MX346367B - Derivado de triazina y composicion farmaceutica que tiene actividad analgesica que comprende el mismo. - Google Patents

Derivado de triazina y composicion farmaceutica que tiene actividad analgesica que comprende el mismo.

Info

Publication number
MX346367B
MX346367B MX2013001542A MX2013001542A MX346367B MX 346367 B MX346367 B MX 346367B MX 2013001542 A MX2013001542 A MX 2013001542A MX 2013001542 A MX2013001542 A MX 2013001542A MX 346367 B MX346367 B MX 346367B
Authority
MX
Mexico
Prior art keywords
substituted
analgesic activity
pharmaceutical compound
triazine derivative
exhibits analgesic
Prior art date
Application number
MX2013001542A
Other languages
English (en)
Other versions
MX2013001542A (es
Inventor
Endoh Takeshi
Kai Hiroyuki
Tada Yukio
Shintani Takuya
Hasegawa Tsuyoshi
Kameyama Takayuki
Oohara Miho
Horiguchi Tohru
Asahi Kentaro
' Ichiroh Nakamura Ken
Jikihara Sae
Maki Toshikatsu
Iida Akira
Fujii Yasuhiko
Original Assignee
Shionogi & Co Ltd *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co Ltd * filed Critical Shionogi & Co Ltd *
Publication of MX2013001542A publication Critical patent/MX2013001542A/es
Publication of MX346367B publication Critical patent/MX346367B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención proporciona nuevos compuestos que tienen efecto antagonista del receptor PZX3 y/o P2X2/3, y una composición farmacéutica que tiene efecto analgésico o un efecto mejorador de transtorno de micción que comprende un compuesto de la Fórmula (I) (Ver Formula) en donde Rh y Rj se toman conjuntamente para formar un enlace; Ra y Rb y/o Rd y Re se toman conjuntamente para formar oxo o similares; Rc es hidrógeno, alquilo sustituido o no sustituido o similares; -Rf es -(CR4aR4b)n-R2 R4a y R4b son hidrógeno o alquilo sustituido o no sustituido o similares; n es un número entero de 1 a 4; Rg es -X-R3-; -X- es -O-, -S-, o similares; R3 es cicloalquilo sustituido o no sustituido o similares, o su sal farmacéuticamente aceptable o un solvato del mismo.
MX2013001542A 2010-08-10 2011-08-09 Derivado de triazina y composicion farmaceutica que tiene actividad analgesica que comprende el mismo. MX346367B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2010179350 2010-08-10
JP2010182803 2010-08-18
JP2011074763 2011-03-30
PCT/JP2011/068113 WO2012020749A1 (ja) 2010-08-10 2011-08-09 トリアジン誘導体およびそれを含有する鎮痛作用を有する医薬組成物

Publications (2)

Publication Number Publication Date
MX2013001542A MX2013001542A (es) 2013-03-18
MX346367B true MX346367B (es) 2017-03-16

Family

ID=45567712

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013001542A MX346367B (es) 2010-08-10 2011-08-09 Derivado de triazina y composicion farmaceutica que tiene actividad analgesica que comprende el mismo.

Country Status (16)

