ES8305700A1 - Un procedimiento para la preparacion de derivados dipeptidicos. - Google Patents
Un procedimiento para la preparacion de derivados dipeptidicos.Info
- Publication number
- ES8305700A1 ES8305700A1 ES510663A ES510663A ES8305700A1 ES 8305700 A1 ES8305700 A1 ES 8305700A1 ES 510663 A ES510663 A ES 510663A ES 510663 A ES510663 A ES 510663A ES 8305700 A1 ES8305700 A1 ES 8305700A1
- Authority
- ES
- Spain
- Prior art keywords
- thialysine
- antihypertensives
- homologs
- dipeptides containing
- dipeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/80—Antihypertensive peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DEPEPTIDICOS DE FORMULA (I), EN LAS QUE L VALE 1 O 2; M VALE 2 O 3; X ES OXIGENO, AZUFRE O S O; Y R, R , R , A Y B PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN DIPEPTIDO DE FORMULA (II) CON UN CETOACIDO O CETOESTER DE FORMULA R COCOOR, EN LAS QUE Y ES UN GRUPO PROTECTOR DEL AMINOACIDO, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); SEGUIDA DE TRATAMIENTO CON UN AGENTE REDUCTOR, TAL COMO CIANOBOROHIDRURO SODICO EN CONDICIONES NEUTRAS, EN UN DISOLVENTE ACUOSO, O HIDROGENO EN PRESENCIA DE PALADIO SOBRE CARBON. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO INHIBIDORES DEL ENZIMA CONVERTIDOR Y ANTIHIPERTENSIVOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24653281A | 1981-03-23 | 1981-03-23 | |
US06/341,741 US4512979A (en) | 1981-03-23 | 1982-01-26 | Dipeptides containing thialysine and related amino acids as antihypertensives |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8305700A1 true ES8305700A1 (es) | 1983-04-16 |
ES510663A0 ES510663A0 (es) | 1983-04-16 |
Family
ID=26938058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES510663A Granted ES510663A0 (es) | 1981-03-23 | 1982-03-22 | Un procedimiento para la preparacion de derivados dipeptidicos. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4512979A (es) |
EP (1) | EP0061186B1 (es) |
DE (1) | DE3271236D1 (es) |
DK (1) | DK127482A (es) |
ES (1) | ES510663A0 (es) |
GR (1) | GR76467B (es) |
IE (1) | IE52294B1 (es) |
PT (1) | PT74618B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0278530A3 (de) * | 1980-08-30 | 1989-08-02 | Hoechst Aktiengesellschaft | Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung |
US4766110A (en) * | 1981-08-21 | 1988-08-23 | Ryan James W | Novel complex amido and imido derivatives of carboxyalkyl peptides |
EP0081094A1 (en) * | 1981-11-12 | 1983-06-15 | Merck & Co. Inc. | Substituted omega-amino-carboxymethyldipeptide antihypertensive agents |
DE3378266D1 (en) * | 1982-01-11 | 1988-11-24 | Merck & Co Inc | Aminoacyl-containing dipeptide derivatives useful as antihypertensives |
US4584299A (en) * | 1984-05-21 | 1986-04-22 | Warner-Lambert Company | Method of treating heart failure and medicaments therefor |
JPH0662671B2 (ja) * | 1986-01-17 | 1994-08-17 | 株式会社大塚製薬工場 | プロリン誘導体 |
US4847384A (en) * | 1987-03-12 | 1989-07-11 | Sandoz Pharm. Corp. | Process for the preparation of certain nitrogen-containing mono- and bicyclic ace inhibitors, and novel intermediates useful therefor |
ATE106449T1 (de) * | 1989-06-30 | 1994-06-15 | Massachusetts Inst Technology | Hemmung des reaktionswegs für die n-ende-regel in lebenden zellen. |
US6369272B1 (en) | 1997-01-13 | 2002-04-09 | Glaxosmithkline | Nitric oxide synthase inhibitors |
MY117948A (en) * | 1997-01-13 | 2004-08-30 | Glaxo Group Ltd | Nitride oxide synthase inhibitors. |
US6620848B2 (en) * | 1997-01-13 | 2003-09-16 | Smithkline Beecham Corporation | Nitric oxide synthase inhibitors |
GB9811599D0 (en) | 1998-05-30 | 1998-07-29 | Glaxo Group Ltd | Nitric oxide synthase inhibitors |
US9732367B2 (en) | 2012-09-24 | 2017-08-15 | Medimmune Limited | Cell lines |
CA2906292C (en) | 2013-03-15 | 2022-08-02 | Medimmune Limited | Novel dna constructs for the expression of trnapyl genes in eukaryotic cells |
SG11201600473UA (en) * | 2013-08-05 | 2016-02-26 | Medimmune Ltd | Amino acid derivatives |
CN114920676B (zh) * | 2022-06-07 | 2024-04-05 | 四川国康药业有限公司 | 一种治疗呼吸系统疾病的化合物及其制备方法和用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4052511A (en) * | 1976-02-13 | 1977-10-04 | E. R. Squibb & Sons, Inc. | Carboxyacylproline derivatives |
US4105789A (en) * | 1976-05-10 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Carboxyalkylacylamino acids |
US4108886A (en) * | 1977-03-11 | 1978-08-22 | E. R. Squibb & Sons, Inc. | Thiopropanoylamino acid derivatives |
GR73585B (es) * | 1978-09-11 | 1984-03-26 | Univ Miami | |
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
AU537592B2 (en) * | 1979-04-02 | 1984-07-05 | E.R. Squibb & Sons, Inc. | Mercaptoacyldipeptides |
-
1982
- 1982-01-26 US US06/341,741 patent/US4512979A/en not_active Expired - Fee Related
- 1982-03-18 GR GR67638A patent/GR76467B/el unknown
- 1982-03-19 IE IE637/82A patent/IE52294B1/en unknown
- 1982-03-22 DE DE8282102329T patent/DE3271236D1/de not_active Expired
- 1982-03-22 DK DK127482A patent/DK127482A/da not_active Application Discontinuation
- 1982-03-22 ES ES510663A patent/ES510663A0/es active Granted
- 1982-03-22 EP EP82102329A patent/EP0061186B1/en not_active Expired
- 1982-03-22 PT PT74618A patent/PT74618B/pt unknown
Also Published As
Publication number | Publication date |
---|---|
EP0061186B1 (en) | 1986-05-21 |
EP0061186A1 (en) | 1982-09-29 |
IE820637L (en) | 1982-09-23 |
DE3271236D1 (en) | 1986-06-26 |
PT74618A (en) | 1982-04-01 |
GR76467B (es) | 1984-08-10 |
DK127482A (da) | 1982-09-24 |
PT74618B (en) | 1984-11-26 |
US4512979A (en) | 1985-04-23 |
IE52294B1 (en) | 1987-09-02 |
ES510663A0 (es) | 1983-04-16 |
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