CO2018004473A2 - Compuestos agonistas de ppar y composiciones farmaceuticas - Google Patents

Compuestos agonistas de ppar y composiciones farmaceuticas

Info

Publication number
CO2018004473A2
CO2018004473A2 CONC2018/0004473A CO2018004473A CO2018004473A2 CO 2018004473 A2 CO2018004473 A2 CO 2018004473A2 CO 2018004473 A CO2018004473 A CO 2018004473A CO 2018004473 A2 CO2018004473 A2 CO 2018004473A2
Authority
CO
Colombia
Prior art keywords
ppar
diseases
pharmaceutical compositions
agonist compounds
compounds
Prior art date
Application number
CONC2018/0004473A
Other languages
English (en)
Spanish (es)
Inventor
Michael Downes
M Ronald Evans
Arthur Kluge
Bharat Lagu
Masanori Miura
Sunil Kumar Panigrahi
Michael Patane
Susanta Samajdar
Ramesh Senaiar
Taisuke Takahashi
Original Assignee
Mitobridge Inc
Salk Inst Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57200096&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO2018004473(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mitobridge Inc, Salk Inst Biological Studies filed Critical Mitobridge Inc
Publication of CO2018004473A2 publication Critical patent/CO2018004473A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CONC2018/0004473A 2015-10-07 2016-10-05 Compuestos agonistas de ppar y composiciones farmaceuticas CO2018004473A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562238629P 2015-10-07 2015-10-07
US201562243263P 2015-10-19 2015-10-19
US201662352348P 2016-06-20 2016-06-20
PCT/US2016/055521 WO2017062468A1 (en) 2015-10-07 2016-10-05 Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof

Publications (1)

Publication Number Publication Date
CO2018004473A2 true CO2018004473A2 (es) 2018-09-20

Family

ID=57200096

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2018/0004473A CO2018004473A2 (es) 2015-10-07 2016-10-05 Compuestos agonistas de ppar y composiciones farmaceuticas

Country Status (26)

Country Link
US (6) US10399958B2 (enExample)
EP (3) EP3770146B1 (enExample)
JP (2) JP6657413B2 (enExample)
KR (2) KR102667386B1 (enExample)
CN (3) CN113004205B (enExample)
AU (3) AU2016333963C1 (enExample)
BR (1) BR112018006866B1 (enExample)
CA (1) CA3000431A1 (enExample)
CO (1) CO2018004473A2 (enExample)
DK (1) DK3359528T3 (enExample)
EA (1) EA037371B1 (enExample)
ES (3) ES2949852T3 (enExample)
HU (1) HUE058154T2 (enExample)
IL (3) IL258225B (enExample)
JO (3) JO3738B1 (enExample)
MA (2) MA52648A (enExample)
MX (3) MX392524B (enExample)
MY (1) MY203081A (enExample)
PH (1) PH12018500762A1 (enExample)
PL (1) PL3359528T3 (enExample)
PT (1) PT3359528T (enExample)
SG (1) SG10201906400SA (enExample)
TW (3) TWI742479B (enExample)
UA (1) UA122237C2 (enExample)
WO (1) WO2017062468A1 (enExample)
ZA (4) ZA201802029B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11912681B2 (en) 2016-10-05 2024-02-27 Mitobridge, Inc. Crystalline and salt forms of PPAR agonist compounds

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA037371B1 (ru) * 2015-10-07 2021-03-19 Митобридж, Инк. Агонисты ppar, соединения, фармацевтические композиции и способы их применения
US11358954B2 (en) 2016-04-13 2022-06-14 Mitobridge, Inc. PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof
ES2859487T3 (es) * 2016-10-05 2021-10-04 Mitobridge Inc Métodos para tratar las lesiones renales agudas
US20220331267A1 (en) * 2019-09-05 2022-10-20 Rush University Medical Center Methods and compositions for treatment of demyelinating disorders
US11634387B2 (en) 2019-09-26 2023-04-25 Abionyx Pharma Sa Compounds useful for treating liver diseases
WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases
MX2023010537A (es) * 2021-03-08 2023-11-28 Abionyx Pharma Sa Compuestos útiles para tratar enfermedades del hígado.
BR112023025221A2 (pt) 2021-06-02 2024-02-27 Astellas Pharma Inc Métodos de uso de compostos agonistas de ppar e composições farmacêuticas dos mesmos
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease
EP4230196A1 (en) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Compounds for use in the treatment of dystrophinopathies
WO2025207099A1 (en) 2024-03-28 2025-10-02 Astellas Pharma Inc. Ppar-delta inhibitors for preventing post-operative atrial fibrillation

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228281A (en) 1977-09-23 1980-10-14 Ciba-Geigy Corporation Dicarboxylic acids containing triazine rings
DE4123341A1 (de) 1991-07-15 1993-01-21 Thomae Gmbh Dr K Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9511694D0 (en) 1995-06-09 1995-08-02 Fujisawa Pharmaceutical Co Benzamide derivatives
NZ514453A (en) 1999-02-26 2003-04-29 Merck & Co Inc Novel sulfonamide compounds and uses thereof
GB9919413D0 (en) 1999-08-18 1999-10-20 Zeneca Ltd Chemical compounds
ATE447557T1 (de) 2000-08-17 2009-11-15 Pfizer Ltd Substitutuierte imidazole als tafia inhibitoren
CN100457730C (zh) * 2002-08-29 2009-02-04 默克公司 具有抗糖尿病活性的吲哚化合物
US7820682B2 (en) 2002-10-03 2010-10-26 Ono Pharmaceutical Co., Ltd. LPA receptor antagonist
WO2004060367A1 (en) 2002-12-30 2004-07-22 Fujisawa Pharmaceutical Co., Ltd. Imidazole and triazole derivatives useful as selective cox-1 inhibitors
MXPA06003357A (es) 2003-09-26 2006-06-08 Japan Tobacco Inc Metodo para inhibir la produccion de lipoproteina remanente.
BRPI0515140A (pt) 2004-09-06 2008-07-08 Hoffmann La Roche derivados de benzamidina de 4-aminometila e seu emprego como inibidores do fator viia
CA2597148A1 (en) 2005-02-15 2007-03-15 F. Hoffmann-La Roche Ag Amide derivatives as ppar activators
BRPI0615948A2 (pt) 2005-09-07 2011-05-31 Plexxikon Inc composto ativo de ppar, sua composição, seu kit e seu uso
NZ569329A (en) 2006-01-30 2011-09-30 Transtech Pharma Inc Substituted imidazole derivatives and their use as PTPase inhibitors
MX2008012404A (es) 2006-03-28 2008-10-09 Novartis Ag Derivados de amida y su aplicacion para el tratamiento de enfermedades relacionadas con proteina-g.
CN101466687B (zh) 2006-04-18 2012-04-11 日本化学医药株式会社 过氧化物酶体增殖剂激活受体δ的激活剂
DE102006023336A1 (de) 2006-05-18 2007-11-22 Merck Patent Gmbh 1,5-Diphenyl-pyrazole II
CN101085772A (zh) 2006-06-07 2007-12-12 上海艾力斯医药科技有限公司 一类具有PPARγ激动剂活性的化合物及其应用
EP2128138A1 (en) 2007-01-29 2009-12-02 Takeda Pharmaceutical Company Limited Pyrazole compound
KR20080082541A (ko) 2007-03-07 2008-09-11 동아제약주식회사 퍼옥시좀 증식자-활성화 감마 수용체를 조절하는 신규한페닐프로판산 유도체의 제조방법 및 약학적 용도
JP2008285452A (ja) 2007-05-21 2008-11-27 Ono Pharmaceut Co Ltd PPARα/γデュアルアゴニストおよび糖尿病治療薬を組み合わせてなる医薬
CA2710764A1 (en) 2007-12-28 2009-07-09 The Salk Institute For Biological Studies Methods for enhancing muscle performance and tone
JP5895104B2 (ja) 2012-08-28 2016-03-30 コチ・ウニヴェルシテシKoc Universitesi 骨板
EP2981522A4 (en) 2013-04-05 2016-08-31 Salk Inst For Biological Studi PPAR AGONISTS
WO2015035171A1 (en) 2013-09-09 2015-03-12 High Point Pharmaceuticals, Llc Use of a ppar-delta agonist for treating muscle atrophy
WO2016057322A1 (en) 2014-10-08 2016-04-14 Salk Institute For Biological Studies Ppar agonists and methods of use thereof
US20170305894A1 (en) 2014-10-08 2017-10-26 Mitobridge, Inc. Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
EA037371B1 (ru) 2015-10-07 2021-03-19 Митобридж, Инк. Агонисты ppar, соединения, фармацевтические композиции и способы их применения
US11358954B2 (en) 2016-04-13 2022-06-14 Mitobridge, Inc. PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof
ES2887008T3 (es) * 2016-10-05 2021-12-21 Mitobridge Inc Formas cristalinas y de sal de compuestos agonistas del PPAR
ES2859487T3 (es) 2016-10-05 2021-10-04 Mitobridge Inc Métodos para tratar las lesiones renales agudas
SMT202100321T1 (it) * 2016-12-30 2021-07-12 Mitobridge Inc Inibitori della poli-adp ribosio polimerasi (parp)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11912681B2 (en) 2016-10-05 2024-02-27 Mitobridge, Inc. Crystalline and salt forms of PPAR agonist compounds

Also Published As

Publication number Publication date
CN113004205A (zh) 2021-06-22
ZA202003663B (en) 2022-08-31
EP3770146B1 (en) 2024-07-24
MX380281B (es) 2025-03-12
ZA201802029B (en) 2022-01-26
US20200157074A1 (en) 2020-05-21
US10399958B2 (en) 2019-09-03
TWI742479B (zh) 2021-10-11
AU2020281069B2 (en) 2022-10-27
MX392523B (es) 2025-03-24
KR20210126150A (ko) 2021-10-19
EA201890776A1 (ru) 2018-09-28
IL258225B (en) 2021-08-31
CA3000431A1 (en) 2017-04-13
KR102667385B1 (ko) 2024-05-21
US11578052B2 (en) 2023-02-14
IL275392B (en) 2022-05-01
PT3359528T (pt) 2022-04-07
HK1257907A1 (zh) 2019-11-01
AU2016333963A1 (en) 2018-04-12
TW202012375A (zh) 2020-04-01
PL3359528T3 (pl) 2022-05-30
EP3359528B1 (en) 2022-01-12
IL275387A (en) 2020-07-30
MX2020011100A (es) 2022-05-23
CN113004205B (zh) 2024-07-02
UA122237C2 (uk) 2020-10-12
KR20180095797A (ko) 2018-08-28
TWI730006B (zh) 2021-06-11
NZ740846A (en) 2024-12-20
EP3770146C0 (en) 2024-07-24
JP6657413B2 (ja) 2020-03-04
BR112018006866A2 (pt) 2018-10-16
EP3359528A1 (en) 2018-08-15
JO3738B1 (ar) 2021-01-31
TW201722919A (zh) 2017-07-01
JOP20200230A1 (ar) 2022-10-30
TW201943705A (zh) 2019-11-16
PH12018500762A1 (en) 2018-10-29
US10906885B2 (en) 2021-02-02
CN108349904A (zh) 2018-07-31
DK3359528T3 (en) 2022-03-07
WO2017062468A8 (en) 2017-05-11
TWI730408B (zh) 2021-06-11
SG10201906400SA (en) 2019-08-27
EP3795566A1 (en) 2021-03-24
MX392524B (es) 2025-03-24
MX2018004295A (es) 2018-08-09
BR112018006866B1 (pt) 2023-11-21
AU2019283837A1 (en) 2020-01-16
IL258225A (en) 2018-05-31
HUE058154T2 (hu) 2022-07-28
JP2020075939A (ja) 2020-05-21
AU2016333963C1 (en) 2021-05-27
JOP20200230B1 (ar) 2024-04-18
EP3795566B1 (en) 2023-04-19
ZA202003662B (en) 2022-08-31
US10479775B1 (en) 2019-11-19
US20240417383A1 (en) 2024-12-19
IL275392A (en) 2020-07-30
JOP20200231B1 (ar) 2022-03-14
JP2018534355A (ja) 2018-11-22
CN108349904B (zh) 2021-08-31
AU2019283837B2 (en) 2020-12-24
ES2988059T3 (es) 2024-11-19
EA037371B1 (ru) 2021-03-19
ES2949852T3 (es) 2023-10-03
CN113024467A (zh) 2021-06-25
IL275387B (en) 2021-08-31
MA52098A (fr) 2021-01-27
JP6866514B2 (ja) 2021-04-28
AU2016333963B2 (en) 2021-01-07
US20190337920A1 (en) 2019-11-07
AU2020281069A1 (en) 2021-01-07
US20190084958A1 (en) 2019-03-21
US20230373948A1 (en) 2023-11-23
KR102667386B1 (ko) 2024-05-21
MX2020011099A (es) 2022-05-23
MY203081A (en) 2024-06-07
ZA202003664B (en) 2022-08-31
CN113024467B (zh) 2024-08-06
ES2906379T3 (es) 2022-04-18
JOP20200231A1 (ar) 2022-10-30
MA52648A (fr) 2021-10-13
EP3770146A1 (en) 2021-01-27
US20210253549A1 (en) 2021-08-19
WO2017062468A1 (en) 2017-04-13

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