UA86775C2 - Способ очистки раствора альфа-1-антитрипсина - Google Patents

Способ очистки раствора альфа-1-антитрипсина

Info

Publication number
UA86775C2
UA86775C2 UAA200602563A UAA200602563A UA86775C2 UA 86775 C2 UA86775 C2 UA 86775C2 UA A200602563 A UAA200602563 A UA A200602563A UA A200602563 A UAA200602563 A UA A200602563A UA 86775 C2 UA86775 C2 UA 86775C2
Authority
UA
Ukraine
Prior art keywords
preparing
alpha
a1at
detergents
antitrypsin solution
Prior art date
Application number
UAA200602563A
Other languages
English (en)
Ukrainian (uk)
Inventor
Петра Шульц
Юрген Рьёмиш
Original Assignee
Октафарма Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Октафарма Аг filed Critical Октафарма Аг
Publication of UA86775C2 publication Critical patent/UA86775C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0017—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Изобретение относится к способу очистки альфа-1-антитрипсина от других белковых компонентов из растворов, которые содержат альфа-1-антитрипсин, который включает стадии:(a) проведение ионообменной хроматографии раствора, который содержит альфа-1-антитрипсин;(b) добавление детергентов и необязательно растворителя для инактивации покрытых липидной оболочкой вирусов;(c) последующего увеличения концентрации соли для высаливания детергентов.
UAA200602563A 2003-08-12 2004-08-12 Способ очистки раствора альфа-1-антитрипсина UA86775C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49409703P 2003-08-12 2003-08-12

Publications (1)

Publication Number Publication Date
UA86775C2 true UA86775C2 (ru) 2009-05-25

Family

ID=34135316

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200602563A UA86775C2 (ru) 2003-08-12 2004-08-12 Способ очистки раствора альфа-1-антитрипсина

Country Status (22)

Country Link
US (1) US20060194300A1 (ru)
EP (1) EP1654284B1 (ru)
JP (1) JP4668904B2 (ru)
KR (1) KR20060070543A (ru)
CN (1) CN1867582B (ru)
AT (1) ATE428730T1 (ru)
AU (1) AU2004262578B2 (ru)
BR (1) BRPI0412835A (ru)
CA (1) CA2534900A1 (ru)
DE (1) DE602004020632D1 (ru)
DK (1) DK1654284T3 (ru)
ES (1) ES2324168T3 (ru)
IL (1) IL172868A0 (ru)
NO (1) NO20060109L (ru)
PL (1) PL1654284T3 (ru)
PT (1) PT1654284E (ru)
RS (1) RS20060077A (ru)
RU (1) RU2370500C2 (ru)
SI (1) SI1654284T1 (ru)
UA (1) UA86775C2 (ru)
WO (1) WO2005014648A1 (ru)
ZA (1) ZA200601206B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1664123E (pt) * 2003-09-22 2008-07-16 Kamada Ltd Preparação em larga escala de um inibidor da alfa-1 proteinase e sua utilização
ES2246695B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico.
ES2246694B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Nanoparticulas pegiladas.
CN100354301C (zh) * 2005-10-13 2007-12-12 南京工业大学 化学合成多肽的新型大规模分离制备技术
WO2009059082A2 (en) 2007-11-02 2009-05-07 Talecris Biotherapeutics, Inc. Method, composition, and article of manufacture for providing alpha-1 antitrypsin
CN102127165B (zh) * 2010-01-15 2013-09-04 上海莱士血液制品股份有限公司 一种从血浆组分四沉淀中制备高纯ApoA-I的生产工艺
CN102731642B (zh) * 2011-04-14 2014-01-29 上海莱士血液制品股份有限公司 从人血浆组分四沉淀制备高纯Apoa-I的生产工艺
US9353165B2 (en) * 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
AU2013205138B2 (en) 2012-08-09 2015-06-25 Grifols, S.A. Caprylate Viral Deactivation
ES2770860T3 (es) * 2015-06-26 2020-07-03 Ferring Bv Métodos de purificación y/o inactivación viral
AU2017214678B2 (en) * 2016-02-03 2024-02-01 Plasma Technologies, Llc Methods for extracting proteins from a blood-based material
CN111991571B (zh) * 2020-08-12 2022-04-05 湖州师范学院 一种柱上低pH病毒灭活的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS584728A (ja) * 1981-05-01 1983-01-11 メデイカル・リサ−チ・インステイチユ−ト・オブ・サンフランシスコ・コ−ポレ−シヨン α−１−抗トリプシンの精製
US4684723A (en) * 1985-09-11 1987-08-04 Miles Laboratories, Inc. Method of separating proteins from aqueous solutions
US4629567A (en) * 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification
ES2053606T3 (es) * 1987-04-27 1994-08-01 Miles Inc Metodo de preparacion de un inhibidor de alfa-1-proteinasa de alta pureza.
KR920005689B1 (ko) * 1989-12-21 1992-07-13 국제약품공업주식회사 혈청으로부터 알파-1-안티트립신의 분리 정제 및 혈중 알파-1-안티트립신 양의 검정키트
DE4125625C2 (de) * 1991-08-02 1999-12-02 Octapharma Ag Glarus Verfahren zur Herstellung von virusinaktivierten Immunglobulinlösungen
SE9301582D0 (sv) * 1993-05-07 1993-05-07 Kabi Pharmacia Ab Purification of plasma proteins
DE4407837C1 (de) * 1994-03-09 1995-08-17 Octapharma Ag Verfahren zur Gewinnung von hochreinem, virusinaktiviertem alpha¶1¶-Antitrypsin mittels Anionenaustauscher-Chromatographie
US6284874B1 (en) * 1994-06-17 2001-09-04 Alpha Therapeutic Corporation Process for separating α1-proteinase inhibitor from cohn fraction IV1 and IV4 paste
JP4105249B2 (ja) * 1996-08-09 2008-06-25 財団法人化学及血清療法研究所 α２プラスミンインヒビターの製造方法
AT407114B (de) * 1997-06-10 2000-12-27 Immuno Ag Alpha 1-antitrypsin-präparation sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
ZA200601206B (en) 2007-05-30
CN1867582A (zh) 2006-11-22
ES2324168T3 (es) 2009-07-31
RS20060077A (en) 2008-08-07
JP4668904B2 (ja) 2011-04-13
EP1654284B1 (en) 2009-04-15
CN1867582B (zh) 2010-06-16
AU2004262578B2 (en) 2010-05-06
IL172868A0 (en) 2006-06-11
PL1654284T3 (pl) 2009-09-30
DK1654284T3 (da) 2009-07-20
SI1654284T1 (sl) 2009-10-31
US20060194300A1 (en) 2006-08-31
NO20060109L (no) 2006-02-15
WO2005014648A1 (en) 2005-02-17
ATE428730T1 (de) 2009-05-15
BRPI0412835A (pt) 2006-09-26
KR20060070543A (ko) 2006-06-23
PT1654284E (pt) 2009-07-06
EP1654284A1 (en) 2006-05-10
JP2007523883A (ja) 2007-08-23
DE602004020632D1 (de) 2009-05-28
RU2370500C2 (ru) 2009-10-20
AU2004262578A1 (en) 2005-02-17
RU2006107533A (ru) 2006-07-27
CA2534900A1 (en) 2005-02-17

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