ES2949852T3 - Agonistas de PPAR, compuestos, composiciones farmacéuticas y métodos de uso de los mismos - Google Patents

Agonistas de PPAR, compuestos, composiciones farmacéuticas y métodos de uso de los mismos Download PDF

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Publication number
ES2949852T3
ES2949852T3 ES20193962T ES20193962T ES2949852T3 ES 2949852 T3 ES2949852 T3 ES 2949852T3 ES 20193962 T ES20193962 T ES 20193962T ES 20193962 T ES20193962 T ES 20193962T ES 2949852 T3 ES2949852 T3 ES 2949852T3
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ES
Spain
Prior art keywords
methyl
compound
mmol
pharmaceutically acceptable
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES20193962T
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English (en)
Spanish (es)
Inventor
Michael Downes
Ronald Evans
Arthur Kluge
Bharat Lagu
Masanori Miura
Sunil Panigrahi
Michael Patane
Susanta Samajdar
Ramesh Senaiar
Taisuke Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Mitobridge Inc
Original Assignee
Salk Institute for Biological Studies
Mitobridge Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57200096&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2949852(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Salk Institute for Biological Studies, Mitobridge Inc filed Critical Salk Institute for Biological Studies
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Publication of ES2949852T3 publication Critical patent/ES2949852T3/es
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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES20193962T 2015-10-07 2016-10-05 Agonistas de PPAR, compuestos, composiciones farmacéuticas y métodos de uso de los mismos Active ES2949852T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562238629P 2015-10-07 2015-10-07
US201562243263P 2015-10-19 2015-10-19
US201662352348P 2016-06-20 2016-06-20

Publications (1)

Publication Number Publication Date
ES2949852T3 true ES2949852T3 (es) 2023-10-03

Family

ID=57200096

Family Applications (3)

Application Number Title Priority Date Filing Date
ES20193962T Active ES2949852T3 (es) 2015-10-07 2016-10-05 Agonistas de PPAR, compuestos, composiciones farmacéuticas y métodos de uso de los mismos
ES16785611T Active ES2906379T3 (es) 2015-10-07 2016-10-05 Agonistas de PPAR, compuestos, composiciones farmacéuticas y métodos de uso de los mismos
ES20193960T Active ES2988059T3 (es) 2015-10-07 2016-10-05 Agonistas de PPAR, compuestos, composiciones farmacéuticas y métodos de uso de los mismos

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES16785611T Active ES2906379T3 (es) 2015-10-07 2016-10-05 Agonistas de PPAR, compuestos, composiciones farmacéuticas y métodos de uso de los mismos
ES20193960T Active ES2988059T3 (es) 2015-10-07 2016-10-05 Agonistas de PPAR, compuestos, composiciones farmacéuticas y métodos de uso de los mismos

Country Status (26)

Country Link
US (6) US10399958B2 (enExample)
EP (3) EP3770146B1 (enExample)
JP (2) JP6657413B2 (enExample)
KR (2) KR102667385B1 (enExample)
CN (3) CN108349904B (enExample)
AU (3) AU2016333963C1 (enExample)
BR (1) BR112018006866B1 (enExample)
CA (1) CA3000431A1 (enExample)
CO (1) CO2018004473A2 (enExample)
DK (1) DK3359528T3 (enExample)
EA (1) EA037371B1 (enExample)
ES (3) ES2949852T3 (enExample)
HU (1) HUE058154T2 (enExample)
IL (3) IL258225B (enExample)
JO (3) JO3738B1 (enExample)
MA (2) MA52098A (enExample)
MX (3) MX380281B (enExample)
MY (1) MY203081A (enExample)
PH (1) PH12018500762A1 (enExample)
PL (1) PL3359528T3 (enExample)
PT (1) PT3359528T (enExample)
SG (1) SG10201906400SA (enExample)
TW (3) TWI730408B (enExample)
UA (1) UA122237C2 (enExample)
WO (1) WO2017062468A1 (enExample)
ZA (4) ZA201802029B (enExample)

Families Citing this family (11)

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WO2017062468A1 (en) 2015-10-07 2017-04-13 Mitobridge, Inc. Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
WO2017180818A1 (en) 2016-04-13 2017-10-19 Mitobridge, Inc. Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
JOP20190039B1 (ar) 2016-10-05 2023-03-28 Mitobridge Inc أشكال بلورية وملحية لمركبات مساعدة لمستقبل منشط لناشر لجسيمات تأكسدية ppar
CN109789117B (zh) * 2016-10-05 2022-08-23 米托布里奇公司 治疗急性肾损伤的方法
WO2021046081A1 (en) * 2019-09-05 2021-03-11 Rush University Medical Center Methods and compositions for treatment of demyelinating disorders
US11634387B2 (en) 2019-09-26 2023-04-25 Abionyx Pharma Sa Compounds useful for treating liver diseases
WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases
KR20240037940A (ko) 2021-06-02 2024-03-22 아스테라스 세이야쿠 가부시키가이샤 Ppar 작용제 화합물의 사용 방법 및 이의 약학 조성물
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease
EP4230196A1 (en) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Compounds for use in the treatment of dystrophinopathies
WO2025207099A1 (en) 2024-03-28 2025-10-02 Astellas Pharma Inc. Ppar-delta inhibitors for preventing post-operative atrial fibrillation

