CY1126110T1 - Παραγωγα βενζοϋδροξαμικου οξεος ως εκλεκτικοι αναστολε1σ του hdac6 - Google Patents

Παραγωγα βενζοϋδροξαμικου οξεος ως εκλεκτικοι αναστολε1σ του hdac6

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Publication number
CY1126110T1
CY1126110T1 CY20231100364T CY231100364T CY1126110T1 CY 1126110 T1 CY1126110 T1 CY 1126110T1 CY 20231100364 T CY20231100364 T CY 20231100364T CY 231100364 T CY231100364 T CY 231100364T CY 1126110 T1 CY1126110 T1 CY 1126110T1
Authority
CY
Cyprus
Prior art keywords
hdac6
acid derivatives
selective inhibitors
benzohydroxamic acid
benzohydroxamic
Prior art date
Application number
CY20231100364T
Other languages
English (en)
Inventor
Barbara Vergani
Gianluca CAPRINI
Gianluca Fossati
Maria Lattanzio
Mattia MARCHINI
Gianfranco Pavich
Marcello PEZZUTO
Chiara RIPAMONTI
Giovanni SANDRONE
Christian STEINKÜHLER
Andrea Stevenazzi
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Publication of CY1126110T1 publication Critical patent/CY1126110T1/el

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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Abstract

Η παρούσα εφεύρεση αφορά νέες ενώσεις βενζοϋδροξαμικού του τύπου (Ι) και (II) και φαρμακευτικά αποδεκτά άλατα, ισομερή και προφάρμακα αυτών, που παρουσιάζουν υψηλή εκλεκτική ανασταλτική δραστικότητα έναντι του ενζύμου αποακετυλάσης ιστονών 6 (HDAC6).
CY20231100364T 2017-04-14 2023-07-26 Παραγωγα βενζοϋδροξαμικου οξεος ως εκλεκτικοι αναστολε1σ του hdac6 CY1126110T1 (el)

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IT102017000041723A IT201700041723A1 (it) 2017-04-14 2017-04-14 Nuovi inibitori selettivi di HDAC6
PCT/EP2018/059468 WO2018189340A1 (en) 2017-04-14 2018-04-12 Selective hdac6 inhibitors

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WO2024071935A1 (ko) * 2022-09-27 2024-04-04 사회복지법인 삼성생명공익재단 히스톤 탈아세틸화효소 억제제를 포함하는 암 치료용 조성물, 및 암 면역치료용 항암 보조제
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