HUE061065T2 - Benzotiofén-alapú szelektív ösztrogénreceptor represszorok - Google Patents

Benzotiofén-alapú szelektív ösztrogénreceptor represszorok

Info

Publication number
HUE061065T2
HUE061065T2 HUE16874012A HUE16874012A HUE061065T2 HU E061065 T2 HUE061065 T2 HU E061065T2 HU E16874012 A HUE16874012 A HU E16874012A HU E16874012 A HUE16874012 A HU E16874012A HU E061065 T2 HUE061065 T2 HU E061065T2
Authority
HU
Hungary
Prior art keywords
benzothiophene
estrogen receptor
selective estrogen
based selective
receptor downregulators
Prior art date
Application number
HUE16874012A
Other languages
English (en)
Hungarian (hu)
Inventor
Gregory Thatcher
Original Assignee
The Board Of Trustees Of The Univ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Trustees Of The Univ filed Critical The Board Of Trustees Of The Univ
Publication of HUE061065T2 publication Critical patent/HUE061065T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Steroid Compounds (AREA)
HUE16874012A 2015-12-09 2016-12-09 Benzotiofén-alapú szelektív ösztrogénreceptor represszorok HUE061065T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562264971P 2015-12-09 2015-12-09
US201662322878P 2016-04-15 2016-04-15

Publications (1)

Publication Number Publication Date
HUE061065T2 true HUE061065T2 (hu) 2023-05-28

Family

ID=59013340

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE16874012A HUE061065T2 (hu) 2015-12-09 2016-12-09 Benzotiofén-alapú szelektív ösztrogénreceptor represszorok

Country Status (25)

Country Link
US (7) US10118910B2 (enExample)
EP (2) EP3386968B1 (enExample)
JP (2) JP6920709B2 (enExample)
KR (1) KR102785173B1 (enExample)
CN (2) CN108699024B (enExample)
AU (1) AU2016366680B2 (enExample)
BR (1) BR112018011607B1 (enExample)
CA (1) CA3008020C (enExample)
DK (1) DK3386500T3 (enExample)
EA (1) EA038180B1 (enExample)
ES (1) ES2935125T3 (enExample)
HR (1) HRP20221462T1 (enExample)
HU (1) HUE061065T2 (enExample)
IL (1) IL259566B (enExample)
LT (1) LT3386500T (enExample)
MX (2) MX373946B (enExample)
NZ (1) NZ743651A (enExample)
PL (1) PL3386500T3 (enExample)
PT (1) PT3386500T (enExample)
RS (1) RS63791B1 (enExample)
RU (1) RU2747802C2 (enExample)
SI (1) SI3386500T1 (enExample)
SM (1) SMT202300018T1 (enExample)
WO (2) WO2017100712A1 (enExample)
ZA (2) ZA201803422B (enExample)

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Publication number Publication date
SMT202300018T1 (it) 2023-03-17
EP3386500A4 (en) 2019-05-22
BR112018011607B1 (pt) 2024-01-30
KR102785173B1 (ko) 2025-03-25
ES2935125T3 (es) 2023-03-01
IL259566B (en) 2021-09-30
PT3386500T (pt) 2023-01-06
EA038180B1 (ru) 2021-07-20
WO2017100712A1 (en) 2017-06-15
CN108495628A (zh) 2018-09-04
RU2018125046A3 (enExample) 2020-02-10
US10377735B2 (en) 2019-08-13
PL3386500T3 (pl) 2023-03-13
RS63791B1 (sr) 2022-12-30
LT3386500T (lt) 2022-12-27
CN108495628B (zh) 2022-01-11
US11072595B2 (en) 2021-07-27
US20170166551A1 (en) 2017-06-15
ZA202003023B (en) 2022-12-21
KR20180088457A (ko) 2018-08-03
EP3386500A1 (en) 2018-10-17
AU2016366680A1 (en) 2018-07-12
SI3386500T1 (sl) 2023-01-31
BR112018011607A2 (pt) 2018-11-27
CA3008020C (en) 2024-02-20
NZ743651A (en) 2023-07-28
US20200079752A1 (en) 2020-03-12
WO2017100715A1 (en) 2017-06-15
HRP20221462T1 (hr) 2023-01-20
US11447461B2 (en) 2022-09-20
US12054469B2 (en) 2024-08-06
RU2018125046A (ru) 2020-01-09
DK3386500T3 (da) 2022-12-12
ZA201803422B (en) 2020-08-26
CN108699024A (zh) 2018-10-23
MX2018007079A (es) 2018-11-12
US20220194917A1 (en) 2022-06-23
RU2747802C2 (ru) 2021-05-14
US20190055209A1 (en) 2019-02-21
MX2020006991A (es) 2022-07-14
JP2019502675A (ja) 2019-01-31
EA201891376A1 (ru) 2019-02-28
US20170166550A1 (en) 2017-06-15
JP6920709B2 (ja) 2021-08-18
EP3386968A4 (en) 2019-09-25
US10118910B2 (en) 2018-11-06
CN108699024B (zh) 2022-03-11
AU2016366680B2 (en) 2021-06-24
JP2021169498A (ja) 2021-10-28
MX373946B (es) 2020-07-13
US10807964B2 (en) 2020-10-20
EP3386968B1 (en) 2025-04-02
US20210047286A1 (en) 2021-02-18
CA3008020A1 (en) 2017-06-15
US20200123126A1 (en) 2020-04-23
IL259566A (en) 2018-07-31
EP3386968A1 (en) 2018-10-17
MX393926B (es) 2025-03-24
EP3386500B1 (en) 2022-09-07

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