ME02426B - Peptidni inhibitori jnk signalnog transdukcijskog puta koji su permeabilni za ćeliju - Google Patents

Peptidni inhibitori jnk signalnog transdukcijskog puta koji su permeabilni za ćeliju

Info

Publication number
ME02426B
ME02426B MEP-2016-62A MEP6216A ME02426B ME 02426 B ME02426 B ME 02426B ME P6216 A MEP6216 A ME P6216A ME 02426 B ME02426 B ME 02426B
Authority
ME
Montenegro
Prior art keywords
chimeric peptide
peptide according
domain
xnb
cancer
Prior art date
Application number
MEP-2016-62A
Other languages
English (en)
Inventor
Christophe Bonny
Original Assignee
Xigen Inflammation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xigen Inflammation Ltd filed Critical Xigen Inflammation Ltd
Publication of ME02426B publication Critical patent/ME02426B/me

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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Description

 
LISTA SEKVENCI
<110> XIGEN S.A.
<120> Peptidni inhibitori JNK signalnog transdukcijskog puta koji mogu da ulaze u ćeliju
<130> UO01P006WO1
<150> PCT/EP2005/009782
<151> 2005-09-12
<160> 27
<170> PatentIn verzija 3.3
<210> 1
<211> 19
<212> PRT
<213> Veštačka
<220>
<223> Peptid L-IB1(s) (videti Tabelu 1)
<400> 1
 
<210> 2
<211> 19
<212> PRT
<213> Veštačka
<220>
<223> Peptid D-IB1(s) (videti Tabelu 1)
<400> 2
 
<210> 3
<211> 18
<212> PRT
<213> Veštačka
<220>
<223> Peptid L-IB (generički) (s) (videti Tabelu 1)
<220>
<221> misc_feature
<222> (1)..(18)
<223> Opšta formula: NH2-Xnb-Xna-RPTTLXLXXXXXXXQD-Xnb-COOH, gde X je bilo koji (nativni) amino kiselinski ostatak, Xna je bilo koji amino kiselinski ostatak osim serina i treonina, a Xnb može da bude bilo koji amino kiselinski ostatak;
<220>
<221> ponavljanje
<222> (1)...(1)
<223> Xaa je Xna-Xnb kao šta je definisano u opštoj formuli, gde n je 0 ili 1 za Xna i 0-5, 5-10, 10-15, 15-20, 20-30 ili više za Xnb
<220>
<221> ponavljanje
<222> (18)...(18)
<223> Xaa je Xnb kao šta je definisano u opštoj formuli, gde n je 0-5, 5-10, 10-15, 15-20, 20-30 ili više za Xnb
<400> 3
 
<210> 4
<211> 18
<212> PRT
<213> Veštačka
<220>
<223> Peptid D-IB (generički) (s) (videti Tabelu 1)
<220>
<221> misc_feature
<222> (1)..(18)
<223> Opšta formula: NH2-Xnb-DQXXXXXXXLXLTTPR-Xna-Xnb-COOH, gde X je bilo koji (nativni) amino kiselinski ostatak, Xna je bilo koji amino kiselinski ostatak osim serina i treonina, a Xnb može da bude bilo koji amino kiselinski ostatak;
<220>
<221> ponavljanje
<222> (1)...(1)
<223> Xaa je Xnb kao šta je definisano u opštoj formuli, gde n je 0-5, 5-10, 10-15, 15-20, 20-30 ili više za Xnb
<220>
<221> ponavljanje
<222> (18)...(18)
<223> Xaa je Xna-Xnb kao šta je definisano u opštoj formuli, gde n je 0 ili 1 za Xna, a 0-5, 5-10, 10-15, 15-20, 20-30 ili više za Xnb
<400> 4
 
<210> 5
<211> 10
<212> PRT
<213> Veštačka
<220>
<223> Peptid L-TAT (videti Tabelu 1)
<400> 5
 
<210> 6
<211> 10
<212> PRT
<213> Veštačka
<220>
<223> Peptid D-TAT (videti Tabelu 1)
<400> 6
 
<210> 7
<211> 17
<212> PRT
<213> Veštačka
<220>
<223> Peptid L-generički-TAT (s) (videti Tabelu 1)
<220>
<221> misc_feature
<222> (1)..(17)
<223> Opšta formula: NH2-Xnb-RKKRRQRRR-Xnb-COOH, gde Xnb može da bude bilo koji amino kiselinski ostatak;
<220>
<221> ponavljanje
<222> (1)...(4)
<223> Xaa je Xnb kao šta je definisano u opštoj formuli, gde n je 0-5, 5-10, 10-15, 15-20, 20-30 ili više za Xnb
<220>
<221> ponavljanje
<222> (14)...(17)
<223> Xaa je Xnb kao šta je definisano u opštoj formuli, gde n je 0-5, 5-10, 10-15, 15-20, 20-30 ili više za Xnb
<400> 7
 
<210> 8
<211> 17
<212> PRT
<213> Veštačka
<220>
<223> Peptid D-generički-TAT (s) (videti Tabelu 1)
<220>
<221> misc_feature
<222> (1)..(17)
<223> Opšta formula: NH2-Xnb-RRRQRRKKR-Xnb-COOH, gde Xnb može da bude bilo koji amino kiselinski ostatak;
<220>
<221> ponavljanje
<222> (1)...(4)
<223> Xaa je Xnb kao šta je definisano u opštoj formuli, gde n je 0-5, 5-10, 10-15, 15-20, 20-30 ili više za Xnb
<220>
<221> ponavljanje
<222> (14)...(17)
<223> Xaa je Xnb kao šta je definisano u opštoj formuli, gde n je 0-5, 5-10, 10-15, 15-20, 20-30 ili više za Xnb
<400> 8
 
<210> 9
<211> 31
<212> PRT
<213> Veštačka
<220>
<223> L-TAT-IB1 (s) (videti Tabelu 1)
<400> 9
 
<210> 10
<211> 38
<212> PRT
<213> Veštačka
<220>
<223> Peptid L-TAT (generički) (s) (videti Tabelu 1)
<220>
<221> misc_feature
<222> (1)..(38)
<223> Opšta formula: NH2-Xnb-RKKRRQRRR-Xnb-Xna-RPTTLXLXXXXXXXQD-Xnb-COOH, gde X je bilo koji (nativni) amino kiselinski ostatak, Xna je bilo koji amino kiselinski ostatak osim serina i treonina, a Xnb može da bude bilo koji amino kiselinski ostatak;
<220>
<221> ponavljanje
<222> (1)...(7)
<223> Xaa je Xnb kao šta je definisano u opštoj formuli, gde n je 0-5, 5-10, 10-15, 15-20, 20-30 ili više za Xnb
<220>
<221> ponavljanje
<222> (17)...(21)
<223> Xaa je Xna-Xnb kao šta je definisano u opštoj formuli, gde n je 0 ili 1 za Xna, a 0-5, 5-10, 10-15, 15-20, 20-30 ili više za Xnb
<220>
<221> ponavljanje
<222> (38)...(38)
<223> Xaa je Xnb kao šta je definisano u opštoj formuli, gde n je 0-5, 5-10, 10-15, 15-20, 20-30 ili više za Xnb
<400> 10
 
<210> 11
<211> 31
<212> PRT
<213> Veštačka
<220>
<223> Peptid D-TAT-IB1 (s) (videti Tabelu 1)
<400> 11
 
<210> 12
<211> 38
<212> PRT
<213> Veštačka
<220>
<223> Peptid: D-TAT (generički) (s) (videti Tabelu 1)
<220>
<221> misc_feature
<222> (1)..(38)
<223> Opšta formula: NH2-Xnb-DQXXXXXXXLXLTTPR-Xna-Xnb-RRRQRRKKR-Xnb-COOH, gde X je bilo koji (nativni) amino kiselinski ostatak, Xna je bilo koji amino kiselinski ostatak osim serina i treonina, a Xnb može da bude bilo koja amino kiselina;
<220>
<221> ponavljanje
<222> (1)...(7)
<223> Xaa je Xnb kao šta je definisano u opštoj formuli, gde n je 0-5, 5-10, 10-15, 15-20, 20-30 ili više za Xnb
<220>
<221> ponavljanje
<222> (18)...(22)
<223> Xaa je Xna-Xnb kao šta je definisano u opštoj formuli, gde n je 0 ili 1 za Xna, a 0-5, 5-10, 10-15, 15-20, 20-30 ili više za Xnb
<220>
<221> ponavljanje
<222> (38)...(38)
<223> Xaa je Xnb kao šta je definisano u opštoj formuli, gde n je 0-5, 5-10, 10-15, 15-20, 20-30 ili više za Xnb
<400> 12
 
<210> 13
<211> 29
<212> PRT
<213> Veštačka
<220>
<223> peptid IB1-dugi (videti Tabelu 1)
<400> 13
 
 
<210> 14
<211> 27
<212> PRT
<213> Veštačka
<220>
<223> Peptid IB2-dugi (videti Tabelu 1)
<400> 14
 
<210> 15
<211> 29
<212> PRT
<213> Veštačka
<220>
<223> Peptid izveden iz c-Jun (videti Tabelu 1)
<400> 15
 
<210> 16
<211> 29
<212> PRT
<213> Veštačka
<220>
<223> Peptid izveden iz ATF2 (videti Tabelu 1)
<400> 16
 
<210> 17
<211> 23
<212> PRT
<213> Veštačka
<220>
<223> Peptid L-IB1 (videti Tabelu 1)
<400> 17
 
<210> 18
<211> 23
<212> PRT
<213> Veštačka
<220>
<223> Peptid D-IB1 (videti Tabelu 1)
<400> 18
 
<210> 19
<211> 19
<212> PRT
<213> Veštačka
<220>
<223> Peptid L-IB (generički) (videti Tabelu 1)
<220>
<221> misc_feature
<222> (1) .. (17)
<223> X je izabran iz bilo kojeg (nativnog) amino kiselinskog ostatka,
<220>
<221> misc_feature
<222> (18) .. (18)
<223> X je izabran iz serina ili treonina
<220>
<221> misc_feature
<222> (19) .. (19)
223> X je izabran iz bilo kojeg (nativnog) amino kiselinskog ostatka,
<400> 19
 
<210> 20
<211> 19
<212> PRT
<213> Veštačka
<220>
<223> Peptid D-IB (generički) (videti Tabelu 1)
<220>
<221> misc_feature
<222> (1) .. (1)
<223> X je izabran iz bilo kojeg (nativnog) amino kiselinskog ostatka,
<220>
<221> misc feature
<222> (2)..(2)
<223> X je izabran iz serina ili treonina
<220>
<221> misc_feature
<222> (3) .. (19)
<223> X je izabran iz bilo kojeg (nativnog) amino kiselinskog ostatka,
<400> 20
 
<210> 21
<211> 17
<212> PRT
<213> Veštačka
<220>
<223> Peptid L-generički-TAT (videti Tabelu 1)
<220>
<221> misc_feature
<222> (1)..(17)
<223> X je izabran iz bilo kojeg (nativnog) amino kiselinskog ostatka,
<400> 21
 
<210> 22
<211> 17
<212> PRT
<213> Veštačka
<220>
<223> Peptid D-generički-TAT (videti Tabelu 1)
<220>
<221> misc_feature
<222> (1) .. (17)
<223> X je izabran iz bilo kojeg (nativnog) amino kiselinskog ostatka,
<400> 22
 
<210> 23
<211> 35
<212> PRT
<213> Veštačka
<220>
<223> Peptid L-TAT-IB1 (videti Tabelu 1)
<400> 23
 
<210> 24
<211> 42
<212> PRT
<213> Veštačka
<220>
<223> Peptid L-TAT (generički) (videti Tabelu 1)
<220>
<221> misc feature
<222> (1) .. (40)
<223> X je izabran iz bilo kojeg (nativnog) amino kiselinskog ostatka,
<220>
<221> misc_feature
<222> (41) .. (41)
<223> X je izabran iz serina ili treonina
<220>
<221> misc_feature
<222> (42) .. (42)
<223> X je izabran iz bilo kojeg (nativnog) amino kiselinskog ostatka,
<400> 24
 
<210> 25
<211> 35
<212> PRT
<213> Veštačka
<220>
<223> Peptid D-TAT-IB1 (videti Tabelu 1)
<400> 25
 
<210> 26
<211> 42
<212> PRT
<213> Veštačka
<220>
<223> Peptid D-TAT (generički) (videti Tabelu 1)
<220>
<221> misc_feature
<222> (1) .. (1)
<223> X je izabran iz bilo kojeg (nativnog) amino kiselinskog ostatka,
<220>
<221> misc_feature
<222> (2) .. (2)
<223> X je izabran iz serina ili treonina;
<220>
<221> misc_feature
<222> (3) .. (42)
<223> X je izabran iz bilo kojeg (nativnog) amino kiselinskog ostatka,
<400> 26
 
<210> 27
<211> 21
<212> DNA
<213> Veštačka
<220>
<223> Proba za test retardacije gela (videti Primer 13)
<400> 27
CGCTTGATGA GTCAGCCGGA A 21
     
 

Claims (12)

1.Himerni peptid koji sadrži prvi domen, drugi domen i opciono vezujuću sekvencu, te prvi domen sadrži transportnu sekvencu i drugi domen sadrži JNK inhibitornu sekvencu, naznačen time što prvi domen sadrži sve-D retro-inverzo sekvence amino kiseline u skladu sa SEQ ID NO:6 te time što drugi domen sadrži sve-D retro-inverzo sekvence amino kiseline u skladu sa SEQ ID NO:2, pri čemu je prvi domen vezan na C-terminalni kraj drugog domena direktno ili pomoću pomenute vezujuće sekvence koja obuhvata 1 do 10 amino kiselina.
2.Himerni peptid prema zahtevu 1, naznačen time što vezujuća sekvenca sadrži 1 do 5 amino kiselina.
3.Himerni peptid prema zahtevu 1 ili 2, naznačen time što je vezujuća sekvenca sastavljena od L amino kiselina, D amino kiselina ili od njihove kombinacije.
4.Himerni peptid prema bilo kom od zahteva od 1 do 3, naznačen time što transportna sekvenca povećava staničnu absorpciju peptida.
5.Himerni peptid prema bilo kom od zahteva od 1 do 4, naznačen time što transportna sekvenca usmerava nuklearnu lokalizaciju peptida.
6.Himerni peptid prema bilo kom od zahteva od 1 do 5, naznačen time što himerni peptid ima modifikaciju na C-terminalnom kraju.
7.Himerni peptid prema zahtevu 6, naznačen time što je C-terminalni kraj modifikovan sa amidnom modifikacijom.
8.Farmaceutska kompozicija, naznačena time što sadrži himerni peptid prema bilo kom od zahteva od 1 do 7, te farmaceutski prihvatljiv nosač.
9.Upotreba himernog peptida prema bilo kom od zahteva od 1 do 8 naznačena time što je za pripremanje farmaceutske kompozicije za tretman patofiziologije koja je izabrana iz malignih bolesti pluća, dojki, limfoidnog, gastrointestinalnog i genito-urinarnog trakta kao i iz adenokarcinoma, uključujući maligna stanja poput raka debelog creva, karcinoma renalnih ćelija, raka prostate, karcinoma velikih ćelija u plućima, raka tankog creva i raka ezofagusa, kao i leukemija, kancera sa Bcr-Abl onkogenim transformacijama, psorijaza, pemphigus vulgaris, Behcet-ovog sindroma, akutnog respiratornog stresnog sindroma (ARDS), ishemične bolesti srca, sindroma nakon dijalize, reumatoidnog artritisa, sindroma stečene imuno dificijencije, vaskulitisa, septičkog šoka, restenoze, gubitka sluha, trauma uva, ishemije, kapi; reperfuzijskih ozleda, hipoksije, sekundarnih efekata zbog tretmana sa proinflamatornim citokinima, dijabetesa, srčane i kardijalne hipertrofije i arteriosklerotičnih lezija, patoloških stanja usled jonizacijske radijacije tokom radioterapije i zračenja sa ultravioletnim svetlom (UV svetlo), patološka stanja indukovana uz pomoć agenasa koji oštećuju DNK, uključujući hemoterapeutske lekove, hipo- i hipertermija, bolesti zapaljenja, auto-zapaljenja, imunih i auto-imunih bolesti, degenerativnih bolesti, miopatija, kardiomiopatija i odbacivanje transplantata.
10.Upotreba himernog peptida prema zahtevu 9 naznačena time što je za pripremanje farmaceutske kompozicije za lečenje šloga, moždane traume, ozlede kičmene moždine, amiotrofične lateralne skleroze, Huntingtonove bolesti, Alzheimerove bolesti i Parkinsonove bolesti.
11.Upotreba prema zahtevu 9, naznačena time, što je farmaceutska kompozicija namenjena za davanje putem za administraciju koji je izabran iz grupe koja obuhvata intraperitonealnu, nazalnu, intravenoznu, oralnu administraciju i administraciju pomoću flastera.
12.Komplet (kit), naznačen time, što sadrži himerni peptid prema bilo kom od zahteva od 1 do 7.
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