KR100799788B1 - 면역촉진성 올리고디옥시뉴클레오티드 - Google Patents
면역촉진성 올리고디옥시뉴클레오티드 Download PDFInfo
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- KR100799788B1 KR100799788B1 KR20027016711A KR20027016711A KR100799788B1 KR 100799788 B1 KR100799788 B1 KR 100799788B1 KR 20027016711 A KR20027016711 A KR 20027016711A KR 20027016711 A KR20027016711 A KR 20027016711A KR 100799788 B1 KR100799788 B1 KR 100799788B1
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- monothiophosphate
- monophosphate
- vaccine composition
- odn
- peptide
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Abstract
Description
Claims (22)
- 다음의 화학식(Ⅰ)의 디옥시이노신 올리고디옥시핵산 분자(I-ODN)을 활성 성분으로 하는 백신 조성물:화학식 Ⅰ이때, X1, X2, X3, X4 각각은 독립적으로 O 또는 S이다,NMP는 디옥시아데노신-, 디옥시구아노신-, 디옥시이노신-, 디옥시시토신-, 디옥시우리딘-, 디옥시티미딘-, 2-메틸-디옥시이노신-, 5-메틸-디옥시시토신-, 디옥시슈우도우리딘-, 디옥시리보즈푸린-, 2-아미노-디옥시리보즈푸린-, 6-S-디옥시구아닌-, 2-디메틸-디옥시구아노신-, 또는 N-이소펜틸-디옥시아데노신-모노인산염 혹은 -모노티오인산염에서 선택되는 2' 디옥시뉴클레오시드 모노인산염 또는 모노티오인산염이고;NUC는 디옥시아데노신-, 디옥시구아노신-, 디옥시이노신-, 디옥시시토신-, 디옥시우리딘-, 디옥시티미딘-, 2-메틸-디옥시이노신-, 5-메틸-디옥시시토신-, 디옥시슈우도우리딘-, 디옥시리보즈푸린-, 2-아미노-디옥시리보즈푸린-, 6-S-디옥시구아닌-, 2-디메틸-디옥시구아노신- 또는 N-이소펜틸-디옥시아데노신에서 선택되는 2' 디옥시뉴클레오시드이며;a와 b는 a + b가 4 내지 150이라는 조건하에 1 내지 100의 정수이고;B와 E는 핵산 분자의 5' 또는 3' 말단에서 공통 작용기로써, -H, -CH3, -COH, -COCH3, -OH, -CHO, -PO4, -PSO3, -PS2O2, PS3O, -PS4, -SO3, -PO4-(CH2)1-6-NH2 또는 -PO4-(CH2)1-6-NH2-라벨에서 독립적으로 선택된다.
- 제 1 항에 있어서, NMP는 디옥시아데노신-, 디옥시구아노신-, 디옥시이노신-, 디옥시시토신-, 디옥시우리딘-, 디옥시티미딘-, 2-메틸-디옥시이노신-, 5-메틸-디옥시시토신-모노인산염 또는 -모노티오인산염에서 선택되는 것을 특징으로 하는 백신 조성물.
- 제 1 항에 있어서, a + b는 10 내지 60인 것을 특징으로 하는 백신 조성물.
- 제 1 항 또는 제2항에 있어서, X1과 X2의 적어도 한가지는 S이고; X3과 X4의 적어도 한가지는 O이며, NMP는 뉴클레오시드-모노티오인산염인 것을 특징으로 하는 백신 조성물.
- 제 1 항에 있어서, I-ODN의 5' 또는 3' 말단에 다음에서 선택된 한 가지 서열이 존재하는 것을 특징으로 하는 백신 조성물:hhh wdi dhh h;nhh hhh wdi nhh hhh hhh wn;nhh wdi din hhh hdi ndi nh;nhh hhh wdi dhh hhh hhh wn; 또는nhh wdi did hhh hdi ddi dh,여기서, n은 디옥시아데노신-, 디옥시구아노신-, 디옥시시토신-, 또는 디옥시티미딘-모노인산염 혹은 -모노티오인산염에서 선택되는 2'-디옥시뉴클레오시드 모노인산염 또는 모노티오인산염이고;h는 디옥시아데노신-, 디옥시시토신-, 또는 디옥시티미딘-모노인산염 혹은 -모노티오인산염에서 선택되는 2'-디옥시뉴클레오시드 모노인산염 또는 모노티오인산염이며;i는 디옥시이노신-모노인산염 또는 -모노티오인산염이고;w는 디옥시아데노신-, 또는 디옥시티미딘-모노인산염 혹은 -모노티오인산염에서 선택되는 2'-디옥시뉴클레오시드 모노인산염 또는 모노티오인산염이며;d는 디옥시아데노신-, 디옥시구아노신-, 또는 디옥시티미딘-모노인산염 혹은 -모노티오인산염에서 선택되는 2'-디옥시뉴클레오시드 모노인산염 또는 모노티오인산염이다.
- 제 1 항에 있어서, 3'에서 2'-디옥시이노신-모노인산염 또는 -모노티오인산염에 인접하는 2'-디옥시시토신-모노인산염 또는 -모노티오인산염을 보유하는 것을 특징으로 하는 백신 조성물.
- 제 1 항에 있어서, I-ODN의 5' 또는 3' 말단에 다음에서 선택된 한 가지 서열이 존재하는 것을 특징으로 하는 백신 조성물:gacitt,iacitt;gaictt;iaictt.여기서, a는 디옥시아데노신-모노인산염 또는 -모노티오인산염이고;g는 디옥시구아노신-모노인산염 또는 -모노티오인산염이며;i는 디옥시이노신-모노인산염 또는 -모노티오인산염이고;c는 디옥시시토신-모노인산염 또는 -모노티오인산염이며;t는 디옥시티미딘-모노인산염 또는 -모노티오인산염이다.
- 제 1 항에 있어서, I-ODN의 5' 또는 3' 말단에 다음에서 선택된 한 가지 서열이 존재하는 것을 특징으로 하는 백신 조성물:wdi;wdidin;wdid;wdidid,여기서,i는 디옥시이노신-모노인산염 또는 -모노티오인산염이고;w는 디옥시아데노신-, 또는 디옥시티미딘-모노인산염 혹은 -모노티오인산염에서 선택되는 2'-디옥시뉴클레오시드 모노인산염 또는 모노티오인산염이며;d는 디옥시아데노신-, 디옥시구아노신-, 또는 디옥시티미딘-모노인산염 혹은 -모노티오인산염에서 선택되는 2'-디옥시뉴클레오시드 모노인산염 또는 모노티오인산염이며;n은 디옥시아데노신-, 디옥시구아노신-, 디옥시시토신-, 또는 디옥시티미딘-모노인산염 혹은 -모노티오인산염에서 선택되는 2'-디옥시뉴클레오시드 모노인산염 또는 모노티오인산염이다.
- 제 3 항에 있어서, a+b는 15 내지 40의 정수인 것을 특징으로 하는 백신 조성물.
- 삭제
- 제 1 항에 있어서, I-ODN의 5' 또는 3' 말단에 다음에서 선택된 한 가지 서열이 존재하는 것을 특징으로 하는 백신 조성물.tcc atg aci ttc ctg atg ct;여기서, a는 디옥시아데노신-모노인산염 또는 -모노티오인산염이고;g는 디옥시구아노신-모노인산염 또는 -모노티오인산염이며;i는 디옥시이노신-모노인산염 또는 -모노티오인산염이고;c는 디옥시시토신-모노인산염 또는 -모노티오인산염이며;t는 디옥시티미딘-모노인산염 또는 -모노티오인산염이다.
- 제 1항에 있어서, 임의 항원이 추가로 포함된 것을 특징으로 하는 백신 조성물.
- 제 1 항에 있어서, 다가양이온 펩티드 또는 항균 펩티드 또는 성장 호르몬을 추가 성분으로 함유하고, 이때 다가양이온 펩티드는 염기성 아미노산이 20%이상이며, 최소 3개 아미노산 잔기로 구성된 쇄(chain)를 가지는 것을 특징으로 하는 백신 조성물.
- 제 1 항, 제 12항 또는 제13항중 어느 한 항에 있어서, 사이토킨, 항염증성 물질, 항균 물질 또는 이들의 조합을 추가로 함유하는 것을 특징으로 하는 백신 조성물.
- 제 1 항, 제 12항 또는 제13항중 어느 한 항에 있어서, 제약학적으로 수용가능한 담체, 완충제, 안정제 또는 이들의 조합을 부형제로 추가 함유하는 것을 특징으로 하는 백신 조성물.
- 제 1 항, 제 12항 또는 제13항중 어느 한 항에 있어서, I-ODN을 1 ng 내지 1g 함유하는 것을 특징으로 하는 백신 조성물.
- 제 6 항에 있어서, 3'에서 디옥시이노신-디옥시시토신 26-mer에 접하는 최소 한 개의 2'-디옥시시토신-모노인산염 또는 -모노티오인산염을 보유하는 것을 특징으로 하는 백신 조성물.
- 제 1 항에 있어서, I-ODN을 100 ng 내지 10 ㎎ 함유하는 것을 특징으로 하는 백신 조성물.
- 제 1 항에 있어서, I-ODN을 10㎍ 내지 1 ㎎ 함유하는 것을 특징으로 하는 백신 조성물.
- 제 13 항에 있어서, 다가양이온 펩티드는 폴리아르기닌 또는 폴리리신이며, 항균 펩티드는 카텔린에서 유래된 항균 펩티드로 3개 내지 7개의 소수성 아미노산의 링커(linker)에 의해 분리되는 2KLK(리신-루이신,리신)-모티프를 보유하는 합성 펩티드이고; 성장 호르몬은 사람 성장 호르몬인 것을 특징으로 하는 백신 조성물.
- 제 13 항에 있어서, 다가양이온 펩티드는 20 내지 500개 아미노산 잔기로 구성된 쇄(chain)를 가지는 것을 특징으로 하는 백신 조성물.
- 제 21 항에 있어서, 다가양이온 펩티드는 30 내지 200개 아미노산 잔기로 구성된 쇄(chain)를 가지는 것을 특징으로 하는 백신 조성물.
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