MA52098A - Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation - Google Patents

Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation

Info

Publication number
MA52098A
MA52098A MA052098A MA52098A MA52098A MA 52098 A MA52098 A MA 52098A MA 052098 A MA052098 A MA 052098A MA 52098 A MA52098 A MA 52098A MA 52098 A MA52098 A MA 52098A
Authority
MA
Morocco
Prior art keywords
compounds
pharmaceutical compositions
ppar agonists
use procedures
procedures
Prior art date
Application number
MA052098A
Other languages
English (en)
French (fr)
Inventor
Michael Downes
Ronald M Evans
Arthur Kluge
Bharat Lagu
Masanori Miura
Sunil Kumar Panigrahi
Michael Patane
Susanta Samajdar
Ramesh Senaiar
Taisuke Takahashi
Original Assignee
Mitobridge Inc
Salk Inst Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57200096&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA52098(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mitobridge Inc, Salk Inst Biological Studies filed Critical Mitobridge Inc
Publication of MA52098A publication Critical patent/MA52098A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA052098A 2015-10-07 2016-10-05 Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation MA52098A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562238629P 2015-10-07 2015-10-07
US201562243263P 2015-10-19 2015-10-19
US201662352348P 2016-06-20 2016-06-20

Publications (1)

Publication Number Publication Date
MA52098A true MA52098A (fr) 2021-01-27

Family

ID=57200096

Family Applications (2)

Application Number Title Priority Date Filing Date
MA052098A MA52098A (fr) 2015-10-07 2016-10-05 Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation
MA052648A MA52648A (fr) 2015-10-07 2016-10-05 Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA052648A MA52648A (fr) 2015-10-07 2016-10-05 Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation

Country Status (26)

Country Link
US (6) US10399958B2 (enExample)
EP (3) EP3359528B1 (enExample)
JP (2) JP6657413B2 (enExample)
KR (2) KR102667385B1 (enExample)
CN (3) CN113004205B (enExample)
AU (3) AU2016333963C1 (enExample)
BR (1) BR112018006866B1 (enExample)
CA (1) CA3000431A1 (enExample)
CO (1) CO2018004473A2 (enExample)
DK (1) DK3359528T3 (enExample)
EA (1) EA037371B1 (enExample)
ES (3) ES2906379T3 (enExample)
HU (1) HUE058154T2 (enExample)
IL (3) IL258225B (enExample)
JO (3) JO3738B1 (enExample)
MA (2) MA52098A (enExample)
MX (3) MX380281B (enExample)
MY (1) MY203081A (enExample)
PH (1) PH12018500762A1 (enExample)
PL (1) PL3359528T3 (enExample)
PT (1) PT3359528T (enExample)
SG (1) SG10201906400SA (enExample)
TW (3) TWI730006B (enExample)
UA (1) UA122237C2 (enExample)
WO (1) WO2017062468A1 (enExample)
ZA (4) ZA201802029B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA122237C2 (uk) * 2015-10-07 2020-10-12 Мітобрідж, Інк. Агоністи ppar, сполуки, фармацевтичні композиції та способи їх застосування
MX380531B (es) 2016-04-13 2025-03-12 Mitobridge Inc Agonistas del receptor activado por proliferador de peroxisoma (ppar), compuestos, composiciones farmacéuticas y métodos para usar los mismos.
WO2018067857A1 (en) * 2016-10-05 2018-04-12 Mitobridge, Inc. Methods of treating acute kidney injury
ES2887008T3 (es) * 2016-10-05 2021-12-21 Mitobridge Inc Formas cristalinas y de sal de compuestos agonistas del PPAR
WO2021046081A1 (en) * 2019-09-05 2021-03-11 Rush University Medical Center Methods and compositions for treatment of demyelinating disorders
US11634387B2 (en) 2019-09-26 2023-04-25 Abionyx Pharma Sa Compounds useful for treating liver diseases
EP4305024A1 (en) * 2021-03-08 2024-01-17 Abionyx Pharma SA Compounds useful for treating liver diseases
WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases
US20240358681A1 (en) 2021-06-02 2024-10-31 Mitobridge, Inc. Methods of use of ppar agonist compounds and pharmaceutical compositions thereof
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease
EP4230196A1 (en) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Compounds for use in the treatment of dystrophinopathies
WO2025207099A1 (en) 2024-03-28 2025-10-02 Astellas Pharma Inc. Ppar-delta inhibitors for preventing post-operative atrial fibrillation

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RU2328483C2 (ru) * 2002-08-29 2008-07-10 Мерк Энд Ко., Инк. Индолы, обладающие противодиабетической активностью
TW200408393A (en) 2002-10-03 2004-06-01 Ono Pharmaceutical Co Antagonist of lysophosphatidine acid receptor
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WO2005030185A2 (en) 2003-09-26 2005-04-07 Japan Tobacco Inc. Method of inhibiting remnant lipoprotein production
CN101031541A (zh) 2004-09-06 2007-09-05 弗·哈夫曼-拉罗切有限公司 4-氨基甲基苄脒衍生物及其作为因子Ⅷa抑制剂的用途
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KR20080042170A (ko) * 2005-09-07 2008-05-14 플렉시콘, 인코퍼레이티드 Ppar 활성 화합물
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UA122237C2 (uk) 2015-10-07 2020-10-12 Мітобрідж, Інк. Агоністи ppar, сполуки, фармацевтичні композиції та способи їх застосування
MX380531B (es) 2016-04-13 2025-03-12 Mitobridge Inc Agonistas del receptor activado por proliferador de peroxisoma (ppar), compuestos, composiciones farmacéuticas y métodos para usar los mismos.
ES2887008T3 (es) * 2016-10-05 2021-12-21 Mitobridge Inc Formas cristalinas y de sal de compuestos agonistas del PPAR
WO2018067857A1 (en) 2016-10-05 2018-04-12 Mitobridge, Inc. Methods of treating acute kidney injury
WO2018125961A1 (en) * 2016-12-30 2018-07-05 Mitobridge, Inc. Poly-adp ribose polymerase (parp) inhibitors

Also Published As

Publication number Publication date
MA52648A (fr) 2021-10-13
JP2020075939A (ja) 2020-05-21
CO2018004473A2 (es) 2018-09-20
CN113004205B (zh) 2024-07-02
JOP20200230A1 (ar) 2022-10-30
IL275387A (en) 2020-07-30
JO3738B1 (ar) 2021-01-31
ES2988059T3 (es) 2024-11-19
BR112018006866B1 (pt) 2023-11-21
IL275392B (en) 2022-05-01
TWI730408B (zh) 2021-06-11
WO2017062468A1 (en) 2017-04-13
JP2018534355A (ja) 2018-11-22
CN108349904A (zh) 2018-07-31
JP6866514B2 (ja) 2021-04-28
MY203081A (en) 2024-06-07
NZ740846A (en) 2024-12-20
IL258225A (en) 2018-05-31
SG10201906400SA (en) 2019-08-27
MX392524B (es) 2025-03-24
EP3770146A1 (en) 2021-01-27
KR20210126150A (ko) 2021-10-19
DK3359528T3 (en) 2022-03-07
JOP20200230B1 (ar) 2024-04-18
US20200157074A1 (en) 2020-05-21
US20190084958A1 (en) 2019-03-21
TW202012375A (zh) 2020-04-01
ZA202003664B (en) 2022-08-31
KR102667386B1 (ko) 2024-05-21
MX2020011099A (es) 2022-05-23
US11578052B2 (en) 2023-02-14
EA037371B1 (ru) 2021-03-19
ES2906379T3 (es) 2022-04-18
AU2019283837A1 (en) 2020-01-16
US20240417383A1 (en) 2024-12-19
MX2018004295A (es) 2018-08-09
MX392523B (es) 2025-03-24
AU2019283837B2 (en) 2020-12-24
UA122237C2 (uk) 2020-10-12
EA201890776A1 (ru) 2018-09-28
US10399958B2 (en) 2019-09-03
IL275387B (en) 2021-08-31
TWI730006B (zh) 2021-06-11
CN108349904B (zh) 2021-08-31
CN113024467A (zh) 2021-06-25
US10479775B1 (en) 2019-11-19
US10906885B2 (en) 2021-02-02
ES2949852T3 (es) 2023-10-03
AU2016333963B2 (en) 2021-01-07
EP3795566A1 (en) 2021-03-24
CN113024467B (zh) 2024-08-06
ZA202003662B (en) 2022-08-31
AU2020281069B2 (en) 2022-10-27
IL258225B (en) 2021-08-31
AU2016333963A1 (en) 2018-04-12
AU2016333963C1 (en) 2021-05-27
CN113004205A (zh) 2021-06-22
US20210253549A1 (en) 2021-08-19
JP6657413B2 (ja) 2020-03-04
CA3000431A1 (en) 2017-04-13
TW201943705A (zh) 2019-11-16
AU2020281069A1 (en) 2021-01-07
EP3359528B1 (en) 2022-01-12
EP3795566B1 (en) 2023-04-19
JOP20200231A1 (ar) 2022-10-30
MX380281B (es) 2025-03-12
KR102667385B1 (ko) 2024-05-21
HK1257907A1 (zh) 2019-11-01
IL275392A (en) 2020-07-30
JOP20200231B1 (ar) 2022-03-14
EP3359528A1 (en) 2018-08-15
EP3770146B1 (en) 2024-07-24
PT3359528T (pt) 2022-04-07
TWI742479B (zh) 2021-10-11
KR20180095797A (ko) 2018-08-28
PH12018500762A1 (en) 2018-10-29
HUE058154T2 (hu) 2022-07-28
US20190337920A1 (en) 2019-11-07
ZA202003663B (en) 2022-08-31
WO2017062468A8 (en) 2017-05-11
EP3770146C0 (en) 2024-07-24
US20230373948A1 (en) 2023-11-23
PL3359528T3 (pl) 2022-05-30
TW201722919A (zh) 2017-07-01
ZA201802029B (en) 2022-01-26
BR112018006866A2 (pt) 2018-10-16
MX2020011100A (es) 2022-05-23

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