MX2020003488A - Acidos 3-alquil-4-amido-biciclico [4,5,0] hidroxamicos como inhibidores de histona desacetilasas (hdac). - Google Patents
Acidos 3-alquil-4-amido-biciclico [4,5,0] hidroxamicos como inhibidores de histona desacetilasas (hdac).Info
- Publication number
- MX2020003488A MX2020003488A MX2020003488A MX2020003488A MX2020003488A MX 2020003488 A MX2020003488 A MX 2020003488A MX 2020003488 A MX2020003488 A MX 2020003488A MX 2020003488 A MX2020003488 A MX 2020003488A MX 2020003488 A MX2020003488 A MX 2020003488A
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- sup
- amido
- bicyclic
- alkyl
- hdac inhibitors
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Abstract
(ver fórmula) La presente descripción hace referencia a inhibidores de histona desacetilasas (HDAC) dependientes de cinc útiles en el tratamiento de enfermedades o trastornos asociados con una HDAC, p. ej., HDAC6, con la fórmula I: en la que R, L, X1, X2, X3, X4, Y1, Y2, Y3 e Y4 se describen en la presente.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562110716P | 2015-02-02 | 2015-02-02 | |
US201562205438P | 2015-08-14 | 2015-08-14 | |
PCT/US2016/016201 WO2016126725A1 (en) | 2015-02-02 | 2016-02-02 | 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020003488A true MX2020003488A (es) | 2022-05-24 |
Family
ID=55353351
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017009950A MX2017009950A (es) | 2015-02-02 | 2016-02-02 | Acidos 3-alquil-4-amido-biciclico [4,5,0] hidroxamicos como inhibidores de histona desacetilasas (hdac). |
MX2020003488A MX2020003488A (es) | 2015-02-02 | 2016-02-02 | Acidos 3-alquil-4-amido-biciclico [4,5,0] hidroxamicos como inhibidores de histona desacetilasas (hdac). |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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MX2017009950A MX2017009950A (es) | 2015-02-02 | 2016-02-02 | Acidos 3-alquil-4-amido-biciclico [4,5,0] hidroxamicos como inhibidores de histona desacetilasas (hdac). |
Country Status (27)
Country | Link |
---|---|
US (32) | US10112915B2 (es) |
EP (3) | EP4015514A1 (es) |
JP (1) | JP6668362B2 (es) |
KR (1) | KR102633628B1 (es) |
CN (3) | CN107801396B (es) |
AU (4) | AU2016215431B2 (es) |
BR (1) | BR112017016493B1 (es) |
CA (2) | CA2975605C (es) |
CL (1) | CL2017001968A1 (es) |
CO (1) | CO2017007863A2 (es) |
DK (1) | DK3292116T3 (es) |
EA (2) | EA036711B1 (es) |
EC (1) | ECSP17055491A (es) |
ES (2) | ES2770123T3 (es) |
HK (2) | HK1251550A1 (es) |
HU (1) | HUE057623T2 (es) |
IL (4) | IL280856B (es) |
MA (1) | MA42032A (es) |
MX (2) | MX2017009950A (es) |
MY (1) | MY191591A (es) |
PH (1) | PH12017501383A1 (es) |
PL (1) | PL3292116T3 (es) |
PT (1) | PT3292116T (es) |
SA (1) | SA517382027B1 (es) |
SG (4) | SG10202100915RA (es) |
TW (6) | TWI712591B (es) |
WO (4) | WO2016126721A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201636329A (zh) | 2015-02-02 | 2016-10-16 | 佛瑪治療公司 | 作為hdac抑制劑之雙環[4,6,0]異羥肟酸 |
US10112915B2 (en) | 2015-02-02 | 2018-10-30 | Forma Therapeutics, Inc. | 3-aryl bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors |
WO2016149099A1 (en) | 2015-03-13 | 2016-09-22 | Forma Therapeutics, Inc. | Alpha-cinnamide compounds and compositions as hdac8 inhibitors |
TW201711999A (zh) | 2015-09-03 | 2017-04-01 | 佛瑪治療公司 | ﹝6,6﹞稠合雙環組蛋白脫乙醯基酶8(hdac8)抑制劑 |
US10555935B2 (en) | 2016-06-17 | 2020-02-11 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors |
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JP7064512B2 (ja) * | 2017-05-17 | 2022-05-10 | デナリ セラピューティクス インコーポレイテッド | キナーゼ阻害剤およびその使用 |
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