BRPI0511396A - derivados de retinal e métodos para uso no tratamento de enfermidades visuais - Google Patents

derivados de retinal e métodos para uso no tratamento de enfermidades visuais

Info

Publication number
BRPI0511396A
BRPI0511396A BRPI0511396-2A BRPI0511396A BRPI0511396A BR PI0511396 A BRPI0511396 A BR PI0511396A BR PI0511396 A BRPI0511396 A BR PI0511396A BR PI0511396 A BRPI0511396 A BR PI0511396A
Authority
BR
Brazil
Prior art keywords
methods
treatment
retinal derivatives
visual disorders
visual
Prior art date
Application number
BRPI0511396-2A
Other languages
English (en)
Inventor
Krzysztof Palczewski
Matthew Batten
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of BRPI0511396A publication Critical patent/BRPI0511396A/pt
Publication of BRPI0511396B1 publication Critical patent/BRPI0511396B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/10—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/12—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Abstract

DERIVADOS DE RETINAL E MéTODOS PARA USO NO TRATAMENTO DE ENFERMIDADES VISUAIS, são fornecidos composições e métodos para uso de derivados de retinal sintético como substituições de retinóide e agonistas de opsina.
BRPI0511396-2A 2004-06-18 2005-06-20 Uso de 9-cis-retinil éster e uso de um derivado de retinal sintético BRPI0511396B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58088904P 2004-06-18 2004-06-18
US60/580,889 2004-06-18
PCT/US2005/021812 WO2006002097A2 (en) 2004-06-18 2005-06-20 Retinal derivatives and methods for the use thereof for the treatment of visual disorders

Publications (2)

Publication Number Publication Date
BRPI0511396A true BRPI0511396A (pt) 2007-12-04
BRPI0511396B1 BRPI0511396B1 (pt) 2021-07-27

Family

ID=35782277

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511396-2A BRPI0511396B1 (pt) 2004-06-18 2005-06-20 Uso de 9-cis-retinil éster e uso de um derivado de retinal sintético

Country Status (27)

