TWI730006B - 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法 - Google Patents

過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法 Download PDF

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TWI730006B
TWI730006B TW105132668A TW105132668A TWI730006B TW I730006 B TWI730006 B TW I730006B TW 105132668 A TW105132668 A TW 105132668A TW 105132668 A TW105132668 A TW 105132668A TW I730006 B TWI730006 B TW I730006B
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methyl
compound
disease
pharmaceutically acceptable
imidazol
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TW105132668A
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Chinese (zh)
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TW201722919A (zh
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麥可 道尼思
羅那德 M 伊凡斯
亞瑟 庫勒吉
巴拉特 拉古
理憲 三浦
桑尼爾 庫瑪 潘尼葛西
麥克 帕塔尼
蘇桑塔 薩瑪佳達
拉米許 聖奈爾
泰輔 高橋
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美商米突倍基公司
沙克生物研究機構
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Cardiology (AREA)
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  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW105132668A 2015-10-07 2016-10-07 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法 TWI730006B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562238629P 2015-10-07 2015-10-07
US62/238,629 2015-10-07
US201562243263P 2015-10-19 2015-10-19
US62/243,263 2015-10-19
US201662352348P 2016-06-20 2016-06-20
US62/352,348 2016-06-20

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TW201722919A TW201722919A (zh) 2017-07-01
TWI730006B true TWI730006B (zh) 2021-06-11

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TW108133069A TWI730408B (zh) 2015-10-07 2016-10-07 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法
TW105132668A TWI730006B (zh) 2015-10-07 2016-10-07 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法
TW108144723A TWI742479B (zh) 2015-10-07 2016-10-07 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法

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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX392524B (es) 2015-10-07 2025-03-24 Salk Inst Biological Studies Compuestos, composiciones farmaceuticas y metodos de uso de agonistas de ppar
BR112018069930B1 (pt) 2016-04-13 2024-02-20 Mitobridge, Inc Compostos agonistas de ppar, uso dos mesmos e composição farmacêutica
PL3523283T3 (pl) * 2016-10-05 2021-12-13 Mitobridge, Inc. Postacie krystaliczne i postacie soli związków stanowiących agonistów ppar
MY192385A (en) * 2016-10-05 2022-08-18 Mitobridge Inc Methods of treating acute kidney injury
WO2021046081A1 (en) * 2019-09-05 2021-03-11 Rush University Medical Center Methods and compositions for treatment of demyelinating disorders
US11634387B2 (en) 2019-09-26 2023-04-25 Abionyx Pharma Sa Compounds useful for treating liver diseases
WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases
EP4346807A1 (en) 2021-06-02 2024-04-10 Astellas Pharma Inc. Methods of use of ppar agonist compounds and pharmaceutical compositions thereof
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease
EP4230196A1 (en) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Compounds for use in the treatment of dystrophinopathies
WO2025207099A1 (en) 2024-03-28 2025-10-02 Astellas Pharma Inc. Ppar-delta inhibitors for preventing post-operative atrial fibrillation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014165827A1 (en) * 2013-04-05 2014-10-09 Salk Institute For Biological Studies Ppar agonists

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228281A (en) 1977-09-23 1980-10-14 Ciba-Geigy Corporation Dicarboxylic acids containing triazine rings
DE4123341A1 (de) * 1991-07-15 1993-01-21 Thomae Gmbh Dr K Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9511694D0 (en) 1995-06-09 1995-08-02 Fujisawa Pharmaceutical Co Benzamide derivatives
IL144781A0 (en) 1999-02-26 2002-06-30 Merck & Co Inc Novel sulfonamide compounds and uses thereof
GB9919413D0 (en) 1999-08-18 1999-10-20 Zeneca Ltd Chemical compounds
MXPA03001425A (es) 2000-08-17 2003-06-06 Pfizer Compuestos farmaceuticos.
DK1537078T3 (da) * 2002-08-29 2010-08-02 Merck Sharp & Dohme Indoler med anti-diabetisk aktivitet
US7820682B2 (en) 2002-10-03 2010-10-26 Ono Pharmaceutical Co., Ltd. LPA receptor antagonist
WO2004060367A1 (en) 2002-12-30 2004-07-22 Fujisawa Pharmaceutical Co., Ltd. Imidazole and triazole derivatives useful as selective cox-1 inhibitors
EP2319509A1 (en) 2003-09-26 2011-05-11 Japan Tobacco, Inc. Method of Inhibiting remnant lipoprotein production
WO2006027135A1 (en) 2004-09-06 2006-03-16 F. Hoffmann-La Roche Ag 4-aminomethyl benzamidine derivatives and their use as factor viiia inhibitors
WO2007028424A1 (en) 2005-02-15 2007-03-15 F. Hoffmann-La Roche Ag Amide derivatives as ppar activators
RU2008108221A (ru) 2005-09-07 2009-10-20 Плекссикон, Инк. (Us) Соединения, активные в отношении ppar (рецепторов активаторов пролиферации пероксисом)
EA019385B1 (ru) 2006-01-30 2014-03-31 ТРАНСТЕК ФАРМА ЭлЭлСи ЗАМЕЩЕННЫЕ ИМИДАЗОЛЬНЫЕ ПРОИЗВОДНЫЕ, СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ РТРазы
JP2009531364A (ja) 2006-03-28 2009-09-03 ノバルティス アクチエンゲゼルシャフト アミド誘導体およびgタンパク質関連疾患の処置のためのそれらの使用
JP5290749B2 (ja) 2006-04-18 2013-09-18 日本ケミファ株式会社 ペルオキシソーム増殖剤活性化受容体δの活性化剤
DE102006023336A1 (de) 2006-05-18 2007-11-22 Merck Patent Gmbh 1,5-Diphenyl-pyrazole II
CN101085772A (zh) 2006-06-07 2007-12-12 上海艾力斯医药科技有限公司 一类具有PPARγ激动剂活性的化合物及其应用
WO2009086526A2 (en) 2007-12-28 2009-07-09 The Salk Institute For Biological Studies Methods for enhancing muscle performance and tone
US20100016396A1 (en) 2007-01-29 2010-01-21 Hiroshi Imoto Pyrazole compound
AU2008221718A1 (en) 2007-03-07 2008-09-12 Dong-A Pharm. Co., Ltd. Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators, method of the same, and pharmaceutical composition comprising the same
JP2008285452A (ja) 2007-05-21 2008-11-27 Ono Pharmaceut Co Ltd PPARα/γデュアルアゴニストおよび糖尿病治療薬を組み合わせてなる医薬
ES2607482T3 (es) 2012-08-28 2017-03-31 Koc Universitesi Placa ósea
EP3043789B1 (en) 2013-09-09 2020-07-08 vTv Therapeutics LLC Use of a ppar-delta agonists for treating muscle atrophy
WO2016057322A1 (en) * 2014-10-08 2016-04-14 Salk Institute For Biological Studies Ppar agonists and methods of use thereof
US20170305894A1 (en) 2014-10-08 2017-10-26 Mitobridge, Inc. Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
MX392524B (es) 2015-10-07 2025-03-24 Salk Inst Biological Studies Compuestos, composiciones farmaceuticas y metodos de uso de agonistas de ppar
BR112018069930B1 (pt) 2016-04-13 2024-02-20 Mitobridge, Inc Compostos agonistas de ppar, uso dos mesmos e composição farmacêutica
PL3523283T3 (pl) * 2016-10-05 2021-12-13 Mitobridge, Inc. Postacie krystaliczne i postacie soli związków stanowiących agonistów ppar
MY192385A (en) 2016-10-05 2022-08-18 Mitobridge Inc Methods of treating acute kidney injury
EP3562822B1 (en) * 2016-12-30 2021-03-10 Mitobridge, Inc. Poly-adp ribose polymerase (parp) inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014165827A1 (en) * 2013-04-05 2014-10-09 Salk Institute For Biological Studies Ppar agonists

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JOP20200231A1 (ar) 2022-10-30
CN113004205A (zh) 2021-06-22
MX392524B (es) 2025-03-24
US20190084958A1 (en) 2019-03-21
ZA201802029B (en) 2022-01-26
EP3795566B1 (en) 2023-04-19
HUE058154T2 (hu) 2022-07-28
IL275392A (en) 2020-07-30
CN108349904A (zh) 2018-07-31
MX2018004295A (es) 2018-08-09
US20240417383A1 (en) 2024-12-19
IL275392B (en) 2022-05-01
ZA202003664B (en) 2022-08-31
JOP20200230A1 (ar) 2022-10-30
US20210253549A1 (en) 2021-08-19
AU2020281069A1 (en) 2021-01-07
US20230373948A1 (en) 2023-11-23
UA122237C2 (uk) 2020-10-12
MY203081A (en) 2024-06-07
TW201722919A (zh) 2017-07-01
TW202012375A (zh) 2020-04-01
WO2017062468A1 (en) 2017-04-13
AU2019283837A1 (en) 2020-01-16
KR102667385B1 (ko) 2024-05-21
MA52098A (fr) 2021-01-27
KR20180095797A (ko) 2018-08-28
ES2949852T3 (es) 2023-10-03
CN108349904B (zh) 2021-08-31
PL3359528T3 (pl) 2022-05-30
JP6657413B2 (ja) 2020-03-04
CN113004205B (zh) 2024-07-02
WO2017062468A8 (en) 2017-05-11
BR112018006866A2 (pt) 2018-10-16
EP3770146B1 (en) 2024-07-24
US10479775B1 (en) 2019-11-19
JP6866514B2 (ja) 2021-04-28
AU2019283837B2 (en) 2020-12-24
PT3359528T (pt) 2022-04-07
ES2988059T3 (es) 2024-11-19
JO3738B1 (ar) 2021-01-31
HK1257907A1 (zh) 2019-11-01
JP2020075939A (ja) 2020-05-21
AU2016333963B2 (en) 2021-01-07
ZA202003663B (en) 2022-08-31
IL275387A (en) 2020-07-30
AU2020281069B2 (en) 2022-10-27
MX2020011100A (es) 2022-05-23
IL258225A (en) 2018-05-31
JP2018534355A (ja) 2018-11-22
NZ740846A (en) 2024-12-20
US11578052B2 (en) 2023-02-14
EP3770146C0 (en) 2024-07-24
BR112018006866B1 (pt) 2023-11-21
EA037371B1 (ru) 2021-03-19
TWI742479B (zh) 2021-10-11
ES2906379T3 (es) 2022-04-18
AU2016333963C1 (en) 2021-05-27
CN113024467B (zh) 2024-08-06
EP3359528B1 (en) 2022-01-12
EA201890776A1 (ru) 2018-09-28
MX392523B (es) 2025-03-24
KR20210126150A (ko) 2021-10-19
CO2018004473A2 (es) 2018-09-20
SG10201906400SA (en) 2019-08-27
CN113024467A (zh) 2021-06-25
MA52648A (fr) 2021-10-13
EP3770146A1 (en) 2021-01-27
ZA202003662B (en) 2022-08-31
DK3359528T3 (en) 2022-03-07
EP3795566A1 (en) 2021-03-24
US10399958B2 (en) 2019-09-03
KR102667386B1 (ko) 2024-05-21
MX2020011099A (es) 2022-05-23
MX380281B (es) 2025-03-12
US20190337920A1 (en) 2019-11-07
US10906885B2 (en) 2021-02-02
AU2016333963A1 (en) 2018-04-12
TW201943705A (zh) 2019-11-16
CA3000431A1 (en) 2017-04-13
US20200157074A1 (en) 2020-05-21
TWI730408B (zh) 2021-06-11
EP3359528A1 (en) 2018-08-15
PH12018500762A1 (en) 2018-10-29
IL275387B (en) 2021-08-31
IL258225B (en) 2021-08-31

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