MXPA02012010A - Oligodesoxinucleotidos inmunoestimulantes. - Google Patents
Oligodesoxinucleotidos inmunoestimulantes.Info
- Publication number
- MXPA02012010A MXPA02012010A MXPA02012010A MXPA02012010A MXPA02012010A MX PA02012010 A MXPA02012010 A MX PA02012010A MX PA02012010 A MXPA02012010 A MX PA02012010A MX PA02012010 A MXPA02012010 A MX PA02012010A MX PA02012010 A MXPA02012010 A MX PA02012010A
- Authority
- MX
- Mexico
- Prior art keywords
- deoxyribosepurine
- deoxycytosine
- deoxyinosine
- deoxyguanosine
- deoxyadenosine
- Prior art date
Links
- 230000003308 immunostimulating effect Effects 0.000 title abstract 2
- 229940046166 oligodeoxynucleotide Drugs 0.000 title abstract 2
- RPFPNGBGDKGFRI-XLPZGREQSA-N 9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-methyl-3h-purin-6-one Chemical compound C12=NC(C)=NC(O)=C2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 RPFPNGBGDKGFRI-XLPZGREQSA-N 0.000 abstract 2
- FERYXNKLCFJNMG-QJPTWQEYSA-N (2r,3s,5r)-2-(hydroxymethyl)-5-[6-(3-methylbut-3-enylamino)purin-9-yl]oxolan-3-ol Chemical compound C1=NC=2C(NCCC(=C)C)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 FERYXNKLCFJNMG-QJPTWQEYSA-N 0.000 abstract 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical compound OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 abstract 1
- COVHWGAKPGOZBI-QJPTWQEYSA-N [(2r,3s,5r)-3-hydroxy-5-[6-(3-methylbut-3-enylamino)purin-9-yl]oxolan-2-yl]methyl dihydrogen phosphate Chemical compound C1=NC=2C(NCCC(=C)C)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(O)=O)O1 COVHWGAKPGOZBI-QJPTWQEYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000004712 monophosphates Chemical class 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describe una molecula de acido oligodesoxinucleico inmunoestimulante (ODN) que tienen la estructura de conformidad con la formula (I). (ver formula) en donde cualquier MNP es un monofosfato o monotiofosfato de 2' de desoxinucleosido, seleccionado del grupo que consiste de desoxiadenosino-, desoxiguanosino-, desoxiinosino-, desoxicitosino-, desoxiuridino-, desoxitimidino-, 2-metil-desoxiinosino-, 5-metil-desoxicitosino-, desoxipseudouridino-, desoxiribosepurino-, 2-amino-desoxiribosepurino-, -6-S-desoxiguanino-, 2-dimetil-desoxiguanosino- o monofosfato o monotiofosfato de N-isopentil-desoxiadenosina, NUC es un 2' desoxinucleosido, seleccionado del grupo que consiste de desoxiadenosino-, desoxiguanosino-, desoxiinosino-, desoxicitosino-, desoxiuridino-, desoxitimidino-, 2-metil-desoxiinosino-, 5-metil-desoxicitosino-, desoxipseudouridino-, desoxiribosepurino-, 2-amino-desoxiribosepurino-, 6-S-desoxiguanino-, 2-dimetil-desoxi-guanosino- o N-isopentenil-desoxiadenosina, cualquier X es O o S, a y b son enteros desde 0 hasta 100 con la condicion de que a + b esta entre 4 y 150, B y E son grupos comunes para los extremos 5' o 3' de las moleculas de acido nucleico, asi como una composicion farmaceutica que contiene tales ODN.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0100000A AT410173B (de) | 2000-06-08 | 2000-06-08 | Antigene zusammensetzung |
AT19732000 | 2000-11-23 | ||
PCT/EP2001/006433 WO2001093905A1 (en) | 2000-06-08 | 2001-06-07 | Immunostimulatory oligodeoxynucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA02012010A true MXPA02012010A (es) | 2005-04-22 |
Family
ID=25608484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA02012010A MXPA02012010A (es) | 2000-06-08 | 2001-06-07 | Oligodesoxinucleotidos inmunoestimulantes. |
Country Status (26)
Country | Link |
---|---|
US (3) | US8568742B2 (es) |
EP (1) | EP1296713B1 (es) |
JP (2) | JP5271471B2 (es) |
KR (1) | KR100799788B1 (es) |
CN (1) | CN1309418C (es) |
AT (1) | ATE249839T1 (es) |
AU (2) | AU2001281812B2 (es) |
BR (1) | BRPI0111639B8 (es) |
CA (1) | CA2411575C (es) |
CZ (1) | CZ304195B6 (es) |
DE (1) | DE60100814T2 (es) |
DK (1) | DK1296713T3 (es) |
ES (1) | ES2206424T3 (es) |
HK (1) | HK1056678A1 (es) |
HU (1) | HU228264B1 (es) |
IL (2) | IL152959A0 (es) |
IS (1) | IS1993B (es) |
MX (1) | MXPA02012010A (es) |
NO (1) | NO329492B1 (es) |
PL (1) | PL211036B1 (es) |
PT (1) | PT1296713E (es) |
RU (2) | RU2293573C2 (es) |
SI (1) | SI1296713T1 (es) |
SK (1) | SK287689B6 (es) |
TR (1) | TR200302015T4 (es) |
WO (1) | WO2001093905A1 (es) |
Families Citing this family (88)
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US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
DK1296713T3 (da) * | 2000-06-08 | 2004-01-26 | Intercell Biomedizinische Forschungs & Entwicklungs Gmbh | Immunstimulerende oligodeoxynukleotider |
EP1350262B8 (en) * | 2000-12-08 | 2008-08-13 | Coley Pharmaceuticals GmbH | Cpg-like nucleic acids and methods of use thereof |
JP2004519452A (ja) * | 2001-01-05 | 2004-07-02 | インターツェル・アクチェンゲゼルシャフト | ポリカチオン性化合物の用途 |
WO2002053185A2 (en) * | 2001-01-05 | 2002-07-11 | Intercell Ag | Anti-inflammatory use of polycationic compounds |
US7244438B2 (en) | 2001-01-05 | 2007-07-17 | Intercell Ag | Uses for polycationic compounds |
US20040081655A1 (en) * | 2001-01-05 | 2004-04-29 | Karen Lingnau | Methods and compositions comprising polycationic compounds |
AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
WO2002095027A2 (en) * | 2001-05-21 | 2002-11-28 | Intercell Ag | Immunostimulatory oligodeoxynucleic molecules |
CN1642982A (zh) * | 2001-07-26 | 2005-07-20 | 唐诚公司 | 活化或抑制类Toll受体9的试剂 |
US7666674B2 (en) | 2001-07-27 | 2010-02-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
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MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
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US8466116B2 (en) | 2001-12-20 | 2013-06-18 | The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce epithelial cell growth |
AU2002366710A1 (en) | 2001-12-20 | 2003-07-09 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS |
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US7785608B2 (en) | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
US7378234B2 (en) | 2002-09-13 | 2008-05-27 | Intercell Ag | Method for isolating hepatitis C virus peptides |
US8263091B2 (en) | 2002-09-18 | 2012-09-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides |
EP2314603A3 (en) | 2002-10-15 | 2011-05-18 | Intercell AG | Nucleic acids coding for adhesion factors of group B streptococcus, adhesion factors of group B streptococcus and futher uses thereof |
SI1601770T1 (sl) | 2003-03-04 | 2010-01-29 | Intercell Ag | Streptococcus pyogenes antigeni |
DE602004029657D1 (de) | 2003-03-24 | 2010-12-02 | Intercell Ag | Verbesserte impfstoffe |
JP2006521321A (ja) * | 2003-03-24 | 2006-09-21 | インターツェル・アクチェンゲゼルシャフト | 免疫応答を促進するためのミョウバンおよびTh1免疫応答誘起アジュバントの使用 |
US7628994B2 (en) | 2003-03-31 | 2009-12-08 | Intercell Ag | S. epidermidis antigens |
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US7438912B2 (en) | 2003-05-07 | 2008-10-21 | Intercell Ag | S.agalactiae antigens I + II |
CA2525540A1 (en) | 2003-05-30 | 2004-12-09 | Intercell Ag | Enterococcus antigens |
CA2530062A1 (en) * | 2003-07-11 | 2005-01-20 | Intercell Ag | Hcv vaccines |
JP4817599B2 (ja) * | 2003-12-25 | 2011-11-16 | 独立行政法人科学技術振興機構 | 免疫活性増強剤とこれを用いた免疫活性の増強方法 |
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