreparaten die deze verbindingen als actieve component bevatten.
NL159654B (nl) Werkwijze ter bereiding van diaminoverbindingen met fungicide werking en werkwijze ter bereiding van preparaten, die deze diaminoverbindingen bevatten.
NL7706646A (nl) Werkwijze ter bereiding van diuretisch werkzame farmaceutische preparaten, de door toepassing daarvan verkregen gevormde voortbrengselen, als- mede werkwijze ter bereiding van diuretisch werk- zame verbindingen.
NL157192B (nl) Werkwijze ter bereiding van herbicide preparaten.
NL156135B (nl) Werkwijze voor het bereiden van bloeddruk verlagende preparaten, de aldus verkregen gevormde preparaten, alsmede werkwijze voor het bereiden van de voor deze preparaten geschikte actieve stoffen.
NL142872B (nl) Werkwijze ter bereiding van basische stikstofverbindingen met spasmolytische en/of vaatverwijdende werking; werkwijze ter bereiding van farmaceutische preparaten, alsmede de aldus verkregen voorwerpen.
NL148889B (nl) Werkwijze voor de bereiding van tegen patogene protozoen actieve preparaten, alsmede voor de bereiding van daarvoor geschikte 1-(2-hydroxyalkyl)-5-nitroimidazolen.
NL156575B (nl) Werkwijze ter bereiding van preparaten voor het bestrijden van voor planten pathogene organismen, alsmede werkwijze ter bereiding van voor het bestrijden van voor planten pathogene organismen werkzame verbindingen.
NL160485C (nl) Werkwijze ter bereiding van farmaceutische preparaten met anti-inflammatoire, analgetische en anti-pyretische wer- king, alsmede door toepassing van deze werkwijze verkregen voorwerpen.
NL149792B (nl) Werkwijze voor het bereiden van microbiologisch werkzame preparaten, gevormde preparaten en werkwijze ter bereiding van microbiologisch werkzame dibenzo-verbindingen.
NL167963C (nl) Werkwijze voor de bereiding van onkruid verdelgende preparaten, die thiadiazolylureumverbindingen bevatten, en werkwijze voor de bereiding van dergelijke thiadiazolylureumverbindingen.
NL165743C (nl) Werkwijze ter bereiding van farmaceutische preparaten met antidepressieve werking op basis van 1,3-dialkyl- -4-arylpyrazoloŸ3.4-eŸŸ1.4Ÿ-diazepinederivaten, de onder toepassing daarvan verkregen gevormde farma- ceutische preparaten, alsmede werkwijze ter bereiding van 1,3-dialkyl-4-arylpyrazolo Ÿ3.4-e-ŸŸ1.4Ÿdiazepine- derivaten.
NL157012B (nl) Werkwijze voor de bereiding van farmaceutische preparaten met anti-inflammatoire werking, aldus verkregen gevormde voortbrengselen, alsmede werkwijze ter bereiding van anti-inflammatoir werkzame heterocyclische verbindingen.
NL159261B (nl) Werkwijze voor het behandelen van rijstvelden, werkwijze ter bereiding van daarvoor geschikte herbicide preparaten, aldus bereide gevormde preparaten, alsmede werkwijze voor de bereiding van verbindingen met herbicide werking.
NL177823C (nl) Werkwijze ter bereiding van ureum- en thioureumverbindingen met insecticide werking alsmede van insecticide preparaten.
FI46374C (fi) Menetelmä 2'-substituoitujen steroidi-(17alfa,16alfa-d)-oksatsoliinien valmistamiseksi.
NL160550C (nl) Werkwijze ter bereiding van insekticide en acaricide pre- paraten, gevormde preparaten en werkwijze ter bereiding van verbindingen met insekticide en acaricide werking.
NL160817C (nl) Werkwijze voor de bereiding van herbicide s-triazine- derivaten, alsmede werkwijze voor de bereiding van herbicide preparaten, die deze verbindingen bevatten.
NL152854B (nl) Werkwijze voor het bereiden van een preparaat met een werking tegen bacterien, de verkregen gevormde preparaten en op een werkwijze voor het bereiden van 2,3-digesubstitueerde pyridinederivaten.
NL166267C (nl) Werkwijze ter bereiding van farmaceutische preparaten, de onder toepassing daarvan verkregen gevormde voort- brengselen, alsmede werkwijze ter bereiding van 6,7-methyleen-20-spirox-4-en-3-onderivaten met aldoste- ron remmende werking.
NL159109B (nl) Werkwijze ter bereiding van cytostatisch werkzame derivaten van gefluoreerde pyrimidinenucleosiden, werkwijze ter bereiding van farmaceutische preparaten met cytostatische werking, alsmede de gevormde farmaceutische preparaten.
NL152170B (nl) Werkwijze ter bereiding van antibiotisch werkzame rifamycinederivaten; werkwijze ter bereiding van farmaceutische preparaten en de aldus verkregen preparaten.
NL161423B (nl) Werkwijze voor de bereiding van plantenvoedingsbodem.
NL179535C (nl) Werkwijze ter bereiding van fungicide preparaten op basis van furancarboxamidederivaten, het gevormde fungicide preparaat, alsmede werkwijze ter bereiding van deze furancarboxamidederivaten.

Legal Events

Date Code Title Description
NL80 Information provided on patent owner name for an already discontinued patent

Owner name: JANSSEN

V4 Discontinued because of reaching the maximum lifetime of a patent