CY1108046T1 - Μεθοδος για τον καθορισμο προπροϊνσουλινης - Google Patents

Μεθοδος για τον καθορισμο προπροϊνσουλινης

Info

Publication number
CY1108046T1
CY1108046T1 CY20081100198T CY081100198T CY1108046T1 CY 1108046 T1 CY1108046 T1 CY 1108046T1 CY 20081100198 T CY20081100198 T CY 20081100198T CY 081100198 T CY081100198 T CY 081100198T CY 1108046 T1 CY1108046 T1 CY 1108046T1
Authority
CY
Cyprus
Prior art keywords
propoinsulin
determination
preproinsulins
chromatography
preparing
Prior art date
Application number
CY20081100198T
Other languages
English (en)
Inventor
Horst Thurow
Hans Blumenstock
Chantalle Havenith
Original Assignee
Sanofi-Aventis Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh
Publication of CY1108046T1 publication Critical patent/CY1108046T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

Η εφεύρεση αφορά σε μία μέθοδο για τον χρωματογραφικό καθαρισμό προπροϊνσουλινών κατά την οποία διαχωρίζονται ουσίες με μεγαλύτερο μοριακό βάρος από ένα υδατικό διάλυμα της προπροϊνσουλίνης με μία πρώτη χρωματογραφία επί μίας ουσίας ανταλλαγής ανιόντων με την διαδικασία διαρροής και μία εν συνεχεία δεύτερη χρωματογραφία επί μίας ουσίας ανταλλαγής κατιόντων με την διαδικασία προσρόφησης, ως και μία μέθοδο για την παρασκευή ινσουλινών, η οποία συμπεριλαμβάνει την μέθοδο για την παρασκευή προπροϊνσουλινών.
CY20081100198T 2002-08-01 2008-02-18 Μεθοδος για τον καθορισμο προπροϊνσουλινης CY1108046T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10235168A DE10235168A1 (de) 2002-08-01 2002-08-01 Verfahren zur Reinigung von Preproinsulin
EP03766211A EP1527097B1 (de) 2002-08-01 2003-07-18 Verfahren zur reinigung von preproinsulin

Publications (1)

Publication Number Publication Date
CY1108046T1 true CY1108046T1 (el) 2013-09-04

Family

ID=30128614

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100198T CY1108046T1 (el) 2002-08-01 2008-02-18 Μεθοδος για τον καθορισμο προπροϊνσουλινης

Country Status (16)

Country Link
US (2) US20050080000A1 (el)
EP (1) EP1527097B1 (el)
JP (1) JP4519646B2 (el)
AT (1) ATE384742T1 (el)
AU (1) AU2003254375B2 (el)
BR (1) BR0313131A (el)
CA (1) CA2493539C (el)
CY (1) CY1108046T1 (el)
DE (2) DE10235168A1 (el)
DK (1) DK1527097T3 (el)
ES (1) ES2297223T3 (el)
IL (1) IL166438A (el)
MX (1) MXPA05001042A (el)
PT (1) PT1527097E (el)
SI (1) SI1527097T1 (el)
WO (1) WO2004013176A1 (el)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6428771B1 (en) * 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
DK1196430T3 (da) * 1999-06-29 2012-05-21 Mannkind Corp Rensning og stabilisering af peptider og proteiner i farmaceutiske midler
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
DE60318938T2 (de) 2002-03-20 2009-01-22 Mannkind Corp., Valencia Inhalationsgerät
US7338171B2 (en) * 2003-10-27 2008-03-04 Jen-Chuen Hsieh Method and apparatus for visual drive control
WO2005067964A1 (en) * 2004-01-12 2005-07-28 Mannkind Corporation A method of reducing serum proinsulin levels in type 2 diabetics
US20080090753A1 (en) * 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
PL2319500T3 (pl) * 2004-03-12 2013-05-31 Biodel Inc Szybko działające kompozycje do dostarczania leku
ES2385934T3 (es) 2004-08-20 2012-08-03 Mannkind Corporation Catálisis de la síntesis de dicetopiperazina.
EP2314298B1 (en) 2004-08-23 2015-05-27 MannKind Corporation Microparticles comprising diketopiperazine salts for drug delivery
KR20160022404A (ko) 2005-09-14 2016-02-29 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
US7713929B2 (en) 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
WO2007041481A1 (en) * 2005-09-29 2007-04-12 Biodel, Inc. Rapid acting and prolonged acting insulin preparations
US8084420B2 (en) * 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
MX2008010721A (es) 2006-02-22 2008-09-01 Mannkind Corp Un metodo para mejorar las propiedades farmaceuticas de microparticulas que contienen dicetopiperazina y un agente activo.
AU2007238114B2 (en) * 2006-04-12 2010-10-14 Biodel, Inc. Rapid acting and long acting insulin combination formulations
JP5352596B2 (ja) * 2008-01-04 2013-11-27 バイオデル， インコーポレイテッド 組織グルコースレベルの関数としてのインスリン放出のためのインスリン製剤
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
EP3281663B8 (en) 2008-06-13 2022-09-21 MannKind Corporation Breath powered dry powder inhaler for drug delivery
MX2010014240A (es) 2008-06-20 2011-03-25 Mankind Corp Un metodo y aparato interactivo para perfilar en tiempo real esfuerzos de inhalacion.
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
MX344293B (es) 2008-10-17 2016-12-13 Sanofi Aventis Deutschland Combinacion de una insulina y un agonista de glp-1.
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9060927B2 (en) * 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
CA2754595C (en) 2009-03-11 2017-06-27 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US8551528B2 (en) 2009-06-12 2013-10-08 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
CN102471368A (zh) * 2009-08-11 2012-05-23 拜康有限公司 色谱方法及其纯化的化合物
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
BR112012011403B8 (pt) 2009-11-13 2021-05-25 Sanofi Aventis Deutschland composição farmacêutica líquida compreendendo um agonista glp-1 e metionina e uso da mesma
PT2498802E (pt) 2009-11-13 2015-04-13 Sanofi Aventis Deutschland Composição farmacêutica que compreende um agonista de glp-1, uma insulina e metionina
AU2011202239C1 (en) 2010-05-19 2017-03-16 Sanofi Long-acting formulations of insulins
BR112012033060A2 (pt) 2010-06-21 2018-02-27 Mannkind Corp métodos de sistema de liberação de fármaco em pó seco
RU2546520C2 (ru) 2010-08-30 2015-04-10 Санофи-Авентис Дойчланд Гмбх Применение ave0010 для производства лекарственного средства для лечения сахарного диабета 2 типа
US9447163B2 (en) 2011-02-01 2016-09-20 Novo Nordisk A/S Purification of insulin
DE102011003944A1 (de) 2011-02-10 2012-08-16 Oxprotect Gmbh Detektion und Entfernung von missgefalteten Proteinen/Peptiden
KR101940832B1 (ko) 2011-04-01 2019-01-21 맨카인드 코포레이션 의약 카트리지용 블리스터 패키지
CN102219851B (zh) * 2011-05-09 2012-05-30 甘李药业有限公司 甘精胰岛素结晶的制备方法
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
US9408893B2 (en) 2011-08-29 2016-08-09 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for use in glycemic control in diabetes type 2 patients
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
EP2776053A1 (en) 2011-10-24 2014-09-17 MannKind Corporation Methods and compositions for treating pain
SG11201500218VA (en) 2012-07-12 2015-03-30 Mannkind Corp Dry powder drug delivery systems and methods
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
US10421795B2 (en) * 2012-12-17 2019-09-24 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
EP3587404B1 (en) 2013-03-15 2022-07-13 MannKind Corporation Microcrystalline diketopiperazine compositions, methods for preparation and use thereof
CA2907848A1 (en) 2013-04-03 2014-10-09 Sanofi Treatment of diabetes mellitus by long-acting formulations of insulins
BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
WO2016007682A1 (en) * 2014-07-08 2016-01-14 Amphastar Pharmaceuticals Inc. Micronized insulin, micronized insulin analogues, and methods of manufacturing the same
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
LT3229828T (lt) 2014-12-12 2023-06-12 Sanofi-Aventis Deutschland Gmbh Insulino glargino/liksisenatido fiksuoto santykio kompozicija
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
US10322168B2 (en) 2016-01-07 2019-06-18 Amphastar Pharmaceuticals, Inc. High-purity inhalable particles of insulin and insulin analogues, and high-efficiency methods of manufacturing the same
CN113773392B (zh) * 2020-06-09 2023-04-07 宁波鲲鹏生物科技有限公司 一种甘精胰岛素的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783441A (en) * 1979-04-30 1988-11-08 Hoechst Aktiengesellschaft Aqueous protein solutions stable to denaturation
IL84110A (en) 1986-10-14 1992-11-15 Lilly Co Eli Process for transforming a human insulin precursor to a human insulin
JPH0832726B2 (ja) * 1987-06-08 1996-03-29 武田薬品工業株式会社 ラットｂＦＧＦおよびその製造法
DE3726655A1 (de) * 1987-08-11 1989-02-23 Hoechst Ag Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
IL95495A (en) * 1989-08-29 1996-10-16 Hoechst Ag Fusion proteins their preparation and use
US5358857A (en) * 1989-08-29 1994-10-25 The General Hospital Corp. Method of preparing fusion proteins
JP2916206B2 (ja) * 1990-04-28 1999-07-05 帝國製薬株式会社 生理活性ペプチド
ES2097426T3 (es) * 1992-12-02 1997-04-01 Hoechst Ag Procedimiento para la obtencion de proinsulina con puentes de cistina correctamente unidos.
US5886154A (en) * 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
DE19735711C2 (de) * 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
KR100253916B1 (ko) * 1997-12-29 2000-05-01 김충환 사람 인슐린 전구체의 제조방법
DE19947456A1 (de) * 1999-10-02 2001-04-05 Aventis Pharma Gmbh C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga
UA78676C2 (en) * 2000-02-22 2007-04-25 Applied Research Systems Purified lh
DE10008064B4 (de) * 2000-02-22 2009-07-02 Siemens Ag Verfahren zum Anpassen der einem Turbo-Codierer zuzuführenden Datenblöcke und entsprechende Kommunikationsvorrichtung

Also Published As

Publication number Publication date
SI1527097T1 (sl) 2008-04-30
IL166438A (en) 2010-11-30
US7803763B2 (en) 2010-09-28
AU2003254375A1 (en) 2004-02-23
AU2003254375B2 (en) 2009-01-08
CA2493539A1 (en) 2004-02-12
IL166438A0 (en) 2006-01-15
DE50309087D1 (el) 2008-03-13
MXPA05001042A (es) 2005-04-08
EP1527097B1 (de) 2008-01-23
DK1527097T3 (da) 2008-05-26
PT1527097E (pt) 2008-02-25
ATE384742T1 (de) 2008-02-15
DE10235168A1 (de) 2004-02-12
WO2004013176A1 (de) 2004-02-12
JP4519646B2 (ja) 2010-08-04
BR0313131A (pt) 2005-07-05
US20060183666A1 (en) 2006-08-17
CA2493539C (en) 2012-01-31
US20050080000A1 (en) 2005-04-14
ES2297223T3 (es) 2008-05-01
JP2006513978A (ja) 2006-04-27
EP1527097A1 (de) 2005-05-04

Similar Documents

Publication Publication Date Title
CY1108046T1 (el) Μεθοδος για τον καθορισμο προπροϊνσουλινης
EA200702210A1 (ru) Способ очистки белков
EP1568710A3 (en) Antibody purification method
PT1258476E (pt) Derivados de alfa-amino-acidos, processo para sua preparacao assim como a sua utilizacao como inibidores de dipeptidil-peptidase iv (dpp iv).
WO2007075283A3 (en) Polishing steps used in multi-step protein purification processes
ATE445642T1 (de) Trennung von polypeptiden mit einer racemisierten aminosäure
ATE440858T1 (de) Aufreinigung von antikírpern
PL2092064T3 (pl) Sposób oczyszczania RNA na skalę preparatywną za pomocą HPLC
ATE337058T1 (de) Kolonne und mit dieser durchgeführtes chromatographisches verfahren
IS7755A (is) Aðferð við framleiðslu á (S,S)-cis-2-benshýdríl-3-bensýlamínókínuklídín
ATE428728T1 (de) Verfahren zur reinigung von erythropoietin
NO20042158L (no) Substituert 4-fenyl-tetrahydroisokinoliner, fremgangsmate for fremstilling derav, anvendelse derav som medikamenter, i tillegg til medikamenter inneholdende samme
BRPI9914571B8 (pt) composto, processo para sua preparação, uso do mesmo, bem como composição farmacêutica.
UA86775C2 (ru) Способ очистки раствора альфа-1-антитрипсина
DK1017621T3 (da) Fremgangsmåde til rensning af hydroxylamin
ITPI20030002A1 (it) Sistema di propulsione per sommozzatori, vantaggiosamente
AU2003213642A1 (en) High-affinity, low-molecular-mass displacers for ion-exchange chromatography
BR0305587B1 (pt) procedimento para purificar soluÇÕes de glisofato mediante nanofiltraÇço.
NO20042200L (no) Novel proton type B zeolite, preparation method thereof and process for preparing phenol compound using the same
FR2863182B1 (fr) Procede de concentration de particules.
IS8369A (is) Aðferð til að hreinsa terbínafín
HRP20050414A2 (en) Process for preparing terbinafine by using platinum as catalyst
HK1067930A2 (en) Connection system for securing sunglasses to eyeglasses.
DK1208213T3 (da) Fremgangsmåde til fremstilling af proteiner i værtsceller under anvendelse af chaperoniner
ATE468343T1 (de) Verfahren zur reinigung von tacrolimus