EP3450460A4 - Multi-specific binding conjugate, related pharmaceutical compositions and use - Google Patents

Multi-specific binding conjugate, related pharmaceutical compositions and use Download PDF

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Publication number
EP3450460A4
EP3450460A4 EP16900170.8A EP16900170A EP3450460A4 EP 3450460 A4 EP3450460 A4 EP 3450460A4 EP 16900170 A EP16900170 A EP 16900170A EP 3450460 A4 EP3450460 A4 EP 3450460A4
Authority
EP
European Patent Office
Prior art keywords
pharmaceutical compositions
specific binding
related pharmaceutical
binding conjugate
conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16900170.8A
Other languages
German (de)
French (fr)
Other versions
EP3450460C0 (en
EP3450460A1 (en
EP3450460B1 (en
Inventor
Haoyang Yu
Zhengcheng LI
Jing Su
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Benhealth Biopharmaceutic (shenzhen) Co Ltd
Original Assignee
Benhealth Biopharmaceutic (shenzhen) Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Benhealth Biopharmaceutic (shenzhen) Co Ltd filed Critical Benhealth Biopharmaceutic (shenzhen) Co Ltd
Priority to EP23181122.5A priority Critical patent/EP4245775A3/en
Publication of EP3450460A1 publication Critical patent/EP3450460A1/en
Publication of EP3450460A4 publication Critical patent/EP3450460A4/en
Application granted granted Critical
Publication of EP3450460C0 publication Critical patent/EP3450460C0/en
Publication of EP3450460B1 publication Critical patent/EP3450460B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
EP16900170.8A 2016-04-29 2016-10-13 Multi-specific binding conjugate, related pharmaceutical compositions and use Active EP3450460B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP23181122.5A EP4245775A3 (en) 2016-04-29 2016-10-13 Multi-specific binding conjugate, related pharmaceutical compositions and use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2016080749 2016-04-29
PCT/CN2016/101984 WO2017185662A1 (en) 2016-04-29 2016-10-13 Multi-specific binding conjugate, related pharmaceutical compositions and use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP23181122.5A Division EP4245775A3 (en) 2016-04-29 2016-10-13 Multi-specific binding conjugate, related pharmaceutical compositions and use

Publications (4)

Publication Number Publication Date
EP3450460A1 EP3450460A1 (en) 2019-03-06
EP3450460A4 true EP3450460A4 (en) 2019-12-25
EP3450460C0 EP3450460C0 (en) 2023-07-12
EP3450460B1 EP3450460B1 (en) 2023-07-12

Family

ID=60161787

Family Applications (2)

Application Number Title Priority Date Filing Date
EP23181122.5A Pending EP4245775A3 (en) 2016-04-29 2016-10-13 Multi-specific binding conjugate, related pharmaceutical compositions and use
EP16900170.8A Active EP3450460B1 (en) 2016-04-29 2016-10-13 Multi-specific binding conjugate, related pharmaceutical compositions and use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP23181122.5A Pending EP4245775A3 (en) 2016-04-29 2016-10-13 Multi-specific binding conjugate, related pharmaceutical compositions and use

Country Status (3)

Country Link
EP (2) EP4245775A3 (en)
CN (1) CN109195992A (en)
WO (1) WO2017185662A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11525009B2 (en) 2016-06-22 2022-12-13 Benhealth Biopharmaceutic (Shenzhen) Co. Ltd. Bispecific antibody and antibody conjugate for tumor therapy and use thereof
WO2018058111A1 (en) * 2016-09-26 2018-03-29 The Brigham And Women's Hospital, Inc. Regulators of b cell-mediated immunosuppression
CN110382550A (en) * 2017-01-24 2019-10-25 本康生物制药（深圳）有限公司 Antibody coupling matter, relevant pharmaceutical composition and application
WO2018166527A1 (en) * 2017-03-17 2018-09-20 本康生物制药（深圳）有限公司 Multispecific antibody, antibody conjugate and related pharmaceutical composition and use
US12077586B2 (en) 2018-09-19 2024-09-03 LAVA Therapeutics N.V. Bispecific antibodies for use in the treatment of hematological malignancies
US20220185903A1 (en) * 2019-03-04 2022-06-16 Nantong Yichen Biopharma. Co. Ltd. Novel bispecific binding molecule and drug conjugate thereof
CN113125730B (en) * 2019-12-31 2023-07-07 科美博阳诊断技术(上海)有限公司 Homogeneous detection kit for interleukin 6 and application thereof
CN113125732B (en) * 2019-12-31 2023-08-08 科美博阳诊断技术(上海)有限公司 Homogeneous detection kit for interleukin 6 and application thereof
GB202011993D0 (en) 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies
WO2022036495A1 (en) 2020-08-17 2022-02-24 Utc Therapeutics Inc. Lymphocytes-antigen presenting cells co-stimulators and uses thereof
WO2023079142A2 (en) 2021-11-05 2023-05-11 Targimmune Therapeutics Ag Targeted linear conjugates comprising polyethyleneimine and polyethylene glycol and polyplexes comprising the same
CN114047336A (en) * 2021-12-13 2022-02-15 大连医科大学 Biomarker for assisting in diagnosing recurrent abortion and application thereof
WO2024100044A1 (en) 2022-11-07 2024-05-16 Targimmune Therapeutics Ag Polyplexes of nucleic acids and targeted conjugates comprising polyethyleneimine and polyethylene glycol
WO2024100046A1 (en) 2022-11-07 2024-05-16 Targimmune Therapeutics Ag Targeted linear conjugates comprising polyethyleneimine and polyethylene glycol and polyplexes comprising the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104829730A (en) * 2015-04-14 2015-08-12 苏静 Bispecific antibody capable of combining immune cells to enhance tumor killing ability, preparation method and applications thereof
WO2017219974A1 (en) * 2016-06-22 2017-12-28 本康生物制药（深圳）有限公司 Bispecific antibody and antibody conjugate for tumour therapy and use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69030172T2 (en) 1990-01-26 1997-06-19 Immunomedics Inc Vaccines against cancer and infectious diseases
ES2565543T3 (en) * 2005-01-24 2016-04-05 Board Of Regents, The University Of Texas System Fc fusion constructs to phosphatidylserine binding and its therapeutic use
CN103936859A (en) * 2005-03-03 2014-07-23 免疫医疗公司 Humanized L243 antibodies
CN101534865A (en) * 2005-10-19 2009-09-16 Ibc药品公司 Methods and compositions for generating bioactive assemblies of increased complexity and uses
US7910702B2 (en) 2006-07-28 2011-03-22 The Governors Of The University Of Alberta Recombinant antibodies to sclerotinia antigens
EP4083072A1 (en) * 2008-10-06 2022-11-02 Minerva Biotechnologies Corporation Muc1* antibodies
WO2013090293A1 (en) * 2011-12-15 2013-06-20 The University Of Chicago Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors
JP6571527B2 (en) * 2012-11-21 2019-09-04 ウーハン ワイゼットワイ バイオファルマ カンパニー リミテッドＷｕｈａｎ Ｙｚｙ Ｂｉｏｐｈａｒｍａ Ｃｏ．， Ｌｔｄ． Bispecific antibody
CA2899577C (en) * 2013-04-03 2023-10-17 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104829730A (en) * 2015-04-14 2015-08-12 苏静 Bispecific antibody capable of combining immune cells to enhance tumor killing ability, preparation method and applications thereof
WO2017219974A1 (en) * 2016-06-22 2017-12-28 本康生物制药（深圳）有限公司 Bispecific antibody and antibody conjugate for tumour therapy and use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GLORIUS P. ET AL: "The novel tribody [(CD20)2xCD16] efficiently triggers effector cell-mediated lysis of malignant B cells", LEUKEMIA, vol. 27, no. 1, 4 June 2012 (2012-06-04), pages 190 - 201, XP055268824 *
KELLNER C. ET AL: "Heterodimeric bispecific antibody-derivatives against CD19 and CD16 induce effective antibody-dependent cellular cytotoxicity against B-lymphoid tumor cells", CANCER LETTERS, vol. 303, no. 2, 28 April 2011 (2011-04-28), pages 128 - 139, XP055311969 *
SCHLENZKA J. ET AL.: "Combined effect of recombinant CD19xCD16 diabody and thalidomide in a preclinical model of human B-cell lymphoma", ANTI-CANCER DRUGS, vol. 15, October 2004 (2004-10-01), pages 915 - 919, XP002795673 *

Also Published As

Publication number Publication date
EP3450460C0 (en) 2023-07-12
EP4245775A2 (en) 2023-09-20
WO2017185662A1 (en) 2017-11-02
EP4245775A3 (en) 2023-11-15
EP3450460A1 (en) 2019-03-06
EP3450460B1 (en) 2023-07-12
CN109195992A (en) 2019-01-11

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