MXPA05001042A - Un metodo para purificar preproinsulina. - Google Patents
Un metodo para purificar preproinsulina.Info
- Publication number
- MXPA05001042A MXPA05001042A MXPA05001042A MXPA05001042A MXPA05001042A MX PA05001042 A MXPA05001042 A MX PA05001042A MX PA05001042 A MXPA05001042 A MX PA05001042A MX PA05001042 A MXPA05001042 A MX PA05001042A MX PA05001042 A MXPA05001042 A MX PA05001042A
- Authority
- MX
- Mexico
- Prior art keywords
- gly
- leu
- glu
- ser
- cys
- Prior art date
Links
- 108010066381 preproinsulin Proteins 0.000 title claims abstract description 89
- 238000000034 method Methods 0.000 title claims abstract description 42
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- 239000000126 substance Substances 0.000 claims abstract description 23
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- 239000007864 aqueous solution Substances 0.000 claims abstract description 5
- 238000001179 sorption measurement Methods 0.000 claims abstract description 5
- 150000001450 anions Chemical class 0.000 claims abstract description 3
- 150000001768 cations Chemical class 0.000 claims abstract 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| DE10235168A DE10235168A1 (de) | 2002-08-01 | 2002-08-01 | Verfahren zur Reinigung von Preproinsulin |
| PCT/EP2003/007820 WO2004013176A1 (de) | 2002-08-01 | 2003-07-18 | Verfahren zur reinigung von preproinsulin |
Publications (1)
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|---|---|
| MXPA05001042A true MXPA05001042A (es) | 2005-04-08 |
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| MXPA05001042A MXPA05001042A (es) | 2002-08-01 | 2003-07-18 | Un metodo para purificar preproinsulina. |
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| US (2) | US20050080000A1 (https=) |
| EP (1) | EP1527097B1 (https=) |
| JP (1) | JP4519646B2 (https=) |
| AT (1) | ATE384742T1 (https=) |
| AU (1) | AU2003254375B2 (https=) |
| BR (1) | BR0313131A (https=) |
| CA (1) | CA2493539C (https=) |
| CY (1) | CY1108046T1 (https=) |
| DE (2) | DE10235168A1 (https=) |
| DK (1) | DK1527097T3 (https=) |
| ES (1) | ES2297223T3 (https=) |
| IL (1) | IL166438A (https=) |
| MX (1) | MXPA05001042A (https=) |
| PT (1) | PT1527097E (https=) |
| SI (1) | SI1527097T1 (https=) |
| WO (1) | WO2004013176A1 (https=) |
Families Citing this family (58)
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| US6428771B1 (en) * | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| ES2569916T3 (es) * | 1999-06-29 | 2016-05-13 | Mannkind Corporation | Formulaciones farmacéuticas que comprenden insulina complejada con una dicetopiperazina |
| US6923175B2 (en) | 2002-03-20 | 2005-08-02 | Mannkind Corporation | Inhalation apparatus |
| US7338171B2 (en) * | 2003-10-27 | 2008-03-04 | Jen-Chuen Hsieh | Method and apparatus for visual drive control |
| ES2584867T3 (es) * | 2004-01-12 | 2016-09-29 | Mannkind Corporation | Un método que reduce los niveles séricos de proinsulina en diabéticos de tipo 2 |
| DE602005014962D1 (de) * | 2004-03-12 | 2009-07-30 | Biodel Inc | Insulinzusammensetzungen mit verbesserter wirkstoffabsorption |
| US20080090753A1 (en) * | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
| ATE486064T1 (de) | 2004-08-20 | 2010-11-15 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
| KR20130066695A (ko) | 2004-08-23 | 2013-06-20 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| MX373000B (es) | 2005-09-14 | 2020-05-21 | Mannkind Corp | Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas. |
| US7713929B2 (en) | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
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-
2002
- 2002-08-01 DE DE10235168A patent/DE10235168A1/de not_active Withdrawn
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2003
- 2003-07-18 ES ES03766211T patent/ES2297223T3/es not_active Expired - Lifetime
- 2003-07-18 DE DE50309087T patent/DE50309087D1/de not_active Expired - Lifetime
- 2003-07-18 JP JP2004525238A patent/JP4519646B2/ja not_active Expired - Fee Related
- 2003-07-18 EP EP03766211A patent/EP1527097B1/de not_active Expired - Lifetime
- 2003-07-18 WO PCT/EP2003/007820 patent/WO2004013176A1/de not_active Ceased
- 2003-07-18 AT AT03766211T patent/ATE384742T1/de active
- 2003-07-18 CA CA2493539A patent/CA2493539C/en not_active Expired - Fee Related
- 2003-07-18 AU AU2003254375A patent/AU2003254375B2/en not_active Ceased
- 2003-07-18 DK DK03766211T patent/DK1527097T3/da active
- 2003-07-18 SI SI200331119T patent/SI1527097T1/sl unknown
- 2003-07-18 BR BR0313131-9A patent/BR0313131A/pt active Search and Examination
- 2003-07-18 PT PT03766211T patent/PT1527097E/pt unknown
- 2003-07-18 MX MXPA05001042A patent/MXPA05001042A/es active IP Right Grant
- 2003-08-01 US US10/632,414 patent/US20050080000A1/en not_active Abandoned
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- 2005-01-23 IL IL166438A patent/IL166438A/en not_active IP Right Cessation
- 2005-12-15 US US11/305,508 patent/US7803763B2/en not_active Expired - Fee Related
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| AU2003254375B2 (en) | 2009-01-08 |
| JP2006513978A (ja) | 2006-04-27 |
| US20060183666A1 (en) | 2006-08-17 |
| US20050080000A1 (en) | 2005-04-14 |
| SI1527097T1 (sl) | 2008-04-30 |
| AU2003254375A1 (en) | 2004-02-23 |
| ATE384742T1 (de) | 2008-02-15 |
| JP4519646B2 (ja) | 2010-08-04 |
| DE50309087D1 (https=) | 2008-03-13 |
| PT1527097E (pt) | 2008-02-25 |
| ES2297223T3 (es) | 2008-05-01 |
| BR0313131A (pt) | 2005-07-05 |
| DK1527097T3 (da) | 2008-05-26 |
| EP1527097A1 (de) | 2005-05-04 |
| CY1108046T1 (el) | 2013-09-04 |
| WO2004013176A1 (de) | 2004-02-12 |
| US7803763B2 (en) | 2010-09-28 |
| IL166438A (en) | 2010-11-30 |
| DE10235168A1 (de) | 2004-02-12 |
| CA2493539C (en) | 2012-01-31 |
| CA2493539A1 (en) | 2004-02-12 |
| EP1527097B1 (de) | 2008-01-23 |
| IL166438A0 (en) | 2006-01-15 |
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