MX343324B - Ensayos para detectar auto anticuerpos neutralizadores de la terapia biologica con tnf alpha. - Google Patents

Ensayos para detectar auto anticuerpos neutralizadores de la terapia biologica con tnf alpha.

Info

Publication number
MX343324B
MX343324B MX2013015420A MX2013015420A MX343324B MX 343324 B MX343324 B MX 343324B MX 2013015420 A MX2013015420 A MX 2013015420A MX 2013015420 A MX2013015420 A MX 2013015420A MX 343324 B MX343324 B MX 343324B
Authority
MX
Mexico
Prior art keywords
neutralizing
therapy
biologic
present
assays
Prior art date
Application number
MX2013015420A
Other languages
English (en)
Spanish (es)
Other versions
MX2013015420A (es
Inventor
Singh Sharat
Long Wang Shui
Ohrmund Linda
Hauenstein Scott
Original Assignee
Nestec Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nestec Sa filed Critical Nestec Sa
Publication of MX2013015420A publication Critical patent/MX2013015420A/es
Publication of MX343324B publication Critical patent/MX343324B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/525—Tumor necrosis factor [TNF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rehabilitation Therapy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
MX2013015420A 2011-07-06 2012-07-06 Ensayos para detectar auto anticuerpos neutralizadores de la terapia biologica con tnf alpha. MX343324B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161505031P 2011-07-06 2011-07-06
US201161528072P 2011-08-26 2011-08-26
US201161535884P 2011-09-16 2011-09-16
PCT/US2012/045794 WO2013006810A1 (en) 2011-07-06 2012-07-06 Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha

Publications (2)

Publication Number Publication Date
MX2013015420A MX2013015420A (es) 2015-01-22
MX343324B true MX343324B (es) 2016-11-01

Family

ID=46551894

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013015420A MX343324B (es) 2011-07-06 2012-07-06 Ensayos para detectar auto anticuerpos neutralizadores de la terapia biologica con tnf alpha.

Country Status (12)

Country Link
US (2) US9465027B2 (cg-RX-API-DMAC7.html)
EP (2) EP3130921B1 (cg-RX-API-DMAC7.html)
JP (1) JP6181646B2 (cg-RX-API-DMAC7.html)
KR (1) KR20140047628A (cg-RX-API-DMAC7.html)
CN (1) CN103782172A (cg-RX-API-DMAC7.html)
AU (2) AU2012278802B2 (cg-RX-API-DMAC7.html)
CA (1) CA2840232A1 (cg-RX-API-DMAC7.html)
MX (1) MX343324B (cg-RX-API-DMAC7.html)
RU (1) RU2013158256A (cg-RX-API-DMAC7.html)
SG (1) SG10201605516YA (cg-RX-API-DMAC7.html)
WO (1) WO2013006810A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201309703B (cg-RX-API-DMAC7.html)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009076323A2 (en) 2007-12-06 2009-06-18 Genalyte Inc. Monitoring enzymatic process
ES2939310T3 (es) 2008-10-27 2023-04-20 Genalyte Inc Biosensores basados en sondeo y detección ópticos
MX2012004877A (es) 2009-10-26 2012-05-23 Prometheus Lab Inc Analisis para la deteccion de farmacos anti-tnf y autoanticuerpos.
EP2630495B1 (en) 2010-10-18 2017-02-08 Nestec S.A. Methods for determining anti-drug antibody isotypes
EP3130921B1 (en) 2011-07-06 2018-09-12 Nestec S.A. Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha
CN104838270A (zh) 2012-10-05 2015-08-12 雀巢产品技术援助有限公司 用于预测和监测粘膜愈合的方法
BR112015012482A2 (pt) * 2012-11-30 2017-07-11 Nestec Sa ensaios para detecção de autoanticorpos neutralizantes à terapia com produtos biológicos
WO2014122600A1 (en) 2013-02-05 2014-08-14 Nestec S.A. Methods of selecting combination therapy for colorectal cancer patients
US10316083B2 (en) 2013-07-19 2019-06-11 Cedars-Sinai Medical Center Signature of TL1A (TNFSF15) signaling pathway
WO2015083087A1 (en) 2013-12-03 2015-06-11 Nestec S.A. Methods for predicting post-operative recurrence of crohn's disease
WO2015110989A1 (en) 2014-01-23 2015-07-30 Nestec S.A. Biomarker panel for assessment of mucosal healing
CN107250798A (zh) * 2014-12-05 2017-10-13 雀巢产品技术援助有限公司 用于检测患者样品中的生物制品的间接均相迁移率变动试验
CN105277682A (zh) * 2015-11-17 2016-01-27 苏州浩欧博生物医药有限公司 一种抗TNF-α单抗药物抗体检测试剂盒
US11119096B2 (en) * 2016-07-08 2021-09-14 W. Health L.P. Universal assay for determining the quantity of therapeutic monoclonal antibodies and their corresponding anti-drug-antibodies in samples
EP3990922A1 (en) * 2019-06-25 2022-05-04 ProciseDx Inc. Detection of anti-tnf alpha drug biologics and anti-drug antibodies
KR102626197B1 (ko) * 2020-11-19 2024-01-18 바디텍메드(주) 항 약물 항체의 수준을 정확하게 정량화하는 방법
CN112730846B (zh) * 2020-12-18 2023-12-15 安渡生物医药(杭州)有限公司 一种用于小鼠血样检测免疫复合物的方法
CN114236139A (zh) * 2021-12-30 2022-03-25 苏州和锐生物科技有限公司 一种TNF-α生物制剂的抗体检测试剂盒、制备方法

