MX393926B - Reguladores a la baja del receptor de estrógeno selectivo de benzotiofeno. - Google Patents
Reguladores a la baja del receptor de estrógeno selectivo de benzotiofeno.Info
- Publication number
- MX393926B MX393926B MX2020006991A MX2020006991A MX393926B MX 393926 B MX393926 B MX 393926B MX 2020006991 A MX2020006991 A MX 2020006991A MX 2020006991 A MX2020006991 A MX 2020006991A MX 393926 B MX393926 B MX 393926B
- Authority
- MX
- Mexico
- Prior art keywords
- benzothiophen
- estrogen receptor
- selective estrogen
- receptor downregulators
- downregulators
- Prior art date
Links
- 229940119564 Selective estrogen receptor downregulator Drugs 0.000 title 1
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 2
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 102000015694 estrogen receptors Human genes 0.000 abstract 1
- 108010038795 estrogen receptors Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562264971P | 2015-12-09 | 2015-12-09 | |
| US201662322878P | 2016-04-15 | 2016-04-15 | |
| PCT/US2016/066023 WO2017100712A1 (en) | 2015-12-09 | 2016-12-09 | Benzothiophene-based selective estrogen receptor downregulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2020006991A MX2020006991A (es) | 2022-07-14 |
| MX393926B true MX393926B (es) | 2025-03-24 |
Family
ID=59013340
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020006991A MX393926B (es) | 2015-12-09 | 2016-12-09 | Reguladores a la baja del receptor de estrógeno selectivo de benzotiofeno. |
| MX2018007079A MX373946B (es) | 2015-12-09 | 2016-12-09 | Reguladores a la baja del receptor de estrogeno selectivo de benzotiofeno. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018007079A MX373946B (es) | 2015-12-09 | 2016-12-09 | Reguladores a la baja del receptor de estrogeno selectivo de benzotiofeno. |
Country Status (25)
| Country | Link |
|---|---|
| US (7) | US10118910B2 (enExample) |
| EP (2) | EP3386968B1 (enExample) |
| JP (2) | JP6920709B2 (enExample) |
| KR (1) | KR102785173B1 (enExample) |
| CN (2) | CN108699024B (enExample) |
| AU (1) | AU2016366680B2 (enExample) |
| BR (1) | BR112018011607B1 (enExample) |
| CA (1) | CA3008020C (enExample) |
| DK (1) | DK3386500T3 (enExample) |
| EA (1) | EA038180B1 (enExample) |
| ES (1) | ES2935125T3 (enExample) |
| HR (1) | HRP20221462T1 (enExample) |
| HU (1) | HUE061065T2 (enExample) |
| IL (1) | IL259566B (enExample) |
| LT (1) | LT3386500T (enExample) |
| MX (2) | MX393926B (enExample) |
| NZ (1) | NZ743651A (enExample) |
| PL (1) | PL3386500T3 (enExample) |
| PT (1) | PT3386500T (enExample) |
| RS (1) | RS63791B1 (enExample) |
| RU (1) | RU2747802C2 (enExample) |
| SI (1) | SI3386500T1 (enExample) |
| SM (1) | SMT202300018T1 (enExample) |
| WO (2) | WO2017100715A1 (enExample) |
| ZA (2) | ZA201803422B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3386968B1 (en) | 2015-12-09 | 2025-04-02 | The Board of Trustees of the University of Illinois | Benzothiophene-based selective estrogen receptor downregulator compounds |
| US10599150B2 (en) | 2016-09-29 | 2020-03-24 | The Charles Stark Kraper Laboratory, Inc. | Autonomous vehicle: object-level fusion |
| AU2018205262A1 (en) | 2017-01-06 | 2019-07-11 | G1 Therapeutics, Inc. | Combination therapy for the treatment of cancer |
| EP3580223A4 (en) | 2017-02-10 | 2021-01-06 | G1 Therapeutics, Inc. | Benzothiophene estrogen receptor modulators |
| MX392531B (es) | 2017-06-29 | 2025-03-24 | G1 Therapeutics Inc | Formas morficas de g1t38 y metodos de preparacion de las mismas. |
| KR102765922B1 (ko) | 2018-02-06 | 2025-02-11 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 선택적인 에스트로겐 수용체 분해제로서의 치환된 벤조티오펜 유사체 |
| EP3836916A1 (en) * | 2018-08-16 | 2021-06-23 | G1 Therapeutics, Inc. | Benzothiophene estrogen receptor modulators to treat medical disorders |
| US10741313B1 (en) | 2019-02-06 | 2020-08-11 | Eaton Intelligent Power Limited | Bus bar assembly with integrated surge arrestor |
| US11249184B2 (en) | 2019-05-07 | 2022-02-15 | The Charles Stark Draper Laboratory, Inc. | Autonomous collision avoidance through physical layer tracking |
| CA3146346A1 (en) * | 2019-05-09 | 2020-11-12 | Sanofi | 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid for use in metastatic or advanced breast cancer patients |
| US20220233534A1 (en) * | 2019-07-08 | 2022-07-28 | Dermavant Sciences GmbH | Cerdulatinib-containing topical skin pharmaceutical compositions and uses thereof |
| ES3048084T3 (en) | 2020-05-19 | 2025-12-09 | Pharmacosmos Holding As | Cyclin-dependent kinase inhibiting compounds for the treatment of medical disorders |
| CN115710248B (zh) * | 2022-11-18 | 2024-06-21 | 南京中医药大学 | 新型选择性雌激素受体下调剂化合物、制备方法及用途 |
| CN116574054B (zh) * | 2023-05-15 | 2025-01-28 | 南京中医药大学 | 选择性雌激素受体下调剂化合物、制备方法及用途 |
| WO2025147568A1 (en) * | 2024-01-05 | 2025-07-10 | Starton Therapeutics, Inc. | Solid state active pharmaceutical compositions for transdermal drug delivery |
Family Cites Families (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1947085A (en) | 1931-09-22 | 1934-02-13 | Westinghouse Electric & Mfg Co | Electrical apparatus |
| US4133814A (en) | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4418068A (en) | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| GB8327256D0 (en) | 1983-10-12 | 1983-11-16 | Ici Plc | Steroid derivatives |
| DE4126999A1 (de) | 1991-08-16 | 1993-02-18 | Basf Ag | Herbizide mittel, enthaltend 3-aminobenzo(b)thiophene als antidots |
| CA2083891A1 (en) | 1991-12-03 | 1993-06-04 | Angus Murray Macleod | Heterocyclic compounds, compositions containing them and their use in therapy |
| JPH05345780A (ja) * | 1991-12-24 | 1993-12-27 | Kumiai Chem Ind Co Ltd | ピリミジンまたはトリアジン誘導体及び除草剤 |
| CZ285937B6 (cs) | 1992-01-16 | 1999-12-15 | Hoechst Aktiengesellschaft | Arylcykloalkylové deriváty, způsob přípravy těchto derivátů a jejich použití |
| TW366342B (en) | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
| EP0622673B1 (en) | 1993-04-24 | 1998-02-04 | Kodak Limited | Photographic colour couplers and photographic materials containing them |
| US5478847A (en) | 1994-03-02 | 1995-12-26 | Eli Lilly And Company | Methods of use for inhibiting bone loss and lowering serum cholesterol |
| EP0752421B1 (en) | 1995-07-07 | 2005-10-12 | AstraZeneca AB | Ortho-substituted aromatic compounds, containing three (het)aryl moieties, their preparation and their use as prostaglandin E2-(PGE2)-antagonists |
| US6458811B1 (en) | 1996-03-26 | 2002-10-01 | Eli Lilly And Company | Benzothiophenes formulations containing same and methods |
| TW397821B (en) | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
| US5998402A (en) | 1996-04-19 | 1999-12-07 | American Home Products Corporation | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents |
| US5780497A (en) | 1996-04-19 | 1998-07-14 | American Home Products Corporation | 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents |
| US5880137A (en) | 1996-04-19 | 1999-03-09 | American Home Products Corporation | 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents |
| CN1275911A (zh) * | 1997-08-15 | 2000-12-06 | 杜克大学 | 一种预防或治疗雌激素依赖性疾病及失调的方法 |
| DE69822861T2 (de) | 1997-10-03 | 2005-01-27 | Eli Lilly And Co., Indianapolis | Bentzothiophene |
| US6005102A (en) | 1997-10-15 | 1999-12-21 | American Home Products Corporation | Aryloxy-alkyl-dialkylamines |
| UA68365C2 (en) | 1997-11-06 | 2004-08-16 | Wyeth Corp | Peroral contraception by combination of anti-estrogen and progestin |
| US6326392B1 (en) | 1997-11-06 | 2001-12-04 | American Home Products Corporation | Anti-estrogen plus progestin containing oral contraceptives |
| US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
| US6583170B1 (en) | 1998-05-15 | 2003-06-24 | Wyeth | 2-Phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol and estrogen formulations |
| GB0000313D0 (en) | 2000-01-10 | 2000-03-01 | Astrazeneca Uk Ltd | Formulation |
| CO5271696A1 (es) | 2000-01-12 | 2003-04-30 | Pfizer Prod Inc | Procedimiento para reducir la morbilidad y el riesgo de mortalidad |
| CO5271697A1 (es) | 2000-01-12 | 2003-04-30 | Pfizer Prod Inc | Composiciones y procedimientos para el tratamiento de afecciones que responden a un aumento de testosterona |
| CO5271709A1 (es) | 2000-01-12 | 2003-04-30 | Pfizer Prod Inc | Composiciones y procedimientos para el y tratamiento de afecciones que responden a estrogenos |
| CO5251465A1 (es) | 2000-01-26 | 2003-02-28 | Pfizer Prod Inc | Composiciones y procedimientos para tratar la osteoporosis y reducir el colesterol |
| US7091240B2 (en) | 2000-03-10 | 2006-08-15 | Oxigene, Inc. | Tubulin binding ligands and corresponding prodrug constructs |
| US20020013327A1 (en) | 2000-04-18 | 2002-01-31 | Lee Andrew G. | Compositions and methods for treating female sexual dysfunction |
| AU2001271784A1 (en) | 2000-07-06 | 2002-01-21 | Wyeth | Therapy for prosthesis-related bone degeneration |
| AR030064A1 (es) | 2000-07-06 | 2003-08-13 | Wyeth Corp | Metodos para inhibir los efectos uterotroficos de los agentes estrogenicos |
| US6358991B2 (en) | 2000-07-06 | 2002-03-19 | American Home Products Corporation | Methods of treating neuropeptide Y-related conditions |
| EP1299093A2 (en) | 2000-07-06 | 2003-04-09 | Wyeth | Combinations of bisphosphonates, estrogenic agents and optionally estrogens |
| WO2002003989A2 (en) | 2000-07-06 | 2002-01-17 | Wyeth | Use of substituted indole compounds for treating sphincter incontinence |
| AU2001271706A1 (en) | 2000-07-06 | 2002-01-21 | American Home Products Corporation | Use of substituted indole compounds for treating breast disorders |
| US6509332B2 (en) | 2000-07-06 | 2003-01-21 | Wyeth | Methods of treating excessive intraocular pressure |
| CA2414060A1 (en) | 2000-07-06 | 2002-01-17 | Wyeth | Combinations of statins, estrogenic agents and optionally estrogens |
| HK1052877A1 (zh) | 2000-07-06 | 2003-10-03 | Wyeth | Ssri与雌激素剂之组合 |
| CA2414111A1 (en) | 2000-07-06 | 2002-01-17 | Wyeth | Use of substituted indole compounds for increasing nitric oxide synthase activity |
| EP1177787A3 (en) | 2000-07-28 | 2003-09-10 | Pfizer Products Inc. | Use of an estrogen agonist/antagonist for treating cataracts |
| CN100448487C (zh) | 2000-08-11 | 2009-01-07 | 惠氏公司 | 治疗雌激素受体阳性癌的方法 |
| EP1192945A3 (en) | 2000-09-21 | 2004-03-03 | Pfizer Products Inc. | Use of an estrogen agonist/antagonist for treating osteoarthritis |
| IL145838A (en) | 2000-10-16 | 2008-11-03 | Pfizer Prod Inc | Use of an estrogen agonist/antagonist for the manufacture of a medicament for treating vaginitis |
| AU781168B2 (en) | 2001-01-26 | 2005-05-12 | Pfizer Products Inc. | Method of treating certain cancers using an estrogen agonist/antagonist |
| EP1527076B1 (en) * | 2002-07-24 | 2005-12-28 | Eli Lilly And Company | Dihydro-dibenzo[b,e]oxepine based selective estrogen receptor modulators, compositions and methods |
| ATE423122T1 (de) | 2003-08-15 | 2009-03-15 | Astrazeneca Ab | Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri) |
| JP2005129430A (ja) | 2003-10-27 | 2005-05-19 | Konica Minolta Holdings Inc | 光電変換材料用半導体、光電変換素子及び太陽電池 |
| FR2862646B1 (fr) * | 2003-11-20 | 2006-02-24 | Merck Sante Sas | Nouveaux composes antidiabetiques contenant des derives benzofuranes, benzothiophenes |
| KR20060123186A (ko) | 2003-12-15 | 2006-12-01 | 라보라뚜와르 떼라멕스 | 1-엔-페닐-아미노-1에이치-이미다졸 유도체 및 이들을포함하는 약학적 조성물 |
| CN101146798A (zh) | 2005-01-21 | 2008-03-19 | 詹森药业有限公司 | 用作雌激素受体调节剂的新的杂环苯并[c]色烯衍生物 |
| AU2006212726C1 (en) | 2005-02-14 | 2013-05-16 | Bionomics Limited | Novel tubulin polymerisation inhibitors |
| EP2460793A1 (en) | 2006-02-03 | 2012-06-06 | Bionomics Limited | Substituted Benzofurans, Benzothiophenes, Benzoselenophenes and Indoles And Their Use as Tubulin Polymerisation Inhibitors |
| WO2008002490A2 (en) | 2006-06-23 | 2008-01-03 | Radius Health, Inc. | Treatment of vasomotor symptoms with selective estrogen receptor modulators |
| EP1947085A1 (en) | 2007-01-19 | 2008-07-23 | Laboratorios del Dr. Esteve S.A. | Substituted indole sulfonamide compounds, their preparation and use as medicaments |
| KR20100027231A (ko) | 2007-07-25 | 2010-03-10 | 에프. 호프만-라 로슈 아게 | 벤조퓨란- 및 벤조[ｂ]티오펜-2-카복실산 아마이드 유도체 및 이의 히스타민 3 수용체 조절제로서의 용도 |
| WO2010093578A1 (en) | 2009-02-10 | 2010-08-19 | Glaxo Group Limited | Indolinyl-, benzofuranyl-, and benzothienyl- amides as modulators of chemokine receptors |
| EP2427430B1 (en) | 2009-05-04 | 2014-09-10 | The Royal Institution for the Advancement of Learning/McGill University | 5-oxo-ete receptor antagonist compounds |
| EP2478361A4 (en) | 2009-09-16 | 2014-05-21 | Celgene Avilomics Res Inc | CONJUGATES AND INHIBITORS OF PROTEIN KINASE |
| JP6042802B2 (ja) | 2010-04-27 | 2016-12-14 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 新生物（腫瘍）を治療するための免疫原性組成物及び方法。 |
| ES2627692T3 (es) | 2010-06-10 | 2017-07-31 | Aragon Pharmaceuticals, Inc. | Moduladores de receptores de estrógenos y usos de los mismos |
| US8853423B2 (en) | 2010-06-17 | 2014-10-07 | Seragon Pharmaceuticals, Inc. | Indane estrogen receptor modulators and uses thereof |
| US8642632B2 (en) | 2010-07-02 | 2014-02-04 | Radius Health, Inc. | Selective androgen receptor modulators |
| GB2483736B (en) | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
| WO2012048058A2 (en) | 2010-10-06 | 2012-04-12 | J-Pharma Co., Ltd. | Developing potent urate transporter inhibitors: compounds designed for their uricosuric action |
| WO2012084711A1 (en) | 2010-12-24 | 2012-06-28 | Msd Oss B.V. | N-substituted azetidine derivatives |
| DE102011087987A1 (de) | 2011-12-08 | 2013-06-13 | Bayer Intellectual Property Gmbh | 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
| EA029559B1 (ru) | 2011-12-14 | 2018-04-30 | Серагон Фармасьютикалс, Инк. | Фторированные модуляторы рецепторов эстрогенов и их применение |
| AP2014007657A0 (en) | 2011-12-16 | 2014-05-31 | Olema Pharmaceuticals Inc | Novel benzopyran compounds, compositions and uses thereof |
| MX2014009303A (es) | 2012-01-31 | 2014-10-14 | Novartis Ag | Combinacion de un inhibidor de rtk con un anti-estrogeno y uso del mismo para el tratamiento de cancer. |
| JP6154887B2 (ja) | 2012-03-20 | 2017-06-28 | セラゴン ファーマシューティカルズ，インク． | エストロゲン受容体モジュレーターおよびその使用 |
| WO2014019176A1 (zh) | 2012-08-01 | 2014-02-06 | 华为技术有限公司 | 用于同步的方法、装置及系统 |
| RU2015112134A (ru) | 2012-09-05 | 2016-10-27 | Конинклейке Филипс Н.В. | Капсула для приготовления напитков, устройство и способ |
| ES2774935T3 (es) * | 2012-10-24 | 2020-07-23 | Univ Illinois | Composiciones y métodos para tratar trastornos médicos relacionados con estrógeno |
| WO2014066695A1 (en) * | 2012-10-24 | 2014-05-01 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating estrogen-related medical disorders |
| SI2958907T1 (en) * | 2013-02-19 | 2018-05-31 | Novartis Ag | Benzothiophene derivatives and their compositions as selective estrogen receptor antagonists |
