TWI730006B - 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法 - Google Patents

過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法 Download PDF

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TWI730006B
TWI730006B TW105132668A TW105132668A TWI730006B TW I730006 B TWI730006 B TW I730006B TW 105132668 A TW105132668 A TW 105132668A TW 105132668 A TW105132668 A TW 105132668A TW I730006 B TWI730006 B TW I730006B
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methyl
compound
disease
pharmaceutically acceptable
imidazol
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TW105132668A
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Chinese (zh)
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TW201722919A (zh
Inventor
麥可 道尼思
羅那德 M 伊凡斯
亞瑟 庫勒吉
巴拉特 拉古
理憲 三浦
桑尼爾 庫瑪 潘尼葛西
麥克 帕塔尼
蘇桑塔 薩瑪佳達
拉米許 聖奈爾
泰輔 高橋
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美商米突倍基公司
沙克生物研究機構
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Application filed by 美商米突倍基公司, 沙克生物研究機構 filed Critical 美商米突倍基公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW105132668A 2015-10-07 2016-10-07 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法 TWI730006B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562238629P 2015-10-07 2015-10-07
US62/238,629 2015-10-07
US201562243263P 2015-10-19 2015-10-19
US62/243,263 2015-10-19
US201662352348P 2016-06-20 2016-06-20
US62/352,348 2016-06-20

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TW201722919A TW201722919A (zh) 2017-07-01
TWI730006B true TWI730006B (zh) 2021-06-11

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TW105132668A TWI730006B (zh) 2015-10-07 2016-10-07 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法
TW108133069A TWI730408B (zh) 2015-10-07 2016-10-07 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法
TW108144723A TWI742479B (zh) 2015-10-07 2016-10-07 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法

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TW108144723A TWI742479B (zh) 2015-10-07 2016-10-07 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法

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UA (1) UA122237C2 (enExample)
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ZA (4) ZA201802029B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE058154T2 (hu) 2015-10-07 2022-07-28 Mitobridge Inc PPAR agonisták, vegyületek, gyógyászati készítmények és módszerek alkalmazásukra
MX380531B (es) 2016-04-13 2025-03-12 Mitobridge Inc Agonistas del receptor activado por proliferador de peroxisoma (ppar), compuestos, composiciones farmacéuticas y métodos para usar los mismos.
SG11201901995TA (en) * 2016-10-05 2019-04-29 Mitobridge Inc Crystalline and salt forms of ppar agonist compounds
SMT202100111T1 (it) * 2016-10-05 2021-05-07 Mitobridge Inc Metodi di trattamento del danno renale acuto
WO2021046081A1 (en) * 2019-09-05 2021-03-11 Rush University Medical Center Methods and compositions for treatment of demyelinating disorders
US11634387B2 (en) 2019-09-26 2023-04-25 Abionyx Pharma Sa Compounds useful for treating liver diseases
WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases
BR112023025221A2 (pt) 2021-06-02 2024-02-27 Astellas Pharma Inc Métodos de uso de compostos agonistas de ppar e composições farmacêuticas dos mesmos
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease
EP4230196A1 (en) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Compounds for use in the treatment of dystrophinopathies
WO2025207099A1 (en) 2024-03-28 2025-10-02 Astellas Pharma Inc. Ppar-delta inhibitors for preventing post-operative atrial fibrillation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014165827A1 (en) * 2013-04-05 2014-10-09 Salk Institute For Biological Studies Ppar agonists

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228281A (en) 1977-09-23 1980-10-14 Ciba-Geigy Corporation Dicarboxylic acids containing triazine rings
DE4123341A1 (de) * 1991-07-15 1993-01-21 Thomae Gmbh Dr K Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9511694D0 (en) 1995-06-09 1995-08-02 Fujisawa Pharmaceutical Co Benzamide derivatives
CZ20013000A3 (cs) 1999-02-26 2002-02-13 Merck & Co., Inc. Nové sulfonamidové sloučeniny a jejich pouľití
GB9919413D0 (en) 1999-08-18 1999-10-20 Zeneca Ltd Chemical compounds
BR0113289A (pt) 2000-08-17 2003-06-17 Pfizer Imidazóis substituìdos como inibidores de tafia
BR0313825A (pt) * 2002-08-29 2005-07-12 Merck & Co Inc Composto, composição farmacêutica, método para tratar de diabete mellitus tipo 2 em um mamìfero, e, uso de composto
TW200408393A (en) 2002-10-03 2004-06-01 Ono Pharmaceutical Co Antagonist of lysophosphatidine acid receptor
WO2004060367A1 (en) 2002-12-30 2004-07-22 Fujisawa Pharmaceutical Co., Ltd. Imidazole and triazole derivatives useful as selective cox-1 inhibitors
WO2005030185A2 (en) 2003-09-26 2005-04-07 Japan Tobacco Inc. Method of inhibiting remnant lipoprotein production
BRPI0515140A (pt) 2004-09-06 2008-07-08 Hoffmann La Roche derivados de benzamidina de 4-aminometila e seu emprego como inibidores do fator viia
MX2007009343A (es) 2005-02-15 2007-09-21 Hoffmann La Roche Derivados de amida como activadores de receptor activado por proliferador de peroxisomas.
BRPI0615948A2 (pt) 2005-09-07 2011-05-31 Plexxikon Inc composto ativo de ppar, sua composição, seu kit e seu uso
CA2637024C (en) 2006-01-30 2013-05-14 Transtech Pharma, Inc. Substituted imidazole derivatives, compositions, and methods of use as ptpase inhibitors
WO2007110237A2 (en) 2006-03-28 2007-10-04 Novartis Ag Amide derivatives and their application for the treatment of g protein related diseases
EP2014652B1 (en) 2006-04-18 2014-08-06 Nippon Chemiphar Co., Ltd. Activating agent for peroxisome proliferator activated receptor
DE102006023336A1 (de) 2006-05-18 2007-11-22 Merck Patent Gmbh 1,5-Diphenyl-pyrazole II
CN101085772A (zh) 2006-06-07 2007-12-12 上海艾力斯医药科技有限公司 一类具有PPARγ激动剂活性的化合物及其应用
US20100016396A1 (en) 2007-01-29 2010-01-21 Hiroshi Imoto Pyrazole compound
GB2460784A (en) 2007-03-07 2009-12-16 Dong A Pharmtech Co Ltd Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators,method of the same,and pharmaceutical composition
JP2008285452A (ja) 2007-05-21 2008-11-27 Ono Pharmaceut Co Ltd PPARα/γデュアルアゴニストおよび糖尿病治療薬を組み合わせてなる医薬
EP2234622A4 (en) 2007-12-28 2011-03-09 Salk Inst For Biological Studi METHODS ENHANCING PERFORMANCE AND MUSCLE TONUS
EP2890313B1 (en) 2012-08-28 2016-09-21 KOC Universitesi Bone plate
ES2811087T3 (es) 2013-09-09 2021-03-10 Vtv Therapeutics Llc Uso de agonistas de PPAR-delta para tratar la atrofia muscular
US20170305894A1 (en) 2014-10-08 2017-10-26 Mitobridge, Inc. Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
WO2016057322A1 (en) 2014-10-08 2016-04-14 Salk Institute For Biological Studies Ppar agonists and methods of use thereof
HUE058154T2 (hu) 2015-10-07 2022-07-28 Mitobridge Inc PPAR agonisták, vegyületek, gyógyászati készítmények és módszerek alkalmazásukra
MX380531B (es) 2016-04-13 2025-03-12 Mitobridge Inc Agonistas del receptor activado por proliferador de peroxisoma (ppar), compuestos, composiciones farmacéuticas y métodos para usar los mismos.
SG11201901995TA (en) * 2016-10-05 2019-04-29 Mitobridge Inc Crystalline and salt forms of ppar agonist compounds
SMT202100111T1 (it) 2016-10-05 2021-05-07 Mitobridge Inc Metodi di trattamento del danno renale acuto
UA124777C2 (uk) * 2016-12-30 2021-11-17 Мітобрідж, Інк. Інгібітори полі(адф-рибоза)полімерази (parp)

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014165827A1 (en) * 2013-04-05 2014-10-09 Salk Institute For Biological Studies Ppar agonists

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US10906885B2 (en) 2021-02-02
TW201943705A (zh) 2019-11-16
US10399958B2 (en) 2019-09-03
EA201890776A1 (ru) 2018-09-28
KR20180095797A (ko) 2018-08-28
BR112018006866B1 (pt) 2023-11-21
EA037371B1 (ru) 2021-03-19
AU2019283837B2 (en) 2020-12-24
ZA201802029B (en) 2022-01-26
EP3770146B1 (en) 2024-07-24
JP2018534355A (ja) 2018-11-22
ZA202003663B (en) 2022-08-31
IL275387A (en) 2020-07-30
KR20210126150A (ko) 2021-10-19
US20200157074A1 (en) 2020-05-21
PL3359528T3 (pl) 2022-05-30
JP6866514B2 (ja) 2021-04-28
DK3359528T3 (en) 2022-03-07
US20210253549A1 (en) 2021-08-19
EP3770146A1 (en) 2021-01-27
AU2016333963A1 (en) 2018-04-12
HK1257907A1 (zh) 2019-11-01
CN113024467A (zh) 2021-06-25
US11578052B2 (en) 2023-02-14
AU2020281069A1 (en) 2021-01-07
AU2016333963C1 (en) 2021-05-27
CN113004205A (zh) 2021-06-22
WO2017062468A8 (en) 2017-05-11
CA3000431A1 (en) 2017-04-13
MX2018004295A (es) 2018-08-09
MA52648A (fr) 2021-10-13
US20190084958A1 (en) 2019-03-21
EP3795566A1 (en) 2021-03-24
TWI730408B (zh) 2021-06-11
AU2016333963B2 (en) 2021-01-07
JP6657413B2 (ja) 2020-03-04
US10479775B1 (en) 2019-11-19
MX392524B (es) 2025-03-24
EP3770146C0 (en) 2024-07-24
IL275392A (en) 2020-07-30
IL275387B (en) 2021-08-31
CN108349904B (zh) 2021-08-31
MY203081A (en) 2024-06-07
US20230373948A1 (en) 2023-11-23
JP2020075939A (ja) 2020-05-21
KR102667386B1 (ko) 2024-05-21
MX2020011099A (es) 2022-05-23
ZA202003664B (en) 2022-08-31
JOP20200231A1 (ar) 2022-10-30
HUE058154T2 (hu) 2022-07-28
PT3359528T (pt) 2022-04-07
EP3795566B1 (en) 2023-04-19
ES2949852T3 (es) 2023-10-03
CN113024467B (zh) 2024-08-06
CO2018004473A2 (es) 2018-09-20
WO2017062468A1 (en) 2017-04-13
ZA202003662B (en) 2022-08-31
CN113004205B (zh) 2024-07-02
JOP20200230A1 (ar) 2022-10-30
MA52098A (fr) 2021-01-27
ES2988059T3 (es) 2024-11-19
TWI742479B (zh) 2021-10-11
UA122237C2 (uk) 2020-10-12
EP3359528A1 (en) 2018-08-15
US20240417383A1 (en) 2024-12-19
AU2019283837A1 (en) 2020-01-16
SG10201906400SA (en) 2019-08-27
IL258225A (en) 2018-05-31
MX392523B (es) 2025-03-24
JO3738B1 (ar) 2021-01-31
IL275392B (en) 2022-05-01
ES2906379T3 (es) 2022-04-18
BR112018006866A2 (pt) 2018-10-16
MX2020011100A (es) 2022-05-23
KR102667385B1 (ko) 2024-05-21
US20190337920A1 (en) 2019-11-07
PH12018500762A1 (en) 2018-10-29
CN108349904A (zh) 2018-07-31
TW202012375A (zh) 2020-04-01
AU2020281069B2 (en) 2022-10-27
NZ740846A (en) 2024-12-20
IL258225B (en) 2021-08-31
EP3359528B1 (en) 2022-01-12
MX380281B (es) 2025-03-12
TW201722919A (zh) 2017-07-01

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