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US286774A (en) 1883-10-16 Door-hanger
US5700466A (en) 1981-09-08 1997-12-23 The Rockefeller University Method of ameliorating or preventing septic shock using a monoclonal antibody specific to cachectin/tumor necrosis factor
US4459359A (en) 1981-11-19 1984-07-10 New York Blood Center, Inc. Sensitive immunoassays of antigens or antibodies sequestered within immune complexes
US5672347A (en) 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
US4857456A (en) 1985-04-30 1989-08-15 The Regents Of The University Of California Assay of Bone morphogenetic protein (BMP) and anti-BMP antibody for the diagnosis of bone disorders
FR2590674B1 (fr) 1985-11-25 1989-03-03 Inst Nat Sante Rech Med Nouveaux reactifs de diagnostic
DE3631229A1 (de) 1986-09-13 1988-03-24 Basf Ag Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung
US5223395A (en) 1988-12-01 1993-06-29 Centocor, Inc. Immunometric assays for tumor necrosis factor-alpha and methods for preventing the loss of biological activity of tumor necrosis factor-alpha in biological samples
EP0440044A1 (en) 1990-01-31 1991-08-07 Abbott Laboratories Avoidance of human anti-mouse antibody interference in in vitro diagnostic testing
US5094740A (en) 1990-02-16 1992-03-10 Glycomed, Inc. Two-dimensional electrophoretic separation of carbohydrates
GB9028123D0 (en) 1990-12-28 1991-02-13 Erba Carlo Spa Monoclonal antibodies against human tumor necrosis factor alpha
US6284471B1 (en) 1991-03-18 2001-09-04 New York University Medical Center Anti-TNFa antibodies and assays employing anti-TNFa antibodies
US5582998A (en) 1991-06-19 1996-12-10 Boehringer Ingelheim International Gmbh Monoclonal antibodies against human TNF-binding protein I (TNF-BP I) and immunoassays therefor
JPH0566222A (ja) 1991-09-09 1993-03-19 Tosoh Corp 物質の分析方法
JP3589665B2 (ja) 1992-10-23 2004-11-17 イミュネックス・コーポレーション 可溶性オリゴマー蛋白質の調製法
ATE199392T1 (de) 1992-12-04 2001-03-15 Medical Res Council Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
ES2150970T3 (es) 1993-09-07 2000-12-16 Wako Pure Chem Ind Ltd Procedimiento y reactivo para la medida de la actividad del complemento.
JPH07110331A (ja) 1993-09-07 1995-04-25 Wako Pure Chem Ind Ltd ヒト補体価測定方法及びヒト補体価測定用試薬組成物
JPH07140144A (ja) * 1993-11-19 1995-06-02 S R L:Kk アレルゲン特異的ＩｇＥ抗体の測定方法および抗原抗体複合体の測定方法
AU717779C (en) 1994-12-28 2002-12-05 University Of Kentucky Recombinant anti-idiotype antibody 3H1 sequences relating to human carcinoembryonic antigen
US6903183B1 (en) 1996-06-07 2005-06-07 Texas Tech University Health Services Center Compositions and methods for regulation of steroidogenesis
KR20030097576A (ko) 1996-08-12 2003-12-31 세키스이가가쿠 고교가부시키가이샤 세포기능 측정용 용기 및 세포기능 측정방법
JP3718435B2 (ja) 1996-08-12 2005-11-24 積水化学工業株式会社 細胞機能測定用容器及び細胞機能測定方法
US6391622B1 (en) 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
US6309888B1 (en) 1998-09-04 2001-10-30 Leuven Research & Development Vzw Detection and determination of the stages of coronary artery disease
DE19858777B4 (de) 1998-12-18 2006-07-27 Delta Biotechnology Ltd. Verfahren zur teilweisen oder vollständigen Trennung von glykosilierten und nicht-glykosilierten Proteinen
US6680209B1 (en) 1999-12-06 2004-01-20 Biosite, Incorporated Human antibodies as diagnostic reagents
JP2004500063A (ja) 1999-12-16 2004-01-08 アムジェン　インコーポレイテッド Ｔｎｆｒ／ｏｐｇ様分子およびその使用
