HRP20181647T1 - Novi spojevi koji su selektivni inhibitori histonske deacetilaze i farmaceutski pripravak koji ih sadrži - Google Patents

Novi spojevi koji su selektivni inhibitori histonske deacetilaze i farmaceutski pripravak koji ih sadrži

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Publication number
HRP20181647T1
HRP20181647T1 HRP20181647TT HRP20181647T HRP20181647T1 HR P20181647 T1 HRP20181647 T1 HR P20181647T1 HR P20181647T T HRP20181647T T HR P20181647TT HR P20181647 T HRP20181647 T HR P20181647T HR P20181647 T1 HRP20181647 T1 HR P20181647T1
Authority
HR
Croatia
Prior art keywords
pharmaceutical composition
same
novel compounds
histone deacetylase
deacetylase inhibitors
Prior art date
Application number
HRP20181647TT
Other languages
English (en)
Inventor
Changsik LEE
Hyun-Mo Yang
Hojin Choi
Dohoon Kim
Soyoung Kim
Nina Ha
Hyojin LIM
Eunhee KO
Seongae YOON
Daekwon BAE
Original Assignee
Chong Kun Dang Pharmaceutical Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chong Kun Dang Pharmaceutical Corp. filed Critical Chong Kun Dang Pharmaceutical Corp.
Publication of HRP20181647T1 publication Critical patent/HRP20181647T1/hr

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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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EP2991982A1 (en) 2016-03-09
BR112015027114A8 (pt) 2019-12-24
CA2908542A1 (en) 2014-11-06
KR101645379B1 (ko) 2016-08-03
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WO2014178606A1 (en) 2014-11-06
BR112015027114A2 (pt) 2017-07-25
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