Country Link
US (1) US9718790B2 (es)
EP (1) EP2604595B1 (es)
JP (2) JP5594706B2 (es)
KR (1) KR101867110B1 (es)
CN (1) CN103153968B (es)
AU (1) AU2011290261B2 (es)
BR (1) BR112013002984B1 (es)
CA (1) CA2807947C (es)
DK (1) DK2604595T3 (es)
ES (1) ES2572481T3 (es)
MX (1) MX346367B (es)
PL (1) PL2604595T3 (es)
RU (1) RU2565073C2 (es)
TW (2) TWI505829B (es)
WO (1) WO2012020749A1 (es)
ZA (1) ZA201300920B (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2752269C (en) 2009-02-13 2016-08-30 Hiroyuki Kai Novel triazine derivative and pharmaceutical composition comprising the same
JP2013530231A (ja) * 2010-06-28 2013-07-25 ヤンセン ファーマシューティカ エヌ．ベー． 鎮痛処置用プロキネチシン１受容体アンタゴニスト
EP2604260B1 (en) * 2010-08-10 2017-05-10 Shionogi&Co., Ltd. Novel heterocyclic derivatives and pharmaceutical composition containing same
MX346367B (es) 2010-08-10 2017-03-16 Shionogi & Co Ltd * Derivado de triazina y composicion farmaceutica que tiene actividad analgesica que comprende el mismo.
WO2013089212A1 (ja) * 2011-12-15 2013-06-20 塩野義製薬株式会社 置換トリアジン誘導体およびそれらを含有する医薬組成物
WO2013118855A1 (ja) * 2012-02-09 2013-08-15 塩野義製薬株式会社 複素環および炭素環誘導体
US9403798B2 (en) * 2012-03-30 2016-08-02 Nissan Chemical Industries, Ltd. Triazinone compound and T-type calcium channel inhibitor
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物
EP3059225A4 (en) * 2013-10-17 2017-09-06 Shionogi & Co., Ltd. Novel alkylene derivative
JP6422164B2 (ja) * 2013-12-26 2018-11-14 塩野義製薬株式会社 含窒素６員環誘導体およびそれらを含有する医薬組成物
WO2016084922A1 (ja) * 2014-11-28 2016-06-02 塩野義製薬株式会社 １，２，４－トリアジン誘導体およびその医薬組成物
RU2683245C1 (ru) * 2015-04-24 2019-03-27 Сионоги Энд Ко., Лтд. 6-членные гетероциклические производные и содержащая их фармацевтическая композиция
EP3527568A4 (en) 2016-10-17 2020-03-18 Shionogi & Co., Ltd BICYCLIC NITROGEN HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
GB201810669D0 (en) * 2018-06-28 2018-08-15 Stiftelsen Alzecure New compounds
EP3862000B1 (en) 2018-10-05 2023-10-18 Shionogi & Co., Ltd Medicine for treating chronic cough
EP4032884A4 (en) 2019-09-19 2023-09-13 Shionogi & Co., Ltd. CRYSTAL OF 1,3,5-TRIAZINE DERIVATIVES OR SOLVATE THEREOF AND METHOD FOR THE PRODUCTION THEREOF
EP4039328A4 (en) 2019-10-02 2023-10-25 ASKA Pharmaceutical Co., Ltd. Dysuria-alleviating agent
WO2021065027A1 (ja) 2019-10-02 2021-04-08 あすか製薬株式会社 排尿障害改善剤
TW202203929A (zh) 2020-04-03 2022-02-01 日商塩野義製藥股份有限公司 疼痛治療用醫藥
JP2023550444A (ja) * 2020-11-20 2023-12-01 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 トリアジンジオン系誘導体、その調製方法及びその医薬的応用
WO2022131354A1 (ja) 2020-12-18 2022-06-23 あすか製薬株式会社 固形製剤
RS66997B1 (sr) * 2021-04-14 2025-08-29 Shionogi & Co Derivati triazina koji imaju inhibitorno delovanje na replikaciju virusa i farmaceutska kompozicija koja sadrži iste
WO2022253270A1 (zh) * 2021-06-04 2022-12-08 上海海雁医药科技有限公司 三嗪基甲基环烷基羧酸衍生物及其药物组合物和用途
CN113620888B (zh) * 2021-09-27 2023-06-06 成都施贝康生物医药科技有限公司 二氢嘧啶类化合物及其制备方法和应用
CN113773300B (zh) * 2021-09-27 2022-10-11 成都施贝康生物医药科技有限公司 磺酰胺类化合物、其制备方法及用途
CN113801097B (zh) * 2021-09-27 2022-11-22 成都施贝康生物医药科技有限公司 二氢嘧啶类化合物、其制备方法及用途
WO2023054292A1 (ja) 2021-09-28 2023-04-06 塩野義製薬株式会社 トリアジン誘導体を含有する医薬組成物
EP4410292A4 (en) 2021-09-28 2025-09-03 Shionogi & Co PHARMACEUTICAL COMPOSITION CONTAINING A TRIAZINE DERIVATIVE
CN116514734A (zh) * 2021-11-24 2023-08-01 盐野义制药株式会社 三嗪衍生物的制造方法和含有三嗪衍生物的口服给与的制剂
JP7261529B1 (ja) 2021-11-24 2023-04-20 塩野義製薬株式会社 ウイルス増殖阻害作用を有するトリアジン誘導体の製造方法
WO2023027198A1 (ja) 2021-11-24 2023-03-02 塩野義製薬株式会社 トリアジン誘導体を含有する経口投与する製剤
WO2023095860A1 (ja) * 2021-11-26 2023-06-01 塩野義製薬株式会社 ３ｃｌプロテアーゼ阻害剤及びｃｏｖｉｄ－１９治療用薬剤を組み合わせることを特徴とするｃｏｖｉｄ－１９治療用医薬
MX2024008910A (es) 2022-01-19 2024-07-25 Shionogi & Co Farmaceutico para tratamiento de infeccion de nuevo coronavirus.
CA3248484A1 (en) * 2022-03-10 2025-07-07 Jkt Biopharma Co., Ltd. TRIAZINE COMPOUND, INTERMEDIATE THEREOF, ASSOCIATED PREPARATION PROCESS AND CORRESPONDING USE
CN116284133B (zh) * 2022-03-24 2024-03-29 南京知和医药科技有限公司 一种新型六元杂环类衍生物及其药物组合物和用途
US11655240B1 (en) * 2022-05-10 2023-05-23 Beijing Grand Johamu Pharmaceutical Company, Ltd. Crystal form of compound and fumaric acid, pharmaceutical composition and method for treating coronavirus-induced diseases
WO2023184482A1 (zh) * 2022-04-01 2023-10-05 湖南南新制药股份有限公司 氨基三嗪酮化合物及其制备方法和药物用途
CN116891459A (zh) * 2022-04-08 2023-10-17 湖北九康通生物医药有限公司 一种多取代三嗪烷类化合物的合成方法
CN114805314B (zh) * 2022-04-20 2023-12-15 杭州国瑞生物科技有限公司 一种恩赛特韦的合成方法
CN114751894A (zh) * 2022-04-29 2022-07-15 苏州立新制药有限公司 一种治疗新冠肺炎口服药物的制备方法
CN115650959B (zh) * 2022-05-20 2023-10-20 南京济群医药科技股份有限公司 化合物的制备方法或纯化方法
CN114773282B (zh) * 2022-05-27 2024-07-02 杭州布朗生物医药科技有限公司 3-叔丁基-6-乙硫基-1,3,5-三嗪-2,4(1h,3h)-二酮的制备方法
CN115504968B (zh) 2022-11-21 2023-04-18 歌礼生物科技（杭州）有限公司 三嗪衍生物
WO2024114663A1 (zh) * 2022-11-30 2024-06-06 上海海雁医药科技有限公司 三嗪基甲基环烷基羧酸衍生物的晶型及其应用
CN120303259A (zh) * 2022-11-30 2025-07-11 上海海雁医药科技有限公司 取代的三嗪-2,4-二酮类衍生物中间体及其制备方法
WO2024169781A1 (zh) * 2023-02-15 2024-08-22 南京明德新药研发有限公司 嘧啶酮衍生物及其在药学上的应用

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3598815A (en) * 1968-10-25 1971-08-10 Goodrich Co B F Bis-(hydroxyphenylalkylene) alkyl isocyanurates
JPS5132324A (en) * 1974-09-12 1976-03-18 Fuji Photo Film Co Ltd Netsugenzokankozairyo
CH622536A5 (es) * 1976-07-08 1981-04-15 Ciba Geigy Ag
US4158724A (en) * 1976-10-18 1979-06-19 Ciba-Geigy Corporation Tris-tetrazoles as chemical blowing agents
CH623840A5 (es) * 1976-10-18 1981-06-30 Ciba Geigy Ag
GB1599518A (en) 1977-02-21 1981-10-07 Ici Ltd 1,3,5-triazine-2,6-diones and pharmaceutical compositions thereof
ATE698T1 (de) 1978-05-26 1982-03-15 Imperial Chemical Industries Plc Analgetische 6-acylaminot etrahydro-1,3,5-triazin-2,4-dion-derivate, sie enthaltende pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung.
JPS57144269A (en) 1981-03-03 1982-09-06 Taiho Yakuhin Kogyo Kk Triazine derivative and its preparation
DE3375432D1 (en) * 1982-11-26 1988-02-25 Ciba Geigy Ag Colour-photographic recording material
JPS62156110A (ja) * 1985-12-27 1987-07-11 Res Inst For Prod Dev 測鎖にイソシアヌレ−ト構造を含む吸着能力を有する重合体
NZ233917A (en) 1989-06-05 1991-04-26 Daiichi Seiyaku Co Heterocyclic fused triazinedione and triazolone derivatives for treating heart diseases
RU2057754C1 (ru) 1989-06-05 1996-04-10 Дайити Фармасьютикал Ко., Лтд. Гетероциклические соединения или их кислотно-аддитивные соли
DE4141721A1 (de) * 1991-12-18 1993-06-24 Bayer Ag Substituierte heterocyclyltriazindione
JP3542482B2 (ja) 1997-12-25 2004-07-14 日研化学株式会社 ３−アニリノ−２−シクロアルケノン誘導体
JP4478854B2 (ja) 1998-04-15 2010-06-09 財団法人相模中央化学研究所 ２−アニリノピリミジノン誘導体及び製造中間体、それらの製造方法並びにそれらを有効成分として含有する農薬
JP2995293B1 (ja) 1998-08-25 1999-12-27 工業技術院長 １，６‐ジ置換‐１，３，５‐トリアジン‐２，４（１ｈ，３ｈ）‐ジオン化合物の製造方法
US6177437B1 (en) 1998-09-04 2001-01-23 University Of Massachusetts Medical Center Inhibitors of Herpes Simplex virus uracil-DNA glycosylase
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
JP2002538144A (ja) 1999-03-04 2002-11-12 コリア・リサーチ・インスティテュート・オブ・ケミカル・テクノロジー 抗ウイルス性２，４−ピリミジンジオン誘導体およびその製造方法
DE10027514A1 (de) * 2000-06-06 2002-01-03 Basf Ag Liganden von Integrinrezeptoren
JP4674676B2 (ja) 1999-11-08 2011-04-20 公益財団法人相模中央化学研究所 ２−置換アミノピリミジノン誘導体、それらの製造方法並びにそれらを有効成分とする殺虫、殺ダニ剤
AU2001227084A1 (en) 2000-01-25 2001-08-07 Japan Tobacco Inc. N-arylhydrazide compounds and use thereof as drugs
US20020049320A1 (en) 2000-04-27 2002-04-25 American Cyanamid Company 6-amino-2,4-dioxo-3,4-dihydro-1,3,5-triazine derivatives and methods for the solid phase synthesis thereof
ES2249589T3 (es) 2001-05-18 2006-04-01 Abbott Laboratories Trisustituido-n-((1s)-1,2,3,4-tetrahidro-1-naftalenil)benzamidas que inhiben receptores que contienen antagonistas p2x3 y p2x2/3.
JPWO2004054617A1 (ja) 2002-12-13 2006-04-20 協和醗酵工業株式会社 中枢疾患の予防および／または治療剤
US20070161637A1 (en) 2003-07-22 2007-07-12 Neurogen Corporation Substituted pyridin-2-ylamine analogues
RU2422441C2 (ru) 2004-03-05 2011-06-27 Ф.Хоффманн-Ля Рош Аг Диаминопиримидины в качестве антагонистов рецепторов р2х3
AU2005266887B2 (en) 2004-07-22 2011-08-18 Duska Scientific Co. Method of diagnosing, monitoring and treating pulmonary diseases
JP5208516B2 (ja) 2004-12-30 2013-06-12 エグゼリクシス， インコーポレイテッド キナーゼモジュレーターとしてのピリミジン誘導体および使用方法
BRPI0609317A2 (pt) 2005-03-24 2010-03-16 Janssen Pharmaceutica Nv derivados de pirimidindiona como antagonistas de receptores de procineticina 2
AU2006229793A1 (en) 2005-03-24 2006-10-05 Janssen Pharmaceutica, N.V. Prokineticin 1 receptor antagonists
EP1868609A2 (en) 2005-03-24 2007-12-26 Janssen Pharmaceutica N.V. Prokineticin 1 receptor
US8507415B2 (en) 2005-05-03 2013-08-13 Southwest Research Institute Lubricant oils and greases containing nanoparticle additives
US7745451B2 (en) 2005-05-04 2010-06-29 Renovis, Inc. Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds and compositions thereof useful in the treatment of conditions associated with neurological and inflammatory disorders and dysfunctions
ATE537169T1 (de) 2005-08-15 2011-12-15 Hoffmann La Roche Piperidin- und piperazinderivate als p2x3- antagonisten
ES2439454T3 (es) 2005-09-01 2014-01-23 F. Hoffmann-La Roche Ag Diaminopirimidinas como moduladores de P2X3 y P2X2/3
CN101300235B (zh) 2005-09-01 2011-12-07 弗·哈夫曼-拉罗切有限公司 作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物
CA2619919C (en) 2005-09-01 2014-04-01 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
JP4850912B2 (ja) 2005-09-01 2012-01-11 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ３およびｐ３ｘ２／３モジュレーターとしてのジアミノピリミジン
AR058407A1 (es) 2005-12-29 2008-01-30 Janssen Pharmaceutica Nv Antagonistas del receptor de proquineticina 2
EP2385042B1 (en) 2005-12-29 2015-11-25 Janssen Pharmaceutica N.V. Prokineticin 1 receptor antagonists
CA2656290A1 (en) 2006-07-05 2008-01-10 Exelixis, Inc. Methods of using igf1r and abl kinase modulators
HRP20090114A2 (hr) 2006-07-24 2010-03-31 Gilead Sciences Novi inhibitori hiv reverzne transkriptaze
CL2008000065A1 (es) 2007-01-12 2008-09-22 Smithkline Beecham Corp Compuestos derivados de glicina n-sustituida, inhibidores de hif prolil hidroxilasas; su proceso de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anemia.
MX2009011062A (es) 2007-04-13 2009-10-29 Schering Corp Derivados de pirimidindiona y sus metodos de uso.
US20090099195A1 (en) 2007-05-08 2009-04-16 Astrazeneca Ab Therapeutic Compounds 570
JP2009007258A (ja) 2007-06-26 2009-01-15 Kowa Pharmaceutical Co Ltd Ｐａｉ−１産生抑制作用を有する３−アニリノ−２−シクロアルケノン誘導体
US8324380B2 (en) 2007-10-30 2012-12-04 Janssen Pharmaceutica Nv Amino-heteroaryl-containing prokineticin 1 receptor antagonists
RU2010137862A (ru) 2008-02-13 2012-03-20 ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) Производное бициклоамина
US20110237578A1 (en) 2008-09-18 2011-09-29 Zhi-Liang Wei Amide compounds, compositions and uses thereof
EP2358371B1 (en) 2008-10-31 2015-02-11 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
CA2752269C (en) 2009-02-13 2016-08-30 Hiroyuki Kai Novel triazine derivative and pharmaceutical composition comprising the same
JP5476467B2 (ja) 2009-06-22 2014-04-23 エフ．ホフマン−ラ ロシュ アーゲー 新規なビフェニルピリジンアミドおよびフェニルピリジンアミド
AU2010279587A1 (en) 2009-08-05 2012-02-09 E. I. Du Pont De Nemours And Company Mesoionic pesticides
AU2011282546B2 (en) 2010-07-30 2016-11-17 Expression Pathology, Inc. c-Src selected reaction monitoring assay
EP2604260B1 (en) 2010-08-10 2017-05-10 Shionogi&Co., Ltd. Novel heterocyclic derivatives and pharmaceutical composition containing same
MX346367B (es) 2010-08-10 2017-03-16 Shionogi & Co Ltd * Derivado de triazina y composicion farmaceutica que tiene actividad analgesica que comprende el mismo.
JP5849246B2 (ja) 2010-09-03 2016-01-27 パナソニックＩｐマネジメント株式会社 スクロール圧縮機
HUE046988T2 (hu) 2011-04-01 2020-04-28 Univ Utah Res Found Szubsztituált N-fenilpirimidin-2-amin analógok mint AXL kináz inhibitorok
WO2013089212A1 (ja) 2011-12-15 2013-06-20 塩野義製薬株式会社 置換トリアジン誘導体およびそれらを含有する医薬組成物
WO2013118855A1 (ja) 2012-02-09 2013-08-15 塩野義製薬株式会社 複素環および炭素環誘導体
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物

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