US7323552B2 (en) 2000-07-31 2008-01-29 The General Hospital Corporation Variant integrin polypeptides and uses thereof
CA2427643C (en) * 2000-11-02 2014-04-15 Molecular Discoveries, L.L.C. Monoclonal antibodies and cell surface antigens for the detection and treatment of small cell lung cancer (sclc)
CA2440219A1 (en) 2001-02-21 2002-10-17 Curagen Corporation Proteins, polynucleotides encoding them and methods of using the same
EP1637601A3 (en) 2001-02-21 2006-03-29 Curagen Corporation Proteins, polynucleotides encoding them and methods of using the same
DE60237194D1 (de) 2001-03-02 2010-09-16 Activx Biosciences Inc Plattform für protein-profiling
US7256257B2 (en) 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
WO2003016909A1 (en) 2001-08-16 2003-02-27 Ludwig Institute For Cancer Research Method for determining protein component in a biological sample
JP4304073B2 (ja) 2001-11-12 2009-07-29 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 改変された抗ＴＮＦα抗体
EP1470160A2 (en) 2001-12-05 2004-10-27 Cangene Corporation Immune globulin formulations for the treatment and prevention of an orthopoxvirus infection
GB0208817D0 (en) 2002-04-17 2002-05-29 European Molecular Biology Lab Embl Method for producing monoclonal antibodies
US20040022792A1 (en) 2002-06-17 2004-02-05 Ralph Klinke Method of stabilizing proteins at low pH
MXPA05001268A (es) 2002-08-01 2005-10-06 Wyeth Corp Metodos y reactivos relacionados con la inflamacion y apoptosis.
US20060034845A1 (en) 2002-11-08 2006-02-16 Karen Silence Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
US7662569B2 (en) 2003-04-11 2010-02-16 Cedars-Sinai Medical Center Methods of assessing Crohn's disease patient phenotype by I2 serologic response
JP4717810B2 (ja) * 2003-06-20 2011-07-06 ユニバーシティ オブ フロリダ リサーチ ファウンデーション インコーポレイテッド １型糖尿病と２型糖尿病を識別するためのバイオマーカー
JP2007521315A (ja) 2003-08-01 2007-08-02 アムジェン インコーポレイテッド 結晶性腫瘍壊死因子レセプター２ポリペプチド
JP2007528868A (ja) 2003-08-14 2007-10-18 ワイス 抗ルイスｙ抗イディオタイプ抗体およびその使用
EP1519194A1 (en) 2003-09-24 2005-03-30 Roche Diagnostics GmbH Use of gfap for identification of intracerebral hemorrhage
US7939634B2 (en) 2004-01-27 2011-05-10 Compugen Ltd. Polynucleotides encoding polypeptides and methods using same
US20090275496A1 (en) 2004-05-07 2009-11-05 Peptimmune, Inc. Effective quantitation of complex peptide mixtures in tissue samples and improved therapeutic methods
US20060003384A1 (en) 2004-06-30 2006-01-05 Wagner Carrie L Detection of measurement of antibodies to antigenic proteins in biological tissues or samples
US20060253263A1 (en) 2005-04-11 2006-11-09 Meshkin Brian J Method to optimize drug selection, dosing and evaluation and to help predict therapeutic response and toxicity from immunosuppressant therapy
EP1902320B1 (en) 2005-05-20 2010-03-10 Genentech, Inc. Pretreatment of a biological sample from an autoimmune disease subject
SG164379A1 (en) 2005-07-21 2010-09-29 Genmab As Potency assays for antibody drug substance binding to an fc receptor
EP1937307A4 (en) 2005-09-14 2009-05-13 Hutchinson Fred Cancer Res SPECIFIC REMOVAL OF ACTIVATED IMMUNOCELLS
US7542502B2 (en) 2005-09-27 2009-06-02 Cymer, Inc. Thermal-expansion tolerant, preionizer electrode for a gas discharge laser
US7611702B2 (en) 2005-11-08 2009-11-03 Medarex, Inc. TNF-alpha blocker treatment for enterocolitis associated with immunostimulatory therapeutic antibody therapy
JP2007147367A (ja) 2005-11-25 2007-06-14 Sekisui Chem Co Ltd サイトカイン産生能の測定方法
DE102005057920A1 (de) 2005-12-02 2007-06-28 Strohner, Pavel, Dr. Immunoassay zur simultanen immunchemischen Bestimmung eines Analyten (Antigen) und eines gegen den Analyten gerichteten Therapieantikörpers in Proben
EP1857559A1 (en) * 2006-05-16 2007-11-21 INSERM (Institut National de la Santé et de la Recherche Médicale) A method for predicting responsiveness to TNF alpha blocking agents
WO2008008349A2 (en) 2006-07-11 2008-01-17 Drexel University Methods of quantitatively assessing inflammation with biosensing nanoparticles
US20080286774A1 (en) 2007-05-16 2008-11-20 The Regents Of The University Of California Real-time individualized therapy evaluation
BRPI0813583A2 (pt) 2007-07-13 2014-12-30 Prometheus Lab Inc Métodos para selecionar um medicamento anticâncer, para identificar a resposta de um tumor pulmonar, e para prognosticar a resposta de um paciente, e, arranjo
US20090035216A1 (en) * 2007-08-03 2009-02-05 Biomonitor Aps Method for determining in vivo biopharmaceutical concentration or bioavailability
EP2200613B1 (en) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazine derivatives and uses thereof
CN101214372A (zh) * 2008-01-04 2008-07-09 中国人民解放军第四军医大学 一种体内诱导出针对TNF-α分子的自身抗体的蛋白疫苗的构建方法
US20110020840A1 (en) 2008-01-15 2011-01-27 Gerrit Jan Wolbink Method and kits for detecting antibodies against therapeutic antibodies
US20090234202A1 (en) 2008-03-05 2009-09-17 Goix Philippe J Method and compositions for highly sensitive detection of molecules
MX2012004877A (es) 2009-10-26 2012-05-23 Prometheus Lab Inc Analisis para la deteccion de farmacos anti-tnf y autoanticuerpos.
JP5066222B2 (ja) 2010-05-31 2012-11-07 三菱電機株式会社 ネットワーク解析支援装置、ネットワーク解析支援方法及びプログラム
CN103261222B (zh) 2010-09-10 2017-07-28 医疗免疫有限公司 抗体衍生物
EP2630495B1 (en) 2010-10-18 2017-02-08 Nestec S.A. Methods for determining anti-drug antibody isotypes
DK2676137T3 (en) 2011-02-17 2015-01-19 Nestec Sa TESTS TO DETECT AUTO ANTIBODIES FOR ANTI-TNF PHARMACEUTICALS
WO2012151247A2 (en) 2011-05-02 2012-11-08 Millennium Pharmaceuticals, Inc. FORMULATION FOR ANTI-α4β7 ANTIBODY
AU2012277185A1 (en) 2011-06-30 2014-02-13 Gene Techno Science Co., Ltd. Soluble integrin alpha4 mutant
US20130266963A1 (en) 2011-07-06 2013-10-10 Nestec S.A. Assay for detecting neutralizing autoantibodies to biologic therapy
EP3130921B1 (en) 2011-07-06 2018-09-12 Nestec S.A. Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha
US20140051184A1 (en) 2012-08-15 2014-02-20 Nestec S.A. Mobility shift assays for detecting anti-tnf alpha drugs and autoantibodies thereto
US20130295685A1 (en) 2012-04-10 2013-11-07 Nestec S.A. Mobility shift assays for detecting anti-tnf alpha drugs and autoantibodies
BR112015012482A2 (pt) 2012-11-30 2017-07-11 Nestec Sa ensaios para detecção de autoanticorpos neutralizantes à terapia com produtos biológicos
SG11201602671WA (en) 2013-11-13 2016-05-30 Pfizer Tumor necrosis factor-like ligand 1a specific antibodies and compositions and uses thereof
CN107250798A (zh) 2014-12-05 2017-10-13 雀巢产品技术援助有限公司 用于检测患者样品中的生物制品的间接均相迁移率变动试验
KR102423893B1 (ko) 2015-03-31 2022-07-21 삼성디스플레이 주식회사 플렉서블 표시 장치
CA3045307A1 (en) 2016-12-14 2018-06-21 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a tnf inhibitor

Also Published As

Publication number Publication date
MX2013015420A (es) 2015-01-22
US9465027B2 (en) 2016-10-11
AU2016201196A1 (en) 2016-03-17
EP3130921A1 (en) 2017-02-15
JP2014525036A (ja) 2014-09-25
AU2012278802A1 (en) 2013-05-02
SG10201605516YA (en) 2016-08-30
AU2012278802B2 (en) 2015-11-26
HK1194467A1 (zh) 2014-10-17
EP3130921B1 (en) 2018-09-12
JP6181646B2 (ja) 2017-08-16
EP2729807A1 (en) 2014-05-14
AU2016201196B2 (en) 2018-01-25
KR20140047628A (ko) 2014-04-22
CN103782172A (zh) 2014-05-07
NZ619172A (en) 2016-01-29
EP2729807B1 (en) 2016-08-17
US20170176433A1 (en) 2017-06-22
US10794906B2 (en) 2020-10-06
US20140186973A1 (en) 2014-07-03
WO2013006810A1 (en) 2013-01-10
RU2013158256A (ru) 2015-07-10
CA2840232A1 (en) 2013-01-10
ZA201309703B (en) 2019-09-25

Similar Documents

Publication Publication Date Title
MX343324B (es) Ensayos para detectar auto anticuerpos neutralizadores de la terapia biologica con tnf alpha.
MX2015006852A (es) Ensayos para detectar autoanticuerpos neutralizantes para terapia biologica.
MX343327B (es) Ensayos para detectar autoanticuerpos contra farmacos anti-tnfa.
MX390772B (es) Métodos para tratar cáncer y el uso de biomarcadores como predictor de sensibilidad clínica a terapias.
AU2018260845A1 (en) Evaluation and treatment of bradykinin-mediated disorders
MX367046B (es) Marcadores especificos de via para diagnosticar sindrome del intestino irritable.
BR112012009855A2 (pt) métodos para determinar uma quantidade eficaz de uma droga, para otimizar a terapia e/ou reduzir as toxicidade a uma droga, para determinar a presença ou nível de uma droga, para otimizar a quantidade terapêutica de uma droga e para determinar a presença ou nível de um autoanticorpo para uma droga, e, kit
BRPI1007321A2 (pt) métodos para medir e/ou quantificar a presença e/ou quantidade de her-3 ou her-3 em um complexo em uma amostra de um paciente, e para determinar se um indivíduo com um câncer é provável de responder ao tratamento com uma terapia alvejada, e, anticorpo.
MX349561B (es) Método para detectar nucleosomas que contienen variantes de histonas.
NZ627443A (en) Biological markers for identifying patients for treatment with vegf antagonists
MY162697A (en) Methods, devices and kits for detecting or monitoring acute kidney injury
BR112014031365A2 (pt) métodos de detectar doenças ou condições
WO2014153099A3 (en) Method for using exhaled breath to determine the presence of drug
GB201009641D0 (en) Methods of monitoring conditions by sequence analysis
MX2014007846A (es) Metodo y aparato para evaluar actividad de usuario en un sistema social anonimo.
WO2014121272A3 (en) Measurement and comparison of immune diversity by high-throughput sequencing
MX2015000686A (es) Metodo para detectar cancer.
SG10201806729VA (en) Novel assay to detect human periostin
BR112014001979A2 (pt) uso do anticorpo i-3859 para a detecção e diagnóstico de câncer
BR112015013771A2 (pt) biomarcador preditivo de resposta ao tratamento de ativador do receptor alfa 7 nicotínico de acetilcolina
MX2016005313A (es) Deteccion de la actividad de corte de una enzima.
WO2014052921A3 (en) Patient health record similarity measure
EP4591867A3 (en) Methods for detecting bordetella
WO2011085057A3 (en) Methods for detecting insulin autoantibody
MX2015004419A (es) Deteccion de analito y determinacion de concentracion de analito mediante uso de perlas magnetizables.

Legal Events

Date Code Title Description
FG Grant or registration