EA201301350A1 - Модифицированные полипептиды фактора vii и их применение - Google Patents

Модифицированные полипептиды фактора vii и их применение

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Publication number
EA201301350A1
EA201301350A1 EA201301350A EA201301350A EA201301350A1 EA 201301350 A1 EA201301350 A1 EA 201301350A1 EA 201301350 A EA201301350 A EA 201301350A EA 201301350 A EA201301350 A EA 201301350A EA 201301350 A1 EA201301350 A1 EA 201301350A1
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EA
Eurasian Patent Office
Prior art keywords
factor vii
application
modified
modified polypeptides
polypeptides
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Application number
EA201301350A
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English (en)
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EA024760B1 (ru
Inventor
Эдвин Л. Мэдисон
Кристофер Тсэнос
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Каталист Биосайенсиз, Инк.
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Application filed by Каталист Биосайенсиз, Инк. filed Critical Каталист Биосайенсиз, Инк.
Publication of EA201301350A1 publication Critical patent/EA201301350A1/ru
Publication of EA024760B1 publication Critical patent/EA024760B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Заявлены модифицированные полипептиды фактора VII. Такие модифицированные полипептиды фактора VII включают фактор Vila и другие формы фактора VII. Среди описанных модифицированных полипептидов фактора VII имеются такие, которые имеют измененную активность, обычно измененную прокоагулянтную активность, включая увеличенную прокоагулянтную активность. Следовательно, такие модифицированные полипептиды могут быть использованы в терапии.
EA201301350A 2008-04-11 2009-04-10 Модифицированные полипептиды фактора vii и их применение EA024760B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12402108P 2008-04-11 2008-04-11

Publications (2)

Publication Number Publication Date
EA201301350A1 true EA201301350A1 (ru) 2014-07-30
EA024760B1 EA024760B1 (ru) 2016-10-31

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Family Applications (2)

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EA201301350A EA024760B1 (ru) 2008-04-11 2009-04-10 Модифицированные полипептиды фактора vii и их применение
EA201001628A EA020818B1 (ru) 2008-04-11 2009-04-10 Модифицированные полипептиды фактора vii и их применение

Family Applications After (1)

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EA201001628A EA020818B1 (ru) 2008-04-11 2009-04-10 Модифицированные полипептиды фактора vii и их применение

Country Status (24)

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US (4) US8519103B2 (ru)
EP (4) EP2687596B1 (ru)
JP (3) JP2011517942A (ru)
KR (1) KR101623602B1 (ru)
CN (2) CN105039291A (ru)
AU (1) AU2009234390B2 (ru)
BR (1) BRPI0911060B1 (ru)
CA (1) CA2721038C (ru)
CO (1) CO6331368A2 (ru)
DK (2) DK2687596T3 (ru)
EA (2) EA024760B1 (ru)
ES (3) ES2560236T3 (ru)
HK (3) HK1154273A1 (ru)
HU (1) HUE026937T2 (ru)
IL (2) IL208373A (ru)
MX (2) MX2010011170A (ru)
MY (1) MY161581A (ru)
NZ (1) NZ588322A (ru)
PL (1) PL2281037T3 (ru)
PT (1) PT2281037E (ru)
SG (2) SG190560A1 (ru)
SI (1) SI2281037T1 (ru)
TW (2) TWI538916B (ru)
WO (1) WO2009126307A2 (ru)

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