AU2016366680B2 - Benzothiophene-based selective estrogen receptor downregulators - Google Patents

Benzothiophene-based selective estrogen receptor downregulators Download PDF

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Publication number
AU2016366680B2
AU2016366680B2 AU2016366680A AU2016366680A AU2016366680B2 AU 2016366680 B2 AU2016366680 B2 AU 2016366680B2 AU 2016366680 A AU2016366680 A AU 2016366680A AU 2016366680 A AU2016366680 A AU 2016366680A AU 2016366680 B2 AU2016366680 B2 AU 2016366680B2
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hooc
compound
cancer
alkyl
pharmaceutically acceptable
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AU2016366680A1 (en
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Gregory R. Thatcher
Debra A. Tonetti
Rui XIONG
Jiong ZHAO
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University of Illinois System
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University of Illinois at Urbana-Champaign
University of Illinois System
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
AU2016366680A 2015-12-09 2016-12-09 Benzothiophene-based selective estrogen receptor downregulators Active AU2016366680B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562264971P 2015-12-09 2015-12-09
US62/264,971 2015-12-09
US201662322878P 2016-04-15 2016-04-15
US62/322,878 2016-04-15
PCT/US2016/066023 WO2017100712A1 (en) 2015-12-09 2016-12-09 Benzothiophene-based selective estrogen receptor downregulators

Publications (2)

Publication Number Publication Date
AU2016366680A1 AU2016366680A1 (en) 2018-07-12
AU2016366680B2 true AU2016366680B2 (en) 2021-06-24

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US (7) US20170166551A1 (enExample)
EP (2) EP3386968B1 (enExample)
JP (2) JP6920709B2 (enExample)
KR (1) KR102785173B1 (enExample)
CN (2) CN108495628B (enExample)
AU (1) AU2016366680B2 (enExample)
BR (1) BR112018011607B1 (enExample)
CA (1) CA3008020C (enExample)
CY (1) CY1125767T1 (enExample)
DK (1) DK3386500T3 (enExample)
EA (1) EA038180B1 (enExample)
ES (1) ES2935125T3 (enExample)
HR (1) HRP20221462T1 (enExample)
HU (1) HUE061065T2 (enExample)
IL (1) IL259566B (enExample)
LT (1) LT3386500T (enExample)
MX (2) MX373946B (enExample)
NZ (1) NZ743651A (enExample)
PL (1) PL3386500T3 (enExample)
PT (1) PT3386500T (enExample)
RS (1) RS63791B1 (enExample)
RU (1) RU2747802C2 (enExample)
SI (1) SI3386500T1 (enExample)
SM (1) SMT202300018T1 (enExample)
WO (2) WO2017100712A1 (enExample)
ZA (2) ZA201803422B (enExample)

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KR20190117582A (ko) 2017-02-10 2019-10-16 쥐원 쎄라퓨틱스, 인크. 벤조티오펜 에스트로겐 수용체 조정제
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JP2021534177A (ja) * 2018-08-16 2021-12-09 ジー１ セラピューティクス， インコーポレイテッド 医学的障害を治療するためのベンゾチオフェンエストロゲン受容体モジュレーター
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CN115710248B (zh) * 2022-11-18 2024-06-21 南京中医药大学 新型选择性雌激素受体下调剂化合物、制备方法及用途
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