HK1257907A1 - Ppar激動劑、化合物、藥物組合物及其使用方法 - Google Patents

Ppar激動劑、化合物、藥物組合物及其使用方法

Info

Publication number
HK1257907A1
HK1257907A1 HK19100269.3A HK19100269A HK1257907A1 HK 1257907 A1 HK1257907 A1 HK 1257907A1 HK 19100269 A HK19100269 A HK 19100269A HK 1257907 A1 HK1257907 A1 HK 1257907A1
Authority
HK
Hong Kong
Prior art keywords
compounds
methods
pharmaceutical compositions
ppar agonists
ppar
Prior art date
Application number
HK19100269.3A
Other languages
English (en)
Inventor
M‧唐斯
R‧M‧埃文斯
A‧克魯格
B‧拉古
三浦理憲
S‧K‧潘尼格拉西
M‧帕塔內
S‧薩瑪杰達爾
R‧瑟耐爾
高橋泰輔
Original Assignee
米托布裏奇公司
索爾克生物學研究所
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57200096&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1257907(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 米托布裏奇公司, 索爾克生物學研究所 filed Critical 米托布裏奇公司
Publication of HK1257907A1 publication Critical patent/HK1257907A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK19100269.3A 2015-10-07 2019-01-08 Ppar激動劑、化合物、藥物組合物及其使用方法 HK1257907A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562238629P 2015-10-07 2015-10-07
US201562243263P 2015-10-19 2015-10-19
US201662352348P 2016-06-20 2016-06-20
PCT/US2016/055521 WO2017062468A1 (en) 2015-10-07 2016-10-05 Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof

Publications (1)

Publication Number Publication Date
HK1257907A1 true HK1257907A1 (zh) 2019-11-01

Family

ID=57200096

Family Applications (1)

Application Number Title Priority Date Filing Date
HK19100269.3A HK1257907A1 (zh) 2015-10-07 2019-01-08 Ppar激動劑、化合物、藥物組合物及其使用方法

Country Status (26)

Country Link
US (5) US10399958B2 (zh)
EP (3) EP3770146A1 (zh)
JP (2) JP6657413B2 (zh)
KR (2) KR20210126150A (zh)
CN (3) CN113024467A (zh)
AU (3) AU2016333963C1 (zh)
BR (1) BR112018006866B1 (zh)
CA (1) CA3000431A1 (zh)
CO (1) CO2018004473A2 (zh)
DK (1) DK3359528T3 (zh)
EA (1) EA037371B1 (zh)
ES (2) ES2906379T3 (zh)
HK (1) HK1257907A1 (zh)
HU (1) HUE058154T2 (zh)
IL (3) IL258225B (zh)
JO (3) JO3738B1 (zh)
MA (2) MA52648A (zh)
MX (2) MX2020011099A (zh)
PH (1) PH12018500762A1 (zh)
PL (1) PL3359528T3 (zh)
PT (1) PT3359528T (zh)
SG (1) SG10201906400SA (zh)
TW (3) TWI730408B (zh)
UA (1) UA122237C2 (zh)
WO (1) WO2017062468A1 (zh)
ZA (4) ZA201802029B (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3359528T3 (en) 2015-10-07 2022-03-07 Mitobridge Inc Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
KR102430906B1 (ko) 2016-04-13 2022-08-10 미토브리지, 인크. Ppar 효능제, 화합물, 제약 조성물, 및 그의 사용 방법
US20210283116A1 (en) * 2016-10-05 2021-09-16 Mitobridge, Inc. Methods of treating acute kidney injury
PL3523283T3 (pl) * 2016-10-05 2021-12-13 Mitobridge, Inc. Postacie krystaliczne i postacie soli związków stanowiących agonistów ppar
US20220331267A1 (en) * 2019-09-05 2022-10-20 Rush University Medical Center Methods and compositions for treatment of demyelinating disorders
US11634387B2 (en) 2019-09-26 2023-04-25 Abionyx Pharma Sa Compounds useful for treating liver diseases
WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases
CA3221429A1 (en) 2021-06-02 2022-12-08 Astellas Pharma Inc. Methods of use of ppar agonist compounds and pharmaceutical compositions thereof
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease
EP4230196A1 (en) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Compounds for use in the treatment of dystrophinopathies

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228281A (en) 1977-09-23 1980-10-14 Ciba-Geigy Corporation Dicarboxylic acids containing triazine rings
DE4123341A1 (de) * 1991-07-15 1993-01-21 Thomae Gmbh Dr K Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9511694D0 (en) 1995-06-09 1995-08-02 Fujisawa Pharmaceutical Co Benzamide derivatives
AU773273B2 (en) 1999-02-26 2004-05-20 Bristol-Myers Squibb Company Novel sulfonamide compounds and uses thereof
GB9919413D0 (en) 1999-08-18 1999-10-20 Zeneca Ltd Chemical compounds
SK1732003A3 (en) 2000-08-17 2004-08-03 Pfizer Substituted imidazoles as TAFIa inhibitors
ES2342596T3 (es) * 2002-08-29 2010-07-09 MERCK SHARP & DOHME CORP. Indoles con actividad anti-diabetica.
WO2004031118A1 (ja) 2002-10-03 2004-04-15 Ono Pharmaceutical Co., Ltd. Ｌｐａ受容体拮抗剤
WO2004060367A1 (en) 2002-12-30 2004-07-22 Fujisawa Pharmaceutical Co., Ltd. Imidazole and triazole derivatives useful as selective cox-1 inhibitors
MXPA06003357A (es) 2003-09-26 2006-06-08 Japan Tobacco Inc Metodo para inhibir la produccion de lipoproteina remanente.
JP2008512364A (ja) 2004-09-06 2008-04-24 エフ．ホフマン−ラ ロシュ アーゲー ４−アミノメチルベンズアミジン誘導体及び第ＶＩＩａ因子阻害剤としてのその使用
WO2007028424A1 (en) 2005-02-15 2007-03-15 F. Hoffmann-La Roche Ag Amide derivatives as ppar activators
AU2006287521A1 (en) 2005-09-07 2007-03-15 Plexxikon, Inc. PPARactive compounds
CN101374835B (zh) 2006-01-30 2012-04-25 转化技术制药公司 作为PTPase抑制剂的取代的咪唑衍生物、组合物和使用方法
WO2007110237A2 (en) 2006-03-28 2007-10-04 Novartis Ag Amide derivatives and their application for the treatment of g protein related diseases
PL2014652T3 (pl) 2006-04-18 2015-02-27 Nippon Chemiphar Co Czynnik aktywujący receptor aktywowany przez proliferatory peroksysomów
DE102006023336A1 (de) 2006-05-18 2007-11-22 Merck Patent Gmbh 1,5-Diphenyl-pyrazole II
CN101085772A (zh) * 2006-06-07 2007-12-12 上海艾力斯医药科技有限公司 一类具有PPARγ激动剂活性的化合物及其应用
EP2128138A1 (en) 2007-01-29 2009-12-02 Takeda Pharmaceutical Company Limited Pyrazole compound
GB2460784A (en) 2007-03-07 2009-12-16 Dong A Pharmtech Co Ltd Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators,method of the same,and pharmaceutical composition
JP2008285452A (ja) 2007-05-21 2008-11-27 Ono Pharmaceut Co Ltd ＰＰＡＲα／γデュアルアゴニストおよび糖尿病治療薬を組み合わせてなる医薬
AU2008345009A1 (en) 2007-12-28 2009-07-09 The Salk Institute For Biological Studies Methods for enhancing muscle performance and tone
WO2014033088A1 (en) 2012-08-28 2014-03-06 Koc Universitesi Bone plate
JP2016520552A (ja) 2013-04-05 2016-07-14 ソーク インスティテュート フォー バイオロジカル スタディーズ Ｐｐａｒアゴニスト
ES2811087T3 (es) 2013-09-09 2021-03-10 Vtv Therapeutics Llc Uso de agonistas de PPAR-delta para tratar la atrofia muscular
WO2016057322A1 (en) 2014-10-08 2016-04-14 Salk Institute For Biological Studies Ppar agonists and methods of use thereof
US20170305894A1 (en) 2014-10-08 2017-10-26 Mitobridge, Inc. Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
DK3359528T3 (en) 2015-10-07 2022-03-07 Mitobridge Inc Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
KR102430906B1 (ko) 2016-04-13 2022-08-10 미토브리지, 인크. Ppar 효능제, 화합물, 제약 조성물, 및 그의 사용 방법
PL3523283T3 (pl) * 2016-10-05 2021-12-13 Mitobridge, Inc. Postacie krystaliczne i postacie soli związków stanowiących agonistów ppar
US20210283116A1 (en) 2016-10-05 2021-09-16 Mitobridge, Inc. Methods of treating acute kidney injury