| US9586952B2 (en) | 2013-03-14 | 2017-03-07 | Genentech, Inc. | Polycyclic estrogen receptor modulators and uses thereof |
| BR112015029455A8 (pt) | 2013-05-28 | 2020-03-17 | Astrazeneca Ab | compostos químicos, uso, métodos e composições para prevenção ou tratamento de câncer |
| WO2014203129A1 (en) | 2013-06-19 | 2014-12-24 | Olema Pharmaceuticals, Inc. | Combinations of benzopyran compounds, compositions and uses thereof |
| EA031077B1 (ru) | 2013-06-19 | 2018-11-30 | Серагон Фармасьютикалз, Инк. | Модулятор рецептора эстрогена и его применения |
| MX2015016171A (es) | 2013-06-19 | 2016-08-08 | Seragon Pharmaceuticals Inc | Moduladores del receptor de estrogeno de azetidina y usos de los mismos. |
| WO2014203132A1 (en) | 2013-06-19 | 2014-12-24 | Olema Pharmaceuticals, Inc. | Substituted benzopyran compounds, compositions and uses thereof |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| WO2015028409A1 (de) | 2013-08-27 | 2015-03-05 | Bayer Pharma Aktiengesellschaft | 6,7-dihydro-5h-benzo[7]annulen-derivate, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
| WO2015092634A1 (en) | 2013-12-16 | 2015-06-25 | Novartis Ag | 1,2,3,4-tetrahydroisoquinoline compounds and compositions as selective estrogen receptor antagonists and degraders |
| SG11201607334YA (en) | 2014-03-13 | 2016-10-28 | Hoffmann La Roche | Therapeutic combinations with estrogen receptor modulators |
| BR112016020953A2 (pt) | 2014-03-13 | 2018-01-23 | Hoffmann La Roche | composto, kit, composição farmacêutica, uso de composto, método de tratamento e invenção |
| PL3122426T3 (pl) | 2014-03-28 | 2023-05-15 | Duke University | Leczenie raka sutka z zastosowaniem selektywnych modulatorów receptora estrogenowego |
| KR20250044939A (ko) | 2014-12-18 | 2025-04-01 | 에프. 호프만-라 로슈 아게 | 테트라하이드로-피리도[3,4-b]인돌 에스트로겐 수용체 조절제 및 이의 용도 |
| CN107406433A (zh) | 2014-12-18 | 2017-11-28 | 豪夫迈·罗氏有限公司 | 用于治疗癌症的2,3‑二苯基色烯的衍生物 |
| EP3233828B1 (en) | 2014-12-18 | 2020-03-04 | F. Hoffmann-La Roche AG | Estrogen receptor modulators and uses thereof |
| WO2016174551A1 (en) | 2015-04-27 | 2016-11-03 | Pfizer Inc. | Anti-estrogenic compounds |
| CN107531722B (zh) | 2015-05-26 | 2020-07-17 | 豪夫迈·罗氏有限公司 | 杂环雌激素受体调节剂及其用途 |
| EP3312184A4 (en) | 2015-06-16 | 2019-02-27 | Jiangsu Hengrui Medicine Co., Ltd. | PIPERIDINE DERIVATIVE AND ITS PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF |
| LT3355884T (lt) | 2015-10-01 | 2021-07-26 | Olema Pharmaceuticals, Inc. | Tetrahidro-1h-pirido[3,4-b]indolo antiestrogeniniai vaistai |
| WO2017056115A1 (en) | 2015-10-03 | 2017-04-06 | Sun Pharma Advanced Research Company Limited | Novel n-aryl containing fused heterocyclic compounds |
| JP2018533561A (ja) | 2015-10-07 | 2018-11-15 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | （ｅ）−３−（４−（（ｅ）−２−（２−クロロ−４−フルオロフェニル）−１−（１ｈ−インダゾール−５−イル）ブタ−１−エン−１−イル）フェニル）アクリル酸を調製するためのプロセス |
| JP6855475B2 (ja) | 2015-10-27 | 2021-04-07 | スン プハルマ アドバンセド リサーチ カンパニー リミテド | 新規ヘテロ環状抗エストロゲン剤 |
| WO2017080966A1 (en) | 2015-11-09 | 2017-05-18 | F. Hoffmann-La Roche Ag | Tetrahydronaphthalene estrogen receptor modulators and uses thereof |
| US10519148B2 (en) | 2015-11-12 | 2019-12-31 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Acrylic acid derivative, preparation method and use in medicine thereof |
| EP3386968B1 (en) * | 2015-12-09 | 2025-04-02 | The Board of Trustees of the University of Illinois | Benzothiophene-based selective estrogen receptor downregulator compounds |
| WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
| AU2018205262A1 (en) | 2017-01-06 | 2019-07-11 | G1 Therapeutics, Inc. | Combination therapy for the treatment of cancer |
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