MXPA05014223A - Derivados de bencimidazol y su uso como inhibidores de proteinas quinasas. - Google Patents
Derivados de bencimidazol y su uso como inhibidores de proteinas quinasas.Info
- Publication number
- MXPA05014223A MXPA05014223A MXPA05014223A MXPA05014223A MXPA05014223A MX PA05014223 A MXPA05014223 A MX PA05014223A MX PA05014223 A MXPA05014223 A MX PA05014223A MX PA05014223 A MXPA05014223 A MX PA05014223A MX PA05014223 A MXPA05014223 A MX PA05014223A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- carbon atoms
- ring
- groups
- hydrogen
- Prior art date
Links
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Landscapes
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- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US51437403P | 2003-10-24 | 2003-10-24 | |
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| PCT/GB2004/002824 WO2005002552A2 (en) | 2003-07-03 | 2004-07-05 | Benzimidazole derivatives and their use as protein kinases inhibitors |
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| NZ544756A (en) | 2003-07-22 | 2009-09-25 | Astex Therapeutics Ltd | 3,4-Disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators |
| JP2007514759A (ja) | 2003-12-19 | 2007-06-07 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| US7977322B2 (en) | 2004-08-20 | 2011-07-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| CN1938279B (zh) * | 2004-01-30 | 2011-09-14 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白调控剂 |
| EP1781653A1 (en) * | 2004-07-05 | 2007-05-09 | Astex Therapeutics Limited | 3,4-disubstituted pyrazoles as cyclin dependent kinases (cdk) or aurora kinase or glycogen synthase 3 (gsk-3) inhibitors |
| WO2006023931A2 (en) | 2004-08-18 | 2006-03-02 | Takeda San Diego, Inc. | Kinase inhibitors |
| ATE479687T1 (de) | 2004-10-15 | 2010-09-15 | Takeda Pharmaceutical | Kinaseinhibitoren |
| US7816369B2 (en) | 2004-11-03 | 2010-10-19 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| JP2008526723A (ja) * | 2004-12-30 | 2008-07-24 | アステックス、セラピューティックス、リミテッド | Ｃｄｋ、ｇｓｋ及びオーロラキナーゼの活性を調節するピラゾール誘導体 |
| US20080312223A1 (en) * | 2004-12-30 | 2008-12-18 | Astex Therapeutics Limited | Thiazole And Isothiazole Derivatives That Modulate The Activity Of CDK, GSK And Aurora Kinases |
| JP5507049B2 (ja) * | 2004-12-30 | 2014-05-28 | アステックス、セラピューティックス、リミテッド | 医薬品 |
| WO2006077428A1 (en) | 2005-01-21 | 2006-07-27 | Astex Therapeutics Limited | Pharmaceutical compounds |
| US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
| AR052559A1 (es) * | 2005-01-21 | 2007-03-21 | Astex Therapeutics Ltd | Derivados de pirazol para inhibir cdk's y gsk's |
| AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
| RU2436575C2 (ru) * | 2005-01-21 | 2011-12-20 | Астекс Терапьютикс Лимитед | Соединения для использования в фармацевтике |
| WO2006077424A1 (en) * | 2005-01-21 | 2006-07-27 | Astex Therapeutics Limited | Pharmaceutical compounds |
| US20090156582A1 (en) * | 2005-02-09 | 2009-06-18 | Tetsuya Tsukamoto | Pyrazole Compound |
| WO2006108489A1 (en) | 2005-04-14 | 2006-10-19 | F. Hoffmann-La Roche Ag | Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents |
| EP1749523A1 (en) * | 2005-07-29 | 2007-02-07 | Neuropharma, S.A. | GSK-3 inhibitors |
| US8093401B2 (en) | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| US8088928B2 (en) | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| ES2397275T3 (es) * | 2005-08-04 | 2013-03-05 | Sirtris Pharmaceuticals, Inc. | Derivados de imidazopiridina como agentes moduladores de la sirtuína |
| US7855289B2 (en) | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| EP2377530A3 (en) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
| EP1942879A1 (en) | 2005-10-31 | 2008-07-16 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| JP2009518340A (ja) * | 2005-12-08 | 2009-05-07 | ノバルティス アクチエンゲゼルシャフト | ＥｐｈＢおよびＶＥＧＦＲ２キナーゼ阻害剤としてのピラゾロ［１，５−ａ］ピリジン−３−カルボン酸 |
| EP1966213A1 (en) * | 2005-12-15 | 2008-09-10 | F.Hoffmann-La Roche Ag | Tricyclic lactam derivatives, their manufacture and use as pharmaceutical agents |
| US7572809B2 (en) | 2005-12-19 | 2009-08-11 | Hoffmann-La Roche Inc. | Isoquinoline aminopyrazole derivatives |
| JP5474354B2 (ja) * | 2005-12-30 | 2014-04-16 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
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-
2004
- 2004-07-02 TW TW093120042A patent/TWI372050B/zh not_active IP Right Cessation
- 2004-07-05 PL PL10195498T patent/PL2305250T3/pl unknown
- 2004-07-05 WO PCT/GB2004/002824 patent/WO2005002552A2/en not_active Ceased
- 2004-07-05 ES ES10195498.0T patent/ES2457466T3/es not_active Expired - Lifetime
- 2004-07-05 CN CN2004800249288A patent/CN1845734B/zh not_active Expired - Fee Related
- 2004-07-05 PL PL04743172T patent/PL1648426T3/pl unknown
- 2004-07-05 EP EP10195498.0A patent/EP2305250B1/en not_active Expired - Lifetime
- 2004-07-05 US US10/564,166 patent/US7977477B2/en not_active Expired - Fee Related
- 2004-07-05 CA CA2531050A patent/CA2531050C/en not_active Expired - Fee Related
- 2004-07-05 PT PT101954980T patent/PT2305250E/pt unknown
- 2004-07-05 DK DK10195498.0T patent/DK2305250T3/da active
- 2004-07-05 SI SI200432125T patent/SI1648426T1/sl unknown
- 2004-07-05 MX MXPA05014223A patent/MXPA05014223A/es active IP Right Grant
- 2004-07-05 AU AU2004253338A patent/AU2004253338B2/en not_active Ceased
- 2004-07-05 PT PT47431721T patent/PT1648426E/pt unknown
- 2004-07-05 JP JP2006518329A patent/JP4833059B2/ja not_active Expired - Fee Related
- 2004-07-05 NZ NZ543959A patent/NZ543959A/en not_active IP Right Cessation
- 2004-07-05 EP EP04743172.1A patent/EP1648426B1/en not_active Expired - Lifetime
- 2004-07-05 SI SI200432146T patent/SI2305250T1/sl unknown
- 2004-07-05 DK DK04743172.1T patent/DK1648426T3/da active
- 2004-07-05 ES ES04743172.1T patent/ES2443995T3/es not_active Expired - Lifetime
-
2011
- 2011-05-26 US US13/116,121 patent/US20110224203A1/en not_active Abandoned
-
2013
- 2013-05-24 US US13/902,325 patent/US20140010892A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TWI372050B (en) | 2012-09-11 |
| PT2305250E (pt) | 2014-05-19 |
| EP1648426A2 (en) | 2006-04-26 |
| JP2007516194A (ja) | 2007-06-21 |
| ES2457466T3 (es) | 2014-04-25 |
| DK1648426T3 (da) | 2014-02-10 |
| AU2004253338A1 (en) | 2005-01-13 |
| US20140010892A1 (en) | 2014-01-09 |
| CN1845734A (zh) | 2006-10-11 |
| CA2531050A1 (en) | 2005-01-13 |
| PL2305250T3 (pl) | 2014-07-31 |
| EP2305250A1 (en) | 2011-04-06 |
| US20070135477A1 (en) | 2007-06-14 |
| AU2004253338B2 (en) | 2010-02-18 |
| WO2005002552A3 (en) | 2005-06-16 |
| US7977477B2 (en) | 2011-07-12 |
| NZ543959A (en) | 2009-08-28 |
| EP1648426B1 (en) | 2014-01-08 |
| ES2443995T3 (es) | 2014-02-21 |
| JP4833059B2 (ja) | 2011-12-07 |
| SI2305250T1 (sl) | 2014-06-30 |
| US20110224203A1 (en) | 2011-09-15 |
| EP2305250B1 (en) | 2014-03-26 |
| DK2305250T3 (da) | 2014-04-22 |
| TW200524598A (en) | 2005-08-01 |
| WO2005002552A2 (en) | 2005-01-13 |
| PT1648426E (pt) | 2014-03-07 |
| PL1648426T3 (pl) | 2014-05-30 |
| CN1845734B (zh) | 2011-06-22 |
| CA2531050C (en) | 2013-04-09 |
| SI1648426T1 (sl) | 2014-04-30 |
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