MX365612B - Polipeptidos de factor x modificados y usos de los mismos. - Google Patents
Polipeptidos de factor x modificados y usos de los mismos.Info
- Publication number
- MX365612B MX365612B MX2015001083A MX2015001083A MX365612B MX 365612 B MX365612 B MX 365612B MX 2015001083 A MX2015001083 A MX 2015001083A MX 2015001083 A MX2015001083 A MX 2015001083A MX 365612 B MX365612 B MX 365612B
- Authority
- MX
- Mexico
- Prior art keywords
- polypeptides
- factor
- modified factor
- modified
- zymogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6432—Coagulation factor Xa (3.4.21.6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21006—Coagulation factor Xa (3.4.21.6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Se proporcionan proteínas terapéuticas modificadas. En particular se proporcionan polipéptidos de factor X modificado, que incluyen el zimógeno de Factor X, Factor Xa y otras formas de Factor X y uso de los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261741806P | 2012-07-25 | 2012-07-25 | |
PCT/US2013/032616 WO2014018120A1 (en) | 2012-07-25 | 2013-03-15 | Modified factor x polypeptides and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015001083A MX2015001083A (es) | 2015-04-08 |
MX365612B true MX365612B (es) | 2019-06-07 |
Family
ID=48040462
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015001083A MX365612B (es) | 2012-07-25 | 2013-03-15 | Polipeptidos de factor x modificados y usos de los mismos. |
Country Status (18)
Country | Link |
---|---|
US (2) | US9145552B2 (es) |
EP (1) | EP2877487B1 (es) |
JP (2) | JP6363600B2 (es) |
KR (1) | KR102049900B1 (es) |
CN (1) | CN104755492A (es) |
AU (1) | AU2013293573B2 (es) |
BR (1) | BR112015001628A2 (es) |
CA (1) | CA2879785C (es) |
EA (1) | EA028865B1 (es) |
ES (1) | ES2704083T3 (es) |
HK (1) | HK1210790A1 (es) |
IL (1) | IL236449B (es) |
IN (1) | IN2015DN01404A (es) |
MX (1) | MX365612B (es) |
NZ (1) | NZ703148A (es) |
SG (1) | SG11201500579SA (es) |
WO (1) | WO2014018120A1 (es) |
ZA (1) | ZA201500097B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5629423B2 (ja) | 2004-04-12 | 2014-11-19 | カタリスト バイオサイエンシーズ, インコーポレイテッド | 野生型及び変異型mt−sp1による、vegf及びvegf受容体の切断 |
WO2007047995A2 (en) | 2005-10-21 | 2007-04-26 | Catalyst Biosciences, Inc. | Modified proteases that inhibit complement activation |
KR20150033726A (ko) | 2006-07-05 | 2015-04-01 | 카탈리스트 바이오사이언시즈, 인코포레이티드 | 프로테아제 스크리닝 방법 및 이에 의해 확인된 프로테아제 |
KR20100016462A (ko) * | 2007-04-13 | 2010-02-12 | 카탈리스트 바이오사이언시즈, 인코포레이티드 | 변형 제vii 인자 폴리펩타이드 및 이의 용도 |
TWI538916B (zh) | 2008-04-11 | 2016-06-21 | 介控生化科技公司 | 經修飾的因子vii多肽和其用途 |
TWI595004B (zh) | 2010-11-03 | 2017-08-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
IN2015DN01404A (es) | 2012-07-25 | 2015-07-03 | Catalyst Biosciences Inc | |
WO2015044836A1 (en) | 2013-09-24 | 2015-04-02 | Pfizer Inc. | Compositions comprising heterogeneous populations of recombinant human clotting factor xa proteins |
ES2772802T3 (es) * | 2014-01-24 | 2020-07-08 | Pfizer | Composiciones y procedimientos para tratar la hemorragia intracerebral |
US10444715B2 (en) * | 2014-05-01 | 2019-10-15 | Belkin International, Inc. | Controlling settings and attributes related to operation of devices in a network |
EP3149163B1 (en) * | 2014-05-26 | 2020-06-03 | Academisch Ziekenhuis Leiden | Prohemostatic proteins for the treatment of bleeding |
WO2016110510A1 (en) * | 2015-01-07 | 2016-07-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Mutated factor x polypeptides and uses thereof for the treatment of haemophilia |
WO2017017109A1 (en) * | 2015-07-27 | 2017-02-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Mutated factor x polypeptides and uses thereof for the treatment of haemophilia |
AU2017205364B2 (en) * | 2016-01-07 | 2021-03-04 | Eio Biomedical Ltd | Methods, compositions and kits for reducing tissue adhesions |
FR3050992A1 (fr) * | 2016-05-06 | 2017-11-10 | Lab Francais Du Fractionnement | Mutants du facteur x |
FR3077296A1 (fr) * | 2018-02-01 | 2019-08-02 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Dimeres de variants du facteur x |
WO2019201868A1 (en) * | 2018-04-16 | 2019-10-24 | Swedish Orphan Biovitrum Ab (Publ) | Coagulation factor based fusion protein with half-life extending polypeptide |
US20210069306A1 (en) | 2019-08-15 | 2021-03-11 | Catalyst Biosciences, Inc. | Modified factor vii polypeptides for subcutaneous administration and on-demand treatment |
EP3831843A1 (en) * | 2019-12-08 | 2021-06-09 | Royal College Of Surgeons In Ireland | A hemostatic agent and uses thereof |
US20230190679A1 (en) * | 2021-11-09 | 2023-06-22 | YewSavin, Inc. | Compositions and methods for treating bleeding and bleeding disorders |
CN114681597A (zh) * | 2022-03-11 | 2022-07-01 | 兆科药业(合肥)有限公司 | 蝰蛇蛇毒血凝酶在制备用于逆转凝血因子Xa抑制剂的抗凝作用的药物中的应用 |
CN116426510B (zh) * | 2023-06-13 | 2023-09-22 | 北京沃森赛瑟生物技术有限公司 | 含修饰Xa因子的利伐沙班检测试剂盒及检测方法与应用 |
Family Cites Families (59)
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US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4501731A (en) * | 1983-06-27 | 1985-02-26 | Tishkoff Garson H | Treatment of disparate bleeding disorders with factor X zymogen |
US4952496A (en) | 1984-03-30 | 1990-08-28 | Associated Universities, Inc. | Cloning and expression of the gene for bacteriophage T7 RNA polymerase |
US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
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US5304482A (en) | 1989-03-06 | 1994-04-19 | The Board Of Regents Of The University Of Texas System | Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors |
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US6017882A (en) | 1997-10-23 | 2000-01-25 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
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US20030186329A1 (en) | 1999-03-22 | 2003-10-02 | The Scripps Research Institute | Use of substrate subtraction libraries to distinguish enzyme specificities |
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CA2447023A1 (en) | 2001-05-23 | 2002-11-28 | Dendreon San Diego Llc | Conjugates activated by cell surface proteases and therapeutic uses thereof |
AU2002315525A1 (en) | 2001-07-03 | 2003-01-21 | Dendreon San Diego Llc | Nucleic acid molecules encoding a transmembrane serine protease 20, the encoded polypeptides and methods based thereon |
US20030143219A1 (en) | 2001-10-09 | 2003-07-31 | Madison Edwin L | Nucleic acid molecules encoding a transmembrane serine protease 25, the encoded polypeptides and methods based thereon |
FR2831170B1 (fr) | 2001-10-19 | 2004-03-19 | Inst Nat Sante Rech Med | Proteines c modifiees activables directement par la thrombine |
WO2003044179A2 (en) | 2001-11-20 | 2003-05-30 | Dendreon San Diego Llc | Nucleic acid molecules encoding serine protease 17, the encoded polypeptides and methods based thereon |
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AU2003247776A1 (en) | 2002-07-02 | 2004-01-23 | Dendreon Corporation | Serine protease 16 |
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NZ590187A (en) | 2002-10-02 | 2012-07-27 | Catalyst Biosciences Inc | Methods of generating and screening for proteases with altered specificity |
WO2005022330A2 (en) | 2003-08-27 | 2005-03-10 | Jambo Networks, Inc. | A system and method for providing communication services to mobile device users |
WO2005023308A1 (en) | 2003-09-05 | 2005-03-17 | Maxygen Holdings Ltd. | Formulations of vitamin k-dependent polypeptides and sulfoalkyl ether cycloextrins |
DE10350880A1 (de) | 2003-10-31 | 2005-06-02 | Roche Diagnostics Gmbh | Verfahren zur Bestimmung eines Analyten mittels einer Extraktionsschicht |
JP5629423B2 (ja) | 2004-04-12 | 2014-11-19 | カタリスト バイオサイエンシーズ, インコーポレイテッド | 野生型及び変異型mt−sp1による、vegf及びvegf受容体の切断 |
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JP2008532544A (ja) | 2005-03-15 | 2008-08-21 | ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 活性ビタミンk依存性タンパク質を生産するための方法及び組成物 |
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EP1728798A1 (en) | 2005-06-01 | 2006-12-06 | ZLB Behring GmbH | Coagulation factor X polypeptides with modified activation properties |
WO2007047995A2 (en) | 2005-10-21 | 2007-04-26 | Catalyst Biosciences, Inc. | Modified proteases that inhibit complement activation |
MX336958B (es) | 2005-11-15 | 2016-02-05 | Philadelphia Children Hospital | Metodos y composiciones para modular la hemostasia. |
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TW200804416A (en) | 2006-06-19 | 2008-01-16 | Nautilus Technology Llc | Modified coagulation factor IX polypeptides and use thereof for treatment |
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KR20100016462A (ko) | 2007-04-13 | 2010-02-12 | 카탈리스트 바이오사이언시즈, 인코포레이티드 | 변형 제vii 인자 폴리펩타이드 및 이의 용도 |
DK3078743T3 (da) * | 2007-09-28 | 2020-08-10 | Portola Pharm Inc | Antidoter til faktor xa-inhibitorer og fremgangsmåder til anvendelse af disse |
DK2436765T3 (da) | 2007-10-09 | 2014-01-13 | Chemo Sero Therapeut Res Inst | Rekombinant faktor X uden glycosylering og fremgangsmåde til fremstilling deraf |
CN102014948A (zh) | 2008-02-07 | 2011-04-13 | 安德鲁·贝克 | 腺病毒向性的调节 |
TWI538916B (zh) | 2008-04-11 | 2016-06-21 | 介控生化科技公司 | 經修飾的因子vii多肽和其用途 |
US20110137011A1 (en) * | 2008-04-21 | 2011-06-09 | Novo Nordisk A/S | Hyperglycosylated human coagulation factor ix |
FI3581650T3 (fi) | 2008-09-15 | 2023-03-23 | Uniqure Biopharma B V | IX-tekijän polypeptidimutantti, sen käyttöjä ja menetelmä sen valmistamiseksi |
MX2011004907A (es) | 2008-11-14 | 2011-07-29 | Portola Pharm Inc | Antidotos para inhibidores del factor xa y metodos para el uso de los mismos en combinacion con agentes de coagulacion de sangre. |
EP2358874B1 (en) | 2008-12-19 | 2017-03-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Serine protease derivatives and uses in the prevention or the treatment of blood coagulation disorders |
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PT2453910T (pt) | 2009-07-15 | 2016-12-07 | Portola Pharm Inc | Formulação de dose unitária de antídoto contra inibidores de fator xa para uso na prevenção de sangramento |
TWI595004B (zh) | 2010-11-03 | 2017-08-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
JP6514893B2 (ja) | 2011-09-30 | 2019-05-15 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアThe Children’S Hospital Of Philadelphia | 止血を調節するための組成物および方法 |
IN2015DN01404A (es) | 2012-07-25 | 2015-07-03 | Catalyst Biosciences Inc |
-
2013
- 2013-03-15 IN IN1404DEN2015 patent/IN2015DN01404A/en unknown
- 2013-03-15 KR KR1020157004694A patent/KR102049900B1/ko active IP Right Grant
- 2013-03-15 WO PCT/US2013/032616 patent/WO2014018120A1/en active Application Filing
- 2013-03-15 NZ NZ703148A patent/NZ703148A/en not_active IP Right Cessation
- 2013-03-15 ES ES13713325T patent/ES2704083T3/es active Active
- 2013-03-15 CN CN201380049692.2A patent/CN104755492A/zh active Pending
- 2013-03-15 MX MX2015001083A patent/MX365612B/es active IP Right Grant
- 2013-03-15 CA CA2879785A patent/CA2879785C/en not_active Expired - Fee Related
- 2013-03-15 BR BR112015001628A patent/BR112015001628A2/pt not_active IP Right Cessation
- 2013-03-15 US US13/815,768 patent/US9145552B2/en not_active Expired - Fee Related
- 2013-03-15 EP EP13713325.2A patent/EP2877487B1/en active Active
- 2013-03-15 EA EA201500172A patent/EA028865B1/ru not_active IP Right Cessation
- 2013-03-15 JP JP2015524250A patent/JP6363600B2/ja not_active Expired - Fee Related
- 2013-03-15 AU AU2013293573A patent/AU2013293573B2/en not_active Ceased
- 2013-03-15 SG SG11201500579SA patent/SG11201500579SA/en unknown
-
2014
- 2014-04-03 US US14/244,840 patent/US9856467B2/en active Active
- 2014-12-25 IL IL236449A patent/IL236449B/en active IP Right Grant
-
2015
- 2015-01-07 ZA ZA2015/00097A patent/ZA201500097B/en unknown
- 2015-11-23 HK HK15111538.9A patent/HK1210790A1/xx not_active IP Right Cessation
-
2018
- 2018-06-28 JP JP2018123235A patent/JP2018183147A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN104755492A (zh) | 2015-07-01 |
MX2015001083A (es) | 2015-04-08 |
CA2879785C (en) | 2019-06-18 |
JP2018183147A (ja) | 2018-11-22 |
US20140234290A1 (en) | 2014-08-21 |
JP6363600B2 (ja) | 2018-07-25 |
EA201500172A1 (ru) | 2015-09-30 |
WO2014018120A1 (en) | 2014-01-30 |
US9145552B2 (en) | 2015-09-29 |
KR102049900B1 (ko) | 2019-11-28 |
US20140030247A1 (en) | 2014-01-30 |
JP2015524801A (ja) | 2015-08-27 |
AU2013293573A1 (en) | 2015-02-05 |
ES2704083T3 (es) | 2019-03-14 |
BR112015001628A2 (pt) | 2017-11-07 |
HK1210790A1 (en) | 2016-05-06 |
SG11201500579SA (en) | 2015-02-27 |
EP2877487B1 (en) | 2018-10-17 |
US9856467B2 (en) | 2018-01-02 |
IL236449A0 (en) | 2015-02-26 |
EP2877487A1 (en) | 2015-06-03 |
KR20160073937A (ko) | 2016-06-27 |
CA2879785A1 (en) | 2014-01-30 |
ZA201500097B (en) | 2016-09-28 |
AU2013293573B2 (en) | 2016-10-27 |
IL236449B (en) | 2019-02-28 |
EA028865B1 (ru) | 2018-01-31 |
IN2015DN01404A (es) | 2015-07-03 |
NZ703148A (en) | 2016-08-26 |
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