BR112015027114A8 - compostos inibidores seletivos de histona desacetilase, sua composição farmacêutica e seu uso - Google Patents
compostos inibidores seletivos de histona desacetilase, sua composição farmacêutica e seu uso Download PDFInfo
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- BR112015027114A8 BR112015027114A8 BR112015027114A BR112015027114A BR112015027114A8 BR 112015027114 A8 BR112015027114 A8 BR 112015027114A8 BR 112015027114 A BR112015027114 A BR 112015027114A BR 112015027114 A BR112015027114 A BR 112015027114A BR 112015027114 A8 BR112015027114 A8 BR 112015027114A8
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
resumo novos compostos para os inibidores seletivos de histona desacetilase, e composição farmacêutica compreendendo os mesmos a presente invenção refere-se a novos derivados de ureia e, mais particularmente, a novos derivados de ureia com histona-desacetilase (hdac) atividade inibidora, seus isômeros, sais farmaceuticamente aceitáveis dos mesmos, à sua utilização para a preparação de um medicamentos compreendendo a mesma, uma composição farmacêutica que compreende o mesmo, um método de tratamento utilizando a composição, e um método para a preparação de novos derivados de ureia. os novos derivados de ureia como inibidores da histona-desacetilase seletiva (hdac) são eficazes para o tratamento de doenças mediadas por histona-desacetilase, tais como tumores malignos, doenças inflamatórias, artrite reumatóide, neurodegeneração, etc.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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KR10-2013-0047212 | 2013-04-29 | ||
KR20130047212 | 2013-04-29 | ||
PCT/KR2014/003776 WO2014178606A1 (en) | 2013-04-29 | 2014-04-29 | Novel compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same |
Publications (3)
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BR112015027114A2 BR112015027114A2 (pt) | 2017-07-25 |
BR112015027114A8 true BR112015027114A8 (pt) | 2019-12-24 |
BR112015027114B1 BR112015027114B1 (pt) | 2021-12-21 |
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BR112015027114-6A BR112015027114B1 (pt) | 2013-04-29 | 2014-04-29 | Compostos inibidores seletivos de histona desacetilase e seu uso |
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US (1) | US9878986B2 (pt) |
EP (1) | EP2991982B1 (pt) |
JP (1) | JP6117430B2 (pt) |
KR (1) | KR101645379B1 (pt) |
CN (1) | CN105358556B (pt) |
AU (1) | AU2014260605B2 (pt) |
BR (1) | BR112015027114B1 (pt) |
CA (1) | CA2908542C (pt) |
DK (1) | DK2991982T3 (pt) |
ES (1) | ES2697775T3 (pt) |
HK (1) | HK1216532A1 (pt) |
HR (1) | HRP20181647T1 (pt) |
HU (1) | HUE041881T2 (pt) |
MX (1) | MX2015014962A (pt) |
MY (1) | MY184756A (pt) |
NZ (1) | NZ712696A (pt) |
PH (1) | PH12015502425B1 (pt) |
PL (1) | PL2991982T3 (pt) |
PT (1) | PT2991982T (pt) |
RU (1) | RU2634694C2 (pt) |
WO (1) | WO2014178606A1 (pt) |
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US10555935B2 (en) | 2016-06-17 | 2020-02-11 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors |
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WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
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KR20190099952A (ko) | 2018-02-20 | 2019-08-28 | 주식회사 종근당 | 포도막염의 예방 또는 치료를 위한 조성물 |
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KR20200061310A (ko) * | 2018-11-23 | 2020-06-02 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제를 포함하는 약학적 조성물 |
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2014
- 2014-04-29 RU RU2015150946A patent/RU2634694C2/ru active
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- 2014-04-29 CN CN201480024266.8A patent/CN105358556B/zh active Active
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