MX2012013807A - Proteina de fusion que tiene actividad de factor vii. - Google Patents
Proteina de fusion que tiene actividad de factor vii.Info
- Publication number
- MX2012013807A MX2012013807A MX2012013807A MX2012013807A MX2012013807A MX 2012013807 A MX2012013807 A MX 2012013807A MX 2012013807 A MX2012013807 A MX 2012013807A MX 2012013807 A MX2012013807 A MX 2012013807A MX 2012013807 A MX2012013807 A MX 2012013807A
- Authority
- MX
- Mexico
- Prior art keywords
- fusion protein
- factor vii
- fvii
- vii activity
- transferrin
- Prior art date
Links
- 229940012413 factor vii Drugs 0.000 title abstract 6
- 102000037865 fusion proteins Human genes 0.000 title abstract 3
- 108020001507 fusion proteins Proteins 0.000 title abstract 3
- 102100023804 Coagulation factor VII Human genes 0.000 abstract 5
- 108010023321 Factor VII Proteins 0.000 abstract 5
- 102000004338 Transferrin Human genes 0.000 abstract 2
- 108090000901 Transferrin Proteins 0.000 abstract 2
- 239000012581 transferrin Substances 0.000 abstract 2
- 230000004927 fusion Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Una proteína de fusión que comprende factor VII (FVII) y transferrina de conformidad con la presente invención, tiene una actividad específica mejorada de FVII en comparación con las proteínas de fusión de FVII existentes que comprenden otras parejas de fusión distintas a la transferrina, y por lo tanto se puede usar de manera efectiva en una terapia que usa FVII.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20100052719 | 2010-06-04 | ||
PCT/KR2011/004131 WO2011152694A2 (en) | 2010-06-04 | 2011-06-07 | Fusion protein having factor vii activity |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012013807A true MX2012013807A (es) | 2012-12-17 |
MX348567B MX348567B (es) | 2017-06-20 |
Family
ID=45067214
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012013807A MX348567B (es) | 2010-06-04 | 2011-06-07 | Proteina de fusion que tiene actividad de factor vii. |
Country Status (13)
Country | Link |
---|---|
US (2) | US9644197B2 (es) |
EP (1) | EP2576625B1 (es) |
JP (2) | JP6143297B2 (es) |
KR (1) | KR101331101B1 (es) |
CN (2) | CN107188970A (es) |
AU (1) | AU2011262494B2 (es) |
BR (1) | BR112012030941A2 (es) |
CA (1) | CA2801223C (es) |
ES (1) | ES2676874T3 (es) |
MX (1) | MX348567B (es) |
RU (1) | RU2585231C2 (es) |
WO (1) | WO2011152694A2 (es) |
ZA (1) | ZA201300066B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107188970A (zh) | 2010-06-04 | 2017-09-22 | 株式会社蒂奥姆生物 | 具有因子vii活性的融合蛋白质 |
ES2873253T3 (es) * | 2010-09-28 | 2021-11-03 | Amryt Pharmaceuticals Inc | Leptinas altamente solubles |
US20140056870A1 (en) * | 2012-08-27 | 2014-02-27 | Allergan, Inc. | Fusion proteins |
US20160060612A1 (en) | 2013-02-25 | 2016-03-03 | Sk Chemicals Co., Ltd. | Method of Isolating and Purifying Fusion Protein Comprising Factor VII |
KR102058864B1 (ko) * | 2013-12-16 | 2019-12-24 | 주식회사 티움바이오 | 인자 vii의 융합 단백질을 포함하는 안정성이 개선된 약학적 조성물 |
EP3351263A1 (en) | 2017-01-20 | 2018-07-25 | Universitätsklinikum Hamburg-Eppendorf | Pharmaceutical preparation for treating or preventing tissue adhesion |
MX2020001913A (es) | 2017-08-18 | 2020-09-07 | Neutrolis Inc | Enzimas dnasa modificadas y uso en terapia. |
JP7165884B2 (ja) | 2017-10-30 | 2022-11-07 | パナソニックIpマネジメント株式会社 | 棚札検出装置、棚札検出方法、及び、棚札検出プログラム |
US10988746B2 (en) * | 2018-10-08 | 2021-04-27 | Neutrolis, Inc. | Manufacturing and engineering of DNASE enzymes for therapy |
AU2019358915A1 (en) | 2018-10-08 | 2021-05-20 | Neutrolis, Inc. | Engineering of DNASE enzymes for manufacturing and therapy |
CN110229237A (zh) * | 2019-06-24 | 2019-09-13 | 王跃驹 | 植物生产口服epo与转铁蛋白融合蛋白胶囊的应用 |
CN110218259B (zh) * | 2019-06-24 | 2022-09-16 | 王跃驹 | 植物生产胰高血糖素样肽-1短肽与转铁蛋白的融合蛋白制造口服降糖胶囊的应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
EP1257295B1 (en) | 2000-02-11 | 2009-04-15 | Bayer HealthCare LLC | Factor vii or viia-like molecules |
US8129504B2 (en) | 2001-08-30 | 2012-03-06 | Biorexis Technology, Inc. | Oral delivery of modified transferrin fusion proteins |
MXPA04001804A (es) * | 2001-08-30 | 2005-03-07 | Biorexis Pharmaceutical Corp | Proteinas de fusion de transferrina modificada. |
US7176278B2 (en) * | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
ES2355488T3 (es) | 2001-08-30 | 2011-03-28 | Biorexis Technology, Inc. | Proteína de fusión de tranferrina modificadas. |
US7125843B2 (en) * | 2001-10-19 | 2006-10-24 | Neose Technologies, Inc. | Glycoconjugates including more than one peptide |
WO2003092602A2 (en) | 2002-05-01 | 2003-11-13 | Schering Aktiengesellschaft | Novel tissue factor targeted thrombomodulin fusion proteins as anticoagulants |
WO2004020454A2 (en) * | 2002-08-30 | 2004-03-11 | Biorexis Pharmaceutical Corporation | Modified transferrin fusion proteins comprising duplicate transferrin amino or carboxy terminal domains |
US20070072271A1 (en) | 2004-01-07 | 2007-03-29 | Novo Nordisk Healthcare A/G | Method for the production of recombinant proteins |
EP1816201A1 (en) * | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
DK2004683T3 (en) * | 2006-03-24 | 2016-08-22 | Biogen Hemophilia Inc | PC5 AS A FACTOR IX PROPEPTID PROCESSING ENZYM |
GB0614780D0 (en) * | 2006-07-25 | 2006-09-06 | Ucb Sa | Biological products |
WO2009086132A2 (en) | 2007-12-20 | 2009-07-09 | University Of Southern California | Design of spacers to increase the expression of recombinant fusion proteins |
EP4074327A1 (en) | 2008-06-27 | 2022-10-19 | Duke University | Therapeutic agents comprising elastin-like peptides |
BR112012013554A2 (pt) * | 2009-12-08 | 2017-10-10 | Koninl Philips Electronics Nv | método de correção das medições de absorção do marcador para um paciente, programa de computador e sistema de correção |
CN107188970A (zh) | 2010-06-04 | 2017-09-22 | 株式会社蒂奥姆生物 | 具有因子vii活性的融合蛋白质 |
-
2011
- 2011-06-07 CN CN201710403215.1A patent/CN107188970A/zh active Pending
- 2011-06-07 MX MX2012013807A patent/MX348567B/es active IP Right Grant
- 2011-06-07 ES ES11790052.2T patent/ES2676874T3/es active Active
- 2011-06-07 CA CA2801223A patent/CA2801223C/en active Active
- 2011-06-07 JP JP2013513120A patent/JP6143297B2/ja not_active Expired - Fee Related
- 2011-06-07 EP EP11790052.2A patent/EP2576625B1/en active Active
- 2011-06-07 US US13/701,333 patent/US9644197B2/en active Active
- 2011-06-07 WO PCT/KR2011/004131 patent/WO2011152694A2/en active Application Filing
- 2011-06-07 AU AU2011262494A patent/AU2011262494B2/en active Active
- 2011-06-07 CN CN2011800277076A patent/CN103068854A/zh active Pending
- 2011-06-07 BR BR112012030941A patent/BR112012030941A2/pt not_active Application Discontinuation
- 2011-06-07 RU RU2012157301/10A patent/RU2585231C2/ru active
- 2011-06-07 KR KR1020110054573A patent/KR101331101B1/ko active IP Right Grant
-
2013
- 2013-01-03 ZA ZA2013/00066A patent/ZA201300066B/en unknown
-
2016
- 2016-03-25 US US15/080,757 patent/US10696960B2/en active Active
- 2016-07-01 JP JP2016131637A patent/JP6422918B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20130236945A1 (en) | 2013-09-12 |
BR112012030941A2 (pt) | 2017-06-06 |
KR101331101B1 (ko) | 2013-11-19 |
JP6143297B2 (ja) | 2017-06-07 |
KR20110133454A (ko) | 2011-12-12 |
JP2013529914A (ja) | 2013-07-25 |
AU2011262494A1 (en) | 2013-01-24 |
US10696960B2 (en) | 2020-06-30 |
MX348567B (es) | 2017-06-20 |
AU2011262494B2 (en) | 2016-01-21 |
US9644197B2 (en) | 2017-05-09 |
JP2017000144A (ja) | 2017-01-05 |
ES2676874T3 (es) | 2018-07-25 |
EP2576625B1 (en) | 2018-04-25 |
WO2011152694A3 (en) | 2012-04-19 |
EP2576625A2 (en) | 2013-04-10 |
JP6422918B2 (ja) | 2018-11-14 |
RU2012157301A (ru) | 2014-07-20 |
US20160194622A1 (en) | 2016-07-07 |
WO2011152694A8 (en) | 2013-01-17 |
CA2801223C (en) | 2019-12-03 |
RU2585231C2 (ru) | 2016-05-27 |
CN107188970A (zh) | 2017-09-22 |
AU2011262494A2 (en) | 2013-08-01 |
ZA201300066B (en) | 2014-03-26 |
WO2011152694A2 (en) | 2011-12-08 |
CA2801223A1 (en) | 2011-12-08 |
EP2576625A4 (en) | 2013-11-06 |
CN103068854A (zh) | 2013-04-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX348567B (es) | Proteina de fusion que tiene actividad de factor vii. | |
PH12017501417A1 (en) | Anti-fap antibodies and methods of use | |
MX2015001083A (es) | Polipeptidos de factor x modificados y usos de los mismos. | |
TN2014000438A1 (en) | Anti-fcrn antibodies | |
MX357290B (es) | Mejoramiento de la actividad de proteínas que requieren centros fe-s. | |
MX363533B (es) | Proteínas de fusión que comprenden partes de unión a pdgf y vegf y métodos de uso de las mismas. | |
MX360741B (es) | Constructos de polipéptidos y sus usos. | |
MX2013007168A (es) | Anticuerpo anti-pcsk9 y metodos de uso. | |
IN2012DN05237A (es) | ||
MX346518B (es) | Metodos de desarrollo de variantes de terpeno sintasa. | |
TN2012000511A1 (en) | Compositions and methods of use for therapeutic low density lipoprotein -related protein 6 (lrp6) antibodies | |
PT3434775T (pt) | Proteína que tem atividade de nuclease, proteínas de fusão e utilizações das mesmas | |
PH12016500753B1 (en) | Antibodies specific to fcrn | |
WO2012053823A3 (ko) | 인자 ix 활성을 갖는 융합 단백질 | |
MX357675B (es) | Anticuerpos anti-jagged y métodos de uso. | |
PH12015501854A1 (en) | Factor ix polypeptide formulations | |
WO2013006766A3 (en) | Formulations that stabilize proteins | |
EP2496608A4 (en) | FUSION PROTEIN SPECIFICALLY BINDING TO A CONSTANT REGION OF ANTIBODY, PREPARATION THEREFOR, AND METHOD OF ISOLATING ANTIBODY USING THE SAME | |
WO2013025846A3 (en) | Transferrin-tumstatin fusion protein and methods for producing and using the same | |
WO2013059439A3 (en) | Combination therapy comprising an mmp-14 binding protein | |
MX2016005572A (es) | Uso de monensina para regular la glicosilacion de proteinas recombinantes. | |
MX341733B (es) | Purificacion de inhibidor de proteasa alfa1 derivado de cultivo celular. | |
MX2014001920A (es) | Proteina de fusion acortada de tetranectina-apolipoproteina a-i, una particula lipidica que la contiene, y usos de la misma. | |
UA55856U (ru) | Способ определения биологического эффекта магнитного поля | |
UA72607U (ru) | Питательная среда для культивирования клеток, продуцирующих антиген вируса лейкоза крупного рогатого скота |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |