ME01267B - 4-fenilaminokinazolin-6-ilamidi - Google Patents
4-fenilaminokinazolin-6-ilamidiInfo
- Publication number
- ME01267B ME01267B MEP-2012-2A MEP212A ME01267B ME 01267 B ME01267 B ME 01267B ME P212 A MEP212 A ME P212A ME 01267 B ME01267 B ME 01267B
- Authority
- ME
- Montenegro
- Prior art keywords
- fluorophenylamino
- chloro
- amide
- enoic acid
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 12
- 241000124008 Mammalia Species 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- 230000002159 abnormal effect Effects 0.000 claims 3
- 230000010261 cell growth Effects 0.000 claims 3
- LVXJQMNHJWSHET-UHFFFAOYSA-N N-[4-(3-chloro-4-fluoroanilino)-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 LVXJQMNHJWSHET-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 2
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- IJADXWBHNRTJAH-UHFFFAOYSA-N 4-N-(3-chloro-4-fluorophenyl)-7-methylsulfanylquinazoline-4,6-diamine Chemical compound C=12C=C(N)C(SC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 IJADXWBHNRTJAH-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- QSDKHHKJCWNTCW-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-(2,2,2-trifluoroethoxy)quinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C1=C(Cl)C(F)=CC=C1NC(C1=C2)=NC=NC1=CC(OCC(F)(F)F)=C2NC(=O)C=CCN1CCCCC1 QSDKHHKJCWNTCW-UHFFFAOYSA-N 0.000 claims 1
- ICDUDMAKDBBZOT-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-(2,2-difluoroethoxy)quinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(OCC(F)F)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 ICDUDMAKDBBZOT-UHFFFAOYSA-N 0.000 claims 1
- GFMMDHSSOIPFTF-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-(2-fluoroethoxy)quinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(OCCF)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 GFMMDHSSOIPFTF-UHFFFAOYSA-N 0.000 claims 1
- YIRMJUMHPHHBCF-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-(2-fluoroethylsulfanyl)quinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(SCCF)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 YIRMJUMHPHHBCF-UHFFFAOYSA-N 0.000 claims 1
- JGGXWPNXZZHJAI-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-(fluoromethoxy)quinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(OCF)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 JGGXWPNXZZHJAI-UHFFFAOYSA-N 0.000 claims 1
- QMDUDTAUUIGRAT-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-(methylamino)quinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(NC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 QMDUDTAUUIGRAT-UHFFFAOYSA-N 0.000 claims 1
- CRKXEIAEAGVNNS-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-(trifluoromethoxy)quinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C1=C(Cl)C(F)=CC=C1NC(C1=C2)=NC=NC1=CC(OC(F)(F)F)=C2NC(=O)C=CCN1CCCCC1 CRKXEIAEAGVNNS-UHFFFAOYSA-N 0.000 claims 1
- XDXLWHQJFSMJFZ-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(OCC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XDXLWHQJFSMJFZ-UHFFFAOYSA-N 0.000 claims 1
- XYUWLBQNUJRXRJ-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-(2-fluoropiperidin-1-yl)but-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3C(CCCC3)F)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XYUWLBQNUJRXRJ-UHFFFAOYSA-N 0.000 claims 1
- XFXOYVZSTQCSQN-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-(3-fluoropiperidin-1-yl)but-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CC(F)CCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XFXOYVZSTQCSQN-UHFFFAOYSA-N 0.000 claims 1
- YMQSEEOAYCTNQU-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-(4-fluoropiperidin-1-yl)but-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCC(F)CC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 YMQSEEOAYCTNQU-UHFFFAOYSA-N 0.000 claims 1
- CVPYBKFJICOOOM-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-propan-2-yloxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(OC(C)C)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 CVPYBKFJICOOOM-UHFFFAOYSA-N 0.000 claims 1
- RYNJCJGKEYFFCT-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-propoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide Chemical compound C=12C=C(NC(=O)C=CCN3CCCCC3)C(OCCC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 RYNJCJGKEYFFCT-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 208000014081 polyp of colon Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56887204P | 2004-05-06 | 2004-05-06 | |
| PCT/IB2005/001139 WO2005107758A1 (en) | 2004-05-06 | 2005-04-25 | 4-phenylamino-quinazolin-6-yl-amides |
| EP05732761A EP1746999B1 (en) | 2004-05-06 | 2005-04-25 | 4-phenylamino-quinazolin-6-yl-amides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME01267B true ME01267B (me) | 2013-06-20 |
Family
ID=34965519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2012-2A ME01267B (me) | 2004-05-06 | 2005-04-25 | 4-fenilaminokinazolin-6-ilamidi |
Country Status (47)
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1746999T3 (pl) | 2004-05-06 | 2012-07-31 | Warner Lambert Co | 4-fenyloaminochinazolin-6-yloamidy |
| KR100735639B1 (ko) | 2004-12-29 | 2007-07-04 | 한미약품 주식회사 | 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법 |
| KR100929146B1 (ko) | 2006-06-28 | 2009-12-01 | 한미약품 주식회사 | 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 |
| CA2754808C (en) | 2009-03-11 | 2019-01-08 | Auckland Uniservices Limited | Prodrug forms of kinase inhibitors and their use in therapy |
| CN102146059A (zh) * | 2010-02-08 | 2011-08-10 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、制备方法及其应用 |
| CN102382065B (zh) * | 2010-08-30 | 2014-05-28 | 山东轩竹医药科技有限公司 | 苯胺取代的喹唑啉衍生物 |
| CN102382106A (zh) | 2010-08-30 | 2012-03-21 | 黄振华 | 苯胺取代的喹唑啉衍生物 |
| CN102452989B (zh) * | 2010-10-19 | 2014-10-22 | 山东轩竹医药科技有限公司 | 苯胺取代的喹唑啉衍生物 |
| US8828391B2 (en) | 2011-05-17 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Method for EGFR directed combination treatment of non-small cell lung cancer |
| HUE033575T2 (hu) | 2011-05-26 | 2017-12-28 | Xuanzhu Pharma Co Ltd | Tirozin-kináz inhibitor kinazolin származék, elõállítási eljárása és alkalmazása |
| CN102838590B (zh) * | 2011-06-21 | 2014-07-09 | 苏州迈泰生物技术有限公司 | 氨基喹唑啉衍生物及其在制备抗恶性肿瘤药物中的用途 |
| CN103874696B (zh) * | 2011-10-12 | 2015-06-03 | 苏州韬略生物科技有限公司 | 作为激酶抑制剂的喹唑啉衍生物及其使用方法 |
| CN104080774B (zh) | 2012-01-17 | 2017-02-22 | 安斯泰来制药株式会社 | 吡嗪甲酰胺化合物 |
| KR20150005698A (ko) | 2012-05-07 | 2015-01-14 | 텔리진 엘티디. | 키나제 저해제로서 유용한 치환된 아미노퀴나졸린 |
| TWI609012B (zh) | 2013-04-28 | 2017-12-21 | 廣東東陽光藥業有限公司 | 氨基喹唑啉類衍生物及其鹽和使用方法 |
| CN103288759B (zh) * | 2013-05-16 | 2015-05-20 | 苏州明锐医药科技有限公司 | 达克米替尼的制备方法 |
| CN103288758B (zh) * | 2013-05-16 | 2015-01-21 | 苏州明锐医药科技有限公司 | 一种达克米替尼的制备方法 |
| CN105408334B (zh) | 2013-05-21 | 2017-10-10 | 江苏迈度药物研发有限公司 | 作为激酶抑制剂的取代的吡唑并嘧啶类化合物 |
| CN103304492B (zh) * | 2013-06-20 | 2015-12-23 | 湖南欧亚生物有限公司 | 一种EGFR抑制剂Dacomitinib的合成方法 |
| US9714235B2 (en) * | 2013-07-18 | 2017-07-25 | Shanghai Fochon Pharmaceutical Co., Ltd. | Quinazoline derivatives, compositions thereof, and use as pharmaceuticals |
