MX344220B - Polipeptidos del factor vii que se modifican y usos de los mismos. - Google Patents
Polipeptidos del factor vii que se modifican y usos de los mismos.Info
- Publication number
- MX344220B MX344220B MX2012012083A MX2012012083A MX344220B MX 344220 B MX344220 B MX 344220B MX 2012012083 A MX2012012083 A MX 2012012083A MX 2012012083 A MX2012012083 A MX 2012012083A MX 344220 B MX344220 B MX 344220B
- Authority
- MX
- Mexico
- Prior art keywords
- modified
- factor vii
- polypeptides
- vii polypeptides
- activities
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a polipéptidos del Factor VII modificados y usos de los mismos. Tales polipéptidos FVII incluyen el Factor Vila y otras formas de Factor VII. Entre los polipéptidos FVII modificados proporcionados están aquellos que tienen actividades alteradas típícamente actividad procoagulante alterada, incluyendo actividades procoagulantes incrementadas. Por lo tanto, tales polipéptidos son terapéuticos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12402108P | 2008-04-11 | 2008-04-11 | |
PCT/US2009/002248 WO2009126307A2 (en) | 2008-04-11 | 2009-04-10 | Factor vii polypeptides that are modified and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX344220B true MX344220B (es) | 2016-12-07 |
Family
ID=40872757
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012012083A MX344220B (es) | 2008-04-11 | 2009-04-10 | Polipeptidos del factor vii que se modifican y usos de los mismos. |
MX2010011170A MX2010011170A (es) | 2008-04-11 | 2009-04-10 | Polipeptidos del factor vii que se modifican y usos de los mismos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010011170A MX2010011170A (es) | 2008-04-11 | 2009-04-10 | Polipeptidos del factor vii que se modifican y usos de los mismos. |
Country Status (24)
Country | Link |
---|---|
US (4) | US8519103B2 (es) |
EP (4) | EP2687596B1 (es) |
JP (3) | JP2011517942A (es) |
KR (1) | KR101623602B1 (es) |
CN (2) | CN102083971B (es) |
AU (1) | AU2009234390B2 (es) |
BR (1) | BRPI0911060B1 (es) |
CA (1) | CA2721038C (es) |
CO (1) | CO6331368A2 (es) |
DK (2) | DK2281037T3 (es) |
EA (2) | EA024760B1 (es) |
ES (3) | ES2556596T3 (es) |
HK (3) | HK1194096A1 (es) |
HU (1) | HUE026937T2 (es) |
IL (2) | IL208373A (es) |
MX (2) | MX344220B (es) |
MY (1) | MY161581A (es) |
NZ (1) | NZ588322A (es) |
PL (1) | PL2281037T3 (es) |
PT (1) | PT2281037E (es) |
SG (2) | SG190560A1 (es) |
SI (1) | SI2281037T1 (es) |
TW (2) | TWI538916B (es) |
WO (1) | WO2009126307A2 (es) |
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