BR0313131A - Processo para a purificação de preproinsulina - Google Patents
Processo para a purificação de preproinsulinaInfo
- Publication number
- BR0313131A BR0313131A BR0313131-9A BR0313131A BR0313131A BR 0313131 A BR0313131 A BR 0313131A BR 0313131 A BR0313131 A BR 0313131A BR 0313131 A BR0313131 A BR 0313131A
- Authority
- BR
- Brazil
- Prior art keywords
- preproinsulin
- purification
- preproinsulins
- chromatography
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
"PROCESSO PARA A PURIFICAçãO DE PREPROINSULINA". A presente invenção refere-se a um processo para a purificação cromatográfica de preproinsulina, no qual substâncias de peso molecular mais elevado são separadas a partir de uma solução aquosa da preproinsulina através de uma primeira cromatografia em um trocador de ânions no modo de passagem e uma segunda cromatografia seguinte em um trocador de cátions no modo de adsorção, bem como a um processo para a preparação de insulinas, o qual inclui o processo para a preparação de preproinsulinas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10235168A DE10235168A1 (de) | 2002-08-01 | 2002-08-01 | Verfahren zur Reinigung von Preproinsulin |
PCT/EP2003/007820 WO2004013176A1 (de) | 2002-08-01 | 2003-07-18 | Verfahren zur reinigung von preproinsulin |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0313131A true BR0313131A (pt) | 2005-07-05 |
Family
ID=30128614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0313131-9A BR0313131A (pt) | 2002-08-01 | 2003-07-18 | Processo para a purificação de preproinsulina |
Country Status (16)
Country | Link |
---|---|
US (2) | US20050080000A1 (pt) |
EP (1) | EP1527097B1 (pt) |
JP (1) | JP4519646B2 (pt) |
AT (1) | ATE384742T1 (pt) |
AU (1) | AU2003254375B2 (pt) |
BR (1) | BR0313131A (pt) |
CA (1) | CA2493539C (pt) |
CY (1) | CY1108046T1 (pt) |
DE (2) | DE10235168A1 (pt) |
DK (1) | DK1527097T3 (pt) |
ES (1) | ES2297223T3 (pt) |
IL (1) | IL166438A (pt) |
MX (1) | MXPA05001042A (pt) |
PT (1) | PT1527097E (pt) |
SI (1) | SI1527097T1 (pt) |
WO (1) | WO2004013176A1 (pt) |
Families Citing this family (57)
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US6428771B1 (en) * | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
DK2280020T3 (en) * | 1999-06-29 | 2016-05-02 | Mannkind Corp | Pharmaceutical formulations comprising a peptide complexed with a diketopiperazine |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
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US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
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BR122019022692B1 (pt) | 2004-08-23 | 2023-01-10 | Mannkind Corporation | Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo |
HUE028691T2 (en) | 2005-09-14 | 2016-12-28 | Mannkind Corp | A method for formulating a drug based on increasing the affinity of crystalline microparticle surfaces towards active ingredients |
WO2007041481A1 (en) * | 2005-09-29 | 2007-04-12 | Biodel, Inc. | Rapid acting and prolonged acting insulin preparations |
US8084420B2 (en) * | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US7713929B2 (en) | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
EP1986679B1 (en) | 2006-02-22 | 2017-10-25 | MannKind Corporation | A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
JP2009533471A (ja) * | 2006-04-12 | 2009-09-17 | バイオデル, インコーポレイテッド | 即効型および長時間作用型組合せインスリン製剤 |
CN101951957A (zh) * | 2008-01-04 | 2011-01-19 | 百达尔公司 | 胰岛素释放作为组织的葡萄糖水平的函数的胰岛素制剂 |
AR072114A1 (es) | 2008-06-13 | 2010-08-04 | Mannkind Corp | Un inhalador de polvo seco y sistema para suministro de farmacos |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
BRPI0914308B8 (pt) | 2008-06-20 | 2021-06-22 | Mannkind Corp | sistema de inalação |
TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
KR101820024B1 (ko) | 2008-10-17 | 2018-01-18 | 사노피-아벤티스 도이칠란트 게엠베하 | 인슐린과 glp-1 효능제의 병용물 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US9060927B2 (en) * | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
CA2754595C (en) | 2009-03-11 | 2017-06-27 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
KR101875969B1 (ko) | 2009-06-12 | 2018-07-06 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
CN102471368A (zh) * | 2009-08-11 | 2012-05-23 | 拜康有限公司 | 色谱方法及其纯化的化合物 |
EP2496295A1 (en) | 2009-11-03 | 2012-09-12 | MannKind Corporation | An apparatus and method for simulating inhalation efforts |
HUE037735T2 (hu) | 2009-11-13 | 2018-09-28 | Sanofi Aventis Deutschland | DesPro36exendin-4(1-39)-Lys6-NH2-t és metionint tartalmazó gyógyszerkészítmény |
ES2534191T3 (es) | 2009-11-13 | 2015-04-20 | Sanofi-Aventis Deutschland Gmbh | Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina |
AU2011202239C1 (en) | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
RU2571331C1 (ru) | 2010-06-21 | 2015-12-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
BR112013004756B1 (pt) | 2010-08-30 | 2020-04-28 | Sanofi Aventis Deutschland | uso de ave0010 para a fabricação de um medicamento para o tratamento da diabetes melito tipo 2 |
JP6110312B2 (ja) | 2011-02-01 | 2017-04-05 | ノヴォ ノルディスク アー/エス | インスリンの精製 |
DE102011003944A1 (de) | 2011-02-10 | 2012-08-16 | Oxprotect Gmbh | Detektion und Entfernung von missgefalteten Proteinen/Peptiden |
JP6133270B2 (ja) | 2011-04-01 | 2017-05-24 | マンカインド コーポレイション | 薬剤カートリッジのためのブリスター包装 |
CN102219851B (zh) | 2011-05-09 | 2012-05-30 | 甘李药业有限公司 | 甘精胰岛素结晶的制备方法 |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
RU2650616C2 (ru) | 2011-08-29 | 2018-04-16 | Санофи-Авентис Дойчланд Гмбх | Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа |
TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
JP6018640B2 (ja) | 2011-10-24 | 2016-11-02 | マンカインド コーポレイション | 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム |
SG11201500218VA (en) | 2012-07-12 | 2015-03-30 | Mannkind Corp | Dry powder drug delivery systems and methods |
US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
US10421795B2 (en) * | 2012-12-17 | 2019-09-24 | Merck Sharp & Dohme Corp. | Process for purifying insulin and analogues thereof |
WO2014144895A1 (en) | 2013-03-15 | 2014-09-18 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
DK2983697T3 (en) | 2013-04-03 | 2019-02-25 | Sanofi Sa | TREATMENT OF DIABETES MELLITUS WITH LONG-EFFECTIVE FORMULATIONS OF INSULIN |
AU2014290438B2 (en) | 2013-07-18 | 2019-11-07 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
WO2015021064A1 (en) | 2013-08-05 | 2015-02-12 | Mannkind Corporation | Insufflation apparatus and methods |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
BR112017000175B1 (pt) * | 2014-07-08 | 2023-11-21 | Amphastar Pharmaceuticals,Inc. | Método de preparação de uma insulina inalável adequada para a liberação pulmonar e partículas de insulina micronizadas |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
JP6970615B2 (ja) | 2014-12-12 | 2021-11-24 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | インスリングラルギン/リキシセナチド固定比処方 |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
US10322168B2 (en) | 2016-01-07 | 2019-06-18 | Amphastar Pharmaceuticals, Inc. | High-purity inhalable particles of insulin and insulin analogues, and high-efficiency methods of manufacturing the same |
CN113773392B (zh) * | 2020-06-09 | 2023-04-07 | 宁波鲲鹏生物科技有限公司 | 一种甘精胰岛素的制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4783441A (en) * | 1979-04-30 | 1988-11-08 | Hoechst Aktiengesellschaft | Aqueous protein solutions stable to denaturation |
CA1339955C (en) | 1986-10-14 | 1998-07-14 | Richard Eugene Heiney | Process for transforming a human insulin precursor to human insulin |
JPH0832726B2 (ja) * | 1987-06-08 | 1996-03-29 | 武田薬品工業株式会社 | ラットbFGFおよびその製造法 |
DE3726655A1 (de) * | 1987-08-11 | 1989-02-23 | Hoechst Ag | Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten |
GR1005153B (el) * | 1989-08-29 | 2006-03-13 | The General Hospital Corporation | Πρωτεινες συντηξεως, παρασκευη τους και χρηση τους. |
US5358857A (en) * | 1989-08-29 | 1994-10-25 | The General Hospital Corp. | Method of preparing fusion proteins |
JP2916206B2 (ja) * | 1990-04-28 | 1999-07-05 | 帝國製薬株式会社 | 生理活性ペプチド |
EP0600372B1 (de) * | 1992-12-02 | 1997-02-05 | Hoechst Aktiengesellschaft | Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken |
US5886154A (en) * | 1997-06-20 | 1999-03-23 | Lebing; Wytold R. | Chromatographic method for high yield purification and viral inactivation of antibodies |
DE19735711C2 (de) * | 1997-08-18 | 2001-04-26 | Aventis Pharma Gmbh | Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken |
KR100253916B1 (ko) * | 1997-12-29 | 2000-05-01 | 김충환 | 사람 인슐린 전구체의 제조방법 |
DE19947456A1 (de) * | 1999-10-02 | 2001-04-05 | Aventis Pharma Gmbh | C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga |
DE10008064B4 (de) * | 2000-02-22 | 2009-07-02 | Siemens Ag | Verfahren zum Anpassen der einem Turbo-Codierer zuzuführenden Datenblöcke und entsprechende Kommunikationsvorrichtung |
UA92145C2 (en) * | 2000-02-22 | 2010-10-11 | Мерк Сероно С.А. | Purified lh |
-
2002
- 2002-08-01 DE DE10235168A patent/DE10235168A1/de not_active Withdrawn
-
2003
- 2003-07-18 DK DK03766211T patent/DK1527097T3/da active
- 2003-07-18 EP EP03766211A patent/EP1527097B1/de not_active Expired - Lifetime
- 2003-07-18 WO PCT/EP2003/007820 patent/WO2004013176A1/de active IP Right Grant
- 2003-07-18 DE DE50309087T patent/DE50309087D1/de not_active Expired - Lifetime
- 2003-07-18 BR BR0313131-9A patent/BR0313131A/pt active Search and Examination
- 2003-07-18 ES ES03766211T patent/ES2297223T3/es not_active Expired - Lifetime
- 2003-07-18 CA CA2493539A patent/CA2493539C/en not_active Expired - Fee Related
- 2003-07-18 SI SI200331119T patent/SI1527097T1/sl unknown
- 2003-07-18 PT PT03766211T patent/PT1527097E/pt unknown
- 2003-07-18 AU AU2003254375A patent/AU2003254375B2/en not_active Ceased
- 2003-07-18 JP JP2004525238A patent/JP4519646B2/ja not_active Expired - Fee Related
- 2003-07-18 MX MXPA05001042A patent/MXPA05001042A/es active IP Right Grant
- 2003-07-18 AT AT03766211T patent/ATE384742T1/de active
- 2003-08-01 US US10/632,414 patent/US20050080000A1/en not_active Abandoned
-
2005
- 2005-01-23 IL IL166438A patent/IL166438A/en not_active IP Right Cessation
- 2005-12-15 US US11/305,508 patent/US7803763B2/en not_active Expired - Fee Related
-
2008
- 2008-02-18 CY CY20081100198T patent/CY1108046T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
MXPA05001042A (es) | 2005-04-08 |
SI1527097T1 (sl) | 2008-04-30 |
CA2493539C (en) | 2012-01-31 |
ATE384742T1 (de) | 2008-02-15 |
DE10235168A1 (de) | 2004-02-12 |
US7803763B2 (en) | 2010-09-28 |
ES2297223T3 (es) | 2008-05-01 |
JP2006513978A (ja) | 2006-04-27 |
IL166438A0 (en) | 2006-01-15 |
DK1527097T3 (da) | 2008-05-26 |
JP4519646B2 (ja) | 2010-08-04 |
IL166438A (en) | 2010-11-30 |
AU2003254375B2 (en) | 2009-01-08 |
CY1108046T1 (el) | 2013-09-04 |
US20050080000A1 (en) | 2005-04-14 |
US20060183666A1 (en) | 2006-08-17 |
CA2493539A1 (en) | 2004-02-12 |
EP1527097B1 (de) | 2008-01-23 |
EP1527097A1 (de) | 2005-05-04 |
AU2003254375A1 (en) | 2004-02-23 |
DE50309087D1 (pt) | 2008-03-13 |
WO2004013176A1 (de) | 2004-02-12 |
PT1527097E (pt) | 2008-02-25 |
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Legal Events
Date | Code | Title | Description |
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B25D | Requested change of name of applicant approved |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 13A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |