SV2009003393A - Polipeptidos de factor vii modificaciones y usos de los mismos - Google Patents
Polipeptidos de factor vii modificaciones y usos de los mismosInfo
- Publication number
- SV2009003393A SV2009003393A SV2009003393A SV2009003393A SV2009003393A SV 2009003393 A SV2009003393 A SV 2009003393A SV 2009003393 A SV2009003393 A SV 2009003393A SV 2009003393 A SV2009003393 A SV 2009003393A SV 2009003393 A SV2009003393 A SV 2009003393A
- Authority
- SV
- El Salvador
- Prior art keywords
- polipeptides
- factor
- same
- vii
- modifications
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
Abstract
SE SUMINISTRAN POLIPÉPTIDOS DE FACTOR VII MODIFICADOS Y USOS DE LOS MISMOS. DICHOS POLIPÉPTIDOS FVII MODIFICADOS INCLUYEN FACTOR VLLA Y OTRAS FORMAS DEL FACTOR VII. ENTRE LOS POLIPÉPTIDOS FVII SUMINISTRADOS SE ENCUENTRAN AQUELLOS QUE TIENEN ACTIVIDADES ALTERADAS, TÍPICAMENTE ACTIVIDAD PROCOAGULANTE ALTERADA, INCLUYENDO ACTIVIDADES PROCOAGULANTE AUMENTADAS. ASÍ, DICHOS POLIPÉPTIDOS MODIFICADOS SON TERAPÉUTICOS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92351207P | 2007-04-13 | 2007-04-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
SV2009003393A true SV2009003393A (es) | 2010-04-30 |
Family
ID=39689319
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SV2009003393A SV2009003393A (es) | 2007-04-13 | 2009-10-13 | Polipeptidos de factor vii modificaciones y usos de los mismos |
Country Status (30)
Country | Link |
---|---|
US (1) | US20100166729A9 (es) |
EP (2) | EP2481797A1 (es) |
JP (3) | JP5761782B2 (es) |
KR (2) | KR20100016462A (es) |
CN (2) | CN103451172A (es) |
AU (1) | AU2008239586B2 (es) |
BR (1) | BRPI0810172A2 (es) |
CA (1) | CA2683443A1 (es) |
CO (1) | CO6231052A2 (es) |
CR (1) | CR11058A (es) |
DK (1) | DK2147096T3 (es) |
EC (1) | ECSP099735A (es) |
ES (1) | ES2537328T3 (es) |
GT (1) | GT200900268A (es) |
HK (1) | HK1134520A1 (es) |
HN (1) | HN2009002098A (es) |
IL (2) | IL201173A0 (es) |
MX (1) | MX2009010997A (es) |
NI (1) | NI200900187A (es) |
NZ (2) | NZ579985A (es) |
PH (1) | PH12014501960A1 (es) |
PL (1) | PL2147096T3 (es) |
PT (1) | PT2147096E (es) |
RU (1) | RU2571931C2 (es) |
SG (1) | SG174077A1 (es) |
SI (1) | SI2147096T1 (es) |
SV (1) | SV2009003393A (es) |
UA (1) | UA101155C2 (es) |
WO (1) | WO2008127702A2 (es) |
ZA (2) | ZA200906854B (es) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7700341B2 (en) * | 2000-02-03 | 2010-04-20 | Dendreon Corporation | Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon |
US7939304B2 (en) * | 2002-10-02 | 2011-05-10 | Catalyst Biosciences, Inc. | Mutant MT-SP1 proteases with altered substrate specificity or activity |
EP1608947A4 (en) * | 2002-10-02 | 2009-06-17 | Catalyst Biosciences Inc | PROCESS FOR PRODUCING AND TESTING FOR PROTEASES WITH CHANGED SPECIFICITY |
CA2562729C (en) | 2004-04-12 | 2013-11-12 | Sandra Waugh Ruggles | Cleavage of vegf and vegf receptor by wildtype and mutant mt-sp1 |
SI1940457T1 (sl) * | 2005-10-21 | 2013-04-30 | Catalyst Biosciences, Inc. | Modificirane proteaze, ki inhibirajo komplementno aktivacijo |
EP2423307A1 (en) * | 2006-06-19 | 2012-02-29 | Catalyst Biosciences, Inc. | Modified coagulation factor IV polypeptides and use thereof for treatment |
KR101476458B1 (ko) | 2006-07-05 | 2015-01-05 | 카탈리스트 바이오사이언시즈, 인코포레이티드 | 프로테아제 스크리닝 방법 및 이에 의해 확인된 프로테아제 |
PL2147096T3 (pl) * | 2007-04-13 | 2015-08-31 | Catalyst Biosciences Inc | Zmodyfikowane polipeptydy czynnika VII i ich zastosowania |
TWI538916B (zh) | 2008-04-11 | 2016-06-21 | 介控生化科技公司 | 經修飾的因子vii多肽和其用途 |
EP2177624A1 (en) * | 2008-10-02 | 2010-04-21 | Siemens Healthcare Diagnostics Products GmbH | Blood coagulation assays |
ES2524974T3 (es) * | 2009-06-25 | 2014-12-16 | The University Of North Carolina At Chapel Hill | Moléculas del Factor VII quimérico |
GB0916578D0 (en) * | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
CN103221061A (zh) | 2010-10-06 | 2013-07-24 | 米迪缪尼有限公司 | 用于治疗止血障碍的因子ii以及纤维蛋白原 |
EP2625263B1 (en) | 2010-10-08 | 2020-03-11 | Terumo BCT, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
TWI557135B (zh) * | 2010-11-03 | 2016-11-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
EP3693025B1 (en) | 2011-04-22 | 2021-10-13 | The Regents of The University of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
WO2012149463A1 (en) * | 2011-04-29 | 2012-11-01 | The University Of North Carolina At Chapel Hill | Chimeric factor vii molecules with enhanced half life and methods of use |
EP2554161A1 (en) | 2011-08-02 | 2013-02-06 | LFB Biotechnologies | Pharmaceutical composition comprising factor VII encapsulated in micelles |
BR112014017165B1 (pt) * | 2012-01-12 | 2023-05-02 | Bioverativ Therapeutics Inc | Proteína quimérica compreendendo uma proteína de fator viii, composição farmacêutica, e seus usos |
GB2516388A (en) | 2012-04-16 | 2015-01-21 | Cantab Biopharmaceuticals Patents Ltd | Optimised subcutaneous therapeutic agents |
WO2013177584A2 (en) * | 2012-05-25 | 2013-11-28 | The Children's Hospital Of Philadelphia | FVIIa VARIANTS EXHIBITING ALTERED INTERACTION WITH ENDOTHELIAL PROTEIN C RECEPTOR (EPCR) AND METHODS OF USE THEREOF FOR MODULATING HEMOSTASIS |
US8986991B2 (en) * | 2012-07-03 | 2015-03-24 | Expression Therapeutics, Llc | High yield suspension cell line, system and method for making same |
WO2014018120A1 (en) | 2012-07-25 | 2014-01-30 | Catalyst Biosciences, Inc. | Modified factor x polypeptides and uses thereof |
EP2906247A1 (en) | 2012-10-15 | 2015-08-19 | Novo Nordisk Health Care AG | Factor vii conjugates |
MX2015011873A (es) * | 2013-03-15 | 2016-01-25 | Bayer Healthcare Llc | Dominios gla como agentes de direccionamiento. |
US11136557B2 (en) | 2013-05-31 | 2021-10-05 | The Regents Of The University Of California | Adeno-associated virus variants and methods of use thereof |
CN103397009B (zh) * | 2013-08-16 | 2015-06-03 | 安源生物科技(上海)有限公司 | 改良型人凝血因子FVII-Fc融合蛋白及其制备方法与用途 |
JP2016537321A (ja) | 2013-10-15 | 2016-12-01 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 凝固因子viiポリペプチド |
WO2015073918A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
EP3119798B1 (en) | 2014-03-17 | 2020-08-05 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression in cone cells |
EP3122866B1 (en) | 2014-03-25 | 2019-11-20 | Terumo BCT, Inc. | Passive replacement of media |
WO2015183085A1 (en) | 2014-05-26 | 2015-12-03 | Academisch Ziekenhuis Leiden | Prohemostatic proteins for the treatment of bleeding |
EP3198006B1 (en) | 2014-09-26 | 2021-03-24 | Terumo BCT, Inc. | Scheduled feed |
EA201791939A1 (ru) | 2015-03-02 | 2018-01-31 | Адверум Байотекнолоджиз, Инк. | Композиции и способы интравитреальной доставки полинуклеотидов в колбочки сетчатки |
MX2017012097A (es) | 2015-03-24 | 2018-06-15 | Univ California | Variantes de virus adenoasociado y métodos de uso de estas. |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
EP3464565A4 (en) | 2016-05-25 | 2020-01-01 | Terumo BCT, Inc. | CELL EXPANSION |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
KR20230039779A (ko) | 2016-07-29 | 2023-03-21 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 변이체 캡시드를 갖는 아데노-관련된 바이러스 비리온 및 이의 사용 방법 |
WO2018075798A1 (en) | 2016-10-19 | 2018-04-26 | Adverum Biotechnologies, Inc. | Modified aav capsids and uses thereof |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
EP3656842A1 (en) | 2017-03-31 | 2020-05-27 | Terumo BCT, Inc. | Cell expansion |
US11633504B2 (en) | 2017-05-09 | 2023-04-25 | Emory University | Nucleic acids encoding clotting factor variants and their use |
WO2018222503A1 (en) * | 2017-05-31 | 2018-12-06 | The Regents Of The University Of California | Adeno-associated virus with variant capsid and methods of use thereof |
CN110709511A (zh) | 2017-08-28 | 2020-01-17 | 加利福尼亚大学董事会 | 腺相关病毒衣壳变体及其使用方法 |
AU2018328223A1 (en) | 2017-09-05 | 2020-03-12 | GLAdiator Biosciences, Inc. | Delivery of payloads to stem cells |
EP3830273A4 (en) * | 2018-08-03 | 2022-05-18 | Duke University | PROTEIN C FACTOR VII CHIMERAS |
EP3833381B1 (en) * | 2019-08-15 | 2022-08-03 | Catalyst Biosciences, Inc. | Modified factor vii polypeptides for subcutaneous administration |
Family Cites Families (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4952496A (en) | 1984-03-30 | 1990-08-28 | Associated Universities, Inc. | Cloning and expression of the gene for bacteriophage T7 RNA polymerase |
GR860984B (en) * | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
DK323587D0 (da) | 1987-06-25 | 1987-06-25 | Novo Industri As | Protein |
US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
EP1892296A1 (en) | 1988-09-02 | 2008-02-27 | Dyax Corporation | Generation and selection of recombinant varied binding proteins |
US5033352A (en) | 1989-01-19 | 1991-07-23 | Yamaha Corporation | Electronic musical instrument with frequency modulation |
US5580560A (en) | 1989-11-13 | 1996-12-03 | Novo Nordisk A/S | Modified factor VII/VIIa |
ATE180834T1 (de) * | 1990-01-29 | 1999-06-15 | Zymogenetics Inc | Antikoagulierende proteine |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
DK0585287T3 (da) | 1990-07-10 | 2000-04-17 | Cambridge Antibody Tech | Fremgangsmåde til fremstilling af specifikke bindingsparelementer |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
CA2405246A1 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with alterred binding properties |
US5788965A (en) * | 1991-02-28 | 1998-08-04 | Novo Nordisk A/S | Modified factor VII |
US20040087498A1 (en) * | 1991-02-28 | 2004-05-06 | Novo Nordisk Health Care Ag | Modified factor VII |
US5817788A (en) * | 1991-02-28 | 1998-10-06 | Zymogenetics, Inc. | Modified factor VII |
US5861374A (en) * | 1991-02-28 | 1999-01-19 | Novo Nordisk A/S | Modified Factor VII |
ES2330052T3 (es) | 1991-03-01 | 2009-12-03 | Dyax Corporation | Proteina quimerica que comprende micro-proteinas que tienen dos o mas puentes disulfuro y relaizaciones de las mismas. |
DE69233750D1 (de) | 1991-04-10 | 2009-01-02 | Scripps Research Inst | Bibliotheken heterodimerer Rezeptoren mittels Phagemiden |
DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
JP2001522230A (ja) | 1997-02-14 | 2001-11-13 | アメリカン・レツド・クロス | トランスジェニック動物乳房組織における活性ヒト第▲ix▼因子の発現 |
US20050032690A1 (en) * | 1997-09-10 | 2005-02-10 | Rojkjaer Lisa Payne | Factor VII polypeptides for preventing formation of inhibitors in subjects with haemophilia |
US6017882A (en) | 1997-10-23 | 2000-01-25 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US6693075B1 (en) | 1997-10-23 | 2004-02-17 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US7247708B2 (en) * | 1997-10-23 | 2007-07-24 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
WO1999051773A1 (en) | 1998-04-03 | 1999-10-14 | Phylos, Inc. | Addressable protein arrays |
DE19937219A1 (de) | 1999-08-06 | 2001-02-08 | Aventis Behring Gmbh | Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Ionenaustauscherchromatographie |
WO2001032711A2 (en) | 1999-10-21 | 2001-05-10 | Board Of Trustees Of The University Of Arkansas | Adeno-associated virus aav rep78 major regulatory protein, mutants thereof and uses thereof |
GB9928787D0 (en) | 1999-12-03 | 2000-02-02 | Medical Res Council | Direct screening method |
RU2278123C2 (ru) * | 2000-02-11 | 2006-06-20 | Максиджен Холдингз Лтд. | Молекулы, подобные фактору vii или viia |
AU2001254624A1 (en) | 2000-05-03 | 2001-11-12 | Novo-Nordisk A/S | Human coagulation factor vii variants |
US6905683B2 (en) * | 2000-05-03 | 2005-06-14 | Novo Nordisk Healthcare A/G | Human coagulation factor VII variants |
BR0110659A (pt) * | 2000-05-10 | 2003-02-11 | Novo Nordisk As | Composição farmacêutica, kit, uso de um fator viia em combinação com um fator, xiii, e, métodos para intensificação da formação de coágulo de fibrina em um indivìduo e para tratar de episódios de hemorragia em um indivìduo |
CN101486761A (zh) * | 2000-09-13 | 2009-07-22 | 诺沃挪第克健康护理股份公司 | 人凝血因子vii变体 |
EP1319067A2 (en) | 2000-09-13 | 2003-06-18 | Novo Nordisk A/S | Human coagulation factor vii variants |
DE60137950D1 (de) * | 2000-10-02 | 2009-04-23 | Novo Nordisk Healthcare Ag | Verfahren zur herstellung vitamin-k-abhängiger proteine |
US7173000B2 (en) * | 2000-11-09 | 2007-02-06 | The Scripps Research Institute | Modified factor VIIa |
WO2002059601A1 (en) | 2001-01-23 | 2002-08-01 | President And Fellows Of Harvard College | Nucleic-acid programmable protein arrays |
US20040133930A1 (en) | 2002-03-11 | 2004-07-08 | Cooper Julian D. | Production of high levels of transgenic factor ix without gene rescue, and its therapeutic uses |
US7235638B2 (en) * | 2001-03-22 | 2007-06-26 | Novo Nordisk Healthcare A/G | Coagulation factor VII derivatives |
AU2002249096B2 (en) | 2001-03-22 | 2007-06-28 | Novo Nordisk Health Care Ag | Coagulation factor VII derivatives |
AU2002315525A1 (en) * | 2001-07-03 | 2003-01-21 | Dendreon San Diego Llc | Nucleic acid molecules encoding a transmembrane serine protease 20, the encoded polypeptides and methods based thereon |
US7419949B2 (en) * | 2001-07-16 | 2008-09-02 | Novo Noridsk Healthcare A/G | Single-dose administration of factor VIIa |
US6882883B2 (en) * | 2001-08-31 | 2005-04-19 | Medtronic, Inc. | Implantable medical device (IMD) system configurable to subject a patient to a stress test and to detect myocardial ischemia within the patient |
US7052868B2 (en) * | 2001-09-27 | 2006-05-30 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
CA2461003A1 (en) | 2001-09-27 | 2003-04-03 | Novo Nordisk Health Care Ag | Human coagulation factor vii polypeptides |
HUP0402158A2 (hu) * | 2001-10-02 | 2005-01-28 | Novo Nordisk Health Care Ag | Rekombináns fehérjék előállítási eljárása eukarióta sejtekben |
AU2002347858A1 (en) * | 2001-10-09 | 2003-04-22 | Dendreon Corporation | Transmembrane serine protease 25 |
JP3862996B2 (ja) | 2001-10-31 | 2006-12-27 | 帝人ファイバー株式会社 | ポリトリメチレンテレフタレートフィラメント糸およびその製造方法 |
US6960657B2 (en) * | 2001-11-02 | 2005-11-01 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
US7291587B2 (en) * | 2001-11-09 | 2007-11-06 | Novo Nordisk Healthcare A/G | Pharmaceutical composition comprising factor VII polypeptides and TAFI polypeptides |
AU2002357004A1 (en) * | 2001-11-20 | 2003-06-10 | Dendreon San Diego Llc | Nucleic acid molecules encoding serine protease 17, the encoded polypeptides and methods based thereon |
KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
RU2004122430A (ru) * | 2001-12-21 | 2005-04-20 | Ново Нордиск А/С (DK) | Жидкая композиция полипептидов модифицированного фактора vii |
SI1499719T1 (sl) * | 2002-04-30 | 2011-03-31 | Bayer Healthcare Llc | Polipeptidne variante faktorja VII ali VIIa |
US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
US20040001801A1 (en) * | 2002-05-23 | 2004-01-01 | Corvas International, Inc. | Conjugates activated by cell surface proteases and therapeutic uses thereof |
MXPA04012496A (es) * | 2002-06-21 | 2005-09-12 | Novo Nordisk Healthcare Ag | Glicoformos del factor vii pegilados. |
WO2004005471A2 (en) * | 2002-07-02 | 2004-01-15 | Dendreon Corporation | Serine protease 16 |
US6911323B2 (en) * | 2002-09-25 | 2005-06-28 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
EP1546202B1 (en) | 2002-09-25 | 2007-08-22 | Novo Nordisk Health Care AG | Human coagulation factor vii polypeptides |
US20060166874A1 (en) * | 2002-09-30 | 2006-07-27 | Haaning Jesper M | Fvii or fviia variants having increased clotting activity |
EP1608947A4 (en) | 2002-10-02 | 2009-06-17 | Catalyst Biosciences Inc | PROCESS FOR PRODUCING AND TESTING FOR PROTEASES WITH CHANGED SPECIFICITY |
DK2085470T3 (da) * | 2003-03-20 | 2012-08-06 | Bayer Healthcare Llc | FVII- eller FVIIa-varianter |
FI20030413A (fi) | 2003-03-20 | 2004-09-21 | Suomen Intech Oy | Kaasulaakerointi |
US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
US20040235054A1 (en) | 2003-03-28 | 2004-11-25 | The Regents Of The University Of California | Novel encoding method for "one-bead one-compound" combinatorial libraries |
WO2004108763A2 (en) | 2003-06-05 | 2004-12-16 | Canadian Blood Services | Mutants of the factor vii epidermal growth factor domain |
US20060116324A1 (en) * | 2003-06-13 | 2006-06-01 | Novo Nordisk Healthcare A/G | Novel formulations |
CN1839203B (zh) | 2003-06-19 | 2011-11-16 | 拜耳医药保健有限公司 | 因子VII或VIIa的GLA结构域变体 |
ATE547519T1 (de) * | 2003-09-09 | 2012-03-15 | Novo Nordisk Healthcare Ag | Gerinnungsfaktor-vii-polypeptide |
JP2007509843A (ja) * | 2003-10-07 | 2007-04-19 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 第VII/VIIa因子活性を有するハイブリッド分子 |
US20070072271A1 (en) * | 2004-01-07 | 2007-03-29 | Novo Nordisk Healthcare A/G | Method for the production of recombinant proteins |
JP2007522805A (ja) | 2004-02-03 | 2007-08-16 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 新規化合物 |
CA2562729C (en) * | 2004-04-12 | 2013-11-12 | Sandra Waugh Ruggles | Cleavage of vegf and vegf receptor by wildtype and mutant mt-sp1 |
JP2008503541A (ja) * | 2004-06-21 | 2008-02-07 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | グリコシル化分裂型因子vii変異体 |
US20060019893A1 (en) * | 2004-07-02 | 2006-01-26 | Genentech, Inc. | Factor VIIa variants |
US20080188400A1 (en) * | 2005-04-26 | 2008-08-07 | Maxygen Holdings Ltd. | Methods For Treating Bleeding |
EP2316930A1 (en) * | 2005-09-14 | 2011-05-04 | Novo Nordisk Health Care AG | Human coagulation factor VII polypeptides |
WO2007039475A1 (en) * | 2005-09-21 | 2007-04-12 | Novo Nordisk Health Care Ag | Human coagulation factor vii polypeptides |
SI1940457T1 (sl) * | 2005-10-21 | 2013-04-30 | Catalyst Biosciences, Inc. | Modificirane proteaze, ki inhibirajo komplementno aktivacijo |
EP2423307A1 (en) * | 2006-06-19 | 2012-02-29 | Catalyst Biosciences, Inc. | Modified coagulation factor IV polypeptides and use thereof for treatment |
KR101476458B1 (ko) * | 2006-07-05 | 2015-01-05 | 카탈리스트 바이오사이언시즈, 인코포레이티드 | 프로테아제 스크리닝 방법 및 이에 의해 확인된 프로테아제 |
PL2147096T3 (pl) * | 2007-04-13 | 2015-08-31 | Catalyst Biosciences Inc | Zmodyfikowane polipeptydy czynnika VII i ich zastosowania |
TWI538916B (zh) * | 2008-04-11 | 2016-06-21 | 介控生化科技公司 | 經修飾的因子vii多肽和其用途 |
ES2524974T3 (es) * | 2009-06-25 | 2014-12-16 | The University Of North Carolina At Chapel Hill | Moléculas del Factor VII quimérico |
TWI557135B (zh) * | 2010-11-03 | 2016-11-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
WO2014018120A1 (en) * | 2012-07-25 | 2014-01-30 | Catalyst Biosciences, Inc. | Modified factor x polypeptides and uses thereof |
-
2008
- 2008-04-11 PL PL08742852T patent/PL2147096T3/pl unknown
- 2008-04-11 US US12/082,662 patent/US20100166729A9/en not_active Abandoned
- 2008-04-11 ES ES08742852.0T patent/ES2537328T3/es active Active
- 2008-04-11 CN CN201310367450XA patent/CN103451172A/zh active Pending
- 2008-04-11 NZ NZ579985A patent/NZ579985A/en unknown
- 2008-04-11 KR KR1020097023568A patent/KR20100016462A/ko active IP Right Grant
- 2008-04-11 JP JP2010503081A patent/JP5761782B2/ja not_active Expired - Fee Related
- 2008-04-11 KR KR1020157014839A patent/KR20150067772A/ko not_active Application Discontinuation
- 2008-04-11 MX MX2009010997A patent/MX2009010997A/es active IP Right Grant
- 2008-04-11 RU RU2009141510/10A patent/RU2571931C2/ru not_active IP Right Cessation
- 2008-04-11 NZ NZ593611A patent/NZ593611A/en unknown
- 2008-04-11 CN CN200880016982.6A patent/CN101743309B/zh not_active Expired - Fee Related
- 2008-04-11 CA CA002683443A patent/CA2683443A1/en not_active Abandoned
- 2008-04-11 SG SG2011058658A patent/SG174077A1/en unknown
- 2008-04-11 UA UAA200911564A patent/UA101155C2/ru unknown
- 2008-04-11 PT PT87428520T patent/PT2147096E/pt unknown
- 2008-04-11 EP EP12156573A patent/EP2481797A1/en not_active Withdrawn
- 2008-04-11 SI SI200831442T patent/SI2147096T1/sl unknown
- 2008-04-11 EP EP08742852.0A patent/EP2147096B1/en active Active
- 2008-04-11 AU AU2008239586A patent/AU2008239586B2/en not_active Ceased
- 2008-04-11 BR BRPI0810172-8A2A patent/BRPI0810172A2/pt active Search and Examination
- 2008-04-11 DK DK08742852.0T patent/DK2147096T3/da active
- 2008-04-11 WO PCT/US2008/004795 patent/WO2008127702A2/en active Application Filing
-
2009
- 2009-09-24 IL IL201173A patent/IL201173A0/en unknown
- 2009-10-01 ZA ZA2009/06854A patent/ZA200906854B/en unknown
- 2009-10-08 CO CO09111636A patent/CO6231052A2/es unknown
- 2009-10-09 HN HN2009002098A patent/HN2009002098A/es unknown
- 2009-10-09 CR CR11058A patent/CR11058A/es not_active Application Discontinuation
- 2009-10-12 NI NI200900187A patent/NI200900187A/es unknown
- 2009-10-13 SV SV2009003393A patent/SV2009003393A/es unknown
- 2009-10-13 GT GT200900268A patent/GT200900268A/es unknown
- 2009-11-13 EC EC2009009735A patent/ECSP099735A/es unknown
-
2010
- 2010-03-10 HK HK10102495.4A patent/HK1134520A1/xx not_active IP Right Cessation
-
2011
- 2011-12-13 ZA ZA2011/09181A patent/ZA201109181B/en unknown
-
2012
- 2012-03-22 IL IL218776A patent/IL218776A0/en unknown
-
2013
- 2013-10-23 JP JP2013220232A patent/JP2014042523A/ja not_active Withdrawn
-
2014
- 2014-09-01 PH PH12014501960A patent/PH12014501960A1/en unknown
-
2016
- 2016-03-17 JP JP2016054083A patent/JP2016155836A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SV2009003393A (es) | Polipeptidos de factor vii modificaciones y usos de los mismos | |
CO6331368A2 (es) | Factores modificados de polipeptidos vii (fvii) | |
BR112013010834B1 (pt) | polipeptídeos de fator ix modificados e usos dos mesmos | |
PH12019550222A1 (en) | Drug combinations | |
EA201500172A1 (ru) | Модифицированные полипептиды фактора х и их применение | |
ECSP067046A (es) | Indazoles sustituidos, composiciones que los contienen, procedimiento de preparación y su uso | |
SV2010003704A (es) | Polipeptidos modificados del factor ix y usos de los mismos | |
BRPI0511396A (pt) | derivados de retinal e métodos para uso no tratamento de enfermidades visuais | |
SV2010003559A (es) | Algunos derivados de 2-pirazinona y su uso como inhibidores de elastasa de los neutrofilos | |
BRPI0512235A (pt) | polipeptìdeos ligadores de antìgenos e seus usos | |
GT200600240A (es) | Anticuerpos monoclonales anti-trkb y usos de los mismos | |
GT200600407A (es) | Compuestos ppar activos | |
CL2013000018A1 (es) | Compuestos derivados de indolizina , su procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento del cancer, entre otros. | |
GT201200023A (es) | Polipéptidos del factor ix modificados y usos de los mismos | |
UY29249A1 (es) | Agentes citotóxicos que comprenden taxanos nuevos | |
UY29250A1 (es) | Agentes citotóxicos que comprenden nuevos taxanos modificados en c-2.- | |
EA201390254A1 (ru) | Модифицированные полипептиды релаксина и их применение | |
NI201000015A (es) | Bromhidrato de bupropión y aplicaciones terapéuticas | |
AU317922S (en) | Cutting device | |
Berger | Redefining the domains of decision making by physician and patient | |
GT200600467A (es) | Metodos y formas de dosificación de derivados de benzisoxazol con mejor eficacia | |
CU20100087A7 (es) | Algunos derivados de 2-pirazinona y su uso como inhibidores de elastasa de los neutrófilos | |
AR063676A1 (es) | Moduladores selectivos de los receptores androgenicos analogos y derivados de los mismos y usos de los mismos | |
AU314668S (en) | Cot | |
AU314669S (en) | Cot |