| CN105859641B (zh) * | 2015-05-05 | 2018-11-16 | 杭州华东医药集团新药研究院有限公司 | 喹唑啉巴豆基化合物二马来酸盐的晶体及其制备方法和用途 |
| JP2019504830A (ja) * | 2016-01-06 | 2019-02-21 | トリリアム・セラピューティクス・インコーポレイテッドＴｒｉｌｌｉｕｍ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | Ｅｇｆｒ阻害剤としての新規フッ素化キナゾリン誘導体 |
| CN107721987A (zh) * | 2016-08-12 | 2018-02-23 | 山东轩竹医药科技有限公司 | 喹唑啉类酪氨酸激酶抑制剂的晶型 |
| CN107721986A (zh) * | 2016-08-12 | 2018-02-23 | 山东轩竹医药科技有限公司 | 喹唑啉类酪氨酸激酶抑制剂的晶型 |
| CN107721985A (zh) * | 2016-08-12 | 2018-02-23 | 山东轩竹医药科技有限公司 | 喹唑啉类酪氨酸激酶抑制剂的晶型 |
| CN107793368B (zh) * | 2016-08-31 | 2021-10-15 | 四川科伦药物研究院有限公司 | 达可替尼溶剂化物、其新晶型及其制备方法和用途 |
| KR102213040B1 (ko) * | 2017-12-20 | 2021-02-05 | 한국원자력의학원 | 방사선 손상 보호 또는 완화, 및 폐섬유화 예방 또는 치료 용도 |
| CN109438423A (zh) * | 2018-09-12 | 2019-03-08 | 通化师范学院 | 一种肺癌靶向化合物azd-3759的合成工艺的新方法 |
| CA3113241A1 (en) | 2018-09-25 | 2020-04-02 | Black Diamond Therapeutics, Inc. | Quinazoline derivatives as tyrosine kinase inhibitor, compositions, methods of making them and their use |
| KR20210107069A (ko) | 2018-12-21 | 2021-08-31 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 컨쥬게이트와 키나아제 저해제의 조합 |
| MX2021011810A (es) | 2019-03-29 | 2021-10-26 | Astrazeneca Ab | Osimertinib para su uso en el tratamiento de cancer de pulmon de celulas no peque?as. |
| CA3150701A1 (en) * | 2019-08-15 | 2021-02-18 | Black Diamond Therapeutics, Inc. | Alkynyl quinazoline compounds |
| WO2021094379A1 (en) | 2019-11-12 | 2021-05-20 | Astrazeneca Ab | Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
| CN113045541A (zh) * | 2019-12-27 | 2021-06-29 | 广东东阳光药业有限公司 | Egfr抑制剂新晶型及其制备方法 |
| WO2021148396A1 (en) | 2020-01-20 | 2021-07-29 | Astrazeneca Ab | Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
| CN113717111A (zh) * | 2020-05-25 | 2021-11-30 | 苏州晶云药物科技股份有限公司 | 喹唑啉类化合物的晶型及其制备方法 |
| US20210369709A1 (en) | 2020-05-27 | 2021-12-02 | Astrazeneca Ab | EGFR TKIs FOR USE IN THE TREATMENT OF NON-SMALL CELL LUNG CANCER |
| US11858925B2 (en) | 2020-07-10 | 2024-01-02 | The Regents Of The University Of Michigan | GAS41 inhibitors and methods of use thereof |
| CN112707869B (zh) * | 2020-12-25 | 2022-03-22 | 扬子江药业集团有限公司 | 一种达可替尼杂质及其制备方法 |
| KR20240168418A (ko) | 2022-03-31 | 2024-11-29 | 아스트라제네카 아베 | 암 치료를 위한 akt 억제제와 조합된 표피 성장 인자 수용체(egfr) 티로신 키나아제 억제제 |
| WO2023209090A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Bicyclic heteroaromatic compounds and their application in the treatment of cancer |
| WO2023209088A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Bicyclic heteroaromatic compounds and their use in the treatment of cancer |
| WO2023209084A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Condensed bicyclic heteroaromatic compounds and their use in the treatment of cancer |
| US20240116926A1 (en) | 2022-04-28 | 2024-04-11 | Astrazeneca Ab | Heteroaromatic compounds |
| JP2025525410A (ja) | 2022-06-27 | 2025-08-05 | アストラゼネカ・アクチエボラーグ | 癌を治療するための上皮成長因子受容体チロシンキナーゼ阻害剤を伴う組み合わせ |
Family Cites Families (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340821C (en) | 1988-10-06 | 1999-11-16 | Nobuyuki Fukazawa | Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components |
| MX22406A (es) | 1989-09-15 | 1994-01-31 | Pfizer | Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat). |
| US5362878A (en) | 1991-03-21 | 1994-11-08 | Pfizer Inc. | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) |
| CZ281628B6 (cs) | 1991-07-29 | 1996-11-13 | Warner-Lambert Company | Deriváty chinazolinu a farmaceutické přípravky na jejich bázi |
| DE69214827T2 (de) | 1991-08-22 | 1997-03-06 | Warner-Lambert Co., Ann Arbor, Mich. | Tetrazolamide als acat inhibitoren |
| US5366987A (en) | 1991-08-22 | 1994-11-22 | Warner-Lambert Company | Isoxazolyl-substituted alkyl amide ACAT inhibitors |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| US5412714A (en) * | 1992-02-24 | 1995-05-02 | At&T Corp. | Mnemonic and synonymic addressing in a telecommunications system |
| GB9323290D0 (en) | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
| PH31122A (en) | 1993-03-31 | 1998-02-23 | Eisai Co Ltd | Nitrogen-containing fused-heterocycle compounds. |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| JP2890267B2 (ja) | 1994-02-23 | 1999-05-10 | ファイザー インク． | ４−ヘテロサイクリル−置換キナゾリン誘導体、その調製法および抗癌剤としてのその使用法 |
| GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
| TW321649B (h) | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| GB9424233D0 (en) | 1994-11-30 | 1995-01-18 | Zeneca Ltd | Quinazoline derivatives |
| GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| GB9508537D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5932574A (en) | 1995-04-27 | 1999-08-03 | Zeneca Limited | Quinazoline derivatives |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| GB9514265D0 (en) | 1995-07-13 | 1995-09-13 | Wellcome Found | Hetrocyclic compounds |
| ATE273958T1 (de) | 1995-10-16 | 2004-09-15 | Fujisawa Pharmaceutical Co | Heterocyclische verbindungen als h+-atpasen |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| US5760041A (en) * | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| ES2194181T3 (es) | 1996-02-13 | 2003-11-16 | Astrazeneca Ab | Derivados de quinazolina como inhibidores de vegf. |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| GB9603097D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline compounds |
| NZ331191A (en) | 1996-03-05 | 2000-03-27 | Zeneca Ltd | 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof |
| WO1997038983A1 (en) | 1996-04-12 | 1997-10-23 | Warner-Lambert Company | Irreversible inhibitors of tyrosine kinases |
| GB9607729D0 (en) | 1996-04-13 | 1996-06-19 | Zeneca Ltd | Quinazoline derivatives |
| ATE227283T1 (de) | 1996-07-13 | 2002-11-15 | Glaxo Group Ltd | Kondensierte heterozyklische verbindungen als protein kinase inhibitoren |
| HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| US6225318B1 (en) | 1996-10-17 | 2001-05-01 | Pfizer Inc | 4-aminoquinazolone derivatives |
| CO4940469A1 (es) | 1997-03-05 | 2000-07-24 | Sugen Inc | Composicion oral de estabilidad mejorada que comprende un derivado de indolinona y una mezcla de gliceridos o esteres de polietilenglicol |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| US6002008A (en) | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| AR012634A1 (es) | 1997-05-02 | 2000-11-08 | Sugen Inc | Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion |
| CA2288705C (en) | 1997-05-06 | 2008-03-18 | American Cyanamid Company | Use of quinazoline compounds for the treatment of polycystic kidney disease |
| US5929080A (en) | 1997-05-06 | 1999-07-27 | American Cyanamid Company | Method of treating polycystic kidney disease |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| US6251912B1 (en) | 1997-08-01 | 2001-06-26 | American Cyanamid Company | Substituted quinazoline derivatives |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| BR9814116A (pt) | 1997-11-06 | 2000-10-03 | American Cyanamid Co | Uso de derivados de quinazolina como inibidores de cinase de tirosina para tratamento de pólipo colÈnico |
| US6323209B1 (en) | 1997-11-06 | 2001-11-27 | American Cyanamid Company | Method of treating or inhibiting colonic polyps |
| GB9800575D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| GB9800569D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| CA2333392A1 (en) | 1998-05-28 | 1999-12-02 | Parker Hughes Institute | Quinazolines for treating brain tumor |
| BR9912575A (pt) | 1998-07-30 | 2001-05-02 | American Home Prod | Processo para a preparação de um composto, e, composto. |
| US6384223B1 (en) | 1998-07-30 | 2002-05-07 | American Home Products Corporation | Substituted quinazoline derivatives |
| US6297258B1 (en) | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
| NZ510580A (en) | 1998-09-29 | 2003-03-28 | American Cyanamid Co | Substituted 3-cyanoquinolines useful as protein tyrosine kinases inhibitors |
| KR20010080491A (ko) * | 1998-11-19 | 2001-08-22 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 티로신 키나제의 비가역적 저해제인ｎ-[4-(3-클로로-4-플루오로-페닐아미노)-7-(3-모르폴린-4-일-프로폭시)-퀴나졸린-6-일]-아크릴아미드 |
| CZ20013079A3 (cs) | 1999-02-27 | 2001-11-14 | Boehringer Ingelheim Pharma Kg | Deriváty 4-aminochinazolinu a chinolinu |
| DE19911509A1 (de) | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| RS49836B (sr) | 1999-03-31 | 2008-08-07 | Pfizer Products Inc., | Postupci i intermedijeri za dobijanje anti-kancernih jedinjenja |
| ES2552813T3 (es) | 1999-06-21 | 2015-12-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su uso y procedimiento para su preparación |
| AUPQ113799A0 (en) * | 1999-06-22 | 1999-07-15 | University Of Queensland, The | A method and device for measuring lymphoedema |
| EP1202746B1 (en) | 1999-08-12 | 2006-10-04 | Wyeth Holdings Corporation | Nsaid and egfr kinase inhibitor containing composition for the treatment or inhibition of colonic polyps and colorectal cancer |
| CZ20021010A3 (cs) | 1999-09-21 | 2002-06-12 | Astrazeneca Ab | Nové sloučeniny chinazolinu a farmaceutické kompozice, které je obsahují |
| US6664390B2 (en) | 2000-02-02 | 2003-12-16 | Warner-Lambert Company Llc | Method for the simplified production of (3-chloro-4-fluorophenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitro-quinazoline-4-yl]-amine or (3-chloro-4-fluorophenyl)-[7-(3-morpholin-4-yl-propoxy)-6-amino-quinazoline-4-yl]-amine |
| US6384051B1 (en) | 2000-03-13 | 2002-05-07 | American Cyanamid Company | Method of treating or inhibiting colonic polyps |
| NZ521421A (en) | 2000-04-07 | 2004-09-24 | Astrazeneca Ab | Quinazoline compounds |
| US6627634B2 (en) | 2000-04-08 | 2003-09-30 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them |
| EP1280798B1 (de) | 2000-04-08 | 2007-01-03 | Boehringer Ingelheim Pharma GmbH & Co.KG | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| DE10031971A1 (de) | 2000-06-30 | 2002-01-10 | Goedecke Ag | Polymorphe Formen/Hydrate von N-[4-(3-Chlor-4-fluor-phenylamino)-7-(3-morpholin-4-yl-propoxy)-chinazolin-6-yl]-acrylamid Dihydrochlorid, Verfahren zu ihrer Herstellung sowie die Verwendung derselben zur Herstellung von Medikamenten mit irreversibler Tyrosinkinasehemmwirkung |
| US6446671B2 (en) * | 2000-08-04 | 2002-09-10 | John G. Armenia | Double wall safety hose |
| US6656946B2 (en) | 2000-08-26 | 2003-12-02 | Boehringer Ingelheim Pharma Kg | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
| US6653305B2 (en) | 2000-08-26 | 2003-11-25 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them |
| US6403580B1 (en) | 2000-08-26 | 2002-06-11 | Boehringer Ingelheim Pharma Kg | Quinazolines, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
| US6617329B2 (en) | 2000-08-26 | 2003-09-09 | Boehringer Ingelheim Pharma Kg | Aminoquinazolines and their use as medicaments |
| US6740651B2 (en) | 2000-08-26 | 2004-05-25 | Boehringer Ingelheim Pharma Kg | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
| US20020082270A1 (en) | 2000-08-26 | 2002-06-27 | Frank Himmelsbach | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
| DE60126997T2 (de) | 2000-10-20 | 2007-10-25 | Eisai R&D Management Co., Ltd. | Stickstoff-enthaltende aromatische ringverbindungen zur behandlung von tumorerkrankungen |
| US20030158196A1 (en) | 2002-02-16 | 2003-08-21 | Boehringer Ingelheim Pharma Gmbh Co. Kg | Pharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors |
| US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| DE10063435A1 (de) * | 2000-12-20 | 2002-07-04 | Boehringer Ingelheim Pharma | Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| PA8539401A1 (es) | 2001-02-14 | 2002-10-28 | Warner Lambert Co | Quinazolinas como inhibidores de mmp-13 |
| JP4285996B2 (ja) | 2001-02-21 | 2009-06-24 | 田辺三菱製薬株式会社 | キナゾリン誘導体 |
| WO2002092578A1 (en) | 2001-05-14 | 2002-11-21 | Astrazeneca Ab | Quinazoline derivatives |
| WO2002092577A1 (en) | 2001-05-14 | 2002-11-21 | Astrazeneca Ab | Quinazoline derivatives |
| GB0118752D0 (en) | 2001-08-01 | 2001-09-26 | Pfizer Ltd | Process for the production of quinazolines |
| GB0126433D0 (en) | 2001-11-03 | 2002-01-02 | Astrazeneca Ab | Compounds |
| WO2003040108A1 (en) | 2001-11-03 | 2003-05-15 | Astrazeneca Ab | Quinazoline derivatives as antitumor agents |
| GB0128108D0 (en) | 2001-11-23 | 2002-01-16 | Astrazeneca Ab | Therapeutic use |
| ES2295409T3 (es) | 2001-11-30 | 2008-04-16 | Osi Pharmaceuticals, Inc. | Procedimiento para la preparacion de derivados biciclicos sustituidos para el tratamiento de crecimiento anormal de celulas. |
| CA2469670A1 (en) | 2001-12-12 | 2003-06-19 | Pfizer Products Inc. | Quinazoline derivatives for the treatment of abnormal cell growth |
| US7402585B2 (en) | 2001-12-24 | 2008-07-22 | Astrazeneca Ab | Substituted quinazoline derivatives as inhibitors of aurora kinases |
| DE10204462A1 (de) * | 2002-02-05 | 2003-08-07 | Boehringer Ingelheim Pharma | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse |
| KR101002374B1 (ko) | 2002-02-26 | 2010-12-17 | 아스트라제네카 아베 | 수용성 셀룰로스 유도체를 포함하는 이레사의 약학 조제물 |
| US7645878B2 (en) | 2002-03-22 | 2010-01-12 | Bayer Healthcare Llc | Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof |
| TWI324597B (en) | 2002-03-28 | 2010-05-11 | Astrazeneca Ab | Quinazoline derivatives |
| US20040044014A1 (en) | 2002-04-19 | 2004-03-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof |
| DE10217689A1 (de) * | 2002-04-19 | 2003-11-13 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung |
| DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
| US20030225079A1 (en) | 2002-05-11 | 2003-12-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of inhibitors of the EGFR-mediated signal transduction for the treatment of benign prostatic hyperplasia (BPH)/prostatic hypertrophy |
| US20040048887A1 (en) | 2002-07-09 | 2004-03-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors |
| PA8578001A1 (es) | 2002-08-07 | 2004-05-07 | Warner Lambert Co | Combinaciones terapeuticas de inhibidores de quinasa de erb b y terapias antineoplasicas |
