MA32271B1 - Composes inhibiteurs de kinases raf et procedes d'utilisation - Google Patents
Composes inhibiteurs de kinases raf et procedes d'utilisationInfo
- Publication number
- MA32271B1 MA32271B1 MA33202A MA33202A MA32271B1 MA 32271 B1 MA32271 B1 MA 32271B1 MA 33202 A MA33202 A MA 33202A MA 33202 A MA33202 A MA 33202A MA 32271 B1 MA32271 B1 MA 32271B1
- Authority
- MA
- Morocco
- Prior art keywords
- methods
- reg
- inhibitory compounds
- kinase inhibitory
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Des composés de formule i sont utiles pour inhiber des kinases raf. La présente invention concerne des procédés d'utilisation de composés de formule i, ainsi que des stéréo-isomères, des tautomères, des promédicaments, et des sels pharmaceutiquement acceptables de ceux-ci, en vue du diagnostic, de la prévention, ou du traitement, in vitro, in situ, et in vivo, de ces troubles dans les cellules de mammifères. La présente invention concerne également des conditions pathologiques associées.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3283908P | 2008-02-29 | 2008-02-29 | |
| PCT/US2009/035380 WO2009111278A2 (fr) | 2008-02-29 | 2009-02-27 | Composés inhibiteurs de kinases raf et procédés d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA32271B1 true MA32271B1 (fr) | 2011-05-02 |
Family
ID=40935896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA33202A MA32271B1 (fr) | 2008-02-29 | 2010-09-24 | Composes inhibiteurs de kinases raf et procedes d'utilisation |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8338452B2 (fr) |
| EP (1) | EP2265608A2 (fr) |
| JP (1) | JP2011513330A (fr) |
| KR (1) | KR20100122505A (fr) |
| CN (1) | CN102015707A (fr) |
| AR (1) | AR070535A1 (fr) |
| AU (1) | AU2009222143A1 (fr) |
| CA (1) | CA2716951A1 (fr) |
| CL (1) | CL2009000447A1 (fr) |
| EC (1) | ECSP10010510A (fr) |
| IL (1) | IL207843A0 (fr) |
| MA (1) | MA32271B1 (fr) |
| MX (1) | MX2010009410A (fr) |
| PE (1) | PE20091561A1 (fr) |
| TW (1) | TW200940540A (fr) |
| WO (1) | WO2009111278A2 (fr) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008063888A2 (fr) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Composés modulant l'activité de c-fms et/ou de c-kit et utilisations associées |
| MX2010000617A (es) | 2007-07-17 | 2010-05-17 | Plexxikon Inc | Compuestos y metodos para modulacion de cinasa, e indicaciones de estos. |
| US20110003859A1 (en) * | 2008-02-29 | 2011-01-06 | Array Biopharma Inc. | N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer |
| JP2011513329A (ja) * | 2008-02-29 | 2011-04-28 | アレイ バイオファーマ、インコーポレイテッド | RAF阻害化合物として使用されるイミダゾ[4,5−b]ピリジン誘導体 |
| CL2009000448A1 (es) * | 2008-02-29 | 2009-11-27 | Genentech Inc | Compuestos derivados de 3-sulfonilamino-n-(1h-pirazolo-[3,4-b]piridin-5il)benzamida; procesos de preparacion; compuestos intermediarios; composicion farmaceutica; y uso para el tratamiento del cancer, tal como sarcoma, carcinoma, adenoma, entre otros. |
| FR2941948B1 (fr) * | 2009-02-12 | 2013-04-05 | Nova Decision | Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src |
| EA031116B1 (ru) | 2009-04-03 | 2018-11-30 | Ф. Хоффманн-Ля Рош Аг | КРИСТАЛЛИЧЕСКИЕ ПОЛИМОРФНЫЕ ФОРМЫ {3-[5-(4-ХЛОРФЕНИЛ)-1H-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| UA105813C2 (uk) | 2009-11-06 | 2014-06-25 | Плексікон, Інк. | Сполуки-інгібітори кіназ та фармацевтична композиція (варіанти) |
| PL2672967T3 (pl) | 2011-02-07 | 2019-04-30 | Plexxikon Inc | Związki i sposoby modulacji kinaz i wskazania ku temu |
| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
| EA026924B1 (ru) | 2011-08-01 | 2017-05-31 | Дженентек, Инк. | Способы лечения рака с использованием антагонистов, связывающихся с осью pd-1, и ингибиторов mek |
| US20130078252A1 (en) | 2011-09-19 | 2013-03-28 | Genentech, Inc. | Combination treatments comprising c-met antagonists and b-raf antagonists |
| CA2887928A1 (fr) | 2011-10-31 | 2013-10-10 | The Methodist Hospital Research Institute | Compose comprenant un fragment de ciblage/recherche de mao pour le traitement de gliomes humains |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| SI2884979T1 (sl) | 2012-08-17 | 2019-10-30 | Hoffmann La Roche | Kombinirana zdravljenja melanoma, ki vključujejo dajanje kobimetiniba in vemurafeniba |
| FR3000494B1 (fr) * | 2012-12-28 | 2015-08-21 | Oribase Pharma | Nouveaux derives d'azaindoles en tant qu'inhibiteurs de proteines kinases |
| FR3000493A1 (fr) * | 2012-12-28 | 2014-07-04 | Oribase Pharma | Nouveaux inhibiteurs de proteines kinases |
| FR3000492B1 (fr) * | 2012-12-28 | 2015-09-11 | Oribase Pharma | Nouveaux derives azaindole en tant qu'inhibiteurs multikinases |
| EP2958592A1 (fr) | 2013-02-22 | 2015-12-30 | F. Hoffmann-La Roche AG | Méthodes de traitement du cancer et de prévention de résistance aux médicaments |
| CN105339001A (zh) | 2013-03-15 | 2016-02-17 | 基因泰克公司 | 治疗癌症和预防癌症耐药性的方法 |
| KR20160013028A (ko) * | 2013-05-30 | 2016-02-03 | 플렉시콘, 인코퍼레이티드 | 키나제 조정을 위한 화합물 및 그에 대한 적응증 |
| LT3027603T (lt) * | 2013-08-02 | 2018-08-10 | Pfizer Inc. | Heterobicikloarilo rorc2 inhibitoriai ir jų panaudojimo būdai |
| CN107073121A (zh) | 2014-06-13 | 2017-08-18 | 基因泰克公司 | 治疗及预防癌症药物抗性的方法 |
| WO2015196072A2 (fr) | 2014-06-19 | 2015-12-23 | Whitehead Institute For Biomedical Research | Utilisations d'inhibiteurs de kinase pour l'induction et le maintien de la pluripotence |
| EP3563870A1 (fr) | 2014-07-15 | 2019-11-06 | F. Hoffmann-La Roche AG | Procédés de traitement du cancer au moyen d'antagonistes liant l'axe pd-1 et d'inhibiteurs de mek |
| MA40759A (fr) * | 2014-09-26 | 2017-08-01 | Pfizer | Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation |
| CN121154828A (zh) | 2015-11-19 | 2025-12-19 | 豪夫迈·罗氏有限公司 | 使用b-raf抑制剂和免疫检查点抑制剂治疗癌症的方法 |
| EP3579872A1 (fr) | 2017-02-10 | 2019-12-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés et compositions pharmaceutiques pour le traitement de cancers associés à l'activation de la voie mapk |
| EP3732285A1 (fr) | 2017-12-28 | 2020-11-04 | Tract Pharmaceuticals, Inc. | Systèmes de culture de cellules souches pour cellules souches épithéliales colonnaires, et leurs utilisations |
| BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
| CA3159348A1 (fr) | 2019-11-08 | 2021-05-14 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methodes pour le traitement de cancers qui ont acquis une resistance aux inhibiteurs de kinase |
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| WO2024229406A1 (fr) | 2023-05-04 | 2024-11-07 | Revolution Medicines, Inc. | Polythérapie pour une maladie ou un trouble lié à ras |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025073765A1 (fr) | 2023-10-03 | 2025-04-10 | Institut National de la Santé et de la Recherche Médicale | Méthodes de pronostic et de traitement de patients souffrant de mélanome |
| TW202530228A (zh) | 2023-10-12 | 2025-08-01 | 美商銳新醫藥公司 | Ras抑制劑 |
| WO2025171296A1 (fr) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Inhibiteurs de ras |
| TW202547461A (zh) | 2024-05-17 | 2025-12-16 | 美商銳新醫藥公司 | Ras抑制劑 |
| WO2025255438A1 (fr) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Procédés de traitement d'une maladie ou d'un trouble lié à la protéine ras |
| WO2025265060A1 (fr) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Compositions thérapeutiques et procédés de gestion d'effets liés au traitement |
| WO2026006747A1 (fr) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Inhibiteurs de ras |
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-
2009
- 2009-02-27 MX MX2010009410A patent/MX2010009410A/es not_active Application Discontinuation
- 2009-02-27 CL CL2009000447A patent/CL2009000447A1/es unknown
- 2009-02-27 KR KR1020107021628A patent/KR20100122505A/ko not_active Withdrawn
- 2009-02-27 JP JP2010548885A patent/JP2011513330A/ja not_active Withdrawn
- 2009-02-27 US US12/920,045 patent/US8338452B2/en not_active Expired - Fee Related
- 2009-02-27 AR ARP090100689A patent/AR070535A1/es unknown
- 2009-02-27 TW TW098106540A patent/TW200940540A/zh unknown
- 2009-02-27 PE PE2009000312A patent/PE20091561A1/es not_active Application Discontinuation
- 2009-02-27 CA CA2716951A patent/CA2716951A1/fr not_active Abandoned
- 2009-02-27 CN CN2009801154521A patent/CN102015707A/zh active Pending
- 2009-02-27 WO PCT/US2009/035380 patent/WO2009111278A2/fr not_active Ceased
- 2009-02-27 AU AU2009222143A patent/AU2009222143A1/en not_active Abandoned
- 2009-02-27 EP EP09716491A patent/EP2265608A2/fr not_active Withdrawn
-
2010
- 2010-08-29 IL IL207843A patent/IL207843A0/en unknown
- 2010-09-24 MA MA33202A patent/MA32271B1/fr unknown
- 2010-09-29 EC EC2010010510A patent/ECSP10010510A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP10010510A (es) | 2010-10-30 |
| JP2011513330A (ja) | 2011-04-28 |
| CN102015707A (zh) | 2011-04-13 |
| AU2009222143A1 (en) | 2009-09-11 |
| CA2716951A1 (fr) | 2009-09-11 |
| CL2009000447A1 (es) | 2010-01-04 |
| US8338452B2 (en) | 2012-12-25 |
| KR20100122505A (ko) | 2010-11-22 |
| US20110110889A1 (en) | 2011-05-12 |
| EP2265608A2 (fr) | 2010-12-29 |
| MX2010009410A (es) | 2010-11-30 |
| IL207843A0 (en) | 2010-12-30 |
| TW200940540A (en) | 2009-10-01 |
| AR070535A1 (es) | 2010-04-14 |
| PE20091561A1 (es) | 2009-10-30 |
| WO2009111278A2 (fr) | 2009-09-11 |
| WO2009111278A3 (fr) | 2010-07-15 |
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