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WO2017062468A1 (en) 2015-10-07 2017-04-13 Mitobridge, Inc. Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
WO2017180818A1 (en) 2016-04-13 2017-10-19 Mitobridge, Inc. Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
CN109789117B (zh) 2016-10-05 2022-08-23 米托布里奇公司 治疗急性肾损伤的方法
JOP20190039B1 (ar) * 2016-10-05 2023-03-28 Mitobridge Inc أشكال بلورية وملحية لمركبات مساعدة لمستقبل منشط لناشر لجسيمات تأكسدية ppar
JOP20190115B1 (ar) * 2016-12-30 2023-09-17 Mitobridge Inc مثبّطات إنزيم بولي (adp-ريبوز) بوليمراز (parp)

Also Published As

Publication number Publication date
CN108349904B (zh) 2021-08-31
US20210253549A1 (en) 2021-08-19
KR20180095797A (ko) 2018-08-28
AU2019283837B2 (en) 2020-12-24
US10399958B2 (en) 2019-09-03
TWI730408B (zh) 2021-06-11
EP3770146B1 (en) 2024-07-24
MA52648A (fr) 2021-10-13
NZ740846A (en) 2024-12-20
MX2020011100A (es) 2022-05-23
JP2018534355A (ja) 2018-11-22
ES2906379T3 (es) 2022-04-18
ZA202003663B (en) 2022-08-31
AU2016333963B2 (en) 2021-01-07
AU2016333963C1 (en) 2021-05-27
CN113004205A (zh) 2021-06-22
JOP20200231A1 (ar) 2022-10-30
PL3359528T3 (pl) 2022-05-30
US20240417383A1 (en) 2024-12-19
MA52098A (fr) 2021-01-27
WO2017062468A1 (en) 2017-04-13
US20190337920A1 (en) 2019-11-07
KR102667386B1 (ko) 2024-05-21
MX2020011099A (es) 2022-05-23
AU2020281069B2 (en) 2022-10-27
CN113024467B (zh) 2024-08-06
US10906885B2 (en) 2021-02-02
EP3795566B1 (en) 2023-04-19
BR112018006866A2 (pt) 2018-10-16
PH12018500762A1 (en) 2018-10-29
TWI742479B (zh) 2021-10-11
TW201722919A (zh) 2017-07-01
TW201943705A (zh) 2019-11-16
CN108349904A (zh) 2018-07-31
EP3770146C0 (en) 2024-07-24
IL275392A (en) 2020-07-30
MX380281B (es) 2025-03-12
CN113004205B (zh) 2024-07-02
JO3738B1 (ar) 2021-01-31
IL275387B (en) 2021-08-31
JP2020075939A (ja) 2020-05-21
AU2020281069A1 (en) 2021-01-07
ES2988059T3 (es) 2024-11-19
WO2017062468A8 (en) 2017-05-11
KR102667385B1 (ko) 2024-05-21
EP3795566A1 (en) 2021-03-24
TW202012375A (zh) 2020-04-01
HK1257907A1 (zh) 2019-11-01
AU2016333963A1 (en) 2018-04-12
BR112018006866B1 (pt) 2023-11-21
JP6657413B2 (ja) 2020-03-04
EP3359528A1 (en) 2018-08-15
EP3770146A1 (en) 2021-01-27
US11578052B2 (en) 2023-02-14
MX2018004295A (es) 2018-08-09
IL258225A (en) 2018-05-31
IL275392B (en) 2022-05-01
US20230373948A1 (en) 2023-11-23
AU2019283837A1 (en) 2020-01-16
PT3359528T (pt) 2022-04-07
SG10201906400SA (en) 2019-08-27
CA3000431A1 (en) 2017-04-13
UA122237C2 (uk) 2020-10-12
JP6866514B2 (ja) 2021-04-28
CO2018004473A2 (es) 2018-09-20
IL258225B (en) 2021-08-31
EA201890776A1 (ru) 2018-09-28
MX392524B (es) 2025-03-24
EP3359528B1 (en) 2022-01-12
CN113024467A (zh) 2021-06-25
EA037371B1 (ru) 2021-03-19
US20200157074A1 (en) 2020-05-21
DK3359528T3 (en) 2022-03-07
US10479775B1 (en) 2019-11-19
HUE058154T2 (hu) 2022-07-28
ZA202003662B (en) 2022-08-31
ZA201802029B (en) 2022-01-26
JOP20200230A1 (ar) 2022-10-30
ZA202003664B (en) 2022-08-31
US20190084958A1 (en) 2019-03-21
IL275387A (en) 2020-07-30
TWI730006B (zh) 2021-06-11
MX392523B (es) 2025-03-24
KR20210126150A (ko) 2021-10-19
MY203081A (en) 2024-06-07

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