MX9803317A - Proceso para la preparacion de o-acetilserina, l-cisteina y productos afines a l-cisteina. - Google Patents

Proceso para la preparacion de o-acetilserina, l-cisteina y productos afines a l-cisteina.

Info

Publication number
MX9803317A
MX9803317A MX9803317A MX9803317A MX9803317A MX 9803317 A MX9803317 A MX 9803317A MX 9803317 A MX9803317 A MX 9803317A MX 9803317 A MX9803317 A MX 9803317A MX 9803317 A MX9803317 A MX 9803317A
Authority
MX
Mexico
Prior art keywords
cysteine
mutation
amino acid
acetylserine
preparing
Prior art date
Application number
MX9803317A
Other languages
English (en)
Inventor
Walfred Leinfelder
Peter Heinrich
Original Assignee
Consortium Elektrochem Ind
Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consortium Elektrochem Ind, Gmbh filed Critical Consortium Elektrochem Ind
Publication of MX9803317A publication Critical patent/MX9803317A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

La invencion se refiere a procedimientos para preparar 0-acetilserina, L-cisteina y compuestos sulfurosos derivados de los mismos, usando serin-acetiltransferasas resistentes a la retroalimentacion; en comparacion con la enzima de tipo silvestre, estas serin-acetiltransferasa tienen sensibilidad reducida al inhibidor L-cisteina y una secuencia de proteína que, en comparacion con la enzima de tipo silvestre, despliega por lo menos una mutacion o delecion; los procedimientos se caracterizan porque la mutacion está en la region de secuencia del aminoácido en la posicion 97 hasta e incluyendo el aminoácido en la posicion 273, o la delecion está en la region de secuencia carboxilo terminal como del aminoácido en la posicion 227, la posicion 1 siendo la metionina de partida de la figura 5 (SEQ ID NO. 1) y la mutacion de Met a Ile en la posicion 256 siendo excluida.
MX9803317A 1995-10-26 1998-04-27 Proceso para la preparacion de o-acetilserina, l-cisteina y productos afines a l-cisteina. MX9803317A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19539952A DE19539952A1 (de) 1995-10-26 1995-10-26 Verfahren zur Herstellung von O-Acetylserin, L-Cystein und L-Cystein-verwandten Produkten

Publications (1)

Publication Number Publication Date
MX9803317A true MX9803317A (es) 1998-09-30

Family

ID=7775886

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9803317A MX9803317A (es) 1995-10-26 1998-04-27 Proceso para la preparacion de o-acetilserina, l-cisteina y productos afines a l-cisteina.

Country Status (17)

Country Link
US (1) US6218168B1 (es)
EP (1) EP0858510B1 (es)
JP (1) JP3329825B2 (es)
KR (1) KR100275287B1 (es)
CN (1) CN1155711C (es)
AT (1) ATE211175T1 (es)
BR (1) BR9610910A (es)
CA (1) CA2235752C (es)
CZ (1) CZ294539B6 (es)
DE (2) DE19539952A1 (es)
DK (1) DK0858510T3 (es)
ES (1) ES2169269T3 (es)
HU (1) HU224097B1 (es)
MX (1) MX9803317A (es)
PL (1) PL186403B1 (es)
TW (1) TW554043B (es)
WO (1) WO1997015673A1 (es)

Families Citing this family (92)

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FR2787466B1 (fr) * 1998-12-17 2001-02-16 Rhone Poulenc Agrochimie Procede pour augmenter la teneur en cysteine, methionine et glutathion chez les plantes et plantes obtenues
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DE10136986A1 (de) * 2000-09-03 2002-03-21 Degussa Für Gene cysD, cysN, cysK, cysE und cysH kodierende Nukleotidsequenzen
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