| CA2514479A1 (en) | 2003-01-23 | 2004-08-05 | T.K. Signal Ltd. | Irreversible inhibitors of egf receptor tyrosine kinases and uses thereof |
| PE20040945A1 (es) * | 2003-02-05 | 2004-12-14 | Warner Lambert Co | Preparacion de quinazolinas substituidas |
| US7223749B2 (en) | 2003-02-20 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
| RS20050652A (en) | 2003-04-09 | 2007-11-15 | Pfizer Products Inc., | Process for the preparation of n- (((pyridinyloxy)- phenylamino)quinazolinyl)- alyl)acetamide derivatives and related compounds as well as intermediates of such processes and processes for the preparation of such intermediates |
| US7691867B2 (en) | 2003-04-16 | 2010-04-06 | Astrazeneca Ab | Chemical compounds |
| EP1658080A1 (en) | 2003-08-18 | 2006-05-24 | Pfizer Products Inc. | Dosing schedule for a erbb2 anticancer agents |
| US20070123537A1 (en) | 2003-10-06 | 2007-05-31 | Gpc Biotech Ag | Quinazoline derivatives for the treatment of herpesviral infections |
| CA2547284A1 (en) | 2003-11-28 | 2005-06-09 | Mitsubishi Pharma Corporation | Quinazoline derivative and process for producing the same |
| PL1746999T3 (pl) * | 2004-05-06 | 2012-07-31 | Warner Lambert Co | 4-fenyloaminochinazolin-6-yloamidy |
-
2005
- 2005-04-25 PL PL05732761T patent/PL1746999T3/pl unknown
- 2005-04-25 RS RS20120004A patent/RS52119B/en unknown
- 2005-04-25 BR BRPI0510604A patent/BRPI0510604B8/pt active IP Right Grant
- 2005-04-25 ES ES05732761T patent/ES2374553T3/es not_active Expired - Lifetime
- 2005-04-25 NZ NZ550796A patent/NZ550796A/en not_active IP Right Cessation
- 2005-04-25 ME MEP-2012-2A patent/ME01267B/me unknown
- 2005-04-25 CN CN2005800145175A patent/CN1972688B/zh not_active Expired - Lifetime
- 2005-04-25 AU AU2005239878A patent/AU2005239878B9/en not_active Expired
- 2005-04-25 HR HR20110958T patent/HRP20110958T1/hr unknown
- 2005-04-25 KR KR1020067023121A patent/KR100885835B1/ko not_active Expired - Lifetime
- 2005-04-25 SI SI200531429T patent/SI1746999T1/sl unknown
- 2005-04-25 UA UAA200611675A patent/UA85706C2/ru unknown
- 2005-04-25 DK DK05732761.1T patent/DK1746999T3/da active
- 2005-04-25 PT PT05732761T patent/PT1746999E/pt unknown
- 2005-04-25 CA CA2565812A patent/CA2565812C/en not_active Expired - Lifetime
- 2005-04-25 KR KR1020087022983A patent/KR20080095915A/ko not_active Withdrawn
- 2005-04-25 AT AT05732761T patent/ATE533490T1/de active
- 2005-04-25 JP JP2007512544A patent/JP4205757B2/ja not_active Expired - Lifetime
- 2005-04-25 MX MXPA06012756A patent/MXPA06012756A/es active IP Right Grant
- 2005-04-25 EA EA200601849A patent/EA011237B1/ru active Protection Beyond IP Right Term
- 2005-04-25 WO PCT/IB2005/001139 patent/WO2005107758A1/en active Application Filing
- 2005-04-25 EP EP05732761A patent/EP1746999B1/en not_active Expired - Lifetime
- 2005-04-25 GE GEAP20059692A patent/GEP20084551B/en unknown
- 2005-04-25 AP AP2006003810A patent/AP2204A/xx active
- 2005-04-29 MY MYPI20051908A patent/MY143566A/en unknown
- 2005-05-03 PE PE2005000494A patent/PE20060215A1/es active IP Right Grant
- 2005-05-03 TW TW094114254A patent/TWI334865B/zh active
- 2005-05-04 PA PA20058631901A patent/PA8631901A1/es unknown
- 2005-05-04 NL NL1028967A patent/NL1028967C2/nl not_active IP Right Cessation
- 2005-05-04 AR ARP050101797A patent/AR048652A1/es active IP Right Grant
- 2005-05-04 HN HN2005000192A patent/HN2005000192A/es unknown
- 2005-05-04 GT GT200500103A patent/GT200500103A/es unknown
- 2005-05-05 US US11/122,345 patent/US7772243B2/en active Active
- 2005-05-05 UY UY28885A patent/UY28885A1/es active IP Right Grant
-
2006
- 2006-10-23 IL IL178822A patent/IL178822A/en active IP Right Grant
- 2006-10-30 ZA ZA200609012A patent/ZA200609012B/xx unknown
- 2006-11-02 NI NI200600262A patent/NI200600262A/es unknown
- 2006-11-03 CR CR8727A patent/CR8727A/es unknown
- 2006-11-03 TN TNP2006000360A patent/TNSN06360A1/fr unknown
- 2006-11-03 MA MA29435A patent/MA28632B1/fr unknown
- 2006-11-08 EC EC2006006976A patent/ECSP066976A/es unknown
- 2006-12-06 NO NO20065626A patent/NO339692B1/no active Protection Beyond IP Right Term
-
2008
- 2008-07-11 JP JP2008180894A patent/JP4966923B2/ja not_active Expired - Lifetime
-
2010
- 2010-04-05 US US12/754,556 patent/US8466165B2/en active Active
-
2011
- 2011-12-02 CY CY20111101196T patent/CY1112127T1/el unknown
-
2013
- 2013-06-10 US US13/914,410 patent/US8623883B2/en not_active Expired - Lifetime
-
2019
- 2019-08-29 CY CY2019034C patent/CY2019034I2/el unknown
- 2019-09-10 LT LTPA2019016C patent/LTC1746999I2/lt unknown
- 2019-09-11 HU HUS1900039C patent/HUS1900039I1/hu unknown
- 2019-09-12 LU LU00127C patent/LUC00127I2/fr unknown
- 2019-09-12 FR FR19C1052C patent/FR19C1052I2/fr active Active
- 2019-09-12 BE BE2019C540C patent/BE2019C540I2/nl unknown
- 2019-09-13 NO NO2019035C patent/NO2019035I1/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ME01267B (me) | 4-fenilaminokinazolin-6-ilamidi | |
| CA2698018C (en) | Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof | |
| ES2988336T3 (es) | Un agente antineoplásico 1-((4-(4-fluoro-2-metil-1H-indol-5-iloxi)-6-metoxiquinolin-7-iloxi)metil)ciclopropanamina, su forma cristalina y sus sales | |
| ATE307810T1 (de) | Imidazol-2-carbonsäureamid derivate als raf- kinase-inhibitoren | |
| CY1112800T1 (el) | Η χρηση υποκαθιστουμενων κυανοπυρρολιδινων για τη θεραπεια της υπερλιπιδαιμιας | |
| BRPI0610144A2 (pt) | método de preparar um 3-cianoquinolina substituìda; composto representado pela fórmula i; e composto, representado pela fórmula ii | |
| MX2010006182A (es) | Derivados de isoxazolo-piridazina. | |
| PH12013500265A1 (en) | Pharmaceutically active compounds as axl inhibitors | |
| DK1539700T3 (da) | 8-hydroxyquinolin-derivater | |
| DE60002714D1 (de) | Substituierte azaoxindolederivate | |
| WO2007065662A3 (en) | Trisubstituted quinazolinone derivatives as vanilloid antagonists | |
| Kenawi et al. | Drug–drug interaction between diclofenac, cetirizine and ranitidine | |
| RU2015143841A (ru) | Ингибиторы hdac | |
| TW200716597A (en) | Novel piperidine-substituted indoles | |
| MX2009011836A (es) | Sales de [4-(6-fluoro-7-metilamino-2,4-dioxo-1,4-dihidro-2h-quinaz olin-3-il)-fenil]-5-cloro-tiofen-2-il-sulfonilurea, en diferentes formas cristalinas, y composiciones farmaceuticas de las mismas. | |
| ATE466007T1 (de) | 5-substituierte indol-2-carbonsäureamidderivate | |
| CN110372666B (zh) | 喹唑啉类化合物作为egfr三突变抑制剂及其应用 | |
| MX2023012039A (es) | Compuestos bicíclicos fusionados sustituidos como inhibidores de parp y uso de estos. | |
| BG106806A (bg) | Нови съединения | |
| HRP20120257T1 (hr) | Antagonisti receptora 5-ht7 | |
| BRPI0409374A (pt) | composto, composição farmacêutica, uso de pelo menos um composto, e, método para o tratamento de um distúrbio médico | |
| WO2007147770A3 (en) | Substituted phenyl methanone derivatives | |
| ATE287397T1 (de) | Chinoline derivate und ihre anwendung als antitumor agentien | |
| CA2351644A1 (en) | Pyrimidine derivatives and processes for the preparation thereof | |
| BRPI0418375A (pt) | derivados de diaza-espiropiperidina |