IL166438A - Method for purifying preproinsulin - Google Patents

Method for purifying preproinsulin

Info

Publication number
IL166438A
IL166438A IL166438A IL16643805A IL166438A IL 166438 A IL166438 A IL 166438A IL 166438 A IL166438 A IL 166438A IL 16643805 A IL16643805 A IL 16643805A IL 166438 A IL166438 A IL 166438A
Authority
IL
Israel
Prior art keywords
preproinsulin
purifying
preproinsulins
chromatography
preparing
Prior art date
Application number
IL166438A
Other languages
English (en)
Other versions
IL166438A0 (en
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of IL166438A0 publication Critical patent/IL166438A0/xx
Publication of IL166438A publication Critical patent/IL166438A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
IL166438A 2002-08-01 2005-01-23 Method for purifying preproinsulin IL166438A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10235168A DE10235168A1 (de) 2002-08-01 2002-08-01 Verfahren zur Reinigung von Preproinsulin
PCT/EP2003/007820 WO2004013176A1 (de) 2002-08-01 2003-07-18 Verfahren zur reinigung von preproinsulin

Publications (2)

Publication Number Publication Date
IL166438A0 IL166438A0 (en) 2006-01-15
IL166438A true IL166438A (en) 2010-11-30

Family

ID=30128614

Family Applications (1)

Application Number Title Priority Date Filing Date
IL166438A IL166438A (en) 2002-08-01 2005-01-23 Method for purifying preproinsulin

Country Status (16)

Country Link
US (2) US20050080000A1 (https=)
EP (1) EP1527097B1 (https=)
JP (1) JP4519646B2 (https=)
AT (1) ATE384742T1 (https=)
AU (1) AU2003254375B2 (https=)
BR (1) BR0313131A (https=)
CA (1) CA2493539C (https=)
CY (1) CY1108046T1 (https=)
DE (2) DE10235168A1 (https=)
DK (1) DK1527097T3 (https=)
ES (1) ES2297223T3 (https=)
IL (1) IL166438A (https=)
MX (1) MXPA05001042A (https=)
PT (1) PT1527097E (https=)
SI (1) SI1527097T1 (https=)
WO (1) WO2004013176A1 (https=)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6428771B1 (en) * 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
DK1808438T3 (da) * 1999-06-29 2014-10-27 Mannkind Corp Rensning og stabilisering af peptid og proteiner i lægemidler
WO2003080149A2 (en) 2002-03-20 2003-10-02 Mannkind Corporation Inhalation apparatus
US7338171B2 (en) * 2003-10-27 2008-03-04 Jen-Chuen Hsieh Method and apparatus for visual drive control
NZ548980A (en) * 2004-01-12 2009-10-30 Mannkind Corp Reducing serum proinsulin levels in type 2 diabetics
US7279457B2 (en) * 2004-03-12 2007-10-09 Biodel, Inc. Rapid acting drug delivery compositions
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
PL1786784T3 (pl) 2004-08-20 2011-04-29 Mannkind Corp Kataliza syntezy diketopiperazyn
KR101644250B1 (ko) 2004-08-23 2016-07-29 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
CN104324362B (zh) 2005-09-14 2018-04-24 曼金德公司 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法
US8084420B2 (en) * 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
US7713929B2 (en) 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
WO2007041481A1 (en) * 2005-09-29 2007-04-12 Biodel, Inc. Rapid acting and prolonged acting insulin preparations
IN2015DN00888A (https=) 2006-02-22 2015-07-10 Mannkind Corp
EP2012817A2 (en) * 2006-04-12 2009-01-14 Biodel, Inc. Rapid acting and long acting insulin combination formulations
EP2234644B1 (en) * 2008-01-04 2013-07-31 Biodel, Inc. Insulin formulations for insulin release as a function of tissue glucose levels
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2929343T3 (es) 2008-06-13 2022-11-28 Mannkind Corp Inhalador de polvo seco accionado por aspiración para la administración de fármacos
KR101628410B1 (ko) 2008-06-20 2016-06-08 맨카인드 코포레이션 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
RS59913B1 (sr) 2008-10-17 2020-03-31 Sanofi Aventis Deutschland Kombinacija insulina i glp-1-agonista
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9060927B2 (en) * 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
DK2405963T3 (da) 2009-03-11 2013-12-16 Mannkind Corp Apparat, system og fremgangsmåde til at måle modstand i en inhalator
CN104721825B (zh) 2009-06-12 2019-04-12 曼金德公司 具有确定比表面积的二酮哌嗪颗粒
CN102596175A (zh) 2009-07-06 2012-07-18 赛诺菲-安万特德国有限公司 含有甲硫氨酸的水性胰岛素制备物
CN102471368A (zh) * 2009-08-11 2012-05-23 拜康有限公司 色谱方法及其纯化的化合物
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
MY180661A (en) 2009-11-13 2020-12-04 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine
PT3345593T (pt) 2009-11-13 2023-11-27 Sanofi Aventis Deutschland Composição farmacêutica compreendendo despro36exendina- 4(1-39)-lys6-nh2 e metionina
AU2011202239C1 (en) 2010-05-19 2017-03-16 Sanofi Long-acting formulations of insulins
IL223742A (en) 2010-06-21 2016-06-30 Mannkind Corp A dry powder inhaler and preparation for it
PL2611458T3 (pl) 2010-08-30 2017-02-28 Sanofi-Aventis Deutschland Gmbh Zastosowanie AVE0010 do produkcji leku do leczenia cukrzycy typu 2
WO2012104339A1 (en) 2011-02-01 2012-08-09 Novo Nordisk A/S Purification of insulin
DE102011003944A1 (de) 2011-02-10 2012-08-16 Oxprotect Gmbh Detektion und Entfernung von missgefalteten Proteinen/Peptiden
AU2012236150B2 (en) 2011-04-01 2016-03-31 Mannkind Corporation Blister package for pharmaceutical cartridges
CN102219851B (zh) * 2011-05-09 2012-05-30 甘李药业有限公司 甘精胰岛素结晶的制备方法
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
AR087693A1 (es) 2011-08-29 2014-04-09 Sanofi Aventis Deutschland Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
BR112014009686A2 (pt) 2011-10-24 2018-08-07 Mannkind Corp composição analgésica inalável, pó seco e método para tratar dor
CN104619369B (zh) 2012-07-12 2018-01-30 曼金德公司 干粉药物输送系统和方法
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US10421795B2 (en) * 2012-12-17 2019-09-24 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
AU2014228415B2 (en) 2013-03-15 2018-08-09 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
UA117480C2 (uk) 2013-04-03 2018-08-10 Санофі Лікування цукрового діабету за допомогою складу інсуліну тривалої дії
MX375448B (es) 2013-07-18 2025-03-06 Mannkind Corp Composiciones farmacéuticas en polvo seco estables al calor y métodos.
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
CN106794156B (zh) * 2014-07-08 2021-03-09 美药星制药股份有限公司 微粒化胰岛素、微粒化胰岛素类似物及其制备方法
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
EP3229828B1 (en) 2014-12-12 2023-04-05 Sanofi-Aventis Deutschland GmbH Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
US10322168B2 (en) 2016-01-07 2019-06-18 Amphastar Pharmaceuticals, Inc. High-purity inhalable particles of insulin and insulin analogues, and high-efficiency methods of manufacturing the same
CN113773392B (zh) * 2020-06-09 2023-04-07 宁波鲲鹏生物科技有限公司 一种甘精胰岛素的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783441A (en) * 1979-04-30 1988-11-08 Hoechst Aktiengesellschaft Aqueous protein solutions stable to denaturation
ZA877505B (en) 1986-10-14 1989-05-30 Lilly Co Eli Process for transforming a human insulin precursor to human insulin
JPH0832726B2 (ja) * 1987-06-08 1996-03-29 武田薬品工業株式会社 ラットｂＦＧＦおよびその製造法
DE3726655A1 (de) * 1987-08-11 1989-02-23 Hoechst Ag Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
US5358857A (en) * 1989-08-29 1994-10-25 The General Hospital Corp. Method of preparing fusion proteins
GR1005153B (el) * 1989-08-29 2006-03-13 The General Hospital Corporation Πρωτεινες συντηξεως, παρασκευη τους και χρηση τους.
JP2916206B2 (ja) * 1990-04-28 1999-07-05 帝國製薬株式会社 生理活性ペプチド
ATE148710T1 (de) * 1992-12-02 1997-02-15 Hoechst Ag Verfahren zur gewinnung von proinsulin mit korrekt verbundenen cystinbrücken
US5886154A (en) * 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
DE19735711C2 (de) * 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
KR100253916B1 (ko) * 1997-12-29 2000-05-01 김충환 사람 인슐린 전구체의 제조방법
DE19947456A1 (de) * 1999-10-02 2001-04-05 Aventis Pharma Gmbh C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga
DE10008064B4 (de) * 2000-02-22 2009-07-02 Siemens Ag Verfahren zum Anpassen der einem Turbo-Codierer zuzuführenden Datenblöcke und entsprechende Kommunikationsvorrichtung
CZ303274B6 (cs) * 2000-02-22 2012-07-11 Merck Serono Sa Zpusob vycištení luteinizacního hormonu

Also Published As

Publication number Publication date
US20050080000A1 (en) 2005-04-14
US7803763B2 (en) 2010-09-28
PT1527097E (pt) 2008-02-25
CY1108046T1 (el) 2013-09-04
WO2004013176A1 (de) 2004-02-12
EP1527097A1 (de) 2005-05-04
JP4519646B2 (ja) 2010-08-04
DK1527097T3 (da) 2008-05-26
DE10235168A1 (de) 2004-02-12
CA2493539A1 (en) 2004-02-12
ES2297223T3 (es) 2008-05-01
IL166438A0 (en) 2006-01-15
CA2493539C (en) 2012-01-31
JP2006513978A (ja) 2006-04-27
AU2003254375B2 (en) 2009-01-08
DE50309087D1 (https=) 2008-03-13
US20060183666A1 (en) 2006-08-17
AU2003254375A1 (en) 2004-02-23
MXPA05001042A (es) 2005-04-08
EP1527097B1 (de) 2008-01-23
SI1527097T1 (sl) 2008-04-30
ATE384742T1 (de) 2008-02-15
BR0313131A (pt) 2005-07-05

Similar Documents

Publication Publication Date Title
IL166438A (en) Method for purifying preproinsulin
EA200702210A1 (ru) Способ очистки белков
PL2092064T3 (pl) Sposób oczyszczania RNA na skalę preparatywną za pomocą HPLC
PL1664108T3 (pl) Rozdzielanie polipeptydów zawierających racemizowany aminokwas
UA99263C2 (ru) СПОСОБ ОЧИСТКИ Fc-СЛИТОГО БЕЛКА
MX9801072A (es) Metodo para purificar virus por cromatografia.
RU2011137030A (ru) Способы очистки малых модулярных иммунофармацевтических белков
WO2002053516A3 (fr) Derives de la n(phenylsulfonyl)glycine et leur utilisation en therapeutique
WO2004112707A3 (en) Method for purifying virus
MX9707909A (es) Purificacion de anticuerpos.
WO2007075283A3 (en) Polishing steps used in multi-step protein purification processes
AU2003207232A1 (en) Method for preparing hydrogenation purification catalyst
WO2004106288A3 (de) Ionische flüssigkeiten mit guanidinium-kationen
NO20042158L (no) Substituert 4-fenyl-tetrahydroisokinoliner, fremgangsmate for fremstilling derav, anvendelse derav som medikamenter, i tillegg til medikamenter inneholdende samme
AU6080698A (en) Method for purifying factor viii/vwf complex by cation-exchange chromatography
PL1753778T3 (pl) Sposób oczyszczania erytropoetyny
DE60042343D1 (de) Abtrennung von fibrinogen von plasmaproteasen
PL1841863T3 (pl) Sposób oczyszczania czynnika VII
DK1017621T3 (da) Fremgangsmåde til rensning af hydroxylamin
WO1995027718A3 (en) Purification of oligodeoxynucleotide phosphorothioates using anion exchange chromatography
DK1718673T3 (da) Fremgangsmåde til rensning af albumin omfattende et nanofiltreringstrin, oplösning og sammensætning til terapeutisk anvendelse, som indeholder det
MY157846A (en) Process for the purification of fc-containing proteins
AU2003213642A1 (en) High-affinity, low-molecular-mass displacers for ion-exchange chromatography
AU2002318480A1 (en) Zeolite ssz-57
FR2856682B1 (fr) Procede de purification de diamines

Legal Events

Date Code Title Description
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees