MX346367B - Derivado de triazina y composicion farmaceutica que tiene actividad analgesica que comprende el mismo. - Google Patents
Derivado de triazina y composicion farmaceutica que tiene actividad analgesica que comprende el mismo.Info
- Publication number
- MX346367B MX346367B MX2013001542A MX2013001542A MX346367B MX 346367 B MX346367 B MX 346367B MX 2013001542 A MX2013001542 A MX 2013001542A MX 2013001542 A MX2013001542 A MX 2013001542A MX 346367 B MX346367 B MX 346367B
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- analgesic activity
- pharmaceutical compound
- triazine derivative
- exhibits analgesic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención proporciona nuevos compuestos que tienen efecto antagonista del receptor PZX3 y/o P2X2/3, y una composición farmacéutica que tiene efecto analgésico o un efecto mejorador de transtorno de micción que comprende un compuesto de la Fórmula (I) (Ver Formula) en donde Rh y Rj se toman conjuntamente para formar un enlace; Ra y Rb y/o Rd y Re se toman conjuntamente para formar oxo o similares; Rc es hidrógeno, alquilo sustituido o no sustituido o similares; -Rf es -(CR4aR4b)n-R2 R4a y R4b son hidrógeno o alquilo sustituido o no sustituido o similares; n es un número entero de 1 a 4; Rg es -X-R3-; -X- es -O-, -S-, o similares; R3 es cicloalquilo sustituido o no sustituido o similares, o su sal farmacéuticamente aceptable o un solvato del mismo.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010179350 | 2010-08-10 | ||
JP2010182803 | 2010-08-18 | ||
JP2011074763 | 2011-03-30 | ||
PCT/JP2011/068113 WO2012020749A1 (ja) | 2010-08-10 | 2011-08-09 | トリアジン誘導体およびそれを含有する鎮痛作用を有する医薬組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013001542A MX2013001542A (es) | 2013-03-18 |
MX346367B true MX346367B (es) | 2017-03-16 |
Family
ID=45567712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013001542A MX346367B (es) | 2010-08-10 | 2011-08-09 | Derivado de triazina y composicion farmaceutica que tiene actividad analgesica que comprende el mismo. |
Country Status (16)
Country | Link |
---|---|
US (1) | US9718790B2 (es) |
EP (1) | EP2604595B1 (es) |
JP (2) | JP5594706B2 (es) |
KR (1) | KR101867110B1 (es) |
CN (1) | CN103153968B (es) |
AU (1) | AU2011290261B2 (es) |
BR (1) | BR112013002984B1 (es) |
CA (1) | CA2807947C (es) |
DK (1) | DK2604595T3 (es) |
ES (1) | ES2572481T3 (es) |
MX (1) | MX346367B (es) |
PL (1) | PL2604595T3 (es) |
RU (1) | RU2565073C2 (es) |
TW (2) | TW201542210A (es) |
WO (1) | WO2012020749A1 (es) |
ZA (1) | ZA201300920B (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2752269C (en) | 2009-02-13 | 2016-08-30 | Hiroyuki Kai | Novel triazine derivative and pharmaceutical composition comprising the same |
WO2012006004A1 (en) * | 2010-06-28 | 2012-01-12 | Janssen Pharmaceutica Nv | Prokineticin 1 receptor antagonists for the treatment of pain |
CN103140221A (zh) * | 2010-08-10 | 2013-06-05 | 盐野义制药株式会社 | 新型杂环衍生物和含有其的药物组合物 |
MX346367B (es) | 2010-08-10 | 2017-03-16 | Shionogi & Co Ltd * | Derivado de triazina y composicion farmaceutica que tiene actividad analgesica que comprende el mismo. |
WO2013089212A1 (ja) * | 2011-12-15 | 2013-06-20 | 塩野義製薬株式会社 | 置換トリアジン誘導体およびそれらを含有する医薬組成物 |
US9550763B2 (en) | 2012-02-09 | 2017-01-24 | Shionogi & Co., Ltd. | Heterocyclic ring and carbocyclic derivative |
ES2691082T3 (es) | 2012-03-30 | 2018-11-23 | Nissan Chemical Corporation | Compuesto de triazinona e inhibidor de canales de calcio de tipo T |
TWI637949B (zh) | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
US10150728B2 (en) | 2013-10-17 | 2018-12-11 | Shionogi & Co., Ltd. | Alkylene derivatives |
JP6422164B2 (ja) * | 2013-12-26 | 2018-11-14 | 塩野義製薬株式会社 | 含窒素6員環誘導体およびそれらを含有する医薬組成物 |
WO2016084922A1 (ja) * | 2014-11-28 | 2016-06-02 | 塩野義製薬株式会社 | 1,2,4-トリアジン誘導体およびその医薬組成物 |
DK3287443T3 (da) | 2015-04-24 | 2022-02-07 | Shionogi & Co | 6-leddet heterocyklisk derivat og farmaceutisk sammensætning, som omfatter dette |
WO2018074390A1 (ja) | 2016-10-17 | 2018-04-26 | 塩野義製薬株式会社 | 二環性含窒素複素環誘導体およびそれらを含有する医薬組成物 |
GB201810669D0 (en) * | 2018-06-28 | 2018-08-15 | Stiftelsen Alzecure | New compounds |
US11883407B2 (en) | 2018-10-05 | 2024-01-30 | Shionogi & Co., Ltd. | Medicament for the treatment of chronic cough |
CN117843615A (zh) * | 2019-09-19 | 2024-04-09 | 盐野义制药株式会社 | 1,3,5-三嗪衍生物或其溶剂合物的晶体及其制造方法 |
WO2021065027A1 (ja) | 2019-10-02 | 2021-04-08 | あすか製薬株式会社 | 排尿障害改善剤 |
CN114502239A (zh) | 2019-10-02 | 2022-05-13 | Aska制药株式会社 | 排尿障碍改善剂 |
TW202203929A (zh) | 2020-04-03 | 2022-02-01 | 日商塩野義製藥股份有限公司 | 疼痛治療用醫藥 |
WO2022131354A1 (ja) | 2020-12-18 | 2022-06-23 | あすか製薬株式会社 | 固形製剤 |
CN116650498A (zh) * | 2021-04-14 | 2023-08-29 | 盐野义制药株式会社 | 具有病毒增殖抑制作用的三嗪衍生物及含有其的药物组合物 |
CN117425643A (zh) * | 2021-06-04 | 2024-01-19 | 上海海雁医药科技有限公司 | 三嗪基甲基环烷基羧酸衍生物及其药物组合物和用途 |
CN113801097B (zh) * | 2021-09-27 | 2022-11-22 | 成都施贝康生物医药科技有限公司 | 二氢嘧啶类化合物、其制备方法及用途 |
CN113773300B (zh) * | 2021-09-27 | 2022-10-11 | 成都施贝康生物医药科技有限公司 | 磺酰胺类化合物、其制备方法及用途 |
CN113620888B (zh) * | 2021-09-27 | 2023-06-06 | 成都施贝康生物医药科技有限公司 | 二氢嘧啶类化合物及其制备方法和应用 |
TW202320793A (zh) | 2021-09-28 | 2023-06-01 | 日商塩野義製藥股份有限公司 | 含有三嗪衍生物之醫藥組合物 |
JP7261529B1 (ja) | 2021-11-24 | 2023-04-20 | 塩野義製薬株式会社 | ウイルス増殖阻害作用を有するトリアジン誘導体の製造方法 |
KR20230119022A (ko) | 2021-11-24 | 2023-08-14 | 시오노기 앤드 컴파니, 리미티드 | 트라이아진 유도체를 함유하는 경구 투여하는 제제 |
WO2023095860A1 (ja) * | 2021-11-26 | 2023-06-01 | 塩野義製薬株式会社 | 3clプロテアーゼ阻害剤及びcovid-19治療用薬剤を組み合わせることを特徴とするcovid-19治療用医薬 |
WO2023169572A1 (zh) * | 2022-03-10 | 2023-09-14 | 湖北九康通生物医药有限公司 | 一种三嗪类化合物、其中间体、其制备方法及其用途 |
CN116284133B (zh) * | 2022-03-24 | 2024-03-29 | 南京知和医药科技有限公司 | 一种新型六元杂环类衍生物及其药物组合物和用途 |
US11655240B1 (en) * | 2022-05-10 | 2023-05-23 | Beijing Grand Johamu Pharmaceutical Company, Ltd. | Crystal form of compound and fumaric acid, pharmaceutical composition and method for treating coronavirus-induced diseases |
WO2023184482A1 (zh) * | 2022-04-01 | 2023-10-05 | 湖南南新制药股份有限公司 | 氨基三嗪酮化合物及其制备方法和药物用途 |
CN116891459A (zh) * | 2022-04-08 | 2023-10-17 | 湖北九康通生物医药有限公司 | 一种多取代三嗪烷类化合物的合成方法 |
CN114805314B (zh) * | 2022-04-20 | 2023-12-15 | 杭州国瑞生物科技有限公司 | 一种恩赛特韦的合成方法 |
CN114751894A (zh) * | 2022-04-29 | 2022-07-15 | 苏州立新制药有限公司 | 一种治疗新冠肺炎口服药物的制备方法 |
CN115650959B (zh) * | 2022-05-20 | 2023-10-20 | 南京济群医药科技股份有限公司 | 化合物的制备方法或纯化方法 |
CN114773282A (zh) * | 2022-05-27 | 2022-07-22 | 杭州布朗生物医药科技有限公司 | 3-叔丁基-6-乙硫基-1,3,5-三嗪-2,4(1h,3h)-二酮的制备方法 |
CN115504968B (zh) | 2022-11-21 | 2023-04-18 | 歌礼生物科技(杭州)有限公司 | 三嗪衍生物 |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3598815A (en) * | 1968-10-25 | 1971-08-10 | Goodrich Co B F | Bis-(hydroxyphenylalkylene) alkyl isocyanurates |
JPS5132324A (en) * | 1974-09-12 | 1976-03-18 | Fuji Photo Film Co Ltd | Netsugenzokankozairyo |
CH622536A5 (es) * | 1976-07-08 | 1981-04-15 | Ciba Geigy Ag | |
US4158724A (en) * | 1976-10-18 | 1979-06-19 | Ciba-Geigy Corporation | Tris-tetrazoles as chemical blowing agents |
CH623840A5 (es) * | 1976-10-18 | 1981-06-30 | Ciba Geigy Ag | |
GB1599518A (en) * | 1977-02-21 | 1981-10-07 | Ici Ltd | 1,3,5-triazine-2,6-diones and pharmaceutical compositions thereof |
EP0005911B1 (en) | 1978-05-26 | 1982-02-17 | Imperial Chemical Industries Plc | Analgesic 6-acylaminotetrahydro-1,3,5-triazine-2,4-dione derivatives, pharmaceutical compositions thereof, and process for their manufacture |
JPS57144269A (en) | 1981-03-03 | 1982-09-06 | Taiho Yakuhin Kogyo Kk | Triazine derivative and its preparation |
EP0110828B1 (de) * | 1982-11-26 | 1988-01-20 | Ciba-Geigy Ag | Farbphotographisches Aufzeichnungsmaterial |
JPS62156110A (ja) * | 1985-12-27 | 1987-07-11 | Res Inst For Prod Dev | 測鎖にイソシアヌレ−ト構造を含む吸着能力を有する重合体 |
RU2057754C1 (ru) | 1989-06-05 | 1996-04-10 | Дайити Фармасьютикал Ко., Лтд. | Гетероциклические соединения или их кислотно-аддитивные соли |
IL94592A (en) | 1989-06-05 | 1994-07-31 | Daiichi Seiyaku Co | History Transformed by piperidinoalkyl of 1,2,4-triazolone and 1,3,5-triazinedione in compressed bicycles, their preparation and pharmaceutical preparations containing or |
DE4141721A1 (de) | 1991-12-18 | 1993-06-24 | Bayer Ag | Substituierte heterocyclyltriazindione |
JP3542482B2 (ja) | 1997-12-25 | 2004-07-14 | 日研化学株式会社 | 3−アニリノ−2−シクロアルケノン誘導体 |
JP4478854B2 (ja) | 1998-04-15 | 2010-06-09 | 財団法人相模中央化学研究所 | 2−アニリノピリミジノン誘導体及び製造中間体、それらの製造方法並びにそれらを有効成分として含有する農薬 |
JP2995293B1 (ja) | 1998-08-25 | 1999-12-27 | 工業技術院長 | 1,6‐ジ置換‐1,3,5‐トリアジン‐2,4(1h,3h)‐ジオン化合物の製造方法 |
US6177437B1 (en) | 1998-09-04 | 2001-01-23 | University Of Massachusetts Medical Center | Inhibitors of Herpes Simplex virus uracil-DNA glycosylase |
GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
EP1159271B1 (en) | 1999-03-04 | 2004-08-25 | Korea Research Institute of Chemical Technology | Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof |
DE10027514A1 (de) * | 2000-06-06 | 2002-01-03 | Basf Ag | Liganden von Integrinrezeptoren |
JP4674676B2 (ja) | 1999-11-08 | 2011-04-20 | 公益財団法人相模中央化学研究所 | 2−置換アミノピリミジノン誘導体、それらの製造方法並びにそれらを有効成分とする殺虫、殺ダニ剤 |
AU2001227084A1 (en) | 2000-01-25 | 2001-08-07 | Japan Tobacco Inc. | N-arylhydrazide compounds and use thereof as drugs |
US20020049320A1 (en) | 2000-04-27 | 2002-04-25 | American Cyanamid Company | 6-amino-2,4-dioxo-3,4-dihydro-1,3,5-triazine derivatives and methods for the solid phase synthesis thereof |
MXPA03010586A (es) | 2001-05-18 | 2004-04-02 | Abbott Lab | N-[(1s)-1,2,3,4-tertrahidro-1-naftalenil benzamidas trisubtituidas, las cuales inhiben receptores que contienen p2x2/3. |
JPWO2004054617A1 (ja) | 2002-12-13 | 2006-04-20 | 協和醗酵工業株式会社 | 中枢疾患の予防および/または治療剤 |
US20070161637A1 (en) | 2003-07-22 | 2007-07-12 | Neurogen Corporation | Substituted pyridin-2-ylamine analogues |
PL1725540T3 (pl) | 2004-03-05 | 2013-02-28 | Hoffmann La Roche | Diaminopirymidyny jako antagoniści p2x3 i p2x2/3 |
US20060029548A1 (en) | 2004-07-22 | 2006-02-09 | Amir Pelleg | Methods of diagnosing, monitoring and treating pulmonary diseases |
EP1841760B1 (en) | 2004-12-30 | 2011-08-10 | Exelixis, Inc. | Pyrimidine derivatives as kinase modulators and method of use |
JP2008537548A (ja) | 2005-03-24 | 2008-09-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | プロキネチシン1受容体 |
CN101326168A (zh) | 2005-03-24 | 2008-12-17 | 詹森药业有限公司 | 激肽原1受体拮抗剂 |
BRPI0609317A2 (pt) | 2005-03-24 | 2010-03-16 | Janssen Pharmaceutica Nv | derivados de pirimidindiona como antagonistas de receptores de procineticina 2 |
WO2006119502A2 (en) | 2005-05-03 | 2006-11-09 | Southwest Research Institute | Lubricant oils and greases containing nanoparticle additives |
US7745451B2 (en) | 2005-05-04 | 2010-06-29 | Renovis, Inc. | Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds and compositions thereof useful in the treatment of conditions associated with neurological and inflammatory disorders and dysfunctions |
EP1917262B1 (en) | 2005-08-15 | 2011-12-14 | F. Hoffmann-La Roche AG | Piperidine and piperazine derivatives as p2x3 antagonists |
ES2601178T3 (es) | 2005-09-01 | 2017-02-14 | F. Hoffmann-La Roche Ag | Diaminopirimidinas como moduladores de P2X3 y P3X2/3 |
JP4850913B2 (ja) | 2005-09-01 | 2012-01-11 | エフ.ホフマン−ラ ロシュ アーゲー | P2x3及びp2x2/3調節因子としてのジアミノピリジン |
WO2007025899A1 (en) | 2005-09-01 | 2007-03-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
KR101012926B1 (ko) | 2005-09-01 | 2011-02-09 | 에프. 호프만-라 로슈 아게 | P2x3 및 p2x2/3 조정자로서의 다이아미노피리미딘 |
WO2007079214A2 (en) | 2005-12-29 | 2007-07-12 | Janssen Pharmaceutica N.V. | Prokineticin 2 receptor antagonists |
DK1973886T3 (da) | 2005-12-29 | 2013-03-18 | Janssen Pharmaceutica Nv | Prokineticin-1-receptor-antagonister |
CA2656290A1 (en) | 2006-07-05 | 2008-01-10 | Exelixis, Inc. | Methods of using igf1r and abl kinase modulators |
SG174016A1 (en) | 2006-07-24 | 2011-09-29 | Korea Res Inst Chem Tech | Hiv reverse transcriptase inhibitors |
CL2008000065A1 (es) | 2007-01-12 | 2008-09-22 | Smithkline Beecham Corp | Compuestos derivados de glicina n-sustituida, inhibidores de hif prolil hidroxilasas; su proceso de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anemia. |
AR065996A1 (es) | 2007-04-13 | 2009-07-15 | Schering Corp | Derivados de pirimidindiona,composiciones farmaceuticas que los conitenen y usos en el tratamiento y/o prevencion de la obesidad, diabetes, dislipidemia entre otras patologias. |
US20090099195A1 (en) | 2007-05-08 | 2009-04-16 | Astrazeneca Ab | Therapeutic Compounds 570 |
JP2009007258A (ja) | 2007-06-26 | 2009-01-15 | Kowa Pharmaceutical Co Ltd | Pai−1産生抑制作用を有する3−アニリノ−2−シクロアルケノン誘導体 |
US8324380B2 (en) | 2007-10-30 | 2012-12-04 | Janssen Pharmaceutica Nv | Amino-heteroaryl-containing prokineticin 1 receptor antagonists |
RU2010137862A (ru) | 2008-02-13 | 2012-03-20 | ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) | Производное бициклоамина |
JP5608655B2 (ja) | 2008-09-18 | 2014-10-15 | エヴォテック アーゲー | P2x3受容体活性のモジュレーター |
MX2011004570A (es) | 2008-10-31 | 2011-06-17 | Merck Sharp & Dohme | Antagonistas del receptor p2x3 para el tratamiento del dolor. |
CA2752269C (en) | 2009-02-13 | 2016-08-30 | Hiroyuki Kai | Novel triazine derivative and pharmaceutical composition comprising the same |
WO2010149578A2 (en) | 2009-06-22 | 2010-12-29 | F. Hoffmann-La Roche Ag | Novel biphenyl and phenyl-pyridine amides |
KR20120047996A (ko) | 2009-08-05 | 2012-05-14 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 메소이온성 살충제 |
JP6081912B2 (ja) | 2010-07-30 | 2017-02-15 | エクスプレッション、パソロジー、インコーポレイテッドExpression Pathology, Inc. | c−Src選択反応モニタリングアッセイ |
CN103140221A (zh) | 2010-08-10 | 2013-06-05 | 盐野义制药株式会社 | 新型杂环衍生物和含有其的药物组合物 |
MX346367B (es) | 2010-08-10 | 2017-03-16 | Shionogi & Co Ltd * | Derivado de triazina y composicion farmaceutica que tiene actividad analgesica que comprende el mismo. |
JP5849246B2 (ja) | 2010-09-03 | 2016-01-27 | パナソニックIpマネジメント株式会社 | スクロール圧縮機 |
EP3628665B1 (en) | 2011-04-01 | 2022-11-02 | University of Utah Research Foundation | Substituted n-phenylpyrimidin-2-amine analogs as inhibitors of the axl kinase |
WO2013089212A1 (ja) | 2011-12-15 | 2013-06-20 | 塩野義製薬株式会社 | 置換トリアジン誘導体およびそれらを含有する医薬組成物 |
US9550763B2 (en) | 2012-02-09 | 2017-01-24 | Shionogi & Co., Ltd. | Heterocyclic ring and carbocyclic derivative |
TWI637949B (zh) | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
-
2011
- 2011-08-09 MX MX2013001542A patent/MX346367B/es active IP Right Grant
- 2011-08-09 BR BR112013002984-6A patent/BR112013002984B1/pt active IP Right Grant
- 2011-08-09 KR KR1020137005919A patent/KR101867110B1/ko active IP Right Grant
- 2011-08-09 RU RU2013110068/04A patent/RU2565073C2/ru active
- 2011-08-09 WO PCT/JP2011/068113 patent/WO2012020749A1/ja active Application Filing
- 2011-08-09 EP EP11816413.6A patent/EP2604595B1/en active Active
- 2011-08-09 ES ES11816413T patent/ES2572481T3/es active Active
- 2011-08-09 CN CN201180049081.9A patent/CN103153968B/zh active Active
- 2011-08-09 DK DK11816413.6T patent/DK2604595T3/en active
- 2011-08-09 PL PL11816413.6T patent/PL2604595T3/pl unknown
- 2011-08-09 CA CA2807947A patent/CA2807947C/en active Active
- 2011-08-09 JP JP2012528681A patent/JP5594706B2/ja active Active
- 2011-08-09 AU AU2011290261A patent/AU2011290261B2/en not_active Ceased
- 2011-08-09 US US13/814,346 patent/US9718790B2/en active Active
- 2011-08-10 TW TW104126031A patent/TW201542210A/zh unknown
- 2011-08-10 TW TW100128458A patent/TWI505829B/zh active
-
2013
- 2013-02-04 ZA ZA2013/00920A patent/ZA201300920B/en unknown
-
2014
- 2014-07-29 JP JP2014153414A patent/JP5765753B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
MX2013001542A (es) | 2013-03-18 |
US9718790B2 (en) | 2017-08-01 |
TW201210600A (en) | 2012-03-16 |
ES2572481T3 (es) | 2016-05-31 |
BR112013002984A2 (pt) | 2016-06-07 |
TWI505829B (zh) | 2015-11-01 |
JP2014198738A (ja) | 2014-10-23 |
PL2604595T3 (pl) | 2016-09-30 |
CA2807947C (en) | 2018-06-19 |
AU2011290261A1 (en) | 2013-03-07 |
TW201542210A (zh) | 2015-11-16 |
RU2565073C2 (ru) | 2015-10-20 |
JP5765753B2 (ja) | 2015-08-19 |
KR101867110B1 (ko) | 2018-06-12 |
WO2012020749A1 (ja) | 2012-02-16 |
US20130172317A1 (en) | 2013-07-04 |
DK2604595T3 (en) | 2016-05-23 |
BR112013002984B1 (pt) | 2021-10-26 |
RU2013110068A (ru) | 2014-09-20 |
KR20130138734A (ko) | 2013-12-19 |
JP5594706B2 (ja) | 2014-09-24 |
CN103153968A (zh) | 2013-06-12 |
CA2807947A1 (en) | 2012-02-16 |
CN103153968B (zh) | 2016-02-03 |
EP2604595B1 (en) | 2016-03-16 |
ZA201300920B (en) | 2014-04-30 |
EP2604595A1 (en) | 2013-06-19 |
EP2604595A4 (en) | 2014-04-23 |
JPWO2012020749A1 (ja) | 2013-10-28 |
AU2011290261B2 (en) | 2014-11-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX346367B (es) | Derivado de triazina y composicion farmaceutica que tiene actividad analgesica que comprende el mismo. | |
CA2875877C (en) | Syk inhibitors | |
MX2011008362A (es) | Derivado novedoso de triazina y composicion farmaceutica que comprende el mismo. | |
MX362995B (es) | Derivado de aminotriazina y composicion farmaceutica que comprende el mismo. | |
PH12014502540A1 (en) | Benzimidazole-proline derivatives | |
BRPI1009333B8 (pt) | compostos inibidores de beta-secretase, seus usos, bem como composição farmacêutica | |
AR071763A1 (es) | Pirazoles trisustituidos, composiciones farmaceuticas que los contienen, y usos de los mismos en el tratamiento de trastornos neurologicos y psiquiatricos | |
ZA201002987B (en) | Tropane compounds | |
CO6801736A2 (es) | Derivados heterocíclicos de amina | |
RS53503B1 (en) | AMORPHIC AND CRYSTAL FORM GENZ 112638 HEMITARTARATE AS A GLYCOSILKERAMIDE SYNTHASIS INHIBITOR | |
MX338707B (es) | Compuestos heterociclicos activadores de proteina cinasa activada por 5'-amp (ampk) y metodos para emplearlos. | |
MX2013005833A (es) | Nuevos compuestos de piridina fusionada como inhibidores de caseina quinasa. | |
PH12016502358B1 (en) | Novel pyrrolidine compound and application as melanocortin receptor agonist | |
TW200531694A (en) | Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists | |
MY159151A (en) | 2-pyridone compounds | |
AR085549A1 (es) | DERIVADOS TRIAZOLIL PIPERAZINA Y TRIAZOLIL PIPERIDINA SUSTITUIDOS COMO MODULADORES DE g SECRETASA | |
JO3098B1 (ar) | مركبات داي فينيل- بيرازول بيريدين وطريقة تحضيرها واستخدامها كمعدلات المستقبل النووي not | |
MX2012000103A (es) | Nuevos derivados de 1,2,3,4-tetrahidro-pirimido (1,2-a) pirimidin-6-ona, su preparacion y su uso farmaceutica. | |
NO20085317L (no) | Imidazoazepinonforbindelser | |
MY197742A (en) | Morphinan derivative | |
MX343077B (es) | Nuevo derivado de octahidrotienoquinolina, composicion farmaceutica que comprende el derivado, y uso de los mismos. | |
BRPI0911659B8 (pt) | composto 3-fenilpirazolo[5,1-b]tiazol e composição farmacêutica compreendendo o mesmo | |
MY167897A (en) | A compound separated from monascus-fermented rice, the preparation method and uses thereof | |
NZ603966A (en) | Nicotinic receptor non-competitive antagonists | |
GB2480038B (en) | 2-Fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative, production method thereof, and production method of monofluoromethyl group-containing compound |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |