MEP26608A - Aminothiazole derivatives and their use as crf receptor ligands - Google Patents
Aminothiazole derivatives and their use as crf receptor ligandsInfo
- Publication number
- MEP26608A MEP26608A MEP-266/08A MEP26608A MEP26608A ME P26608 A MEP26608 A ME P26608A ME P26608 A MEP26608 A ME P26608A ME P26608 A MEP26608 A ME P26608A
- Authority
- ME
- Montenegro
- Prior art keywords
- receptor ligands
- crf receptor
- aminothiazole derivatives
- aminothiazole
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Dermatology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9909144A FR2796380B3 (fr) | 1999-07-15 | 1999-07-15 | Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant |
| PCT/FR2000/001995 WO2001005776A1 (fr) | 1999-07-15 | 2000-07-11 | Derives d'aminothiazole et leur utilisation comme ligands des recepteurs crf |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MEP26608A true MEP26608A (en) | 2010-06-10 |
Family
ID=9548107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-266/08A MEP26608A (en) | 1999-07-15 | 2000-07-11 | Aminothiazole derivatives and their use as crf receptor ligands |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US6586456B1 (de) |
| EP (1) | EP1200419B1 (de) |
| JP (1) | JP4949582B2 (de) |
| KR (1) | KR100707320B1 (de) |
| CN (1) | CN1167692C (de) |
| AR (1) | AR024747A1 (de) |
| AT (1) | ATE264315T1 (de) |
| AU (1) | AU772683B2 (de) |
| BR (1) | BR0012478B1 (de) |
| CA (1) | CA2378792C (de) |
| CO (1) | CO5200792A1 (de) |
| CZ (1) | CZ300937B6 (de) |
| DE (1) | DE60009911T2 (de) |
| DK (1) | DK1200419T3 (de) |
| EA (1) | EA005159B1 (de) |
| EE (1) | EE05004B1 (de) |
| ES (1) | ES2220504T3 (de) |
| FR (1) | FR2796380B3 (de) |
| HK (1) | HK1045692B (de) |
| HU (1) | HU229069B1 (de) |
| IL (2) | IL147282A0 (de) |
| IS (1) | IS2314B (de) |
| ME (1) | MEP26608A (de) |
| MX (1) | MXPA02000545A (de) |
| NO (1) | NO324352B1 (de) |
| NZ (1) | NZ516397A (de) |
| PL (1) | PL206515B1 (de) |
| PT (1) | PT1200419E (de) |
| RS (1) | RS50443B (de) |
| SI (1) | SI1200419T1 (de) |
| SK (1) | SK287069B6 (de) |
| TR (1) | TR200200125T2 (de) |
| TW (1) | TWI278453B (de) |
| UA (1) | UA73125C2 (de) |
| WO (1) | WO2001005776A1 (de) |
| ZA (1) | ZA200200221B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001296255B2 (en) * | 2000-09-21 | 2005-07-28 | Bristol-Myers Squibb Company | Substituted azole derivatives as inhibitors of corticotropin releasing factor |
| WO2003015777A1 (en) * | 2001-08-13 | 2003-02-27 | Lion Bioscience Ag | Nr1h4 nuclear receptor binding compounds |
| US6993173B2 (en) | 2001-10-12 | 2006-01-31 | Duke University | Methods for estimating probe cell locations in high-density synthetic DNA microarrays |
| EP1766014A4 (de) | 2004-06-03 | 2008-12-10 | Athlomics Pty Ltd | Mittel und verfahren zur diagnose von stress |
| EP1781287A4 (de) * | 2004-08-13 | 2008-02-27 | Genentech Inc | Thiazolbasierte inhibitoren atp-verwendender enzyme |
| EP1834641A1 (de) | 2006-03-16 | 2007-09-19 | Sanofi-Aventis | CRF1-Rezeptorantagonisten zur Herstellung von Medikamenten zur Behandlung des Metabolischen Syndromes, und/oder Übergewicht und/oder Dyslipoproteinemie |
| HUP0900267A2 (en) | 2009-04-30 | 2011-03-28 | Sanofi Aventis | Process for preparing of thiazole amines and intermediates thereof |
| JP2015516979A (ja) * | 2012-04-23 | 2015-06-18 | ホルスボールマッシュマイヤー ニューロケミー ゲーエムベーハーＨｏｌｓｂｏｅｒｍａｓｃｈｍｅｙｅｒ Ｎｅｕｒｏｃｈｅｍｉｅ Ｇｍｂｈ | Ｃｒｈ過剰活性を有する患者の治療に用いるためのｃｒｈｒ１アンタゴニスト |
| GB201210686D0 (en) | 2012-06-15 | 2012-08-01 | Holsboermaschmeyer Neurochemie Gmbh | V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level |
| GB201310782D0 (en) | 2013-06-17 | 2013-07-31 | Max Planck Innovation Gmbh | Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms |
| NZ722122A (en) | 2014-01-21 | 2020-06-26 | Neurocrine Biosciences Inc | Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia |
| JP7532328B2 (ja) * | 2018-12-07 | 2024-08-13 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 先天性副腎過形成を処置するためのｃｒｆ１受容体アンタゴニスト、その医薬製剤および固体形態 |
| JP7238130B2 (ja) * | 2018-12-07 | 2023-03-13 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 先天性副腎過形成を処置するためのｃｒｆ１受容体アンタゴニスト、その医薬製剤および固体形態 |
| JP2022549496A (ja) * | 2019-09-27 | 2022-11-25 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | Ｃｒｆ受容体アンタゴニストおよび使用方法 |
| BR112022024875A2 (pt) | 2020-06-10 | 2022-12-27 | Neurocrine Biosciences Inc | Antagonista de receptor crf1 para o tratamento de hiperplasia adrenal congênita |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2692893B1 (fr) * | 1992-06-24 | 1994-09-02 | Sanofi Elf | Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2714059B1 (fr) | 1993-12-21 | 1996-03-08 | Sanofi Elf | Dérivés amino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2735777B1 (fr) | 1995-06-21 | 1997-09-12 | Sanofi Sa | Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
| FR2754258B1 (fr) * | 1996-10-08 | 1998-12-31 | Sanofi Sa | Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
-
1999
- 1999-07-15 FR FR9909144A patent/FR2796380B3/fr not_active Expired - Lifetime
-
2000
- 2000-07-11 SK SK38-2002A patent/SK287069B6/sk not_active IP Right Cessation
- 2000-07-11 IL IL14728200A patent/IL147282A0/xx active IP Right Grant
- 2000-07-11 NZ NZ516397A patent/NZ516397A/xx not_active IP Right Cessation
- 2000-07-11 PT PT00951647T patent/PT1200419E/pt unknown
- 2000-07-11 EA EA200101234A patent/EA005159B1/ru not_active IP Right Cessation
- 2000-07-11 TR TR2002/00125T patent/TR200200125T2/xx unknown
- 2000-07-11 RS YUP-13/02A patent/RS50443B/sr unknown
- 2000-07-11 AU AU64521/00A patent/AU772683B2/en not_active Ceased
- 2000-07-11 JP JP2001511437A patent/JP4949582B2/ja not_active Expired - Lifetime
- 2000-07-11 CZ CZ20020137A patent/CZ300937B6/cs not_active IP Right Cessation
- 2000-07-11 CN CNB008116911A patent/CN1167692C/zh not_active Expired - Fee Related
- 2000-07-11 MX MXPA02000545A patent/MXPA02000545A/es active IP Right Grant
- 2000-07-11 EE EEP200200022A patent/EE05004B1/xx not_active IP Right Cessation
- 2000-07-11 AT AT00951647T patent/ATE264315T1/de active
- 2000-07-11 BR BRPI0012478-8B1A patent/BR0012478B1/pt not_active IP Right Cessation
- 2000-07-11 SI SI200030377T patent/SI1200419T1/xx unknown
- 2000-07-11 KR KR1020027000549A patent/KR100707320B1/ko not_active IP Right Cessation
- 2000-07-11 US US10/031,038 patent/US6586456B1/en not_active Expired - Lifetime
- 2000-07-11 WO PCT/FR2000/001995 patent/WO2001005776A1/fr active IP Right Grant
- 2000-07-11 CA CA002378792A patent/CA2378792C/en not_active Expired - Fee Related
- 2000-07-11 DE DE60009911T patent/DE60009911T2/de not_active Expired - Lifetime
- 2000-07-11 PL PL352901A patent/PL206515B1/pl unknown
- 2000-07-11 ME MEP-266/08A patent/MEP26608A/xx unknown
- 2000-07-11 ES ES00951647T patent/ES2220504T3/es not_active Expired - Lifetime
- 2000-07-11 DK DK00951647T patent/DK1200419T3/da active
- 2000-07-11 EP EP00951647A patent/EP1200419B1/de not_active Expired - Lifetime
- 2000-07-11 HU HU0202387A patent/HU229069B1/hu not_active IP Right Cessation
- 2000-07-13 CO CO00052852A patent/CO5200792A1/es active IP Right Grant
- 2000-07-14 AR ARP000103626A patent/AR024747A1/es not_active Application Discontinuation
- 2000-07-14 TW TW089114114A patent/TWI278453B/zh not_active IP Right Cessation
- 2000-11-07 UA UA2001129084A patent/UA73125C2/uk unknown
-
2001
- 2001-12-24 IL IL147282A patent/IL147282A/en not_active IP Right Cessation
-
2002
- 2002-01-03 IS IS6219A patent/IS2314B/is unknown
- 2002-01-10 ZA ZA200200221A patent/ZA200200221B/en unknown
- 2002-01-11 NO NO20020155A patent/NO324352B1/no not_active IP Right Cessation
- 2002-10-04 HK HK02107310.6A patent/HK1045692B/zh not_active IP Right Cessation
-
2007
- 2007-04-25 US US11/740,001 patent/US8420679B2/en not_active Expired - Lifetime
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