MX338489B - Derivados de hidantoina utiles como inhibidores de kv3. - Google Patents
Derivados de hidantoina utiles como inhibidores de kv3.Info
- Publication number
- MX338489B MX338489B MX2013006343A MX2013006343A MX338489B MX 338489 B MX338489 B MX 338489B MX 2013006343 A MX2013006343 A MX 2013006343A MX 2013006343 A MX2013006343 A MX 2013006343A MX 338489 B MX338489 B MX 338489B
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitors
- derivatives useful
- hydantoin derivatives
- hydantoin
- compounds
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 229940053195 antiepileptics hydantoin derivative Drugs 0.000 title 1
- 150000001469 hydantoins Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2010/068946 WO2011069951A1 (en) | 2009-12-11 | 2010-12-06 | Imidazolidinedione derivatives |
| GBGB1020607.6A GB201020607D0 (en) | 2010-12-06 | 2010-12-06 | Novel compounds |
| GBGB1109508.0A GB201109508D0 (en) | 2011-06-07 | 2011-06-07 | Novel compounds |
| GBGB1113757.7A GB201113757D0 (en) | 2011-08-10 | 2011-08-10 | Novel compounds |
| PCT/GB2011/052414 WO2012076877A1 (en) | 2010-12-06 | 2011-12-06 | Hydantoin derivatives useful as kv3 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013006343A MX2013006343A (es) | 2013-09-13 |
| MX338489B true MX338489B (es) | 2016-04-18 |
Family
ID=45464001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013006343A MX338489B (es) | 2010-12-06 | 2011-12-06 | Derivados de hidantoina utiles como inhibidores de kv3. |
Country Status (17)
| Country | Link |
|---|---|
| US (13) | US9346790B2 (enExample) |
| EP (1) | EP2649066B1 (enExample) |
| JP (2) | JP5913357B2 (enExample) |
| KR (1) | KR101862375B1 (enExample) |
| CN (1) | CN103328467B (enExample) |
| AU (1) | AU2011340258C1 (enExample) |
| BR (1) | BR112013013914B1 (enExample) |
| CA (1) | CA2817205C (enExample) |
| DK (1) | DK2649066T3 (enExample) |
| EA (2) | EA023768B1 (enExample) |
| ES (1) | ES2560304T3 (enExample) |
| IL (3) | IL226256A0 (enExample) |
| MX (1) | MX338489B (enExample) |
| PL (1) | PL2649066T3 (enExample) |
| SG (2) | SG190203A1 (enExample) |
| WO (1) | WO2012076877A1 (enExample) |
| ZA (1) | ZA201403529B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012015868A2 (pt) * | 2009-12-11 | 2017-06-20 | Autifony Therapeutics Ltd | derivados de imidazolidinadiona |
| SG190203A1 (en) | 2010-12-06 | 2013-06-28 | Autifony Therapeutics Ltd | Hydantoin derivatives useful as kv3 inhibitors |
| EP2718285B1 (en) | 2011-06-07 | 2016-03-16 | Autifony Therapeutics Limited | Hydantoin derivatives as kv3 inhibitors |
| GB201209986D0 (en) | 2012-06-06 | 2012-07-18 | Autifony Therapeutics Ltd | Novel compounds |
| ES2576628T3 (es) * | 2011-12-06 | 2016-07-08 | Autifony Therapeutics Limited | Derivados de hidantoína útiles como inhibidores de Kv3 |
| WO2013175211A1 (en) * | 2012-05-22 | 2013-11-28 | Autifony Therapeutics Limited | Hydantoin derivatives as kv3 inhibitors |
| US9422252B2 (en) | 2012-05-22 | 2016-08-23 | Autifony Therapeutics Limited | Triazoles as Kv3 inhibitors |
| WO2013182851A1 (en) * | 2012-06-06 | 2013-12-12 | Autifony Therapeutics Limited | Prophylaxis or treatment of diseases where a modulator of kv3.3 channels is required |
| US9416115B2 (en) * | 2013-12-20 | 2016-08-16 | Gilead Scineces, Inc. | Fused heterocyclic compounds as ion channel modulators |
| KR102381584B1 (ko) | 2014-01-16 | 2022-04-04 | 에프엠씨 코포레이션 | 제초제로서의 피리미디닐옥시 벤젠 유도체 |
| WO2015140326A1 (en) * | 2014-03-21 | 2015-09-24 | Biotage Ab | Method and apparatus for the equilibration of a packed chromatography column |
| CN103980205B (zh) * | 2014-06-05 | 2016-01-20 | 武汉格罗宁根医药科技有限公司 | N-3-取代磺酰胺乙基-5-环丙烷螺环乙内酰脲衍生物及其制备方法和应用 |
| TWI713530B (zh) | 2015-06-05 | 2020-12-21 | 美商艾佛艾姆希公司 | 作為除草劑之嘧啶氧基苯衍生物 |
| GB201521751D0 (en) * | 2015-12-10 | 2016-01-27 | Autifony Therapeutics Ltd | Novel uses |
| GB201522179D0 (en) * | 2015-12-16 | 2016-01-27 | Autifony Therapeutics Ltd | Novel compounds |
| GB201613163D0 (en) | 2016-07-29 | 2016-09-14 | Autifony Therapeutics Ltd | Novel compounds |
| WO2018109484A1 (en) | 2016-12-16 | 2018-06-21 | Autifony Therapeutics Limited | Hydantoin modulators of kv3 channels |
| CA3062135A1 (en) * | 2017-05-02 | 2018-11-08 | Fmc Corporation | Pyrimidinyloxy benzo-fused compounds as herbicides |
| WO2018220762A1 (ja) * | 2017-05-31 | 2018-12-06 | 大塚製薬株式会社 | ピリミジン化合物 |
| CN107556262B (zh) * | 2017-08-14 | 2020-05-22 | 四川大学 | 一种2-取代基芳并噁唑的制备方法 |
| US11486289B2 (en) * | 2018-07-03 | 2022-11-01 | Cummins Emission Solutions Inc. | Body mixing decomposition reactor |
| US12358901B2 (en) | 2018-10-16 | 2025-07-15 | Autifony Therapeutics Limited | KV3 modulators |
| ES2988842T3 (es) | 2018-10-16 | 2024-11-21 | Autifony Therapeutics Ltd | Nuevos compuestos |
| TWI877067B (zh) | 2018-11-30 | 2025-03-11 | 日商大塚製藥股份有限公司 | 雜環化合物 |
| GB201821066D0 (en) * | 2018-12-21 | 2019-02-06 | Univ Oxford Innovation Ltd | Sleep modulation |
| AU2019296526A1 (en) * | 2019-03-25 | 2021-09-16 | Bionomics Limited | Substituted-N-heteroaryl compounds and uses thereof |
| EP4100402A1 (en) | 2020-02-06 | 2022-12-14 | Autifony Therapeutics Limited | Kv3 modulators |
| US11638606B2 (en) | 2020-04-15 | 2023-05-02 | Bard Peripheral Vascular, Inc. | Bipolar electrosurgical pleura sealing device, system, and method of operating same |
| EP3901152A1 (en) | 2020-04-23 | 2021-10-27 | F. Hoffmann-La Roche AG | Kv3 enhancers for the treatment of cognitive disorders |
| CN112213428A (zh) * | 2020-10-13 | 2021-01-12 | 辽宁科技大学 | 一种超临界co2中进行非催化乙酰基化反应及其在线检测方法 |
| JP2024530208A (ja) | 2021-08-10 | 2024-08-16 | アウトイフオンイ トヘラペウトイクス リミテッド | カリウムチャネルモジュレーター |
| KR20230084419A (ko) * | 2021-12-03 | 2023-06-13 | (주)인비보텍 | 난청 또는 이명의 예방 또는 치료용 조성물 |
| EP4630117A1 (en) | 2022-12-06 | 2025-10-15 | Autifony Therapeutics Limited | Compounds for the treatment of centra nervous system disorders |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3474170A (en) * | 1964-01-23 | 1969-10-21 | Fmc Corp | Pesticidal carbamates of dihydrobenzofuranols |
| US4143055A (en) * | 1978-03-27 | 1979-03-06 | Gruppo Lepetit S.P.A. | 2,4,6-trisubstituted-2,3-dihydro-benzofuran derivatives |
| DE3015090A1 (de) | 1980-04-19 | 1981-10-22 | Basf Ag, 6700 Ludwigshafen | ]-(trihalogenmethyl-sulfenyl)-4-aryl-1,2,4-triazolidin-5-one, verfahren zu ihrer herstellung, diese enthaltende fungizide und verfahren zur bekaempfung von pilzen mit diesen verbindungen |
| DE3133405A1 (de) | 1981-08-24 | 1983-03-10 | Basf Ag, 6700 Ludwigshafen | 1-(trihalogenmethyl-sulfenyl)-4-aryl-1,2,4-triazolidin-5-one und diese enthaltende fungizide |
| US4675403A (en) | 1985-10-16 | 1987-06-23 | American Home Products Corporation | 3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity |
| JP2514945B2 (ja) * | 1987-02-05 | 1996-07-10 | 三井石油化学工業株式会社 | 芳香族アミン誘導体 |
| DE3810848A1 (de) | 1988-03-30 | 1989-10-19 | Boehringer Ingelheim Kg | Neue 2,3,4-substituierte imidazole und 3,4,5-substituierte 1,2,4-triazole, ihre herstellung und verwendung |
| DE3836175A1 (de) | 1988-10-24 | 1990-05-03 | Bayer Ag | Fluor enthaltende phenole |
| CA2007830A1 (en) * | 1989-01-18 | 1990-07-18 | Shuji Ozawa | 2,3-dihydro-3, 3-dimethyl-5-trifluoromethanesulfonyloxy-benzofurans, process for producing them and herbicides containing them |
| MX22406A (es) | 1989-09-15 | 1994-01-31 | Pfizer | Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat). |
| JPH03153606A (ja) * | 1989-11-10 | 1991-07-01 | Mitsui Petrochem Ind Ltd | 除草剤組成物 |
| US5362878A (en) | 1991-03-21 | 1994-11-08 | Pfizer Inc. | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) |
| DK123493D0 (da) | 1993-11-01 | 1993-11-01 | Lundbeck & Co As H | Compounds |
| WO1996036229A1 (en) | 1995-05-17 | 1996-11-21 | E.I. Du Pont De Nemours And Company | Fungicidal cyclic amides |
| BR9608520A (pt) | 1995-05-17 | 1999-06-08 | Du Pont | Composto composição fungida e método para controlede doenças de plantas |
| KR19990028230A (ko) | 1995-06-20 | 1999-04-15 | 미리암 디. 메코너헤이 | 살절지동물성 및 살진균성 시클릭 아미드 |
| EP0934283A2 (en) | 1996-08-01 | 1999-08-11 | E.I. Du Pont De Nemours And Company | Arthropodicidal and fungicidal cyclic amides |
| WO1998023155A1 (en) | 1996-11-26 | 1998-06-04 | E.I. Du Pont De Nemours And Company | Arthropodicidal and fungicidal cyclic amides |
| EP0944314A1 (en) | 1996-11-26 | 1999-09-29 | E.I. Du Pont De Nemours And Company | Methyl substituted fungicides and arthropodicides |
| AU6040398A (en) | 1997-01-30 | 1998-08-25 | E.I. Du Pont De Nemours And Company | Fungicidal compositions |
| JP4171549B2 (ja) | 1998-01-28 | 2008-10-22 | 大正製薬株式会社 | 含フッ素アミノ酸誘導体 |
| JP2000072731A (ja) | 1998-08-31 | 2000-03-07 | Taisho Pharmaceut Co Ltd | ４−置換−２−アミノビシクロ［３．１．０］ヘキサン−２，６−ジカルボン酸誘導体及び製薬用組成物 |
| JP4194715B2 (ja) | 1998-08-31 | 2008-12-10 | 大正製薬株式会社 | ６−フルオロビシクロ［３．１．０］ヘキサン誘導体 |
| US7008954B1 (en) | 1999-07-23 | 2006-03-07 | Shionogi & Co., Ltd. | Th2 differentiation inhibitors |
| EP1273287A1 (en) | 2000-04-04 | 2003-01-08 | Shionogi & Co., Ltd. | Oily compositions containing highly fat-soluble drugs |
| WO2001076582A1 (fr) | 2000-04-05 | 2001-10-18 | Shionogi & Co., Ltd. | Micro-emulsions huile dans eau contenant des composes tricycliques ou des preconcentres de ceux-ci |
| FR2812633A1 (fr) | 2000-08-04 | 2002-02-08 | Aventis Cropscience Sa | Derives de phenyl(thio)urees et phenyl(thio)carbamates fongicides |
| WO2003048134A1 (en) | 2001-12-05 | 2003-06-12 | Japan Tobacco Inc. | Triazole compound and medicinal use thereof |
| JP2005521676A (ja) | 2002-02-07 | 2005-07-21 | ザ キュレイターズ オブ ザ ユニバーシティ オブ ミズーリ | オピオイドレセプター作動性４−（３−ヒドロキシフェニル）または４−（３−アルコキシフェニル）−１，２，４−トリアゾール化合物 |
| FI20030030A0 (fi) * | 2003-01-09 | 2003-01-09 | Orion Corp | Uusia yhdisteitä |
| ES2290743T3 (es) | 2003-04-30 | 2008-02-16 | The Institutes For Pharmaceutical Discovery, Llc | Heteroarilos sustituidos como inhibidores de las proteina-tirosina fosfatasas. |
| WO2005000309A2 (en) | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Chemical compounds |
| GB0325175D0 (en) | 2003-10-28 | 2003-12-03 | Novartis Ag | Organic compounds |
| US7256208B2 (en) | 2003-11-13 | 2007-08-14 | Bristol-Myers Squibb Company | Monocyclic N-Aryl hydantoin modulators of androgen receptor function |
| US20060211697A1 (en) | 2004-12-08 | 2006-09-21 | Liren Huang | 2-(2 Or 4-substituted aryloxy)-phenol derivatives as antibacterial agents |
| AU2007245022A1 (en) | 2006-03-29 | 2007-11-08 | The Regents Of The University Of California | Diarylthiohydantoin compounds |
| US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
| CA2608436C (en) | 2005-05-13 | 2015-03-24 | The Regents Of The University Of California | Diarylhydantoin compounds and their use in the treatment of hyperproliferative disorders |
| EP3100727B1 (en) | 2006-03-27 | 2018-08-22 | The Regents of The University of California | Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases |
| WO2008017381A1 (de) | 2006-08-08 | 2008-02-14 | Sanofi-Aventis | Arylaminoaryl-alkyl-substituierte imidazolidin-2,4-dione, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| EP2146717A4 (en) | 2007-04-20 | 2010-08-11 | Deciphera Pharmaceuticals Llc | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYOLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES |
| EP2252592A1 (de) | 2008-02-07 | 2010-11-24 | Sanofi-Aventis | Arylchalcogeno-arylalkyl-substituierte imidazolidin-2,4-dione, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| CN103396402A (zh) * | 2008-09-02 | 2013-11-20 | 赛诺菲-安万特 | 取代的氨基茚满及其类似物以及其医药用途 |
| EP2379534A1 (en) * | 2008-12-22 | 2011-10-26 | F. Hoffmann-La Roche AG | Heterocyclic antiviral compounds |
| BR112012015868A2 (pt) | 2009-12-11 | 2017-06-20 | Autifony Therapeutics Ltd | derivados de imidazolidinadiona |
| TW201144298A (en) * | 2009-12-14 | 2011-12-16 | Hoffmann La Roche | Heterocyclic antiviral compounds |
| SG190203A1 (en) * | 2010-12-06 | 2013-06-28 | Autifony Therapeutics Ltd | Hydantoin derivatives useful as kv3 inhibitors |
| EP2718285B1 (en) | 2011-06-07 | 2016-03-16 | Autifony Therapeutics Limited | Hydantoin derivatives as kv3 inhibitors |
| JP2018533579A (ja) | 2015-10-30 | 2018-11-15 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 高分子量かつ密な被覆を有する粘液浸透粒子 |
-
2011
- 2011-12-06 SG SG2013035357A patent/SG190203A1/en unknown
- 2011-12-06 EA EA201390609A patent/EA023768B1/ru not_active IP Right Cessation
- 2011-12-06 ES ES11805571.4T patent/ES2560304T3/es active Active
- 2011-12-06 PL PL11805571T patent/PL2649066T3/pl unknown
- 2011-12-06 CA CA2817205A patent/CA2817205C/en active Active
- 2011-12-06 US US13/991,486 patent/US9346790B2/en active Active
- 2011-12-06 EP EP11805571.4A patent/EP2649066B1/en active Active
- 2011-12-06 BR BR112013013914-5A patent/BR112013013914B1/pt active IP Right Grant
- 2011-12-06 AU AU2011340258A patent/AU2011340258C1/en active Active
- 2011-12-06 JP JP2013542606A patent/JP5913357B2/ja active Active
- 2011-12-06 CN CN201180058712.3A patent/CN103328467B/zh active Active
- 2011-12-06 DK DK11805571.4T patent/DK2649066T3/en active
- 2011-12-06 MX MX2013006343A patent/MX338489B/es active IP Right Grant
- 2011-12-06 KR KR1020137017537A patent/KR101862375B1/ko active Active
- 2011-12-06 WO PCT/GB2011/052414 patent/WO2012076877A1/en not_active Ceased
-
2012
- 2012-12-06 EA EA201490922A patent/EA027532B1/ru not_active IP Right Cessation
- 2012-12-06 US US14/361,510 patent/US9133175B2/en active Active
- 2012-12-06 SG SG11201402529RA patent/SG11201402529RA/en unknown
-
2013
- 2013-05-09 IL IL226256A patent/IL226256A0/en unknown
-
2014
- 2014-05-15 ZA ZA2014/03529A patent/ZA201403529B/en unknown
-
2015
- 2015-08-03 US US14/816,476 patent/US9422272B2/en active Active
-
2016
- 2016-02-10 JP JP2016023519A patent/JP6118927B2/ja active Active
- 2016-04-07 US US15/093,004 patent/US20160251340A1/en not_active Abandoned
- 2016-07-11 US US15/206,465 patent/US9833452B2/en active Active
-
2017
- 2017-06-13 US US15/621,400 patent/US10265316B2/en active Active
- 2017-06-22 IL IL253104A patent/IL253104A0/en unknown
- 2017-06-22 IL IL253102A patent/IL253102B/en active IP Right Grant
- 2017-10-11 US US15/730,559 patent/US10098881B2/en active Active
-
2018
- 2018-09-07 US US16/125,148 patent/US10555945B2/en active Active
-
2019
- 2019-02-26 US US16/285,996 patent/US20190192516A1/en not_active Abandoned
- 2019-12-23 US US16/725,709 patent/US10835534B2/en active Active
-
2020
- 2020-08-04 US US16/985,160 patent/US11197859B2/en active Active
- 2020-09-23 US US17/030,268 patent/US11541052B2/en active Active
-
2021
- 2021-11-02 US US17/517,620 patent/US11583527B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX338489B (es) | Derivados de hidantoina utiles como inhibidores de kv3. | |
| MX356813B (es) | Derivados de hidantoina utiles como inhibidores de kv3. | |
| IN2015DN01156A (enExample) | ||
| SG179085A1 (en) | Pi3 kinase inhibitors and uses thereof | |
| WO2014028600A3 (en) | 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF | |
| PH12012500674A1 (en) | Heterocyclic compounds useful as pdk1 inhibitors | |
| JO2892B1 (en) | CYP inhibitors 17 | |
| CA2871471C (en) | Dna-pk inhibitors | |
| PH12016500105A1 (en) | Sulfonamides as modulators of sodium channels | |
| MY181898A (en) | Heterocyclic compounds and uses thereof | |
| EA201170832A1 (ru) | Пуриновые соединения | |
| MY165620A (en) | Cyclopropylamines as lsd1 inhibitors | |
| TN2011000673A1 (en) | Bace inhibitors | |
| UA105911C2 (uk) | Сульфонамідні похідні | |
| UA104885C2 (uk) | Ізотіазолілоксифеніламідини та їх застосування як фунгіцидів | |
| UA111075C2 (uk) | Триазолопіридинові сполуки як інгібітори кінази рім | |
| MX2012004780A (es) | Inhibidores de akt. | |
| MX2014012477A (es) | Inhibidores pirrolopirazona de tanquirasa. | |
| EP2603216A4 (en) | HETEROARYLE AND USES THEREOF | |
| CA2929436C (en) | Compounds, pharmaceutical composition and methods for use in treating inflammatory diseases | |
| MX342947B (es) | Tratamiento de diabetes tipo 2. | |
| CA2887539C (en) | Azaquinazoline carboxamide derivatives | |
| MX2013002121A (es) | Quinolina-3-carboxamidas sustituidas como moduladores de kcnq2/3. | |
| EA201270728A1 (ru) | Пуриновые соединения | |
| UA109793C2 (uk) | Арилсульфонаміди для лікування захворювань центральної нервової системи (цнс) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |