MX355904B - Microorganismo para producir simultáneamente l-amino ácidos y riboflavina, y método para producir l-amino acidos y riboflavina usando el mismo. - Google Patents
Microorganismo para producir simultáneamente l-amino ácidos y riboflavina, y método para producir l-amino acidos y riboflavina usando el mismo.Info
- Publication number
- MX355904B MX355904B MX2014006502A MX2014006502A MX355904B MX 355904 B MX355904 B MX 355904B MX 2014006502 A MX2014006502 A MX 2014006502A MX 2014006502 A MX2014006502 A MX 2014006502A MX 355904 B MX355904 B MX 355904B
- Authority
- MX
- Mexico
- Prior art keywords
- riboflavin
- producing
- microorganism
- amino acid
- threonine
- Prior art date
Links
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 title abstract 16
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 title abstract 8
- 229960002477 riboflavin Drugs 0.000 title abstract 8
- 239000002151 riboflavin Substances 0.000 title abstract 8
- 235000019192 riboflavin Nutrition 0.000 title abstract 8
- 244000005700 microbiome Species 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 8
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 6
- 239000004473 Threonine Substances 0.000 abstract 4
- 229960002898 threonine Drugs 0.000 abstract 4
- 235000019766 L-Lysine Nutrition 0.000 abstract 3
- 239000004472 Lysine Substances 0.000 abstract 3
- 150000008575 L-amino acids Chemical class 0.000 abstract 2
- 229960003646 lysine Drugs 0.000 abstract 2
- 241000186216 Corynebacterium Species 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 239000003674 animal food additive Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P25/00—Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/15—Corynebacterium
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Virology (AREA)
- Animal Husbandry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Fodder In General (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a un método para producir simultáneamente L-amino ácidos altamente concentrados y riboflavina, y a un microorganismo para producir de forma simultánea L-amino ácidos y riboflavina. Más particularmente, la presente invención se refiere a un-microorganismo mutado para producir simultáneamente L-lisina o L-treonina y riboflavina, en el que el microorganismo se modifica mediante el mejoramiento de la actividad de una familia de enzimas expresada por un operón costilla que contiene una familia de genes de biosíntesis de riboflavina en Corynebacterium, sp. capaz de producir L-lisina o Ltreonina. También, la presente invención se refiere a un método para la producción simultánea de L-lisina, o L-treonina y riboflavina utilizando el microorganismo mutado, y se refiere a una preparación o preparación granular de alimentos y aditivos de alimentos que contienen L-lisina o L-treonina y riboflavina producidos a partir de un medio de cultivo del microorganismo mutado. El microorganismo caracterizado porque el microorganismo Corynebacterium sp. Se selecciona del grupo constitutido por Corynebacterium glutamicum, Corynebacterium ammoniagenes, Corynebacterium thermoaminogenes, Brevibacterium flavum y Brevebacterium lactofermentum.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020110127955A KR101335853B1 (ko) | 2011-12-01 | 2011-12-01 | Ｌ-아미노산 및 리보플라빈을 동시에 생산하는 미생물 및 이를 이용한 ｌ-아미노산 및 리보플라빈을 생산하는 방법 |
| PCT/KR2012/008456 WO2013081296A1 (ko) | 2011-12-01 | 2012-10-17 | Ｌ-아미노산 및 리보플라빈을 동시에 생산하는 미생물 및 이를 이용한 ｌ-아미노산 및 리보플라빈을 생산하는 방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014006502A MX2014006502A (es) | 2015-08-10 |
| MX355904B true MX355904B (es) | 2018-05-03 |
Family
ID=48535709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014006502A MX355904B (es) | 2011-12-01 | 2012-10-17 | Microorganismo para producir simultáneamente l-amino ácidos y riboflavina, y método para producir l-amino acidos y riboflavina usando el mismo. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10590446B2 (es) |
| EP (1) | EP2787082A4 (es) |
| JP (1) | JP5966016B2 (es) |
| KR (1) | KR101335853B1 (es) |
| CN (2) | CN105713947B (es) |
| BR (1) | BR112014013239B1 (es) |
| MX (1) | MX355904B (es) |
| MY (1) | MY166528A (es) |
| RU (1) | RU2588657C2 (es) |
| WO (1) | WO2013081296A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101335853B1 (ko) | 2011-12-01 | 2013-12-02 | 씨제이제일제당 (주) | Ｌ-아미노산 및 리보플라빈을 동시에 생산하는 미생물 및 이를 이용한 ｌ-아미노산 및 리보플라빈을 생산하는 방법 |
| KR101518860B1 (ko) | 2013-10-11 | 2015-05-12 | 씨제이제일제당 (주) | L-아미노산의 생산 방법 |
| EP2860256B1 (en) | 2013-10-11 | 2017-03-08 | CJ Cheiljedang Corporation | Method of producing l-amino acids |
| KR101498630B1 (ko) * | 2013-10-28 | 2015-03-04 | 씨제이제일제당 주식회사 | Ｌ-라이신 생산능이 향상된 코리네박테리움 속 미생물 및 이를 이용한 l-라이신 생산방법 |
| CN104818346A (zh) * | 2015-04-29 | 2015-08-05 | 宁夏诚志万胜生物工程有限公司 | 一种高产酸量l-精氨酸发酵过程的调控方法 |
| KR101793328B1 (ko) * | 2015-07-03 | 2017-11-03 | 씨제이제일제당 (주) | Ｌ-라이신 생산능을 갖는 미생물 및 이를 이용한 ｌ-라이신 생산 방법 |
| CN108559747B (zh) * | 2016-08-31 | 2021-08-31 | Cj第一制糖株式会社 | 新型启动子及其应用 |
| EP3415622A1 (en) | 2017-06-14 | 2018-12-19 | Evonik Degussa GmbH | Method for production of fine chemicals using a corynebacterium secreting modified alpha-1,6-glucosidases |
| KR102175112B1 (ko) * | 2019-04-22 | 2020-11-06 | 씨제이제일제당 주식회사 | L-쓰레오닌 생산능이 강화된 미생물 및 이를 이용한 쓰레오닌 생산방법 |
| WO2020251208A1 (ko) * | 2019-06-14 | 2020-12-17 | 씨제이제일제당 (주) | 코리네박테리움 속 균주 및 이의 배양물을 포함하는 위장질환 예방, 치료 또는 개선용 조성물 |
| CN110964769B (zh) * | 2019-11-29 | 2022-11-11 | 河南巨龙生物工程股份有限公司 | 一种提高枯草芽孢杆菌发酵生产核黄素收率的方法 |
| CN110951662B (zh) * | 2019-12-26 | 2024-03-12 | 新疆梅花氨基酸有限责任公司 | 一种高产赖氨酸的棒状细菌及其构建方法与应用 |
| KR102207867B1 (ko) | 2020-01-21 | 2021-01-26 | 씨제이제일제당 주식회사 | Nadp 의존적 글리세르알데하이드-3-포스페이트 디하이드로지나제를 포함하는 미생물을 이용하여 ｌ-아미노산을 생산하는 방법 |
| KR102265807B1 (ko) * | 2020-03-03 | 2021-06-16 | 나종주 | 생균제를 이용한 사료첨가제의 제조방법 |
| KR102635860B1 (ko) | 2021-04-20 | 2024-02-13 | 씨제이제일제당 주식회사 | L-아미노산을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-아미노산의 생산 방법 |
| TW202333581A (zh) * | 2021-12-24 | 2023-09-01 | 南韓商Ｃｊ第一製糖股份有限公司 | 由發酵液製備含胺基酸製品之方法 |
| CN114317557B (zh) * | 2022-01-06 | 2023-07-07 | 河南农业大学 | 玉米ZmRIBA1基因在高赖氨酸玉米育种中的应用 |
| KR20230168477A (ko) * | 2022-06-07 | 2023-12-14 | 씨제이제일제당 (주) | 리보플라빈 생산능이 향상된 코리네박테리움 속 미생물 및 이를 이용한 리보플라빈을 생산하는 방법 |
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| DE102007017184A1 (de) | 2007-04-12 | 2008-10-16 | Evonik Degussa Gmbh | Verfahren zur integrierten Verwertung der Energie- und Stoffinhalte von Hydrolysaten |
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| KR100987281B1 (ko) | 2008-01-31 | 2010-10-12 | 씨제이제일제당 (주) | 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법 |
| EP2186880A1 (en) * | 2008-11-07 | 2010-05-19 | DSM IP Assets B.V. | Improved production of riboflavin |
| KR101182033B1 (ko) * | 2009-07-08 | 2012-09-11 | 씨제이제일제당 (주) | 외래종 유래의 글리세르알데하이드-3-포스페이트 디하이드로지나제의 활성을 획득한 코리네박테리움 속의 ｌ-라이신 생산방법 |
| KR101226384B1 (ko) * | 2010-03-05 | 2013-01-25 | 씨제이제일제당 (주) | 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법 |
| KR101335853B1 (ko) | 2011-12-01 | 2013-12-02 | 씨제이제일제당 (주) | Ｌ-아미노산 및 리보플라빈을 동시에 생산하는 미생물 및 이를 이용한 ｌ-아미노산 및 리보플라빈을 생산하는 방법 |
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- 2012-10-17 MX MX2014006502A patent/MX355904B/es active IP Right Grant
- 2012-10-17 RU RU2014123540/10A patent/RU2588657C2/ru active
- 2012-10-17 JP JP2014544651A patent/JP5966016B2/ja active Active
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| Publication number | Publication date |
|---|---|
| BR112014013239B1 (pt) | 2022-04-12 |
| RU2588657C2 (ru) | 2016-07-10 |
| CN103224964A (zh) | 2013-07-31 |
| MY166528A (en) | 2018-07-10 |
| CN105713947A (zh) | 2016-06-29 |
| EP2787082A1 (en) | 2014-10-08 |
| US10590446B2 (en) | 2020-03-17 |
| BR112014013239A2 (pt) | 2017-06-13 |
| KR20130061570A (ko) | 2013-06-11 |
| EP2787082A4 (en) | 2015-07-08 |
| WO2013081296A1 (ko) | 2013-06-06 |
| JP2015505671A (ja) | 2015-02-26 |
| CN103224964B (zh) | 2017-06-13 |
| CN105713947B (zh) | 2020-06-09 |
| MX2014006502A (es) | 2015-08-10 |
| KR101335853B1 (ko) | 2013-12-02 |
| JP5966016B2 (ja) | 2016-08-10 |
| US20140356518A1 (en) | 2014-12-04 |
| RU2014123540A (ru) | 2016-01-27 |
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