Country Link
US (8) US7951841B2 (pt)
EP (5) EP2397133B1 (pt)
JP (2) JP5166026B2 (pt)
KR (4) KR20140140616A (pt)
CN (2) CN1988898B (pt)
AU (1) AU2005257997B2 (pt)
BR (1) BRPI0511396B1 (pt)
CA (2) CA2931917A1 (pt)
CY (2) CY1114873T1 (pt)
DK (2) DK1765322T3 (pt)
ES (4) ES2443194T3 (pt)
HK (1) HK1098696A1 (pt)
HR (1) HRP20140116T1 (pt)
HU (1) HUE036596T2 (pt)
IL (4) IL180078A (pt)
IN (1) IN2012DN09335A (pt)
LT (1) LT2397133T (pt)
MX (2) MXPA06014750A (pt)
NO (1) NO339969B1 (pt)
NZ (2) NZ552080A (pt)
PL (2) PL2397133T3 (pt)
PT (2) PT1765322E (pt)
RS (1) RS53178B (pt)
RU (2) RU2554003C2 (pt)
SI (2) SI2397133T1 (pt)
WO (1) WO2006002097A2 (pt)
ZA (1) ZA200700368B (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006520393A (ja) 2003-03-14 2006-09-07 ユニバーシティ オブ ワシントン レチノイド補充物およびオプシンアゴニスト、ならびにそれらの使用法
CN1988898B (zh) 2004-06-18 2012-12-26 华盛顿大学 用于治疗视觉障碍的视黄醛衍生物及其使用方法
ES2313368T3 (es) 2004-06-23 2009-03-01 Sirion Therapeutics, Inc. Metodos y composiciones para el tratamiento de afecciones oftalmicas con derivados de retinilo.
CN102240278A (zh) * 2004-12-08 2011-11-16 矫正诊疗公司 治疗与视黄醇有关的疾病的方法、分析和组合物
AU2007277033A1 (en) * 2006-07-27 2008-01-31 University Of Florida Research Foundation, Inc. Compositions and methods for treating or preventing ophthalmic disease
AU2007277032A1 (en) * 2006-07-27 2008-01-31 University Of Florida Research Foundation, Inc. Opsin stabilizing compounds and methods of use
WO2008063768A2 (en) * 2006-10-12 2008-05-29 Case Western Reserve University Compositions and methods for treating metabolic diseases
MY161818A (en) 2007-04-20 2017-05-15 Acucela Inc Styrenyl derivate compounds for treating ophthalmic diseases and disorders
AU2015200520B2 (en) * 2008-02-11 2017-02-09 University Of Washington Methods for the treatment and prevention of age-related retinal dysfunction
US8324270B2 (en) * 2008-02-11 2012-12-04 University Of Washington Methods for the treatment and prevention of age-related retinal dysfunction
JP5443470B2 (ja) * 2008-04-29 2014-03-19 株式会社日健総本社 眼障害の治療方法
IN2012DN00352A (pt) 2009-06-16 2015-08-21 Bikam Pharmaceuticals Inc
RU2546005C2 (ru) * 2009-09-15 2015-04-10 Кью Эл Ти ИНК. Фармацевтические составы, содержащие 9-цис-ретиниловые сложные эфиры в липидном наполнителе
WO2011071995A2 (en) 2009-12-08 2011-06-16 Case Western Reserve University Compounds and methods of treating ocular disorders
US8889660B2 (en) 2010-01-20 2014-11-18 Case Western Reserve University Methods for treating obesity or an obesity related condition
KR20180043846A (ko) * 2010-04-19 2018-04-30 노벨리언 테라퓨틱스 인코포레이티드 내인성 레티노이드 결핍과 연관된 시각 장애의 치료 또는 완화를 위한 치료 요법 및 방법
EP2635109A4 (en) * 2010-11-05 2014-03-19 Univ Leland Stanford Junior OPTICALLY CONTROLLED CNS DYSFUNCTION
US10226536B2 (en) * 2011-11-28 2019-03-12 Case Western Reserve University Polysaccharide therapeutic conjugates
JP6576636B2 (ja) * 2012-03-01 2019-09-18 ノベリオン セラピューティクス インコーポレイテッド 内因性レチノイド欠乏に関連する視覚障害における視覚機能を改善するための治療的計画および方法
US20150038582A1 (en) * 2012-03-01 2015-02-05 Qlt Inc. Therapeutic regimens and methods for improving visual function in visual disorders associated with an endogenous retinoid deficiency
EP2858648B1 (en) 2012-06-07 2018-08-22 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the inhibition of pin1
US20150119388A1 (en) * 2012-06-15 2015-04-30 The Children's Hospital Philadelphia Novel pro- and codrug derivatives for nanoparticle delivery of select anticancer agents formed using rapidly cleavable phenolic ester bridges
WO2015184453A1 (en) 2014-05-30 2015-12-03 Case Western Reserve University Retinylamine derivitives for treatment of ocular disorders
US11129845B2 (en) 2014-06-18 2021-09-28 Case Western Reserve University Compositions and methods for the delivery of nucleic acids
WO2016011265A2 (en) 2014-07-17 2016-01-21 Beth Israel Deaconess Medical Center, Inc. Biomarkers for pin1-associated disorders
US10925980B2 (en) 2014-08-04 2021-02-23 Case Western Reserve University Molecular probes and methods of use
WO2016145186A1 (en) * 2015-03-12 2016-09-15 Beth Israel Deaconess Medical Center, Inc. Enhanced atra-related compounds for the treatment of proliferative diseases, autoimmune diseases, and addiction conditions
US11407786B2 (en) 2015-06-18 2022-08-09 Case Western Reserve University Compositions and methods for the delivery of nucleic acids
AU2017258776B2 (en) * 2016-04-28 2023-07-13 Spark Therapeutics, Inc. Relative potency assay for viral vector encoding isomerohydrolases
WO2023150258A1 (en) * 2022-02-04 2023-08-10 New York University Use of retinoids for treatment of atrial fibrillation

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB797977A (en) * 1956-01-16 1958-07-09 Hoffmann La Roche Vitamin-a esters and a process for the manufacture thereof
US3196048A (en) 1961-12-19 1965-07-20 Exxon Research Engineering Co Cathode catalyst for fuel cells
US3196078A (en) * 1962-01-30 1965-07-20 Ortho Pharma Corp Process for combating retinits pigmentosa
US3517067A (en) * 1964-02-11 1970-06-23 Eastman Kodak Co Syntheses of quaternary phosphonium salts
DE2300107C2 (de) * 1973-01-03 1982-03-11 Basf Ag, 6700 Ludwigshafen Vitamin A-Säureanilid-4-carbonsäureäthylester, Verfahren zu seiner Herstellung und diesen enthaltende Zubereitungen
DE2456959A1 (de) * 1974-12-03 1976-06-16 Basf Ag 4-(e)- und 4-(z)-7-methyl-9-(2,6,6trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8tetraencarbonsaeure, ihre derivate und diese enthaltende zubereitungen
JPS61275266A (ja) 1985-05-28 1986-12-05 Taisho Pharmaceut Co Ltd レチノイド誘導体
US5310764A (en) * 1992-05-08 1994-05-10 Steven Baranowitz Treatment of age related macular degeneration with beta-carotene
JPH06340525A (ja) * 1993-06-02 1994-12-13 Lion Corp 安定な低眼刺激性ビタミンａ類可溶化点眼剤
JPH09511507A (ja) 1994-04-04 1997-11-18 フリーマン，ウイリアム・アール 上昇した眼圧を治療するためのホスホニルメトキシアルキルヌクレオシドの使用
RU2106843C1 (ru) * 1994-06-29 1998-03-20 Красноярская государственная медицинская академия Способ лечения близорукости
JPH08198746A (ja) 1995-01-18 1996-08-06 Lion Corp 可溶化点眼剤
US5837728A (en) * 1995-01-27 1998-11-17 Molecular Design International 9-cis retinoic acid esters and amides and uses thereof
US5489611A (en) 1995-02-10 1996-02-06 Warner-Lambert Company Method for lowering plasma levels of lipoprotein (a)
WO1996031194A2 (en) * 1995-04-03 1996-10-10 Johnson & Johnson Consumer Products, Inc. Skin care compositions containing retinoids and liposomes
US5620970A (en) * 1995-06-05 1997-04-15 Alcon Laboratories, Inc. Topical ophthalmic carbonic anhydrase inhibitor formulations
US5716627A (en) * 1996-04-25 1998-02-10 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing fatty acid amides, azoles, and retinol or retinyl ester
EP0908179A1 (en) * 1997-08-23 1999-04-14 Werner Bollag Treatment of cell-mediated immune diseases
US6391924B1 (en) 1997-12-10 2002-05-21 Hampar Karageozian Taurine derivatives useable in the treatment of ophthalmic disorders
US6552009B2 (en) * 1998-07-16 2003-04-22 Gentrix Llc Compositions and methods of treating abnormal cell proliferation
US6372463B1 (en) 1999-05-06 2002-04-16 The President & Fellows Of Harvard College Mutations in nucleic acid molecules encoding 11-CIS retinol dehydrogenase, the mutated proteins, and uses thereof
US6300328B1 (en) * 1999-08-06 2001-10-09 Alcon Universal Ltd. Selective inhibitors of adenosine monophosphate deaminase for the treatment of optic nerve and retinal damage
JP2003529567A (ja) 2000-03-10 2003-10-07 インサイト・ビジョン・インコーポレイテッド 後眼部眼疾患を治療および予防する方法と組成物
US20020028849A1 (en) * 2000-04-18 2002-03-07 Godkin James D. Use of retinol in assisted-reproduction protocols
US6696069B2 (en) * 2000-06-30 2004-02-24 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Skin care cosmetic compositions containing phosphates and/or sulfates of branched alcohols and/or ethoxylates thereof
CN1455780A (zh) * 2001-01-11 2003-11-12 株式会社开备传 新视黄醇衍生物、其制备方法和用途
CA2435410A1 (en) 2001-01-26 2002-08-01 Steven Baranowitz Systemic formulations containing beta-carotene and derivatives thereof
GB0103998D0 (en) 2001-02-19 2001-04-04 King S College London Method
CA2442670A1 (en) 2001-04-13 2002-10-24 The Trustees Of The University Of Pennsylvania Method of treating or retarding the development of blindness
JP2005524626A (ja) 2002-01-18 2005-08-18 タットン テクノロジーズ エルエルシー． 眼疾患を治療するための方法
US20030215413A1 (en) * 2002-03-22 2003-11-20 L'oreal Compositions containing stabilized retinoid
US20040097587A1 (en) * 2002-03-27 2004-05-20 Arbiser Jack L Compositions and methods of treatment of ulcerating diseases, burns, and related conditions
JP2006512279A (ja) 2002-03-29 2006-04-13 マキシム ファーマシューティカルス，インコーポレイテッド 眼内損傷を治療および予防するためのｒｏｍ生成および放出阻害剤の使用
CN2601278Y (zh) 2003-01-07 2004-01-28 杨天民 自动闭合式排水盖
JP2006520393A (ja) 2003-03-14 2006-09-07 ユニバーシティ オブ ワシントン レチノイド補充物およびオプシンアゴニスト、ならびにそれらの使用法
PL380611A1 (pl) 2004-02-17 2007-02-19 President And Fellows Of Harvard College Postępowanie z zaburzeniami oftalmologicznymi, włącznie ze zwyrodnieniem plamki
US7566808B2 (en) * 2004-02-17 2009-07-28 President And Fellows Of Harvard College Management of ophthalmologic disorders, including macular degeneration
NZ550340A (en) 2004-03-17 2010-08-27 Lars Michael Larsen Prevention of retinopathy by inhibition of the visual cycle using a retinoid
CN1988898B (zh) 2004-06-18 2012-12-26 华盛顿大学 用于治疗视觉障碍的视黄醛衍生物及其使用方法
ES2313368T3 (es) 2004-06-23 2009-03-01 Sirion Therapeutics, Inc. Metodos y composiciones para el tratamiento de afecciones oftalmicas con derivados de retinilo.
JP2008515778A (ja) 2004-08-18 2008-05-15 シリオン セラピューティクス， インコーポレイテッド 眼の状態を１３−シス−レチニル誘導体で処置するための組み合わせ方法、組成物および治療
US20080275133A1 (en) 2004-09-30 2008-11-06 University Of Calfornia-San Francisco Local Administration of Retinoids to Treat Deficiencies in Dark Adaptation
PT2187880E (pt) 2007-09-12 2014-03-25 Univ Columbia Composições e métodos para o tratamento da degenerescência macular
US8324270B2 (en) 2008-02-11 2012-12-04 University Of Washington Methods for the treatment and prevention of age-related retinal dysfunction

Also Published As

Publication number Publication date
PT1765322E (pt) 2014-02-05
SI1765322T1 (sl) 2014-03-31
AU2005257997A1 (en) 2006-01-05
EP2397131A2 (en) 2011-12-21
US20130072556A1 (en) 2013-03-21
KR101323122B1 (ko) 2013-10-30
HRP20140116T1 (hr) 2014-03-28
JP5596749B2 (ja) 2014-09-24
KR101337321B1 (ko) 2013-12-06
KR20120062946A (ko) 2012-06-14
IN2012DN09335A (pt) 2015-08-21
US9403765B2 (en) 2016-08-02
EP1765322B1 (en) 2013-11-06
US20170014368A1 (en) 2017-01-19
US20130079403A1 (en) 2013-03-28
CA2931917A1 (en) 2006-01-05
EP2397130A3 (en) 2012-10-31
CN102976937B (zh) 2016-12-21
KR101490145B1 (ko) 2015-02-05
US9174936B2 (en) 2015-11-03
EP2397132A3 (en) 2012-07-11
US9162978B2 (en) 2015-10-20
SI2397133T1 (sl) 2017-12-29
NZ552080A (en) 2011-03-31
PL2397133T3 (pl) 2018-01-31
US9388130B2 (en) 2016-07-12
ZA200700368B (en) 2008-10-29
DK2397133T3 (en) 2017-10-30
EP2397132B1 (en) 2017-07-26
NZ587006A (en) 2011-12-22
JP2008503496A (ja) 2008-02-07
CA2571049C (en) 2016-08-09
LT2397133T (lt) 2018-01-10
US9169204B2 (en) 2015-10-27
WO2006002097A2 (en) 2006-01-05
US10117845B2 (en) 2018-11-06
IL230242A (en) 2015-10-29
US20110288170A1 (en) 2011-11-24
ES2443194T3 (es) 2014-02-18
IL180078A0 (en) 2007-05-15
RU2010138410A (ru) 2012-03-27
KR20070026817A (ko) 2007-03-08
JP2012229234A (ja) 2012-11-22
HUE036596T2 (hu) 2018-07-30
NO20070330L (no) 2007-03-15
ES2644981T3 (es) 2017-12-01
WO2006002097A3 (en) 2006-05-04
HK1098696A1 (en) 2007-07-27
CN1988898B (zh) 2012-12-26
CN102976937A (zh) 2013-03-20
CN1988898A (zh) 2007-06-27
EP1765322A2 (en) 2007-03-28
KR20130079669A (ko) 2013-07-10
RU2408578C2 (ru) 2011-01-10
JP5166026B2 (ja) 2013-03-21
EP2397131A3 (en) 2012-10-31
NO339969B1 (no) 2017-02-20
CY1114873T1 (el) 2016-12-14
EP2397133B1 (en) 2017-07-26
CA2571049A1 (en) 2006-01-05
MXPA06014750A (es) 2007-03-21
KR20140140616A (ko) 2014-12-09
EP2397133A2 (en) 2011-12-21
US20130072560A1 (en) 2013-03-21
RU2554003C2 (ru) 2015-06-20
RS53178B (en) 2014-06-30
PT2397133T (pt) 2017-10-23
IL230241A (en) 2015-06-30
US7951841B2 (en) 2011-05-31
IL180078A (en) 2014-01-30
ES2752924T3 (es) 2020-04-06
EP2397132A2 (en) 2011-12-21
EP2397130B1 (en) 2019-04-03
ES2644984T3 (es) 2017-12-01
EP2397131B1 (en) 2019-09-11
US20130072559A1 (en) 2013-03-21
EP2397130A2 (en) 2011-12-21
US20190167626A1 (en) 2019-06-06
AU2005257997B2 (en) 2012-04-05
IL222347A (en) 2017-08-31
US20080221208A1 (en) 2008-09-11
BRPI0511396B1 (pt) 2021-07-27
DK1765322T3 (da) 2014-02-10
MX359668B (es) 2018-10-05
PL1765322T3 (pl) 2014-04-30
EP1765322A4 (en) 2008-09-17
CY1119480T1 (el) 2018-03-07
RU2007101735A (ru) 2008-07-27
EP2397133A3 (en) 2012-07-11

Similar Documents

Publication Publication Date Title
BRPI0511396A (pt) derivados de retinal e métodos para uso no tratamento de enfermidades visuais
CY1120741T1 (el) Θεραπεια οζωδους σκληρυνσης
DOP2010000304A (es) Composiciones y metodos de preparacion y uso de las mismas
CY1121135T1 (el) Ενωσεις υποκατεστημενης τετρακυκλιnhς για την θεραπευτικη αγωγη φλεγμονωδων διαταραχων του δερματος
CL2016002589A1 (es) Uso del compuesto genz-112638 (eliglustat), inhibidor de glucosilceramida sintasa, en el tratamiento de la enfermedad de gaucher y enfermedad de fabry (divisional de solicitud 201201348).
CL2011002739A1 (es) Compuestos derivados de 3-(1h-pirrolo[2,3-b]piridina-3-carbonil)-bencenosulfonamida; composicion farmaceutica que los comprende; kit; y su uso como inhibidores de raf para el tratamiento de una enfermedad o condicion seleccionada de melanoma, glioma, glioblastoma multiforme, cancer colorrectal, cancer de pulmon, entre otras.
CL2007002017A1 (es) Compuestos derivados de [4,5']-bipirimidinil-6,4'-diamina; composicion farmaceutica; y uso como inhibidor de la actividad de cinasa en cancer de vejiga, cancer cervical y mieloma multiple.
SV2010003662A (es) Derivados de azetidina y ciclobutano como inhibidores de jak ref. x-19081
UY28933A1 (es) Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos
HN2005029978A (es) Formulaciones
CL2008001234A1 (es) Compuestos derivados de heterociclos nitrogenados, inhibidores de las proteinas de apoptosis; y uso en el tratamiento del cancer.
SV2010003559A (es) Algunos derivados de 2-pirazinona y su uso como inhibidores de elastasa de los neutrofilos
UY31673A1 (es) "derivados heterocíclicos de urea y métodos de uso de los mismos-211"
EA201170227A1 (ru) Имидазолкарбоксамиды
GT200800250A (es) Arilimidazolonas y ariltriazolonas sustituidas como inhibidores de receptores de vasopresina
EA201071291A2 (ru) Nmda рецепторные антагонисты для лечения нейропсихиатрических расстройств
CL2008001633A1 (es) Compuestos derivados de pirrolidin-3-carboxamida; composición farmacéutica; y uso comominhibidores de erk para el tratamiento del cancer.
ECSP088763A (es) Nuevas combinaciones terapéuticas para el tratamiento de la depresión
CL2012002887A1 (es) Combinación farmacéutica que comprende compuestos derivados de 2,3-dihidroimidazo[1,2-c]quinazolina sustituida, compuestos derivados de n-(2-arilamino)arilsulfonamida y opcionalmente otros agentes farmacéuticos adicionales; kit faramacéutico; método de tratamiento; y su uso para el tratamiento o la profilaxis del cáncer.
UY29434A1 (es) Derivados de tetrahidronaftalina, procedimientos para su preparación y su uso como inhibidores de la inflamacinn
NO20074780L (no) Heterocyklylamidsubstituerte imidazoler
UY29109A1 (es) Derivados de alquiliden-tetrahidronaftaleno, procedimiento para su preparacion y su uso como antiinflamatorios
IN2012DN03844A (pt)
PA8806501A1 (es) Triazolotriazinas y triazolopirazinas y su uso
DOP2006000257A (es) Derivados de 9-cloro-15-desoxiprostaglandina, procesos para su preparación y su uso como medicamento

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07C Technical examination (opinion): republication [chapter 7.3 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/06/2005, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 18A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2727 DE 11-04-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.