IL121748A0 - Vanadium complexes of hydroxamates and pharmaceutical compositions comprising them - Google Patents

Vanadium complexes of hydroxamates and pharmaceutical compositions comprising them

Info

Publication number
IL121748A0
IL121748A0 IL12174897A IL12174897A IL121748A0 IL 121748 A0 IL121748 A0 IL 121748A0 IL 12174897 A IL12174897 A IL 12174897A IL 12174897 A IL12174897 A IL 12174897A IL 121748 A0 IL121748 A0 IL 121748A0
Authority
IL
Israel
Prior art keywords
hydroxamates
pharmaceutical compositions
vanadium complexes
vanadium
complexes
Prior art date
Application number
IL12174897A
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL12174897A priority Critical patent/IL121748A0/en
Publication of IL121748A0 publication Critical patent/IL121748A0/en
Priority to AU90939/98A priority patent/AU748278B2/en
Priority to KR1020007002553A priority patent/KR20010023870A/en
Priority to JP2000510690A priority patent/JP2001515874A/en
Priority to PCT/IL1998/000441 priority patent/WO1999012875A1/en
Priority to IL13495198A priority patent/IL134951A0/en
Priority to BR9812640-7A priority patent/BR9812640A/en
Priority to CA002303444A priority patent/CA2303444A1/en
Priority to CN98810940A priority patent/CN1278785A/en
Priority to US09/508,411 priority patent/US6414029B1/en
Priority to EP98942991A priority patent/EP1023251A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C9/00—Aliphatic saturated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/005—Compounds of elements of Group 5 of the Periodic System without metal-carbon linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
IL12174897A 1997-09-11 1997-09-11 Vanadium complexes of hydroxamates and pharmaceutical compositions comprising them IL121748A0 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IL12174897A IL121748A0 (en) 1997-09-11 1997-09-11 Vanadium complexes of hydroxamates and pharmaceutical compositions comprising them
EP98942991A EP1023251A1 (en) 1997-09-11 1998-09-10 Vanadium complexes of monohydroxamates and pharmaceutical compositions comprising them
PCT/IL1998/000441 WO1999012875A1 (en) 1997-09-11 1998-09-10 Vanadium complexes of monohydroxamates and pharmaceutical compositions comprising them
KR1020007002553A KR20010023870A (en) 1997-09-11 1998-09-10 Vanadium complexes of monohydroxamates and pharmaceutical compositions comprising them
JP2000510690A JP2001515874A (en) 1997-09-11 1998-09-10 Vanadium complex of monohydroxamic acid salt and pharmaceutical composition comprising the complex
AU90939/98A AU748278B2 (en) 1997-09-11 1998-09-10 Vanadium complexes of monohydroxamates and pharmaceutical compositions comprising them
IL13495198A IL134951A0 (en) 1997-09-11 1998-09-10 Vanadium complexes of hydroxamates and pharmaceutical compositions comprising them
BR9812640-7A BR9812640A (en) 1997-09-11 1998-09-10 Vanadium monohydroxamate complexes and pharmaceutical compositions comprising the same
CA002303444A CA2303444A1 (en) 1997-09-11 1998-09-10 Vanadium complexes of monohydroxamates and pharmaceutical compositions comprising them
CN98810940A CN1278785A (en) 1997-09-11 1998-09-10 Vanadium complexes of monohydroxamates and pharmaceutical compositions comprising them
US09/508,411 US6414029B1 (en) 1997-09-11 1998-09-10 Vanadium complexes of monohydroxamates and pharmaceutical compositions comprising them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL12174897A IL121748A0 (en) 1997-09-11 1997-09-11 Vanadium complexes of hydroxamates and pharmaceutical compositions comprising them

Publications (1)

Publication Number Publication Date
IL121748A0 true IL121748A0 (en) 1998-02-22

Family

ID=11070622

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12174897A IL121748A0 (en) 1997-09-11 1997-09-11 Vanadium complexes of hydroxamates and pharmaceutical compositions comprising them

Country Status (10)

Country Link
US (1) US6414029B1 (en)
EP (1) EP1023251A1 (en)
JP (1) JP2001515874A (en)
KR (1) KR20010023870A (en)
CN (1) CN1278785A (en)
AU (1) AU748278B2 (en)
BR (1) BR9812640A (en)
CA (1) CA2303444A1 (en)
IL (1) IL121748A0 (en)
WO (1) WO1999012875A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036066A2 (en) * 2000-11-01 2002-05-10 Yeda Research And Development Co. Ltd. Pharmaceutical compositions comprising organic vanadium complexes for treatment of ischemia
WO2007043606A1 (en) * 2005-10-12 2007-04-19 Genolac Bl Corporation Antidiabetic agent comprising anionic polyamino acid-metal complex
WO2009032591A1 (en) * 2007-08-28 2009-03-12 Akesis Pharmaceuticals Inc. Food effect in treatment of diabetes with vanadium salts
CN101953846B (en) * 2010-06-24 2011-12-28 攀枝花兴辰钒钛有限公司 Application of medicinal composition to preparing medicament for treating diabetes
CN101972273B (en) * 2010-10-29 2011-12-21 攀枝花兴辰钒钛有限公司 Application of medicine in preparing medicines for treating diabetes mellitus
CN102134738B (en) * 2010-12-24 2012-11-28 华东师范大学 Preparation method of oxalic acid hydroxylamine vanadium coordination compound crystalloid with bioactivity
AU2012226703A1 (en) * 2011-03-07 2013-10-17 Cfm Pharma Holding Bv Use of vanadium compounds for maintaining normaglycemia in a mammal
US20140018340A1 (en) 2011-03-25 2014-01-16 Mihir K. Chaudhuri Insulin Mimetic Active Comprising Oxodiperoxo Vanadates and a Pharmaceutical Composition Obtained Thereof
PL231079B1 (en) 2012-11-07 2019-01-31 Univ Jagiellonski Vanadium complexes with hydrazide-hydrazones, process for their preparation, pharmaceutical formulations and their use
MX2020003488A (en) 2015-02-02 2022-05-24 Forma Therapeutics Inc 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors.
AR103598A1 (en) 2015-02-02 2017-05-24 Forma Therapeutics Inc BICYCLIC ACIDS [4,6,0] HYDROXAMICS AS HDAC INHIBITORS
EP3472131B1 (en) 2016-06-17 2020-02-19 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2619382B1 (en) * 1987-08-11 1990-05-04 Lazaro Rene ORGANO-MINERAL VANADYL COMPOUND, PROCESS FOR OBTAINING SUCH A COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING THIS ORGANO-MINERAL COMPOUND
IL99666A (en) * 1991-10-07 1996-09-12 Yeda Res & Dev Vanadyl complexes of hydroxamate chelators and pharmaceutical compositions comprising them
US5338758A (en) * 1992-04-03 1994-08-16 Schering Corporation Bicyclic diterpene PAF antagonist compounds
US5804601A (en) * 1995-04-10 1998-09-08 Takeda Chemical Industries, Ltd. Aromatic hydroxamic acid compounds, their production and use

Also Published As

Publication number Publication date
CN1278785A (en) 2001-01-03
CA2303444A1 (en) 1999-03-18
BR9812640A (en) 2000-08-22
JP2001515874A (en) 2001-09-25
WO1999012875A1 (en) 1999-03-18
AU9093998A (en) 1999-03-29
US6414029B1 (en) 2002-07-02
EP1023251A1 (en) 2000-08-02
AU748278B2 (en) 2002-05-30
KR20010023870A (en) 2001-03-26

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