Also Published As

Publication number Publication date
IL258225A (en) 2018-05-31
EP3359528B1 (en) 2022-01-12
US10906885B2 (en) 2021-02-02
IL275392B (en) 2022-05-01
JOP20200231A1 (ar) 2022-10-30
US20230373948A1 (en) 2023-11-23
IL258225B (en) 2021-08-31
UA122237C2 (uk) 2020-10-12
DK3359528T3 (en) 2022-03-07
JP6657413B2 (ja) 2020-03-04
TW201943705A (zh) 2019-11-16
EP3359528A1 (en) 2018-08-15
TWI742479B (zh) 2021-10-11
TWI730006B (zh) 2021-06-11
ES2949852T3 (es) 2023-10-03
US10399958B2 (en) 2019-09-03
AU2019283837A1 (en) 2020-01-16
PL3359528T3 (pl) 2022-05-30
CN113024467A (zh) 2021-06-25
US20190337920A1 (en) 2019-11-07
MA52098A (fr) 2021-01-27
EA037371B1 (ru) 2021-03-19
JOP20200230A1 (ar) 2022-10-30
SG10201906400SA (en) 2019-08-27
TWI730408B (zh) 2021-06-11
EA201890776A1 (ru) 2018-09-28
US10479775B1 (en) 2019-11-19
JP6866514B2 (ja) 2021-04-28
AU2016333963A1 (en) 2018-04-12
AU2016333963C1 (en) 2021-05-27
CN113004205A (zh) 2021-06-22
CO2018004473A2 (es) 2018-09-20
MA52648A (fr) 2021-10-13
BR112018006866A2 (pt) 2018-10-16
WO2017062468A1 (en) 2017-04-13
KR20180095797A (ko) 2018-08-28
EP3795566B1 (en) 2023-04-19
ZA202003663B (en) 2022-08-31
PH12018500762A1 (en) 2018-10-29
TW202012375A (zh) 2020-04-01
TW201722919A (zh) 2017-07-01
US11578052B2 (en) 2023-02-14
US20200157074A1 (en) 2020-05-21
MX2020011099A (es) 2022-05-23
ZA201802029B (en) 2022-01-26
JP2018534355A (ja) 2018-11-22
US20190084958A1 (en) 2019-03-21
CA3000431A1 (en) 2017-04-13
IL275387B (en) 2021-08-31
JP2020075939A (ja) 2020-05-21
AU2020281069B2 (en) 2022-10-27
US20210253549A1 (en) 2021-08-19
IL275392A (en) 2020-07-30
CN108349904B (zh) 2021-08-31
ES2906379T3 (es) 2022-04-18
AU2016333963B2 (en) 2021-01-07
ZA202003662B (en) 2022-08-31
EP3795566A1 (en) 2021-03-24
AU2020281069A1 (en) 2021-01-07
BR112018006866B1 (pt) 2023-11-21
ZA202003664B (en) 2022-08-31
WO2017062468A8 (en) 2017-05-11
JO3738B1 (ar) 2021-01-31
MX2020011100A (es) 2022-05-23
EP3770146A1 (en) 2021-01-27
AU2019283837B2 (en) 2020-12-24
CN108349904A (zh) 2018-07-31
KR20210126150A (ko) 2021-10-19
PT3359528T (pt) 2022-04-07
IL275387A (en) 2020-07-30
HUE058154T2 (hu) 2022-07-28

Similar Documents

Publication Publication Date Title
ZA202003662B (en) Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
HK1243999A1 (zh) 新型3-吲哚取代的衍生物、藥物組合物及使用方法
IL247062A0 (en) Heterocyclic compounds, their preparation and pharmaceutical preparations containing them
EP3139920A4 (en) Anti-viral compounds, pharmaceutical compositions, and methods of use thereof
HUE056172T2 (hu) Szelenoorganikus vegyületeket tartalmazó készítmények és eljárások alkalmazásukra
HK1259372A1 (zh) 治療化合物、其組合物及使用方法
EP3297640A4 (en) Pharmaceutical co-crystal composition and use thereof
HK1243354B (zh) 新穎碘伏組合物及其使用方法
HK1256674A1 (zh) 氘修飾的brigatinib衍生物、含有該化合物的藥物組合物及其用途
IL280690A (en) Pharmaceutical preparations that include DGLA and their use
EP3285758A4 (en) Co-crystal composition and its pharmaceutical use
RO130539B8 (ro) Compoziţie erbicidă, procedeu de preparare şi utilizarea acesteia
HK1258765A1 (zh) 治療性化合物、組合物和它們的使用方法
EP3151826A4 (en) Omega-3 compositions, dosage forms, and methods of use
EP3175851A4 (en) Use of butenylphthalide, usage method thereof and method for preparing same into pharmaceutical composition
HK1254738A1 (zh) 用於進行最小量潤滑的組合物及其用途
IL248578A0 (en) Quinzoline derivatives, pharmaceutical compounds containing them and their uses
IL247645A0 (en) Preparations of seleno-organic compounds and methods of using them
GB201408233D0 (en) Use of polyanionic composition
GB201720445D0 (en) Use of TRPV1 agonists
GB201620933D0 (en) Use of TRPV1 agonists
PL3061765T3 (pl) Pochodna protoescygeniny, sposób jej otrzymywania, zastosowanie i użycie w kompozycjach farmaceutycznych zawierających ten związek
GB201415969D0 (en) Pharmaceutical compositions comprising of hetero-bicyclic derivatives, and methods of use thereof
TH149389B (th) องค์ประกอบสารเคลือบใส กระบวนการสำหรับการเตรียมและการใช้