ZA200700368B - Retinal derivatives and methods for the use thereof for the treatment of visual disorders - Google Patents

Retinal derivatives and methods for the use thereof for the treatment of visual disorders

Info

Publication number
ZA200700368B
ZA200700368B ZA200700368A ZA200700368A ZA200700368B ZA 200700368 B ZA200700368 B ZA 200700368B ZA 200700368 A ZA200700368 A ZA 200700368A ZA 200700368 A ZA200700368 A ZA 200700368A ZA 200700368 B ZA200700368 B ZA 200700368B
Authority
ZA
South Africa
Prior art keywords
treatment
methods
visual disorders
retinal derivatives
retinal
Prior art date
Application number
ZA200700368A
Other languages
English (en)
Inventor
Palczewski Krzysztof
Batten Matthew
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of ZA200700368B publication Critical patent/ZA200700368B/xx

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/12—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by esterified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/10—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA200700368A 2004-06-18 2005-06-20 Retinal derivatives and methods for the use thereof for the treatment of visual disorders ZA200700368B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58088904P 2004-06-18 2004-06-18

Publications (1)

Publication Number Publication Date
ZA200700368B true ZA200700368B (en) 2008-10-29

Family

ID=35782277

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200700368A ZA200700368B (en) 2004-06-18 2005-06-20 Retinal derivatives and methods for the use thereof for the treatment of visual disorders

Country Status (27)

Country Link
US (8) US7951841B2 (xx)
EP (5) EP2397130B1 (xx)
JP (2) JP5166026B2 (xx)
KR (4) KR101337321B1 (xx)
CN (2) CN1988898B (xx)
AU (1) AU2005257997B2 (xx)
BR (1) BRPI0511396B1 (xx)
CA (2) CA2931917A1 (xx)
CY (2) CY1114873T1 (xx)
DK (2) DK2397133T3 (xx)
ES (4) ES2443194T3 (xx)
HK (1) HK1098696A1 (xx)
HR (1) HRP20140116T1 (xx)
HU (1) HUE036596T2 (xx)
IL (4) IL180078A (xx)
IN (1) IN2012DN09335A (xx)
LT (1) LT2397133T (xx)
MX (2) MX359668B (xx)
NO (1) NO339969B1 (xx)
NZ (2) NZ552080A (xx)
PL (2) PL2397133T3 (xx)
PT (2) PT2397133T (xx)
RS (1) RS53178B (xx)
RU (2) RU2554003C2 (xx)
SI (2) SI1765322T1 (xx)
WO (1) WO2006002097A2 (xx)
ZA (1) ZA200700368B (xx)

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Publication number Publication date
KR101337321B1 (ko) 2013-12-06
KR20120062946A (ko) 2012-06-14
EP2397130B1 (en) 2019-04-03
IL222347A (en) 2017-08-31
US9162978B2 (en) 2015-10-20
RS53178B (en) 2014-06-30
CN1988898A (zh) 2007-06-27
HK1098696A1 (en) 2007-07-27
CN1988898B (zh) 2012-12-26
HUE036596T2 (hu) 2018-07-30
JP5166026B2 (ja) 2013-03-21
WO2006002097A2 (en) 2006-01-05
PT2397133T (pt) 2017-10-23
DK2397133T3 (en) 2017-10-30
EP2397132B1 (en) 2017-07-26
US10117845B2 (en) 2018-11-06
EP1765322A2 (en) 2007-03-28
NO339969B1 (no) 2017-02-20
EP2397133A3 (en) 2012-07-11
US9174936B2 (en) 2015-11-03
DK1765322T3 (da) 2014-02-10
US20190167626A1 (en) 2019-06-06
AU2005257997B2 (en) 2012-04-05
EP1765322B1 (en) 2013-11-06
IL230242A (en) 2015-10-29
AU2005257997A1 (en) 2006-01-05
PL2397133T3 (pl) 2018-01-31
NZ587006A (en) 2011-12-22
CA2571049C (en) 2016-08-09
US20130072559A1 (en) 2013-03-21
ES2752924T3 (es) 2020-04-06
KR101323122B1 (ko) 2013-10-30
KR20070026817A (ko) 2007-03-08
US20110288170A1 (en) 2011-11-24
US9388130B2 (en) 2016-07-12
CA2571049A1 (en) 2006-01-05
EP2397132A3 (en) 2012-07-11
RU2010138410A (ru) 2012-03-27
SI2397133T1 (sl) 2017-12-29
EP2397133B1 (en) 2017-07-26
LT2397133T (lt) 2018-01-10
RU2554003C2 (ru) 2015-06-20
US20170014368A1 (en) 2017-01-19
HRP20140116T1 (hr) 2014-03-28
KR101490145B1 (ko) 2015-02-05
MXPA06014750A (es) 2007-03-21
MX359668B (es) 2018-10-05
EP2397131B1 (en) 2019-09-11
EP2397131A2 (en) 2011-12-21
KR20130079669A (ko) 2013-07-10
BRPI0511396A (pt) 2007-12-04
CY1114873T1 (el) 2016-12-14
EP2397130A3 (en) 2012-10-31
US20130079403A1 (en) 2013-03-28
KR20140140616A (ko) 2014-12-09
IN2012DN09335A (xx) 2015-08-21
CN102976937A (zh) 2013-03-20
NO20070330L (no) 2007-03-15
PT1765322E (pt) 2014-02-05
US9403765B2 (en) 2016-08-02
CA2931917A1 (en) 2006-01-05
SI1765322T1 (sl) 2014-03-31
CN102976937B (zh) 2016-12-21
BRPI0511396B1 (pt) 2021-07-27
US20130072560A1 (en) 2013-03-21
RU2007101735A (ru) 2008-07-27
EP2397130A2 (en) 2011-12-21
PL1765322T3 (pl) 2014-04-30
US20080221208A1 (en) 2008-09-11
EP2397131A3 (en) 2012-10-31
EP1765322A4 (en) 2008-09-17
ES2644984T3 (es) 2017-12-01
WO2006002097A3 (en) 2006-05-04
US20130072556A1 (en) 2013-03-21
JP2008503496A (ja) 2008-02-07
ES2644981T3 (es) 2017-12-01
JP2012229234A (ja) 2012-11-22
EP2397132A2 (en) 2011-12-21
ES2443194T3 (es) 2014-02-18
EP2397133A2 (en) 2011-12-21
IL180078A (en) 2014-01-30
NZ552080A (en) 2011-03-31
US7951841B2 (en) 2011-05-31
IL230241A (en) 2015-06-30
US9169204B2 (en) 2015-10-27
IL180078A0 (en) 2007-05-15
CY1119480T1 (el) 2018-03-07
RU2408578C2 (ru) 2011-01-10
JP5596749B2 (ja) 2014-09-24

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