MX350828B - Uso de ligandos sigma en la hiperalgesica inducida por opioides. - Google Patents
Uso de ligandos sigma en la hiperalgesica inducida por opioides.Info
- Publication number
- MX350828B MX350828B MX2013001328A MX2013001328A MX350828B MX 350828 B MX350828 B MX 350828B MX 2013001328 A MX2013001328 A MX 2013001328A MX 2013001328 A MX2013001328 A MX 2013001328A MX 350828 B MX350828 B MX 350828B
- Authority
- MX
- Mexico
- Prior art keywords
- opioid
- induced hyperalgesia
- sigma ligands
- sigma
- hyperalgesia
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La invención se refiere al uso de un ligando sigma, particularmente un ligando sigma de fórmula (I), para prevenir y/o tratar la hiperalgesia inducida por opioides (HIO) asociada a la terapia con opioides.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10382215A EP2415471A1 (en) | 2010-08-03 | 2010-08-03 | Use of sigma ligands in opioid-induced hyperalgesia |
PCT/EP2011/063286 WO2012016980A2 (en) | 2010-08-03 | 2011-08-02 | Use of sigma ligands in opioid-induced hyperalgesia |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013001328A MX2013001328A (es) | 2013-03-08 |
MX350828B true MX350828B (es) | 2017-09-25 |
Family
ID=42763359
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013001328A MX350828B (es) | 2010-08-03 | 2011-08-02 | Uso de ligandos sigma en la hiperalgesica inducida por opioides. |
Country Status (22)
Country | Link |
---|---|
US (1) | US9789115B2 (es) |
EP (2) | EP2415471A1 (es) |
JP (1) | JP5923502B2 (es) |
KR (1) | KR101855357B1 (es) |
CN (2) | CN107417620A (es) |
AR (1) | AR082441A1 (es) |
AU (1) | AU2011287627B2 (es) |
BR (1) | BR112013002541A2 (es) |
CA (1) | CA2807069C (es) |
CO (1) | CO6680628A2 (es) |
ES (1) | ES2673729T3 (es) |
IL (1) | IL224530A (es) |
MA (1) | MA34506B1 (es) |
MX (1) | MX350828B (es) |
NZ (1) | NZ606539A (es) |
PT (1) | PT2600863T (es) |
RU (1) | RU2589899C2 (es) |
SG (1) | SG187668A1 (es) |
TW (1) | TWI511730B (es) |
UA (1) | UA110213C2 (es) |
WO (1) | WO2012016980A2 (es) |
ZA (1) | ZA201300795B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
EP2426111A1 (en) * | 2010-08-09 | 2012-03-07 | Laboratorios Del. Dr. Esteve, S.A. | 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms |
PL2688403T3 (pl) | 2011-03-23 | 2017-09-29 | Trevena, Inc. | Ligandy receptora opioidowego oraz sposoby ich stosowania i wytwarzania |
EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
DE102011117128A1 (de) * | 2011-10-28 | 2013-05-02 | Christian-Albrechts-Universität Zu Kiel | Verbindungen zur Therapie der Influenza |
EP2792352A1 (en) * | 2013-04-16 | 2014-10-22 | Laboratorios Del. Dr. Esteve, S.A. | Alpha-2 adrenoreceptor and sigma receptor ligand combinations |
MA39147B1 (fr) | 2013-12-17 | 2019-12-31 | Esteve Labor Dr | Combinaisons d'inhibiteurs de la recapture de sérotonine-norépinéphrine (snri) et de ligands des récepteurs sigma |
TN2016000229A1 (en) * | 2013-12-17 | 2017-10-06 | Esteve Labor Dr | Gabapentinoids and sigma receptor ligands combinations. |
MA41177A (fr) * | 2014-12-15 | 2017-10-24 | Esteve Labor Dr | Utilisation de ligands des récepteurs sigma dans l'arthrose |
WO2017106306A1 (en) * | 2015-12-14 | 2017-06-22 | Trevena, Inc. | Methods of treating hyperalgesia |
EP3563848A1 (en) * | 2018-04-30 | 2019-11-06 | S.I.S.S.A. Scuola Internazionale Superiore di Studi Avanzati | Serpin inhibitors for the treatment of prion and prion-like diseases |
WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (132)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU11248A1 (ru) | 1927-03-29 | 1929-09-30 | В.С. Григорьев | Способ очистки антрацена |
US2908677A (en) | 1955-03-30 | 1959-10-13 | Eastman Kodak Co | Nickel and cobalt complexes of pyrazolone monoazo compounds |
US3428634A (en) | 1965-03-13 | 1969-02-18 | Acraf | 3-tertiary amino alkoxy-1-hydrocarbon indazoles |
CH471199A (de) | 1965-07-06 | 1969-04-15 | Sandoz Ag | Verfahren zur Herstellung metallhaltiger Azofarbstoffe |
DE2313722C3 (de) | 1973-03-20 | 1987-04-16 | Bayer Ag, 5090 Leverkusen | Chromischkomplex-Farbstoff und dessen Verwendung zum Färben und Bedrucken von stickstoffhaltigen Fasermaterialien |
IT1005472B (it) | 1974-02-15 | 1976-08-20 | Montedison Spa | Procedimento per la preparazione del 2,5, dimetil 3,2h, furanone |
DE2460891C2 (de) | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
FR2301250A1 (fr) | 1975-02-21 | 1976-09-17 | Bellon Labor Sa Roger | Nouveaux diaryl-1, 4o-aminoalcoxy-3 pyrazoles et leurs sels |
CA1121651A (en) | 1978-07-27 | 1982-04-13 | Chi-Kuen Shu | 2,5-dialkyl dihydrofuranones and 2,4,5-trialkyl dihydrofuranones, mixtures of same and organoleptic uses thereof |
US4207392A (en) | 1978-10-30 | 1980-06-10 | Eastman Kodak Company | Heat developable and stabilizable photographic materials and process |
FR2460299A1 (fr) | 1979-07-05 | 1981-01-23 | Bellon Labor Sa Roger | Nouveaux derives du pyrazole et leur application therapeutique |
US4234616A (en) | 1979-08-03 | 1980-11-18 | International Flavors & Fragrances Inc. | Flavoring with mixtures of 2,5-dialkyl dihydrofuranones and 2,4,5-trialkyl dihydrofuranones |
FR2472564A1 (fr) | 1979-12-31 | 1981-07-03 | Bellon Labor Sa Roger | Nouveaux aryl-1 arylsulfonyl-4 1h-pyrazolols-3, et procede pour les preparer |
US4826868A (en) | 1986-05-29 | 1989-05-02 | Ortho Pharmaceutical Corporation | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use |
GB8917069D0 (en) | 1989-07-26 | 1989-09-13 | Merck Sharp & Dohme | Therapeutic agents |
IL96507A0 (en) | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
EP0507863A4 (en) | 1989-12-28 | 1993-07-07 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
JPH03232817A (ja) | 1990-02-07 | 1991-10-16 | Showa Yakuhin Kako Kk | 貼付剤 |
EP0445974A3 (en) | 1990-03-05 | 1992-04-29 | Merck Sharp & Dohme Ltd. | Spirocyclic antipsychotic agents |
JPH04364129A (ja) | 1990-10-26 | 1992-12-16 | Asahi Chem Ind Co Ltd | 6−置換アルコキシキノキサリン誘導体含有医薬組成物およびその製造法 |
AU9137091A (en) | 1990-11-27 | 1992-06-25 | Northwestern University | Gaba and l-glutamic acid analogs for antiseizure treatment |
NZ243065A (en) | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
US5240925A (en) | 1991-08-26 | 1993-08-31 | Rohm And Haas Company | Fungicidal 2-aryl-2-cyano-2-(heterocyclylalkyl)ethyl-1,2,4-triazoles |
WO1993023383A1 (en) | 1992-05-20 | 1993-11-25 | Northwestern University | Gaba and l-glutamic acid analogs for antiseizure treatment |
GB9423542D0 (en) | 1994-11-22 | 1995-01-11 | Marples Brian A | Pharmaceutical compounds |
JPH1036259A (ja) | 1996-04-11 | 1998-02-10 | Kikkoman Corp | 白内障の予防または治療薬剤 |
JPH1055048A (ja) | 1996-08-08 | 1998-02-24 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
ES2213892T3 (es) | 1997-01-21 | 2004-09-01 | Smithkline Beecham Corporation | Nuevos moduladores del receptor de canabinoides. |
WO1998041519A1 (en) | 1997-03-18 | 1998-09-24 | Smithkline Beecham Corporation | Novel cannabinoid receptor agonists |
ES2201482T3 (es) | 1997-04-14 | 2004-03-16 | Ufc Limited | Derivados de la morfina. |
TW577887B (en) | 1997-07-02 | 2004-03-01 | Merck & Co Inc | Polymorphic form I of a tachykinin receptor antagonist |
CU23048A3 (es) | 1997-10-27 | 2005-06-24 | Warner Lambert Co | Aminoacidos ciclicos y derivados de los mismos, utiles como agentes farmaceuticos |
KR20010033154A (ko) | 1997-12-16 | 2001-04-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 제약물로서의 신규한 아민 |
KR20010033153A (ko) | 1997-12-16 | 2001-04-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 4(3)-치환-4(3)-아미노메틸-(티오)피란 또는 -피페리딘유도체(=가바펜틴 동족체), 그의 제법 및 신경 질환 치료용도 |
ES2227896T3 (es) | 1997-12-16 | 2005-04-01 | Warner-Lambert Company Llc | Derivados de 1-aminometil-cicloalcanos sustituidos en 1 (=analogos de gabapentina), su preparacion y su uso en el tratamiento de trastornos neurologicos. |
WO1999059409A1 (en) | 1998-05-21 | 1999-11-25 | Matsumoto Rae R | Compounds and uses thereof |
WO1999061424A1 (en) | 1998-05-26 | 1999-12-02 | Warner-Lambert Company | Conformationally constrained amino acid compounds having affinity for the alpha2delta subunit of a calcium channel |
US6166072A (en) | 1998-08-03 | 2000-12-26 | Allelix Neuroscience, Inc. | Amino acid derivatives |
WO2000020005A1 (en) | 1998-10-01 | 2000-04-13 | EGIS Gyógyszergyár Rt. | Pharmaceutical compositions containing an opiate analgesic and a synergizing substance |
GB9824310D0 (en) | 1998-11-05 | 1998-12-30 | Univ London | Activators of soluble guanylate cyclase |
CA2349452C (en) | 1998-11-09 | 2009-02-10 | Santen Pharmaceutical Co., Ltd. | Therapeutic agents for drug dependence |
WO2000031020A1 (en) | 1998-11-25 | 2000-06-02 | Warner-Lambert Company | Improved gamma amino butyric acid analogs |
NO310544B1 (no) | 1999-01-04 | 2001-07-23 | Algeta As | Opparbeidelse og anvendelse av radium-223 til fremstilling av preparat samt kit til behandling av kalsifisert vev for palliasjon, benkreft-terapi og/eller overflatebehandling av ben |
EP1180094B1 (en) | 1999-05-26 | 2004-07-28 | Warner-Lambert Company | Fused polycyclic amino acids as pharmaceutical agents |
ATE287880T1 (de) | 1999-05-28 | 2005-02-15 | Warner Lambert Co | 3-heteroarylalkyl-substituierte gaba-analoga |
WO2000073300A1 (en) | 1999-06-02 | 2000-12-07 | Warner-Lambert Company | Amino heterocycles useful as pharmaceutical agents |
US7091257B2 (en) | 1999-07-27 | 2006-08-15 | Alcatel | Radiation-curable composition with simultaneous color formation during cure |
US6469030B2 (en) | 1999-11-29 | 2002-10-22 | Adolor Corporation | Methods for the treatment and prevention of ileus |
US6492529B1 (en) | 2000-01-18 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Bis pyrazole-1H-pyrazole intermediates and their synthesis |
CA2401711C (en) | 2000-02-29 | 2008-06-03 | Mitsubishi Pharma Corporation | Cyclic amide derivatives |
EP1272567A2 (en) | 2000-04-03 | 2003-01-08 | Sun Chemical Corporation | Mono- and bis-hydrazone pigments |
KR100618743B1 (ko) | 2001-04-19 | 2006-08-31 | 워너-램버트 캄파니 엘엘씨 | 융합된 비사이클릭 또는 트리사이클릭 아미노산 |
JP4316893B2 (ja) | 2001-05-16 | 2009-08-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | Srcおよび他のプロテインキナーゼのインヒビター |
WO2002102387A1 (en) | 2001-06-18 | 2002-12-27 | H. Lundbeck A/S | Treatment of neuropathic pain |
US6509367B1 (en) | 2001-09-22 | 2003-01-21 | Virginia Commonwealth University | Pyrazole cannabinoid agonist and antagonists |
RU2218187C2 (ru) | 2002-02-11 | 2003-12-10 | Ростовский научно-исследовательский онкологический институт | Способ лечения болевого синдрома у онкологических больных |
GB0206505D0 (en) | 2002-03-19 | 2002-05-01 | Euro Celtique Sa | Pharmaceutical combination |
WO2004016592A1 (en) | 2002-08-14 | 2004-02-26 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
TW200413351A (en) | 2002-08-21 | 2004-08-01 | Astrazeneca Ab | Chemical compounds |
WO2004046129A2 (en) | 2002-11-15 | 2004-06-03 | E.I. Du Pont De Nemours And Company | Novel anthranilamide insecticides |
JP2004196678A (ja) | 2002-12-17 | 2004-07-15 | Dainippon Pharmaceut Co Ltd | ピラゾール系誘導体 |
US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
US20050032827A1 (en) | 2003-06-12 | 2005-02-10 | Donna Oksenberg | Sigma ligands for neuronal regeneration and functional recovery |
WO2005061462A2 (en) | 2003-12-19 | 2005-07-07 | Neurogen Corporation | Diaryl pyrazole derivatives and their use as neurokinin-3 receptor modulators |
MX2007000793A (es) | 2004-07-24 | 2007-03-21 | Esteve Labor Dr | Uso de compuestos activos sobre el receptor sigma para el tratamiento de alodinia mecanica. |
ES2251316B1 (es) | 2004-10-14 | 2007-03-16 | Laboratorios Del Dr. Esteve, S.A. | Inhibidores del receptor sigma. |
KR101352012B1 (ko) | 2004-08-27 | 2014-01-15 | 라보라토리오스 델 드라. 에스테브.에스.에이. | 시그마 수용체 저해제 |
AU2005276591B2 (en) | 2004-08-27 | 2011-03-31 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
EP1634872A1 (en) | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Pyrazole derivatives as sigma receptor inhibitors |
EP1634873A1 (en) | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
DK1781618T3 (da) | 2004-08-27 | 2012-10-29 | Esteve Labor Dr | Sigma-receptorinhibitorer |
EP1632227A1 (en) | 2004-09-07 | 2006-03-08 | Laboratorios del Dr. Esteve S.A. | Derivatives of aryl (or heteroaryl) azolylcarbinols (in particular cizolirtin citrate) for the treatment of opioid addiction |
JP5833804B2 (ja) * | 2005-04-13 | 2015-12-16 | ニューラクソン,インコーポレーテッド | Nos阻害活性を有する置換インドール化合物 |
US20080161604A1 (en) | 2005-04-26 | 2008-07-03 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Acetyl L-Carnitine For Preventing Painful Peripheral Diabetic Neuropathy |
JP2008179541A (ja) | 2005-05-02 | 2008-08-07 | Mochida Pharmaceut Co Ltd | 神経因性疼痛治療薬 |
ITRM20050332A1 (it) | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
KR101363278B1 (ko) | 2005-06-27 | 2014-02-21 | 엑셀리시스 페이턴트 컴퍼니 엘엘씨 | 이미다졸계 lxr 변조제 |
US20090325975A1 (en) | 2005-07-15 | 2009-12-31 | Helmut H Buschmann | Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain |
EP1787679A1 (en) | 2005-07-29 | 2007-05-23 | Laboratorios Del Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain |
WO2007041593A2 (en) | 2005-10-03 | 2007-04-12 | Combinatorx, Incorporated | Anti-scarring drug combinations and use thereof |
WO2007046550A1 (en) | 2005-10-21 | 2007-04-26 | Mitsubishi Tanabe Pharma Corporation | Pyrazole compounds having cannabinoid receptor (cb1) antagonizing activity |
AU2006305031B2 (en) | 2005-10-22 | 2011-05-12 | Se Joon Park | Microorganisms having bad smell removal activity of organic waste and use thereof |
WO2007079086A1 (en) | 2005-12-28 | 2007-07-12 | Coley Pharmaceutical Group, Inc. | Pyrazoloalkyl substituted imidazo ring compounds and methods |
EP1820502A1 (en) | 2006-02-10 | 2007-08-22 | Laboratorios Del Dr. Esteve, S.A. | Active substance combination comprising azolylcarbinol compounds |
US20090181976A1 (en) | 2006-02-28 | 2009-07-16 | Buschmann Helmut H | Use of Compounds Binding to the Sigma Receptor for the Treatment of Metabolic Syndrome |
EP1829875A1 (en) | 2006-03-01 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Pyrazole derivatives as sigma receptor inhibitors |
US8202872B2 (en) | 2006-03-01 | 2012-06-19 | Laboratorios Del Dr. Esteve, S.A. | Pyrazole derivatives as sigma receptor inhibitors |
EP1829873A1 (en) | 2006-03-02 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Pyrrazole derivatives as sigma receptors antagonists |
EP1829866A1 (en) | 2006-03-02 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
KR101012232B1 (ko) | 2006-03-22 | 2011-02-08 | 파나소닉 주식회사 | 혈액 검사 장치 |
CN101563079B (zh) | 2006-03-27 | 2012-12-05 | 威克斯药业有限公司 | 钠通道阻滞剂在制备治疗由于化疗而产生的神经病理性疼痛的药物中的用途 |
EP1847542A1 (en) | 2006-04-21 | 2007-10-24 | Laboratorios del Dr. Esteve S.A. | Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor |
MX2008015341A (es) | 2006-06-08 | 2009-02-10 | Sanol Arznei Schwarz Gmbh | Combinacion terapeutica para condiciones medicas dolorosas. |
RU2322977C1 (ru) | 2006-08-01 | 2008-04-27 | Закрытое акционерное общество "Физиофарм" | Синтетическое анальгетическое средство и способ лечения на основе этого средства |
WO2008015266A1 (en) | 2006-08-04 | 2008-02-07 | Laboratorios Del Dr. Esteve, S.A. | Substituted dimethylcyclobutyl compounds, their preparation and use in medicaments |
US7645767B2 (en) | 2006-08-31 | 2010-01-12 | Trinity Laboratories, Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
EP1921071A1 (en) | 2006-11-10 | 2008-05-14 | Laboratorios del Dr. Esteve S.A. | 1,2,3- triazole derivatives as sigma receptor inhibitors |
EP1921073A1 (en) | 2006-11-10 | 2008-05-14 | Laboratorios del Dr. Esteve S.A. | 1,2,4-Triazole derivatives as sigma receptor inhibitors |
US20090018151A1 (en) | 2007-02-23 | 2009-01-15 | Ezekiel Fink | Topical Treatment of Peripheral diabetic complications |
KR100868353B1 (ko) | 2007-03-08 | 2008-11-12 | 한국화학연구원 | 도파민 d4 수용체 길항제인 신규 피페라지닐프로필피라졸유도체, 이의 제조방법 및 이를 포함하는 약학적 조성물 |
GB0710981D0 (en) | 2007-06-07 | 2007-07-18 | Acacia Pharma Ltd | New Therapeutic use |
EP2191830A4 (en) | 2007-09-21 | 2011-11-23 | Shionogi & Co | SOLID PREPARATION COMPRISING A NPYY5 RECEPTOR ANTAGONIST |
EP2070933A1 (en) | 2007-12-07 | 2009-06-17 | Laboratorios del Dr. Esteve S.A. | Tricyclic triazolic compounds |
EP2254579B1 (en) | 2008-02-18 | 2018-01-10 | Laboratorios Del. Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor ligands for the treatment of neuropathic pain developing as a consequence of chemotherapy |
EP2090311A1 (en) | 2008-02-18 | 2009-08-19 | Laboratorios Del. Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor ligands for the treatment of neuropathic pain developing as a consequence of chemotherapy |
EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
EP2112139A1 (en) | 2008-04-25 | 2009-10-28 | Laboratorios Del. Dr. Esteve, S.A. | Process for the preparation of naphthalen-2-yl-pyrazol-3-one intermediates useful in the synthesis of sigma receptor inhibitors |
EP2113501A1 (en) | 2008-04-25 | 2009-11-04 | Laboratorios Del. Dr. Esteve, S.A. | 5-Methyl-1-(naphthalen-2-YL)-1H-Pyrazoles useful as sigma receptor inhibitors |
RU2382646C1 (ru) * | 2008-11-20 | 2010-02-27 | Федеральное государственное учреждение "Московский научно-исследовательский онкологический институт им. П.А. Герцена Федерального агентства по высокотехнологичной медицинской помощи" | Способ профилактики и лечения послеоперационного болевого синдрома при обширных торакоабдоминальных операциях |
US8192885B2 (en) | 2009-01-26 | 2012-06-05 | GM Global Technology Operations LLC | Shutdown strategy for enhanced water management |
EP2292236A1 (en) | 2009-08-14 | 2011-03-09 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention or treatment of pain induced by chemotherapy |
DK2503993T3 (en) | 2009-11-25 | 2016-08-22 | Esteve Labor Dr | Hydrochloridsalt af 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]-morpholin |
EP2335688A1 (en) | 2009-11-25 | 2011-06-22 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical compositions comprising sigma receptor ligands |
EP2361904A1 (en) | 2010-02-04 | 2011-08-31 | Laboratorios Del. Dr. Esteve, S.A. | 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride and crystalline forms thereof |
EP2426112A1 (en) | 2010-08-09 | 2012-03-07 | Laboratorios Del. Dr. Esteve, S.A. | 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride polymorphs and solvates |
EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
NZ601316A (en) | 2010-02-04 | 2013-12-20 | Esteve Labor Dr | 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride polymorphs and solvates |
US20110269727A1 (en) | 2010-04-29 | 2011-11-03 | Toledano Annette C | Composition to reduce allodynic back pain and related method of use |
EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
EP2395003A1 (en) | 2010-05-27 | 2011-12-14 | Laboratorios Del. Dr. Esteve, S.A. | Pyrazole compounds as sigma receptor inhibitors |
EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
EP2426111A1 (en) | 2010-08-09 | 2012-03-07 | Laboratorios Del. Dr. Esteve, S.A. | 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms |
EP2460519A1 (en) | 2010-12-03 | 2012-06-06 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in bone cancer pain |
EP2460804A1 (en) | 2010-12-03 | 2012-06-06 | Laboratorios Del Dr. Esteve, S.A. | 5-methyl-1-(naphthalen-2-yl)-1h-pyrazole derivatives and their use in potentiating the effect of opioid analgesics |
CN105130967B (zh) | 2011-05-13 | 2018-04-17 | 阵列生物制药公司 | 作为trka激酶抑制剂的吡咯烷基脲和吡咯烷基硫脲化合物 |
EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
EP2792352A1 (en) | 2013-04-16 | 2014-10-22 | Laboratorios Del. Dr. Esteve, S.A. | Alpha-2 adrenoreceptor and sigma receptor ligand combinations |
EP2818166A1 (en) | 2013-06-26 | 2014-12-31 | Laboratorios del Dr. Esteve S.A. | Use of sigma receptor ligands for the prevention and treatment of pain associated to interstitial cystitis/bladder pain syndrome (IC/BPS) |
WO2015036470A1 (en) | 2013-09-12 | 2015-03-19 | Laboratorios Del Dr. Esteve, S.A. | Nsaid and sigma receptor ligand combinations |
MA39147B1 (fr) | 2013-12-17 | 2019-12-31 | Esteve Labor Dr | Combinaisons d'inhibiteurs de la recapture de sérotonine-norépinéphrine (snri) et de ligands des récepteurs sigma |
TN2016000229A1 (en) | 2013-12-17 | 2017-10-06 | Esteve Labor Dr | Gabapentinoids and sigma receptor ligands combinations. |
-
2010
- 2010-08-03 EP EP10382215A patent/EP2415471A1/en not_active Withdrawn
-
2011
- 2011-02-08 UA UAA201302559A patent/UA110213C2/ru unknown
- 2011-08-01 TW TW100127236A patent/TWI511730B/zh not_active IP Right Cessation
- 2011-08-02 EP EP11738245.7A patent/EP2600863B1/en not_active Not-in-force
- 2011-08-02 MX MX2013001328A patent/MX350828B/es active IP Right Grant
- 2011-08-02 CN CN201710623504.2A patent/CN107417620A/zh active Pending
- 2011-08-02 CN CN201180038322XA patent/CN103052388A/zh active Pending
- 2011-08-02 JP JP2013522233A patent/JP5923502B2/ja not_active Expired - Fee Related
- 2011-08-02 ES ES11738245.7T patent/ES2673729T3/es active Active
- 2011-08-02 PT PT117382457T patent/PT2600863T/pt unknown
- 2011-08-02 AU AU2011287627A patent/AU2011287627B2/en not_active Ceased
- 2011-08-02 BR BR112013002541A patent/BR112013002541A2/pt not_active Application Discontinuation
- 2011-08-02 KR KR1020137005269A patent/KR101855357B1/ko active IP Right Grant
- 2011-08-02 CA CA2807069A patent/CA2807069C/en not_active Expired - Fee Related
- 2011-08-02 NZ NZ606539A patent/NZ606539A/en not_active IP Right Cessation
- 2011-08-02 WO PCT/EP2011/063286 patent/WO2012016980A2/en active Application Filing
- 2011-08-02 RU RU2013109291/15A patent/RU2589899C2/ru not_active IP Right Cessation
- 2011-08-02 SG SG2013007752A patent/SG187668A1/en unknown
- 2011-08-02 MA MA35700A patent/MA34506B1/fr unknown
- 2011-08-02 AR ARP110102778A patent/AR082441A1/es unknown
- 2011-08-02 US US13/814,148 patent/US9789115B2/en not_active Expired - Fee Related
-
2013
- 2013-01-30 ZA ZA2013/00795A patent/ZA201300795B/en unknown
- 2013-01-31 IL IL224530A patent/IL224530A/en active IP Right Grant
- 2013-02-01 CO CO13019557A patent/CO6680628A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MA34506B1 (fr) | 2013-09-02 |
AU2011287627A1 (en) | 2013-02-21 |
TWI511730B (zh) | 2015-12-11 |
KR20130105613A (ko) | 2013-09-25 |
US9789115B2 (en) | 2017-10-17 |
JP5923502B2 (ja) | 2016-05-24 |
ES2673729T3 (es) | 2018-06-25 |
EP2600863A2 (en) | 2013-06-12 |
EP2415471A1 (en) | 2012-02-08 |
ZA201300795B (en) | 2014-04-30 |
AU2011287627B2 (en) | 2016-11-10 |
CN107417620A (zh) | 2017-12-01 |
CN103052388A (zh) | 2013-04-17 |
WO2012016980A3 (en) | 2012-03-29 |
MX2013001328A (es) | 2013-03-08 |
BR112013002541A2 (pt) | 2016-05-31 |
RU2013109291A (ru) | 2014-09-10 |
CA2807069C (en) | 2018-12-04 |
CO6680628A2 (es) | 2013-05-31 |
EP2600863B1 (en) | 2018-03-28 |
TW201216964A (en) | 2012-05-01 |
CA2807069A1 (en) | 2012-02-09 |
US20130158033A1 (en) | 2013-06-20 |
KR101855357B1 (ko) | 2018-05-04 |
PT2600863T (pt) | 2018-06-25 |
AR082441A1 (es) | 2012-12-05 |
RU2589899C2 (ru) | 2016-07-10 |
WO2012016980A2 (en) | 2012-02-09 |
IL224530A (en) | 2015-07-30 |
SG187668A1 (en) | 2013-03-28 |
NZ606539A (en) | 2014-03-28 |
UA110213C2 (en) | 2015-12-10 |
JP2013532709A (ja) | 2013-08-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX350828B (es) | Uso de ligandos sigma en la hiperalgesica inducida por opioides. | |
TN2013000227A1 (en) | Use of sigma ligands in bone cancer pain | |
TN2013000508A1 (en) | Combination therapy comprising a cdk4/6 inhibitor and a pi3k inhibitor for use in the treatment of cancer | |
SG10201903119QA (en) | Polypeptide vaccine | |
EP2569434A4 (en) | COMPOSITIONS AND METHODS FOR TREATING LEUKEMIA | |
MY160390A (en) | Vinyl indazolyl compounds | |
TW201711676A (en) | Ferric citrate dosage forms | |
TN2013000460A1 (en) | Use of sigma ligands in diabetes type-2 associated pain | |
PH12014501639A1 (en) | Pharmaceutical compositions and methods | |
MX2014012477A (es) | Inhibidores pirrolopirazona de tanquirasa. | |
WO2012170776A3 (en) | Methods of determining a patient's prognosis for recurrence of prostate cancer and/or determining a course of treatment for prostate cancer following a radical prostatectomy | |
MX2014014832A (es) | Pirrolopirimidona y pirrolopiridona, inhibidores de tanquirasa. | |
IL217911A0 (en) | Sigma ligands for the prevention or treatment of pain induced by chemotherapy | |
TN2012000348A1 (en) | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof | |
HK1183447A1 (zh) | 預防和/或治療化學療法或放射療法引起的嘔吐的σ配體 | |
MY178390A (en) | Inhibitors of iap | |
JO3145B1 (ar) | مركبات مفيدة لتثبيط chk1 | |
MX343968B (es) | Inhibidor de proteasoma delanzomib para uso en el tratamiento de lupus. | |
EP2547666A4 (en) | CONJUGATES OF 1,4,7-TRIAZA CYCLONONANES, DINUCLEAR METAL COMPLEXES FROM SUCH CONJUGATES AND METHOD OF USE FOR THE 1,4,7-TRIAZA CYCLONONANES AND THE CONJUGATES | |
WO2011113041A3 (en) | Neutralization of flt3 ligand as a leukemia therapy | |
TN2013000026A1 (en) | Use of sigma ligands in opioid - induced hyperalgesia | |
WO2012158776A3 (en) | Combination therapy for treatment of cancer | |
MX350868B (es) | Medicamentos y metodos para tratar cancer. | |
GB201116057D0 (en) | Synthesis and anticancer activity of ruthenium (II) cis-cis-1,3,5-triaminocyclohexane complexes | |
UA65243U (ru) | Применение радиоактивного цисплатина как вещества с усиленным противоопухолевым действием |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |