MY103744A - Azithromycin dihydrate - Google Patents
Azithromycin dihydrateInfo
- Publication number
- MY103744A MY103744A MYPI88000744A MYPI19880744A MY103744A MY 103744 A MY103744 A MY 103744A MY PI88000744 A MYPI88000744 A MY PI88000744A MY PI19880744 A MYPI19880744 A MY PI19880744A MY 103744 A MY103744 A MY 103744A
- Authority
- MY
- Malaysia
- Prior art keywords
- azithromycin dihydrate
- azithromycin
- dihydrate
- homoerythromycin
- deoxo
- Prior art date
Links
- VQEMDSRIOVZAOM-UHFFFAOYSA-N 4-(4-methylsulfonylphenyl)-1,3-thiazol-2-amine Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CSC(N)=N1 VQEMDSRIOVZAOM-UHFFFAOYSA-N 0.000 title 1
- 229960004924 azithromycin dihydrate Drugs 0.000 title 1
- 229960004099 azithromycin Drugs 0.000 abstract 1
- SRMPHJKQVUDLQE-KUJJYQHYSA-N azithromycin dihydrate Chemical compound O.O.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 SRMPHJKQVUDLQE-KUJJYQHYSA-N 0.000 abstract 1
- 150000004683 dihydrates Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1987/001612 WO1989000576A1 (en) | 1987-07-09 | 1987-07-09 | Azithromycin dihydrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY103744A true MY103744A (en) | 1993-09-30 |
Family
ID=22202456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI88000744A MY103744A (en) | 1987-07-09 | 1988-07-05 | Azithromycin dihydrate |
Country Status (45)
| Country | Link |
|---|---|
| US (1) | US6268489B1 (h) |
| EP (1) | EP0298650B1 (h) |
| JP (1) | JPH0631300B2 (h) |
| KR (1) | KR900006218B1 (h) |
| CN (1) | CN1016785B (h) |
| AP (1) | AP44A (h) |
| AR (1) | AR243532A1 (h) |
| AT (1) | ATE72446T1 (h) |
| AU (1) | AU604553B2 (h) |
| BA (1) | BA98213B1 (h) |
| BG (1) | BG47348A3 (h) |
| CA (1) | CA1314876C (h) |
| CS (1) | CS272241B2 (h) |
| CY (1) | CY1776A (h) |
| DD (1) | DD271705A5 (h) |
| DE (1) | DE3868296D1 (h) |
| DK (1) | DK172573B1 (h) |
| EG (1) | EG18527A (h) |
| ES (1) | ES2038756T3 (h) |
| FI (1) | FI91263C (h) |
| GR (1) | GR3003737T3 (h) |
| HK (1) | HK127594A (h) |
| HU (1) | HU211862A9 (h) |
| IE (1) | IE60354B1 (h) |
| IL (1) | IL86979A (h) |
| IN (1) | IN168879B (h) |
| IS (1) | IS1540B (h) |
| LV (1) | LV10624B (h) |
| MA (1) | MA21323A1 (h) |
| MX (1) | MX12213A (h) |
| MY (1) | MY103744A (h) |
| NO (1) | NO171556C (h) |
| NZ (1) | NZ225338A (h) |
| OA (1) | OA08743A (h) |
| PH (1) | PH30953A (h) |
| PL (1) | PL157145B1 (h) |
| PT (1) | PT87933B (h) |
| RO (1) | RO107257B1 (h) |
| RU (1) | RU2066324C1 (h) |
| SG (1) | SG27794G (h) |
| SI (1) | SI8811325A8 (h) |
| UA (1) | UA27040C2 (h) |
| WO (1) | WO1989000576A1 (h) |
| YU (1) | YU45075B (h) |
| ZA (1) | ZA884925B (h) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20020231A2 (en) * | 2002-03-18 | 2003-12-31 | Pliva D D | ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A |
| US5912331A (en) * | 1991-03-15 | 1999-06-15 | Merck & Co., Inc. | Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A |
| US5985844A (en) * | 1992-03-26 | 1999-11-16 | Merck & Co., Inc. | Homoerythromycin A derivatives modified at the 4"-and 8A-positions |
| US5189159A (en) * | 1992-04-02 | 1993-02-23 | Merck & Co., Inc. | 8a-AZA-8a-homoerythromycin cyclic iminoethers |
| EP0539223A1 (en) * | 1991-10-25 | 1993-04-28 | Ono Pharmaceutical Co., Ltd. | Glycine derivative monosodium salt tetrahydrate having an inhibitory effect on elastase |
| US5215980A (en) * | 1992-01-17 | 1993-06-01 | Merck & Co., Inc. | 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof |
| US5210235A (en) * | 1992-08-26 | 1993-05-11 | Merck & Co., Inc. | Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics |
| US5332807A (en) * | 1993-04-14 | 1994-07-26 | Merck & Co., Inc. | Process of producing 8A- and 9A-azalide antibiotics |
| CN1034734C (zh) * | 1993-12-10 | 1997-04-30 | 北京市集才药物研究所 | 一种新的阿齐红霉素结晶及其制备方法 |
| US5605889A (en) | 1994-04-29 | 1997-02-25 | Pfizer Inc. | Method of administering azithromycin |
| FI964452A7 (fi) * | 1994-05-06 | 1996-11-05 | Pfizer | Atsitromysiinin kontrolloidun vapautumisen annostusmuotoja |
| ES2122905B1 (es) * | 1996-07-11 | 1999-11-16 | Astur Pharma Sa | Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato). |
| NZ503897A (en) * | 1997-10-16 | 2002-10-25 | Pliva Pharm & Chem Works | 3,6-hemiketals from the class of 9a-azalides |
| US6861411B1 (en) | 1997-12-02 | 2005-03-01 | Pfizer, Inc. | Method of treating eye infections with azithromycin |
| PT102130A (pt) * | 1998-03-13 | 1999-09-30 | Hovione Sociedade Quimica S A | Processo de preparacao de dihidrato de azitromicina |
| TW546302B (en) * | 1998-05-08 | 2003-08-11 | Biochemie Sa | Improvements in macrolide production |
| CA2245398C (en) | 1998-08-21 | 2002-01-29 | Apotex Inc. | Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof |
| PL197894B1 (pl) * | 1998-11-30 | 2008-05-30 | Teva Pharma | Etanolan azytromycyny, sposób jego wytwarzania i zawierająca go kompozycja farmaceutyczna |
| US7056893B2 (en) | 1999-03-31 | 2006-06-06 | Insite Vision, Inc. | Topical treatment for prevention of ocular infections |
| US6239113B1 (en) | 1999-03-31 | 2001-05-29 | Insite Vision, Incorporated | Topical treatment or prevention of ocular infections |
| HK1045521B (zh) * | 1999-05-18 | 2005-12-09 | 辉瑞产品公司 | 大环内酯抗生素的新晶形 |
| HRP20010956B1 (hr) | 1999-06-29 | 2010-09-30 | Biochemie S.A. | Makrolidi |
| ES2177373B1 (es) * | 1999-11-26 | 2003-11-01 | Astur Pharma Sa | Preparacion de azitromicina en su forma no cristalina |
| DE60133083D1 (de) | 2000-01-04 | 2008-04-17 | Teva Pharma | Verfahren zur herstellung von azithromycin-dihydrat |
| ES2162764B1 (es) * | 2000-05-17 | 2003-04-01 | Ercros Ind Sa | Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion. |
| WO2002010144A1 (es) | 2000-07-25 | 2002-02-07 | Laboratorio Silanes, S.A. De C.V. | PROCESO PARA LA PREPARACION EN UN SOLO PASO DE 7,16-DIOXA-2-AZA-10-O-CLADINOSIL-12-O-DESOSAMINIL-4,5-DIHIDROXI-6-ETIL-3,5,9,11,13,15-HEXAMETILBICICLO[11.2.1]HEXADECA-1(2)-EN-8-ONA Y OBTENCION DE UNA FORMA NUEVA DE 9-DESOXO-9a-AZA-9a-METIL-9a-HOMOERITROMICINA A |
| ES2172417B1 (es) * | 2000-07-31 | 2003-09-16 | Sint Quimica Sa | Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden. |
| CA2419873A1 (en) * | 2000-08-23 | 2002-02-28 | Wockhardt Limited | Process for preparation of anhydrous azithromycin |
| CN100341886C (zh) * | 2000-11-27 | 2007-10-10 | 桑多斯股份公司 | 大环内酯类化合物的溶剂化物 |
| EE05200B1 (et) * | 2000-11-27 | 2009-08-17 | Biochemie S.A. | Asitromtsiin monohdraadina, selle valmistamismeetod ja selle kasutamine ravimkoostises |
| IN190080B (h) * | 2001-01-29 | 2003-06-07 | Alembic Ltd | |
| KR100491183B1 (ko) | 2001-03-21 | 2005-05-25 | 한미약품 주식회사 | 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물 |
| SI1390377T1 (sl) | 2001-05-22 | 2006-06-30 | Pfizer Prod Inc | Nova kristalna oblika azitromicina |
| US6861413B2 (en) | 2001-05-22 | 2005-03-01 | Pfizer Inc. | Stable non-dihydrate azithromycin oral suspensions |
| BR0209918A (pt) * | 2001-05-22 | 2004-03-30 | Pfizer Prod Inc | Formas cristalinas da azitromicina |
| CA2458135A1 (en) * | 2001-08-21 | 2003-03-06 | Pfizer Products Inc. | Single dose azithromycin for treating respiratory infections |
| RU2277914C2 (ru) | 2001-12-21 | 2006-06-20 | Пфайзер Продактс Инк. | Составы, содержащие азитромицин, поддающиеся прямому прессованию |
| JP2005515212A (ja) * | 2001-12-21 | 2005-05-26 | ファイザー・プロダクツ・インク | アジスロマイシンの湿式造粒法 |
| CA2474809A1 (en) * | 2002-02-01 | 2003-08-07 | Pfizer Products Inc. | Dry granulated formulations of azithromycin |
| US7376064B2 (en) | 2002-02-25 | 2008-05-20 | Samsung Electronics Co., Ltd. | Method and apparatus for recording data on optical recording medium |
| ITMI20021209A1 (it) * | 2002-06-04 | 2003-12-04 | Chemi Spa | Processo di preparazione di azitromicina ad elevata purezza |
| US6855813B2 (en) * | 2002-07-19 | 2005-02-15 | Alembic Limited | Process for the preparation of azithromycin monohydrate |
| HRP20020614A2 (en) | 2002-07-22 | 2004-06-30 | PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. | Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a |
| GB2395482A (en) * | 2003-07-03 | 2004-05-26 | Jubilant Organosys Ltd | Process for preparing non-hygroscopic azithromycin dihydrate |
| US20050013835A1 (en) * | 2003-07-15 | 2005-01-20 | Pfizer Inc. | Stable non-dihydrate azithromycin oral suspensions |
| WO2005053639A2 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Controlled release multiparticulates formed with dissolution enhancers |
| MXPA06005913A (es) * | 2003-12-04 | 2006-06-27 | Pfizer Prod Inc | Formas de dosificacion de multiparticulas de azitromicina por procedimientos basados en liquidos. |
| WO2005053652A1 (en) | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride |
| DK1691787T3 (da) * | 2003-12-04 | 2008-09-22 | Pfizer Prod Inc | Fremgangsmåde til at danne småpartikler |
| WO2005053651A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Multiparticulate compositions with improved stability |
| WO2005053656A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride |
| AU2004294813A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Spray-congeal process using an extruder for preparing multiparticulate azithromycin compositions containing preferably a poloxamer and a glyceride |
| US6984403B2 (en) * | 2003-12-04 | 2006-01-10 | Pfizer Inc. | Azithromycin dosage forms with reduced side effects |
| RU2260012C1 (ru) * | 2004-01-29 | 2005-09-10 | Открытое акционерное общество "Акционерное курганское общество медицинских препаратов и изделий "Синтез" | Способ кристаллизации азитромицина дигидрата |
| US7468428B2 (en) | 2004-03-17 | 2008-12-23 | App Pharmaceuticals, Llc | Lyophilized azithromycin formulation |
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| WO2006011160A1 (en) | 2004-06-28 | 2006-02-02 | Alembic Limited | Process for the preparation of azithromycin monohydrate isopropanol clathrate |
| CN1308361C (zh) * | 2004-08-09 | 2007-04-04 | 大连振邦氟涂料股份有限公司 | 乙烯－三氟氯乙烯共聚物的制备方法 |
| US7683162B2 (en) * | 2004-08-30 | 2010-03-23 | Taro Pharmaceutical Industries Limited | Process of preparing a crystalline azithromycin monohydrate |
| TW200628483A (en) * | 2004-12-01 | 2006-08-16 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Processes for producing crystalline macrolides |
| EP1830815A1 (en) * | 2004-12-21 | 2007-09-12 | Pfizer Products Incorporated | Enteric coated azithromycin multiparticulates |
| US8546423B2 (en) | 2005-05-18 | 2013-10-01 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
| CN100366686C (zh) * | 2006-01-12 | 2008-02-06 | 济南瑞氟化工科技有限公司 | 一种氟硅超双疏不粘涂料 |
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| US7704959B2 (en) | 2006-10-03 | 2010-04-27 | Dow Pharmaceutical Sciences | Azithromycin for the treatment of nodular acne |
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| CN101177441B (zh) * | 2007-12-05 | 2012-05-23 | 浙江耐司康药业有限公司 | 一种稳定的阿奇霉素一水合物结晶的制备方法 |
| CN101624412B (zh) * | 2008-07-10 | 2012-07-04 | 刘力 | 大环内酯类衍生物及其制备和用途 |
| SG194406A1 (en) | 2008-10-07 | 2013-11-29 | Mpex Pharmaceuticals Inc | Aerosol fluoroquinolone formulations for improved pharmacokinetics |
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| CN101418026B (zh) * | 2008-10-09 | 2011-05-18 | 南京工业大学 | 一种晶型和粒度可控的阿奇霉素结晶工艺 |
| CN101787063B (zh) * | 2009-01-23 | 2012-12-19 | 刘力 | 抗感染药物及其制备和用途 |
| KR20120004448A (ko) | 2009-03-13 | 2012-01-12 | 다 볼떼라 | 그람음성 박테리아 제거용 조성물 및 방법 |
| CA2938650C (en) | 2009-09-04 | 2018-01-09 | Raptor Pharmaceuticals Inc. | Use of aerosolized levofloxacin for treating cystic fibrosis |
| CN102911219A (zh) * | 2011-08-03 | 2013-02-06 | 山东方明药业集团股份有限公司 | 一种阿齐霉素在水相直接结晶的方法 |
| CN103159811A (zh) * | 2011-12-10 | 2013-06-19 | 山东方明药业集团股份有限公司 | 一种阿齐霉素中间体9a-脱氧-9a-氮杂-9a-高红霉素A的制备方法 |
| WO2013088274A1 (en) | 2011-12-14 | 2013-06-20 | Wockhardt Limited | Anhydrous amorphous azithromycin composition free of azithromycin dihydrate |
| CN102417531B (zh) * | 2011-12-20 | 2014-06-11 | 浙江国邦药业有限公司 | 一种阿奇霉素一水合物的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4020270A (en) * | 1974-05-02 | 1977-04-26 | Societa' Farmaceutici Italia S.P.A. | L-lyxohex-1-enopyranose derivative |
| US4219641A (en) * | 1979-06-14 | 1980-08-26 | The Upjohn Company | Process for preparing erythromycin succinate |
| SI8110592A8 (en) | 1981-03-06 | 1996-06-30 | Pliva Pharm & Chem Works | Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof |
| US4474768A (en) * | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
| US4526889A (en) * | 1982-11-15 | 1985-07-02 | Pfizer Inc. | Epimeric azahomoerythromycin A derivative, intermediates and method of use |
| PH19293A (en) * | 1982-11-15 | 1986-03-04 | Pfizer | Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof |
| US4512982A (en) * | 1984-04-13 | 1985-04-23 | Pfizer Inc. | 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method |
| YU43402B (en) * | 1985-03-04 | 1989-06-30 | Pliva Pharm & Chem Works | Process for preparation of 11-aza-10-deoxo-10-dihydroeritromycin "a" by using electro-chemical reduction |
| WO1989002271A1 (en) | 1987-09-10 | 1989-03-23 | Pfizer | Azithromycin and derivatives as antiprotozoal agents |
-
1987
- 1987-07-09 RO RO143593A patent/RO107257B1/ro unknown
- 1987-07-09 WO PCT/US1987/001612 patent/WO1989000576A1/en active IP Right Grant
- 1987-07-09 MX MX1221388A patent/MX12213A/es unknown
- 1987-07-09 RU SU874742955A patent/RU2066324C1/ru active
- 1987-07-09 UA UA93004522A patent/UA27040C2/uk unknown
-
1988
- 1988-05-11 IN IN418/DEL/88A patent/IN168879B/en unknown
- 1988-06-15 AP APAP/P/1988/000093A patent/AP44A/en active
- 1988-06-28 EP EP88305921A patent/EP0298650B1/en not_active Expired - Lifetime
- 1988-06-28 ES ES198888305921T patent/ES2038756T3/es not_active Expired - Lifetime
- 1988-06-28 DE DE8888305921T patent/DE3868296D1/de not_active Expired - Lifetime
- 1988-06-28 AT AT88305921T patent/ATE72446T1/de not_active IP Right Cessation
- 1988-07-04 IL IL86979A patent/IL86979A/xx not_active IP Right Cessation
- 1988-07-05 BG BG084783A patent/BG47348A3/xx unknown
- 1988-07-05 MY MYPI88000744A patent/MY103744A/en unknown
- 1988-07-06 CS CS884896A patent/CS272241B2/cs not_active IP Right Cessation
- 1988-07-06 JP JP63168637A patent/JPH0631300B2/ja not_active Expired - Lifetime
- 1988-07-07 EG EG376/88A patent/EG18527A/xx active
- 1988-07-07 PL PL1988273590A patent/PL157145B1/pl unknown
- 1988-07-07 PT PT87933A patent/PT87933B/pt not_active IP Right Cessation
- 1988-07-07 IS IS3370A patent/IS1540B/is unknown
- 1988-07-07 AR AR88311356A patent/AR243532A1/es active
- 1988-07-07 PH PH37189A patent/PH30953A/en unknown
- 1988-07-07 CA CA000571381A patent/CA1314876C/en not_active Expired - Lifetime
- 1988-07-07 DD DD88317672A patent/DD271705A5/de unknown
- 1988-07-08 NZ NZ225338A patent/NZ225338A/xx unknown
- 1988-07-08 SI SI8811325A patent/SI8811325A8/sl unknown
- 1988-07-08 AU AU18839/88A patent/AU604553B2/en not_active Expired
- 1988-07-08 ZA ZA884925A patent/ZA884925B/xx unknown
- 1988-07-08 IE IE210888A patent/IE60354B1/en not_active IP Right Cessation
- 1988-07-08 OA OA59384A patent/OA08743A/xx unknown
- 1988-07-08 DK DK198803806A patent/DK172573B1/da not_active IP Right Cessation
- 1988-07-08 KR KR1019880008463A patent/KR900006218B1/ko not_active Expired
- 1988-07-08 CN CN88104331A patent/CN1016785B/zh not_active Expired
- 1988-07-08 YU YU1325/88A patent/YU45075B/xx unknown
- 1988-07-11 MA MA21565A patent/MA21323A1/fr unknown
-
1990
- 1990-01-08 NO NO90900077A patent/NO171556C/no not_active IP Right Cessation
- 1990-01-08 FI FI900087A patent/FI91263C/fi not_active IP Right Cessation
-
1992
- 1992-02-06 GR GR920400067T patent/GR3003737T3/el unknown
- 1992-12-21 US US07/994,040 patent/US6268489B1/en not_active Expired - Lifetime
-
1993
- 1993-11-17 LV LVP-93-1240A patent/LV10624B/xx unknown
-
1994
- 1994-02-22 SG SG27794A patent/SG27794G/en unknown
- 1994-11-17 HK HK127594A patent/HK127594A/en not_active IP Right Cessation
-
1995
- 1995-06-30 HU HU95P/P00738P patent/HU211862A9/hu unknown
- 1995-10-20 CY CY177695A patent/CY1776A/xx unknown
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1998
- 1998-03-30 BA BA980213A patent/BA98213B1/bs active
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